RGD Reference Report - The rat oncogenome: comparative genetics and genomics of rat models of mammary carcinogenesis. - Rat Genome Database

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The rat oncogenome: comparative genetics and genomics of rat models of mammary carcinogenesis.

Authors: Shull, JD 
Citation: Shull JD Breast Dis. 2007;28:69-86.
RGD ID: 2291885
Pubmed: (View Article at PubMed) PMID:18057545

The Norway rat has for many years been widely used as an experimental model for the study of breast cancer etiology and prevention. Mammary cancer can be induced in rats by a variety of agents. The mammary cancers that develop in the various rat models resemble in many respects the breast cancers that develop in humans. It is now clear that significant differences exist between different rat models with respect to the genetic bases of susceptibility to mammary cancer as well as the somatic genetic events that are associated with development of mammary cancer. In this review I summarize our current understanding of the genetic and genomics of mammary cancer in the rat, compare and contrast the genetic/genomic features of different rat mammary cancer models and discuss the relevance of these models to breast cancer in humans.



Objects referenced in this article
QTL Emca1 Estrogen-induced mammary cancer QTL 1 Rattus norvegicus
QTL Emca2 Estrogen-induced mammary cancer QTL 2 Rattus norvegicus
QTL Emca4 Estrogen-induced mammary cancer QTL 4 Rattus norvegicus
QTL Emca5 Estrogen-induced mammary cancer QTL 5 Rattus norvegicus
QTL Emca6 Estrogen-induced mammary cancer QTL 6 Rattus norvegicus
QTL Emca7 Estrogen-induced mammary cancer QTL 7 Rattus norvegicus
QTL Emca8 Estrogen-induced mammary cancer QTL 8 Rattus norvegicus
QTL Mcs1 Mammary carcinoma susceptibility QTL 1 Rattus norvegicus
QTL Mcs2 Mammary carcinoma susceptibility QTL 2 Rattus norvegicus
QTL Mcs3 Mammary carcinoma susceptibility QTL 3 Rattus norvegicus
QTL Mcs4 Mammary carcinoma susceptibility QTL 4 Rattus norvegicus
QTL Mcs5 Mammary carcinoma susceptibility QTL 5 Rattus norvegicus
QTL Mcs6 Mammary carcinoma susceptibility QTL 6 Rattus norvegicus
QTL Mcs7 Mammary carcinoma susceptibility QTL 7 Rattus norvegicus
QTL Mcs8 Mammary carcinoma susceptibility QTL 8 Rattus norvegicus
Strain SPRD/Hsd null Rattus norvegicus
Strain SPRD/Ztm null Rattus norvegicus
Strain WF/NHsd null Rattus norvegicus

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