Bcl2l12 (BCL2 like 12) - Rat Genome Database

Name: Bcl2l12
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Bcl2l12 (BCL2 like 12) Chinchilla lanigera

Analyze

Symbol:

Bcl2l12

Name:

BCL2 like 12

RGD ID:

8817316

Description:

ENCODES a protein that exhibits p53 binding (ortholog); INVOLVED IN negative regulation of cellular senescence (ortholog); negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH developmental and epileptic encephalopathy 12 (ortholog); genetic disease (ortholog); melanoma (ortholog); FOUND IN nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

bcl-2-like protein 12; BCL2-like 12 (proline rich)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	BCL2L12 (BCL2 like 12)	NCBI	Ortholog
Mus musculus (house mouse):	Bcl2l12 (BCL2 like 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Bcl2l12 (Bcl2 like 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	BCL2L12 (BCL2 like 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	BCL2L12 (BCL2 like 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Bcl2l12 (BCL2 like 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	BCL2L12 (BCL2 like 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	BCL2L12 (BCL2 like 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Bcl2l12 (BCL2 like 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955559	1,217,809 - 1,224,875 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955559	1,217,797 - 1,224,875 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

developmental and epileptic encephalopathy 12 (ISO)

genetic disease (ISO)

melanoma (ISO)

skin melanoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of cellular senescence (ISO)

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

Cellular Component

nucleus (ISO)

Molecular Function

p53 binding (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Bcl2l12
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955559	1,217,809 - 1,224,875 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955559	1,217,797 - 1,224,875 (-)	NCBI	ChiLan1.0	ChiLan1.0

BCL2L12
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	49,665,142 - 49,673,916 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	49,665,142 - 49,673,916 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	50,168,399 - 50,177,173 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	54,860,211 - 54,868,985 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	19	47,037,733 - 47,046,507 (+)	NCBI		Celera
Cytogenetic Map	19	q13.33	NCBI
HuRef	19	46,545,171 - 46,553,945 (+)	NCBI		HuRef
CHM1_1	19	50,170,188 - 50,178,962 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	52,665,212 - 52,673,986 (+)	NCBI		T2T-CHM13v2.0

Bcl2l12
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	44,640,646 - 44,647,011 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	44,640,646 - 44,648,136 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	44,991,222 - 44,997,638 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	44,991,222 - 44,998,712 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	52,246,592 - 52,252,949 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	44,859,267 - 44,865,621 (-)	NCBI		MGSCv36	mm8
Celera	7	40,442,782 - 40,449,139 (-)	NCBI		Celera
Cytogenetic Map	7	B3	NCBI
cM Map	7	29.07	NCBI

Bcl2l12
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	104,608,753 - 104,617,472 (-)	NCBI		GRCr8
mRatBN7.2	1	95,472,272 - 95,480,991 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	95,472,272 - 95,480,991 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	100,857,672 - 100,866,391 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	109,330,338 - 109,339,057 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	102,620,731 - 102,629,450 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	100,984,550 - 100,993,269 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	100,984,550 - 100,993,269 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	102,048,990 - 102,057,872 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	95,462,429 - 95,471,148 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	95,541,167 - 95,547,485 (-)	NCBI
Celera	1	89,733,600 - 89,742,319 (-)	NCBI		Celera
Cytogenetic Map	1	q22	NCBI

BCL2L12
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	55,783,098 - 55,791,205 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	57,703,837 - 57,711,944 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	46,679,749 - 46,688,539 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	55,599,170 - 55,607,901 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

BCL2L12
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	106,865,346 - 106,873,329 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	106,449,262 - 106,456,965 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	107,386,929 - 107,394,627 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	107,387,031 - 107,393,829 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	107,059,171 - 107,066,863 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	106,701,245 - 106,708,951 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	107,542,142 - 107,550,072 (-)	NCBI		UU_Cfam_GSD_1.0

Bcl2l12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	21,864,314 - 21,870,478 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936664	3,482,595 - 3,488,663 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936664	3,482,562 - 3,488,663 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BCL2L12
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	54,707,237 - 54,715,127 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	54,706,453 - 54,715,127 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	50,436,162 - 50,443,172 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BCL2L12
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	42,841,391 - 42,849,207 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666073	22,785,894 - 22,793,788 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Bcl2l12
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624832	4,605,821 - 4,611,366 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624832	4,605,765 - 4,611,392 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013508948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01073636	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01073637	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01137503	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000006161 ⟹ ENSCLAP00000006058

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955559	1,217,809 - 1,224,875 (-)	Ensembl

RefSeq Acc Id:

ENSCLAT00000006162 ⟹ ENSCLAP00000006059

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955559	1,221,132 - 1,223,148 (-)	Ensembl

RefSeq Acc Id:

XM_013508948 ⟹ XP_013364402

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955559	1,217,797 - 1,224,875 (-)	NCBI

