Mcs23 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Mcs23 (Mammary carcinoma susceptibility QTL 23) Rattus norvegicus

Symbol: Mcs23
Name: Mammary carcinoma susceptibility QTL 23
RGD ID: 2290007
Previously known as: Mcs5a1
Trait: mammary gland integrity trait   (VT:0010552)    
Measurement Type: mammary tumor number   (CMO:0000343)    
LOD Score: Not Available
P Value: Not Available
Variance: Not Available
Position No map positions available.
Cross Type: Not Available
Strains Crossed: WKY/NHsd WF/NHsd 



Candidate Gene Status
Fbxo10 is a candidate Gene for Mcs23

Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain
WF/NHsd  (IEA)
WKY/NHsd  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Rat Mcs5a is a compound quantitative trait locus with orthologous human loci that associate with breast cancer risk. Samuelson DJ, et al., Proc Natl Acad Sci U S A. 2007 Apr 2; 104(15):6299-304.
Related QTLs

Related QTL Description Reference
Mcs12 sub_region RGD:1601189


Region

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch

Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_general animals used: 50-55 days old females 1601189
qtl_general software used: Mann-Whitney nonparametric test used for analysing mammary cancer multiplicity data 1601189
qtl_general inducing agent: DMBA (65 mg/kg of body wt) 1601189
qtl_general resistance is observed only when Mcs23 and Mcs24 WKY alleles are in cis orientation, when in trans they develop similar number of carcinomas; heterozygous animals have fewer carcinomas 1601189