PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1) Sus scrofa
Analyze
Symbol: PRKAA1
Name: protein kinase AMP-activated catalytic subunit alpha 1
RGD ID: 13939165
Description: ENCODES a protein that exhibits AMP-activated protein kinase activity (ortholog); ATP binding (ortholog); chromatin binding (ortholog); INVOLVED IN bile acid and bile salt transport (ortholog); bile acid signaling pathway (ortholog); cellular response to drug (ortholog); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; bile acid signaling pathway; vascular endothelial growth factor signaling pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); amenorrhea (ortholog); breast cancer (ortholog); FOUND IN apical plasma membrane (ortholog); cytoplasm (ortholog); nucleotide-activated protein kinase complex (ortholog); INTERACTS WITH 17beta-estradiol; cadmium atom; cadmium dichloride
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 5'-AMP-activated protein kinase catalytic subunit alpha-1; 63 kDa subunit; ACACA kinase; acetyl-CoA carboxylase kinase; AMPK; AMPK 63 kDa subunit; AMPK alpha-1 chain; AMPK subunit alpha-1; AMPK1; HMGCR kinase; hydroxymethylglutaryl-CoA reductase kinase; protein kinase, AMP-activated, alpha 1 catalytic subunit; tau-protein kinase PRKAA1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1625,745,321 - 25,783,610 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11625,745,902 - 25,783,524 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autophagy  (IEA)
bile acid and bile salt transport  (ISO)
bile acid signaling pathway  (ISO)
CAMKK-AMPK signaling cascade  (IEA)
cellular response to calcium ion  (IEA)
cellular response to drug  (ISO)
cellular response to ethanol  (ISO)
cellular response to glucose starvation  (IEA,ISS)
cellular response to glucose stimulus  (IEA)
cellular response to hydrogen peroxide  (ISO)
cellular response to hypoxia  (ISO)
cellular response to nutrient levels  (ISS)
cellular response to organonitrogen compound  (ISO)
cellular response to oxidative stress  (IEA)
cellular response to prostaglandin E stimulus  (IEA,ISO)
cholesterol biosynthetic process  (IEA)
cold acclimation  (ISO)
energy homeostasis  (ISS)
fatty acid biosynthetic process  (IEA)
fatty acid homeostasis  (ISS)
fatty acid oxidation  (IEA,ISO)
glucose homeostasis  (ISS)
glucose metabolic process  (IEA,ISO)
histone-serine phosphorylation  (IEA)
intracellular signal transduction  (IBA)
lipid biosynthetic process  (IEA,ISS)
motor behavior  (IEA)
negative regulation of apoptotic process  (IEA,ISS)
negative regulation of gene expression  (IEA)
negative regulation of insulin receptor signaling pathway  (ISO)
negative regulation of lipid catabolic process  (IEA,ISS)
negative regulation of TOR signaling  (IEA,ISS)
negative regulation of tubulin deacetylation  (IEA)
neuron cellular homeostasis  (IEA)
positive regulation of autophagy  (IEA,ISS)
positive regulation of cell population proliferation  (ISO)
positive regulation of cellular protein localization  (ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of glycolytic process  (ISS)
positive regulation of mitochondrial transcription  (IEA)
positive regulation of peptidyl-lysine acetylation  (IEA)
positive regulation of protein targeting to mitochondrion  (IEA)
positive regulation of skeletal muscle tissue development  (IEA,ISO)
protein phosphorylation  (IBA,IEA,ISO)
regulation of bile acid secretion  (ISO)
regulation of circadian rhythm  (IEA,ISS)
regulation of gene expression  (ISO)
regulation of microtubule cytoskeleton organization  (IEA)
regulation of peptidyl-serine phosphorylation  (IEA,ISO)
regulation of stress granule assembly  (IEA)
regulation of vesicle-mediated transport  (ISO)
response to 17alpha-ethynylestradiol  (ISO)
response to activity  (ISO)
response to caffeine  (ISO)
response to camptothecin  (IEA)
response to drug  (ISO)
response to gamma radiation  (IEA,ISS)
response to hydrogen peroxide  (IEA)
response to UV  (IEA)
rhythmic process  (IEA)
Wnt signaling pathway  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:7905477   PMID:8557660   PMID:14681463   PMID:18479897   PMID:20363874   PMID:22451512   PMID:22915817   PMID:23747367   PMID:23773688   PMID:25280462   PMID:26287402   PMID:26967195  
PMID:27242197   PMID:30977277  


Genomics

Comparative Map Data
PRKAA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1625,745,321 - 25,783,610 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11625,745,902 - 25,783,524 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PRKAA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl540,759,379 - 40,798,374 (-)EnsemblGRCh38hg38GRCh38
GRCh38540,759,389 - 40,798,374 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37540,759,481 - 40,798,297 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36540,795,238 - 40,834,054 (-)NCBINCBI36hg18NCBI36
Build 34540,795,238 - 40,834,046NCBI
Celera540,648,066 - 40,686,889 (-)NCBI
Cytogenetic Map5p13.1NCBI
