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Strain Registration

Strain: WF/NHsd

Symbol: WF/NHsd
Strain: WF
Substrain: NHsd
RGD ID: 737908
Citation ID: RRID:RGD_737908
Ontology ID: RS:0000984
Type: inbred
Available Source: Envigo
Origination: Envigo
Description: Substrain of Wistar Furth stock, inbred by National Institute of Health, Bethesda, MD and now available at Harlan Sprague Dawley.
Last Known Status: Cryopreserved Embryo (as of 2022-03-24)






  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
WF/NHsdRatbreast carcinoma MODEL: inducedIAGP7,12-dimethyltetraphene61081 RGD 
WF/NHsdRatbreast carcinoma MODEL: inducedIAGP7,12-dimethyltetraphene62417as compared to control strain WKY/NHsdRGD 
WF/NHsdRatExperimental Mammary Neoplasms MODEL: inducedIAGP7,12-dimethyltetraphene5133689 RGD 
WF/NHsdRatExperimental Mammary Neoplasms MODEL: inducedIAGP7,12-dimethyltetraphene or gene transfer using retrovirus vector5684388 RGD 

1 to 14 of 14 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
WF/NHsdRatabnormal platelet alpha-granule morphology  IAGP 11531117compared to Hsd:WIRGD 
WF/NHsdRatdecreased body weight  IAGP 11531112compared to SDRGD 
WF/NHsdRatdecreased hematocrit  IAGP 11531111compared to LERGD 
WF/NHsdRatdecreased megakaryocyte cell number  IAGP 11531112compared to SDRGD 
WF/NHsdRatenhanced megakaryocyte emperipolesis  IAGP 11531112compared to SDRGD 
WF/NHsdRatincreased bleeding time  IAGP 11531110compared to Hsd:WIRGD 
WF/NHsdRatincreased incidence of tumors by chemical induction inducedIAGP7,12-dimethyltetraphene631852compared to WF.WKY-D5Wox7-D5Uwm37/UwmRGD 
WF/NHsdRatincreased leukocyte cell number  IAGP 11531112compared to SDRGD 
WF/NHsdRatincreased mammary gland tumor incidence inducedIAGP7,12-dimethyltetraphene631852compared to WF.WKY-D5Wox7-D5Uwm37/UwmRGD 
WF/NHsdRatincreased mean platelet volume  IAGP 11531111compared to LERGD 
WF/NHsdRatincreased mean platelet volume  IAGP 11531112compared to SDRGD 
WF/NHsdRatthrombocytopenia  IAGP 11531111compared to LERGD 
WF/NHsdRatthrombocytopenia  IAGP 11531112compared to SDRGD 
WF/NHsdRatthrombocytosis inducedIAGPsplenectomy11531111compared to untreated WF/NhsdRGD 
1 to 14 of 14 rows

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
WF/NHsdRatWF/NHsd  IEA 7241799 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
WF/NHsdRatmammary gland integrity trait  EXP 62417 RGD 
WF/NHsdRatmammary gland integrity trait  EXP 1601189 RGD 


