| 621248 | Acaca | acetyl-CoA carboxylase alpha | ENCODES a protein that exhibits acetyl-CoA carboxylase activity; biotin binding; kinase binding; INVOLVED IN fatty acid biosynthetic process; response to nutrient; response to nutrient levels; PARTICIPATES IN fatty acid biosynthetic pathway; Leigh disease pathway; malonic aciduria pathway; ASSOCIATE D WITH Hypertriglyceridemia; Insulin Resistance; metabolic dysfunction-associated steatohepatitis; FOUND IN cytosol (ortholog); INTERACTS WITH (-)-epigallocatechin 3-gallate; (R)-carnitine; (S)-nicotine | 10 | 69511627 | 69773888 | Rat | 670 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 736015 | ACACA | acetyl-CoA carboxylase alpha | Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alph a is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | 17 | 37084992 | 37406836 | Human | 687 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1552388 | Acaca | acetyl-Coenzyme A carboxylase alpha | Enables acetyl-CoA carboxylase activity. Involved in acetyl-CoA metabolic process; fatty acid biosynthetic process; and protein homotetramerization. Acts upstream of or within several processes, including cellular response to prostaglandin E stimulus; lipid homeostasis; and tissue homeostasis. Locat ed in cytosol. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human ACACA (acetyl-CoA carboxylase alpha). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 84020461 | 84292477 | Mouse | 695 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8829137 | Acaca | acetyl-CoA carboxylase alpha | ENCODES a protein that exhibits acetyl-CoA carboxylase activity (ortholog); biotin binding (ortholog); identical protein binding (ortholog); INVOLVED IN acetyl-CoA metabolic process (ortholog); cellular response to prostaglandin E stimulus (ortholog); fatty acid biosynthetic process (ortholog); PART ICIPATES IN fatty acid biosynthetic pathway; Leigh disease pathway; malonic aciduria pathway; ASSOCIATED WITH Acetyl-Coa Carboxylase Deficiency (ortholog); atherosclerosis (ortholog); congestive heart failure (ortholog); FOUND IN cytosol (ortholog) | NW_004955451 | 679033 | 909892 | Chinchilla | 64 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11996003 | ACACA | acetyl-CoA carboxylase alpha | ENCODES a protein that exhibits acetyl-CoA carboxylase activity (ortholog); biotin binding (ortholog); kinase binding (ortholog); INVOLVED IN cellular response to prostaglandin E stimulus (ortholog); fatty acid biosynthetic process (ortholog); lipid homeostasis (ortholog); PARTICIPATES IN fatty acid biosynthetic pathway; Leigh disease pathway; malonic aciduria pathway; ASSOCIATED WITH Acetyl-Coa Carboxylase Deficiency (ortholog); atherosclerosis (ortholog); congestive heart failure (ortholog); FOUND IN cytosol (ortholog) | 17 | 19670114 | 19998903 | Bonobo | 80 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12418463 | ACACA | acetyl-CoA carboxylase alpha | ENCODES a protein that exhibits acetyl-CoA carboxylase activity (ortholog); biotin binding (ortholog); kinase binding (ortholog); INVOLVED IN cellular response to prostaglandin E stimulus (ortholog); fatty acid biosynthetic process (ortholog); lipid homeostasis (ortholog); PARTICIPATES IN fatty acid biosynthetic pathway; Leigh disease pathway; malonic aciduria pathway; ASSOCIATED WITH Acetyl-Coa Carboxylase Deficiency (ortholog); atherosclerosis (ortholog); congestive heart failure (ortholog); FOUND IN cytosol (ortholog); INTERACTS WITH bisphenol A | 9 | 36904204 | 37188096 | Dog | 81 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12476512 | Acaca | acetyl-CoA carboxylase alpha | ENCODES a protein that exhibits acetyl-CoA carboxylase activity (ortholog); biotin binding (ortholog); kinase binding (ortholog); INVOLVED IN cellular response to prostaglandin E stimulus (ortholog); fatty acid biosynthetic process (ortholog); lipid homeostasis (ortholog); PARTICIPATES IN fatty acid biosynthetic pathway; Leigh disease pathway; malonic aciduria pathway; ASSOCIATED WITH Acetyl-Coa Carboxylase Deficiency (ortholog); atherosclerosis (ortholog); congestive heart failure (ortholog); FOUND IN cytosol (ortholog) | NW_004936490 | 927769 | 1191483 | Squirrel | 80 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626136403 | Acaca | acetyl-CoA carboxylase alpha | ENCODES a protein that exhibits acetyl-CoA