Sequence:

show sequence

ATGGTCCGGCCTGCGCGCACGGGGCGGTTCCTGGGCGCGGGCAGCCTTCTGGGCCCGCTCGCCC
GCCGCTCTCACACCGAGACCTCCCGCTCCCCAGCTACGGGGCAGGCCCTTCACCCGTGTTTTCC
AGGGCTGCAAACCCGGCCCCCCCGCCACGCTCCCGTCCTGAGAGGGCTGTCCATCTCCGGAGCT
GCCTCTCCTCCCTCCCCAAGTAACCCCACTTCCAGAACGGCCTCCTTCCCTAGCTATTTCAGCT
ATTTCCGCTGCCACTCCCCCGACCTCCAGCGCCCGCCAGCGCTGCTCGAGTACACAGCCTTCCT
CCGCAGCTACCAGTGCAGACCCATCCTTTCCCTCGATCCTCGCTCCGGGCGCCACCAGCTTGCC
CCAGCTCTTCCGCGTTACCTACCCTGGGAGCGTCGGGGCGCGCGGGAGCCCTGGGGCTTTCTTC
TCTATCGATTTTCCTGTGGTAAAATCAACTTTACCATCCTTTGGGTAAAAATTCAAAGGAAAAA
GGGGCGGTGCAAAGAACACTGGCCGCCCCTTCCATGCCCTTTTTTGAGCTTCCGACCACAGGCA
TGCTGGGAACGTCATATGCAAATTAGGCGGCACTACGCCCCGCCCTTTCTACCTTGGGGCGGTT
ACCAAATCGCCGCAGTGCGCAGGCGCGGGAAAGTTGAACTAATTAAGTTTGTAAAACGTGAGTG
GAGGCGGGGGCGGGGACGGCGGGGACGGCGACGGCGGGGACGGCGGCTGCGGCGGGGCCCTGCA
ACAGCTGCCTCCATGGCAGGCTCAGAAGAGCTGGGGCTCCGAGAGGACACGCTGAGGGTCCTAG
CTGCCTTTTTGAGGCGGGGTGAGGCTACCGGGTCCCTCCCCGCATCTCCACCCAGGAGTCCTGC
CCAAGTGGAGCCCACGGACTTCCTGAGCCGCCTTCGGAGATGTCTTCCCTGCCCGCTGGGCCGA
GGAGCTGTTCCTCCTGAGTCCTCTCGGCCTTGTTCCTTGCCCCTCCGCCCCTGCTATGGCTCAG
AACCTGGCCCAGCTACCCCTGACTTCTATGCCCTGGTGGCCCAGCGGCTGGAACAGCTGGTCCA
AGAGCAGCTGAGATCTCCACCCAGCCCAGAGTTGCAGGGCCCCCCACCCACGGAGAAGGAAGCC
CTGCTGCGGAGGCTGGTGGCCTTGCTGGAGGAGGAGGCAGAGGTCATCAACCAGAAGCTGGCGC
TGGACCCCGCCCTGCGCGGCAAGCTGGCCCGCCTGTCCACTGGCTCCTTTGCCCGCCTAGTGGA
GCTGTTCTCCAGCCGGGAGTGCAGCCCTGGCCCGAGACGCACCAGCCCTTCGCTGCCGTGCCCC
GGGCCCCCGCCGCCTTCCCCGGAGCCCCTGGCCCGCCTGGCCCTGGCTATGGAGCTGAGCCGGC
GTGTGGCCCGGCTGGGGGGCACCCTGGCCGGCCTCAGCGTGGAGCATGTGCACAGCTTCACACC
CTGGATCCAGGCCCAAGGGGGCTGGGAGGGCATCCTGGCCGCGTCCCCGGTGGACCTGAATTTA
CCCTTGGACTGAGCCGGTCATCAGAAGCTGCTACAAGCCTGGACCTCAAGCCCCACACTCTTCC
TTTGCCTTTCCAATTTTTCTTCCTCTACTCAGGGCTGTGGGGCGGTGGCTGCCCTACCTGATTG
CCAAAAGGAATTTGTCTTGAACTTTACATATTAAAGGCTTTTTAAAAAAGAGTATGTAAAAGAA
AAAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_013364402	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000006058.1
	ENSCLAP00000006059.1

RefSeq Acc Id:

XP_013364402 ⟸ XM_013508948

- Sequence:

show sequence

MVRPARTGRFLGAGSLLGPLARRSHTETSRSPATGQALHPCFPGLQTRPPRHAPVLRGLSISGA
ASPPSPSNPTSRTASFPSYFSYFRCHSPDLQRPPALLEYTAFLRSYQCRPILSLDPRSGRHQLA
PALPRYLPWERRGAREPWGFLLYRFSCGKINFTILWVKIQRKKGRCKEHWPPLPCPFLSFRPQA
CWERHMQIRRHYAPPFLPWGGYQIAAVRRRGKVELIKFVKREWRRGRGRRGRRRRGRRLRRGPA
TAASMAGSEELGLREDTLRVLAAFLRRGEATGSLPASPPRSPAQVEPTDFLSRLRRCLPCPLGR
GAVPPESSRPCSLPLRPCYGSEPGPATPDFYALVAQRLEQLVQEQLRSPPSPELQGPPPTEKEA
LLRRLVALLEEEAEVINQKLALDPALRGKLARLSTGSFARLVELFSSRECSPGPRRTSPSLPCP
GPPPPSPEPLARLALAMELSRRVARLGGTLAGLSVEHVHSFTPWIQAQGGWEGILAASPVDLNL
PLD

hide sequence

RefSeq Acc Id:

ENSCLAP00000006059 ⟸ ENSCLAT00000006162

RefSeq Acc Id:

ENSCLAP00000006058 ⟸ ENSCLAT00000006161

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000004288	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000006161.1	UniProtKB/TrEMBL
	ENSCLAT00000006162.1	UniProtKB/TrEMBL
InterPro	Bcl-2-like_sf	UniProtKB/TrEMBL
NCBI Gene	Bcl2l12	ENTREZGENE
PANTHER	BCL-2-LIKE PROTEIN 12	UniProtKB/TrEMBL
	SI:CH73-248E21.1	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56854	UniProtKB/TrEMBL
UniProt	A0A8C2YKU4_CHILA	UniProtKB/TrEMBL
	A0A8C2YKU9_CHILA	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Bcl2l12	BCL2 like 12		BCL2-like 12 (proline rich)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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