1 to 20 of 20 rows
#
Reference Title
Reference Citation
1. Genetic characterization of inbred strains of the rat (Rattus norvegicus). Bender K, etal., J Exp Anim Sci 1994 Aug;36(4-5):151-65.
2. The Mcs7 quantitative trait locus is associated with an increased susceptibility to mammary cancer in congenic rats and an allele-specific imbalance. Cotroneo MS, etal., Oncogene. 2006 Aug 17;25(36):5011-7. Epub 2006 Mar 27.
3. Polymorphisms of the glucocorticoid receptor gene in laboratory and wild rats: steroid binding properties of trinucleotide CAG repeat length variants. Heeley RP, etal., Mamm Genome 1998 Mar;9(3):198-203.
4. Institute for Animal Experimentation University of Tokushima School of Medicine Institute for Animal Experimentation University of Tokushima School of Medicine
5. The Wistar Furth rat: an animal model of hereditary macrothrombocytopenia. Jackson CW, etal., Blood. 1988 Jun;71(6):1676-86.
6. A unique talin antigenic determinant and anomalous megakaryocyte talin distribution associated with abnormal platelet formation in the Wistar Furth rat. Jackson CW, etal., Blood. 1992 Apr 1;79(7):1729-37.
7. Platelets of the Wistar Furth rat have reduced levels of alpha-granule proteins. An animal model resembling gray platelet syndrome. Jackson CW, etal., J Clin Invest. 1991 Jun;87(6):1985-91.
8. Genetic loci controlling breast cancer susceptibility in the Wistar-Kyoto rat. Lan H, etal., Genetics 2001 Jan;157(1):331-9.
9. Megakaryocyte and platelet ultrastructure in the Wistar Furth rat. Leven RM and Tablin F, Am J Pathol. 1988 Sep;132(3):417-26.
10. The iddm4 locus segregates with diabetes susceptibility in congenic WF.iddm4 rats. Mordes JP, etal., Diabetes 2002 Nov;51(11):3254-62.
11. Strains registered by Harlan Laboratories, Inc. Personal communication with Harlan Laboratories
12. RGD Strain RSO annotation pipeline RGD Automated Pipelines
13. Rat Mcs5a is a compound quantitative trait locus with orthologous human loci that associate with breast cancer risk. Samuelson DJ, et al., Proc Natl Acad Sci U S A. 2007 Apr 2; 104(15):6299-304.
14. Physical evidence of Mcs5, a QTL controlling mammary carcinoma susceptibility, in congenic rats. Samuelson DJ, etal., Carcinogenesis 2003 Sep;24(9):1455-60. Epub 2003 Jul 04.
15. Physical Confirmation and Mapping of Overlapping Rat Mammary Carcinoma Susceptibility QTLs, Mcs2 and Mcs6. Sanders J, etal., PLoS One. 2011;6(5):e19891. Epub 2011 May 18.
16. Genetic identification of multiple loci that control breast cancer susceptibility in the rat Shepel LA, etal., Genetics 1998 May;149(1):289-99
17. The rat oncogenome: comparative genetics and genomics of rat models of mammary carcinogenesis. Shull JD Breast Dis. 2007;28:69-86.
18. Genetic variation in coding regions between and within commonly used inbred rat strains. Smits BM, etal., Genome Res. 2004 Jul;14(7):1285-90.
19. Prolonged bleeding time with defective platelet filopodia formation in the Wistar Furth rat. Stenberg PE, etal., Blood. 1998 Mar 1;91(5):1599-608.
20. Mcs5c: a mammary carcinoma susceptibility locus located in a gene desert that associates with tenascin C expression. Veillet AL, etal., Cancer Prev Res (Phila). 2011 Jan;4(1):97-106.
1 to 20 of 20 rows


1 to 7 of 7 rows
Symbol
Name
Trait
Mcs23 Mammary carcinoma susceptibility QTL 23 mammary gland integrity trait   (VT:0010552)    
Mcs24 Mammary carcinoma susceptibility QTL 24 mammary gland integrity trait   (VT:0010552)    
Mcs5 Mammary carcinoma susceptibility QTL 5 mammary gland integrity trait   (VT:0010552)    
Mcs6 Mammary carcinoma susceptibility QTL 6 mammary gland integrity trait   (VT:0010552)    
Mcs7 Mammary carcinoma susceptibility QTL 7 mammary gland integrity trait   (VT:0010552)    
Mcs8 Mammary carcinoma susceptibility QTL 8 mammary gland integrity trait   (VT:0010552)    
Mcsm1 Mammary carcinoma susceptibility modifier QTL 1 mammary gland integrity trait   (VT:0010552)    
1 to 7 of 7 rows
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
NC_005100.4:g.162817795G>T chr1 162817795 162817795 G T SNV Rnor_6.0
NC_005100.4:g.162830964C>T chr1 162830964 162830964 C T SNV Rnor_6.0


Note Type Note Reference
strain_phys_biochem This strain was screened for genetic polymorphisms for 100 genomic loci in 55 genes ; Polymorphisms observed in this study can be found in NCBI dbSNP under accession numbers ss12588106 - ss12588203. 737878

Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-09-26 WF/NHsd    WF/NHsd    Name updated 68913 APPROVED