carboxylase activity (ortholog); biotin binding (ortholog); identical protein binding (ortholog); INVOLVED IN acetyl-CoA metabolic process (ortholog); cellular response to prostaglandin E stimulus (ortholog); fatty acid biosynthetic process (ortholog); PART ICIPATES IN fatty acid biosynthetic pathway; Leigh disease pathway; malonic aciduria pathway; ASSOCIATED WITH Acetyl-Coa Carboxylase Deficiency (ortholog); atherosclerosis (ortholog); congestive heart failure (ortholog); FOUND IN cytosol (ortholog) | | | | Black Rat | 64 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18920036 | Acaca | acetyl-CoA carboxylase alpha | ENCODES a protein that exhibits acetyl-CoA carboxylase activity (ortholog); biotin binding (ortholog); identical protein binding (ortholog); INVOLVED IN acetyl-CoA metabolic process (ortholog); cellular response to prostaglandin E stimulus (ortholog); fatty acid biosynthetic process (ortholog); PART ICIPATES IN fatty acid biosynthetic pathway; Leigh disease pathway; malonic aciduria pathway; ASSOCIATED WITH Acetyl-Coa Carboxylase Deficiency (ortholog); atherosclerosis (ortholog); congestive heart failure (ortholog); FOUND IN cytosol (ortholog) | | | | Naked Mole-Rat | 79 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13873255 | ACACA | acetyl-CoA carboxylase alpha | ENCODES a protein that exhibits acetyl-CoA carboxylase activity (ortholog); biotin binding (ortholog); kinase binding (ortholog); INVOLVED IN cellular response to prostaglandin E stimulus (ortholog); fatty acid biosynthetic process (ortholog); lipid homeostasis (ortholog); PARTICIPATES IN fatty acid biosynthetic pathway; Leigh disease pathway; malonic aciduria pathway; ASSOCIATED WITH Acetyl-Coa Carboxylase Deficiency (ortholog); atherosclerosis (ortholog); congestive heart failure (ortholog); FOUND IN cytosol (ortholog); INTERACTS WITH 17beta-estradiol; aldehydo-D-glucose; D-glucose | | | | Pig | 90 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18726748 | ACACA | acetyl-CoA carboxylase alpha | ENCODES a protein that exhibits acetyl-CoA carboxylase activity (ortholog); biotin binding (ortholog); kinase binding (ortholog); INVOLVED IN cellular response to prostaglandin E stimulus (ortholog); fatty acid biosynthetic process (ortholog); lipid homeostasis (ortholog); PARTICIPATES IN fatty acid biosynthetic pathway; Leigh disease pathway; malonic aciduria pathway; ASSOCIATED WITH Acetyl-Coa Carboxylase Deficiency (ortholog); atherosclerosis (ortholog); congestive heart failure (ortholog); FOUND IN cytosol (ortholog) | | | | Green Monkey | 80 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155232524 | acaca | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155234576 | acaca.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155240977 | acaca.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 13461793 | LHX1-DT | LHX1 divergent transcript | INTERACTS WITH acrylamide; aflatoxin B1; Aflatoxin B2 alpha | 17 | 36861674 | 36936661 | Human | 11 | old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 3387 | Prkaa1 | protein kinase AMP-activated catalytic subunit alpha 1 | ENCODES a protein that exhibits AMP-activated protein kinase activity; ATP binding; kinase binding; INVOLVED IN cellular response to calcium ion; cellular response to ethanol; cellular response to glucose stimulus; PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pat hway; vascular endothelial growth factor signaling pathway; autophagy pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury; cholestasis; Diabetes Complications; FOUND IN apical plasma membrane; axon; cytoplasm; INTERACTS WITH (+)-schisandrin B; (R,R)-tramadol; 1,2,3,4,7,8-Hexachlorodibenzodioxin | 2 | 55967766 | 56003450 | Rat | 658 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 732865 | PRKAA1 | protein kinase AMP-activated catalytic subunit alpha 1 | The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase th e cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] | 5 | 40759389 | 40798374 | Human | 622 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1550489 | Prkaa1 | protein kinase, AMP-activated, alpha 1 catalytic subunit | Enables AMP-activated protein kinase activity; chromatin binding activity; and histone H2BS36 kinase activity. Involved in several processes, including negative regulation of TORC1 signaling; regulation