HuRef540,711,304 - 40,750,184 (-)NCBIHuRef
CHM1_1540,761,376 - 40,800,178 (-)NCBICHM1_1
Prkaa1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39155,172,641 - 5,211,380 (+)NCBIGRCm39mm39
GRCm39 Ensembl155,173,343 - 5,211,380 (+)Ensembl
GRCm38155,143,861 - 5,181,899 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl155,143,861 - 5,181,899 (+)EnsemblGRCm38mm10GRCm38
MGSCv37155,093,861 - 5,131,899 (+)NCBIGRCm37mm9NCBIm37
MGSCv36155,091,090 - 5,129,114 (+)NCBImm8
Celera154,993,697 - 5,031,451 (+)NCBICelera
Cytogenetic Map15A1NCBI
Prkaa1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2254,240,298 - 54,275,978 (+)NCBI
Rnor_6.0 Ensembl254,857,688 - 54,893,404 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0254,857,688 - 54,893,404 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0273,882,080 - 73,917,812 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4254,327,821 - 54,360,462 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1254,256,055 - 54,288,695 (+)NCBI
Celera249,888,577 - 49,923,847 (+)NCBICelera
Cytogenetic Map2q16NCBI
Prkaa1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542625,079,718 - 25,102,090 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542625,079,718 - 25,102,090 (-)NCBIChiLan1.0ChiLan1.0
PRKAA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1574,627,844 - 74,666,505 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl574,627,830 - 74,666,505 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0569,581,748 - 69,620,721 (+)NCBIMhudiblu_PPA_v0panPan3
PRKAA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1468,579,061 - 68,614,548 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl468,579,037 - 68,611,841 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha468,255,490 - 68,291,515 (+)NCBI
ROS_Cfam_1.0469,085,598 - 69,121,628 (+)NCBI
UMICH_Zoey_3.1468,844,836 - 68,880,871 (+)NCBI
UNSW_CanFamBas_1.0468,957,934 - 68,993,962 (+)NCBI
UU_Cfam_GSD_1.0469,496,965 - 69,533,038 (+)NCBI
Prkaa1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213229,528,457 - 229,554,782 (-)NCBI
SpeTri2.0NW_0049365181,817,051 - 1,843,376 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKAA1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1439,516,307 - 39,553,627 (-)NCBI
Vero_WHO_p1.0NW_02366607129,939,348 - 29,980,047 (-)NCBI
Prkaa1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475914,143,439 - 14,174,971 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 8 2 3 5 15 2 2 2
Low 2 2 2 8 1 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000030818   ⟹   ENSSSCP00000024198
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1625,745,321 - 25,783,610 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000082538   ⟹   ENSSSCP00000068221
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1625,757,125 - 25,783,504 (-)Ensembl
RefSeq Acc Id: NM_001167633   ⟹   NP_001161105
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11625,748,158 - 25,783,481 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021076521   ⟹   XP_020932180
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11625,745,902 - 25,783,524 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021076522   ⟹   XP_020932181
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11625,745,902 - 25,783,499 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001161105 (Get FASTA)   NCBI Sequence Viewer  
  XP_020932180 (Get FASTA)   NCBI Sequence Viewer  
  XP_020932181 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ACC78144 (Get FASTA)   NCBI Sequence Viewer  
  BAI48090 (Get FASTA)   NCBI Sequence Viewer  
  Q09136 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020932180   ⟸   XM_021076521
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020932181   ⟸   XM_021076522
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001161105   ⟸   NM_001167633
- UniProtKB: D0G7E1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000024198   ⟸   ENSSSCT00000030818
RefSeq Acc Id: ENSSSCP00000068221   ⟸   ENSSSCT00000082538
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000024598 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000024198 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000068221 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000030818 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000082538 UniProtKB/TrEMBL
InterPro AMPK_C UniProtKB/TrEMBL
  AMPKA1_C UniProtKB/TrEMBL
  KA1/Ssp2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRKAA1_UBA UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:100145903 UniProtKB/TrEMBL
NCBI Gene PRKAA1 ENTREZGENE
Pfam AdenylateSensor UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103243 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A5G2QTG6_PIG UniProtKB/TrEMBL
  AAPK1_PIG UniProtKB/Swiss-Prot
  D0G7E1 ENTREZGENE, UniProtKB/TrEMBL
  I3LJD8_PIG UniProtKB/TrEMBL
  Q09136 ENTREZGENE
UniProt Secondary B2MV24 UniProtKB/Swiss-Prot
VGNC ID VGNC:91797 ENTREZGENE