RGD Reference Report - Serum cholinesterase activities distinguish between stroke patients and controls and predict 12-month mortality. - Rat Genome Database

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Serum cholinesterase activities distinguish between stroke patients and controls and predict 12-month mortality.

Authors: Ben Assayag, Einor  Shenhar-Tsarfaty, Shani  Ofek, Keren  Soreq, Lilach  Bova, Irena  Shopin, Ludmila  Berg, Ronan M G  Berliner, Shlomo  Shapira, Itzhak  Bornstein, Natan M  Soreq, Hermona 
Citation: Ben Assayag E, etal., Mol Med. 2010 Jul-Aug;16(7-8):278-86. doi: 10.2119/molmed.2010.00015. Epub 2010 Apr 14.
RGD ID: 5688131
Pubmed: PMID:20464061   (View Abstract at PubMed)
PMCID: PMC2896466   (View Article at PubMed Central)
DOI: DOI:10.2119/molmed.2010.00015   (Journal Full-text)

To date there is no diagnostic biomarker for mild stroke, although elevation of inflammatory biomarkers has been reported at early stages. Previous studies implicated acetylcholinesterase (AChE) involvement in stroke, and circulating AChE activity reflects inflammatory response, since acetylcholine suppresses inflammation. Therefore, carriers of polymorphisms that modify cholinergic activity should be particularly susceptible to inflammatory damage. Our study sought diagnostic values of AChE and Cholinergic Status (CS, the total capacity for acetylcholine hydrolysis) in suspected stroke patients. For this purpose, serum cholinesterase activities, butyrylcholinesterase-K genotype and inflammatory biomarkers were determined in 264 ischemic stroke patients and matched controls during the acute phase. AChE activities were lower (P<0.001), and butyrylcholinesterase activities were higher in patients than in controls (P=0.004). When normalized to sampling time from stroke occurrence, both cholinergic parameters were correlated with multiple inflammatory biomarkers, including fibrinogen, interleukin-6 and C-reactive protein (r=0.713, r=0.607; r=0.421, r=0.341; r=0.276, r=0.255; respectively; all P values<0.001). Furthermore, very low AChE activities predicted subsequent nonsurvival (P=0.036). Also, carriers of the unstable butyrylcholinesterase-K variant were more abundant among patients than controls, and showed reduced activity (P<0.001). Importantly, a cholinergic score combining the two cholinesterase activities discriminated between 94.3% matched pairs of patients and controls, compared with only 75% for inflammatory measures. Our findings present the power of circulation cholinesterase measurements as useful early diagnostic tools for the occurrence of stroke. Importantly, these were considerably more distinctive than the inflammatory biomarkers, albeit closely associated with them, which may open new venues for stroke diagnosis and treatment.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Stroke disease_progressionIEP 5688131protein:decreased expression:serumRGD 
Stroke disease_progressionISOACHE (Homo sapiens)5688131; 5688131protein:decreased expression:serumRGD 
Stroke  IEP 5688131protein:increased expression:serumRGD 
Stroke  ISOBCHE (Homo sapiens)5688131; 5688131protein:increased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ache  (acetylcholinesterase)
Bche  (butyrylcholinesterase)

Genes (Mus musculus)
Ache  (acetylcholinesterase)
Bche  (butyrylcholinesterase)

Genes (Homo sapiens)
ACHE  (acetylcholinesterase (Yt blood group))
BCHE  (butyrylcholinesterase)


Additional Information