of organelle organization; and regulation of primary metabolic process. Acts upstream of or withi n several processes, including cellular response to prostaglandin E stimulus; positive regulation of skeletal muscle tissue development; and regulation of macromolecule metabolic process. Located in several cellular components, including axon; dendrite; and neuronal cell body. Is active in chromatin. Is expressed in several structures, including brain; dorsal root ganglion; early conceptus; liver; and spinal cord. Human ortholog(s) of this gene implicated in Huntington's disease; breast cancer; and colon cancer. Orthologous to human PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2025] | 15 | 5172641 | 5211380 | Mouse | 704 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 13939165 | PRKAA1 | protein kinase AMP-activated catalytic subunit alpha 1 | ENCODES a protein that exhibits AMP-activated protein kinase activity (ortholog); ATP binding (ortholog); chromatin binding (ortholog); INVOLVED IN cellular response to ethanol (ortholog); cellular response to glucose starvation (ortholog); cellular response to hydrogen peroxide (ortholog); PARTICIP ATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; vascular endothelial growth factor signaling pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); amenorrhea (ortholog); breast cancer (ortholog); FOUND IN apical plasma membrane (ortholog); cytosol (ortholog); nucleotide-activated protein kinase complex (ortholog); INTERACTS WITH 17beta-estradiol; cadmium atom; cadmium dichloride | | | | Pig | 208 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 620893 | Prkaa2 | protein kinase AMP-activated catalytic subunit alpha 2 | ENCODES a protein that exhibits AMP-activated protein kinase activity; ATP binding; protein kinase activity; INVOLVED IN cellular response to calcium ion; cellular response to glucose stimulus; energy homeostasis; PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling path way; vascular endothelial growth factor signaling pathway; autophagy pathway; ASSOCIATED WITH Cardiac Fibrosis; Cardiotoxicity; Experimental Diabetes Mellitus; FOUND IN apical plasma membrane; axon; cytoplasm; INTERACTS WITH (+)-schisandrin B; (R,R)-tramadol; (S)-nicotine | 5 | 125036945 | 125109010 | Rat | 507 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 730888 | PRKAA2 | protein kinase AMP-activated catalytic subunit alpha 2 | The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008] | 1 | 56645314 | 56715335 | Human | 480 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 730889 | Prkaa2 | protein kinase, AMP-activated, alpha 2 catalytic subunit | Enables AMP-activated protein kinase activity; chromatin binding activity; and histone H2BS36 kinase activity. Involved in several processes, including regulation of autophagy; regulation of organelle organization; and regulation of protein modification process. Acts upstream of or within several pr ocesses, including cellular response to prostaglandin E stimulus; cellular response to xenobiotic stimulus; and response to muscle activity. Located in several cellular components, including cytoplasmic stress granule; dendrite; and neuronal cell body. Is active in cytosol. Is expressed in several structures, including brain; genitourinary system; gut; lung; and spinal cord. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2025] | 4 | 104886846 | 104967095 | Mouse | 550 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 13881774 | PRKAA2 | protein kinase AMP-activated catalytic subunit alpha 2 | ENCODES a protein that exhibits AMP-activated protein kinase activity (ortholog); ATP binding (ortholog); protein kinase activity (ortholog); INVOLVED IN cellular response to glucose starvation (ortholog); cellular response to prostaglandin E stimulus (ortholog); cellular response to xenobiotic stim ulus (ortholog); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; vascular endothelial growth factor signaling pathway; ASSOCIATED WITH Cardiac Fibrosis (ortholog); Cardiomegaly (ortholog); cardiomyopathy (ortholog); FOUND IN apical plasma membrane (ortholog); cytoplasm (ortholog); nucleotide-activated protein kinase complex (ortholog); INTERACTS WITH cadmium atom; cadmium dichloride; deoxynivalenol | | | | Pig | 159 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
