Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (1->4)-beta-D-glucan | multiple interactions | ISO | Spin1 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of SPIN1 mRNA | CTD | PMID:36331819 | 1,2-dimethylhydrazine | decreases expression | ISO | Spin1 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of SPIN1 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of SPIN1 mRNA | CTD | PMID:29097150 | 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one | increases expression | ISO | SPIN1 (Homo sapiens) | 6480464 | Metribolone results in increased expression of SPIN1 mRNA | CTD | PMID:17010196 | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | ISO | Spin1 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | ISO | Spin1 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Spin1 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of SPIN1 mRNA | CTD | PMID:16214954 | 3-chloropropane-1,2-diol | increases expression | EXP | | 6480464 | alpha-Chlorohydrin results in increased expression of SPIN1 mRNA | CTD | PMID:28522335 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | SPIN1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SPIN1 mRNA | CTD | PMID:28628672 | 4-hydroxyphenyl retinamide | increases expression | ISO | Spin1 (Mus musculus) | 6480464 | Fenretinide results in increased expression of SPIN1 mRNA | CTD | PMID:28973697 | acrolein | multiple interactions | ISO | SPIN1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of SPIN1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of SPIN1 mRNA | CTD | PMID:32699268 | aflatoxin B1 | increases methylation | ISO | SPIN1 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of SPIN1 gene and Aflatoxin B1 results in increased methylation of SPIN1 intron | CTD | PMID:27153756 and PMID:30157460 | Aflatoxin B2 alpha | decreases methylation | ISO | SPIN1 (Homo sapiens) | 6480464 | aflatoxin B2 results in decreased methylation of SPIN1 intron | CTD | PMID:30157460 | all-trans-retinoic acid | decreases expression | ISO | SPIN1 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of SPIN1 mRNA | CTD | PMID:33167477 | alpha-pinene | multiple interactions | ISO | SPIN1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of SPIN1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of SPIN1 mRNA | CTD | PMID:32699268 | aristolochic acid A | decreases expression | ISO | SPIN1 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of SPIN1 mRNA | CTD | PMID:33212167 | Aroclor 1254 | decreases expression | ISO | Spin1 (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of SPIN1 mRNA | CTD | PMID:23650126 | arsenite(3-) | multiple interactions | ISO | SPIN1 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to SPIN1 mRNA] | CTD | PMID:32406909 | benzo[a]pyrene | multiple interactions | ISO | Spin1 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SPIN1 mRNA | CTD | PMID:27858113 | benzo[a]pyrene | affects methylation | ISO | SPIN1 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of SPIN1 intron | CTD | PMID:30157460 | benzo[a]pyrene | decreases methylation | ISO | SPIN1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of SPIN1 3' UTR and Benzo(a)pyrene results in decreased methylation of SPIN1 5' UTR | CTD | PMID:27901495 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | SPIN1 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 | benzo[b]fluoranthene | multiple interactions | ISO | Spin1 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SPIN1 mRNA | CTD | PMID:27858113 | benzo[e]pyrene | increases methylation | ISO | SPIN1 (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of SPIN1 intron | CTD | PMID:30157460 | beta-naphthoflavone | increases expression | ISO | SPIN1 (Homo sapiens) | 6480464 | beta-Naphthoflavone results in increased expression of SPIN1 mRNA | CTD | PMID:32858204 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of SPIN1 mRNA | CTD | PMID:25181051 more ... | bisphenol A | multiple interactions | ISO | SPIN1 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of SPIN1 gene | CTD | PMID:31601247 | bisphenol F | multiple interactions | ISO | SPIN1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SPIN1 mRNA | CTD | PMID:28628672 | carbon nanotube | increases expression | ISO | Spin1 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 and PMID:25620056 | chrysene | decreases expression | ISO | Spin1 (Mus musculus) | 6480464 | chrysene results in decreased expression of SPIN1 mRNA | CTD | PMID:26377693 | chrysene | multiple interactions | ISO | Spin1 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SPIN1 mRNA | CTD | PMID:27858113 | clofibrate | multiple interactions | ISO | Spin1 (Mus musculus) | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of SPIN1 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SPIN1 mRNA] | CTD | PMID:17585979 | clofibrate | decreases expression | ISO | Spin1 (Mus musculus) | 6480464 | Clofibrate results in decreased expression of SPIN1 mRNA | CTD | PMID:17585979 | copper(II) sulfate | increases expression | ISO | SPIN1 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of SPIN1 mRNA | CTD | PMID:19549813 | dexamethasone | multiple interactions | ISO | SPIN1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SPIN1 mRNA | CTD | PMID:28628672 | dioxygen | increases expression | ISO | Spin1 (Mus musculus) | 6480464 | Oxygen deficiency results in increased expression of SPIN1 mRNA | CTD | PMID:24205000 | ethanol | affects splicing | ISO | Spin1 (Mus musculus) | 6480464 | Ethanol affects the splicing of SPIN1 mRNA | CTD | PMID:30319688 | folic acid | decreases expression | ISO | Spin1 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of SPIN1 mRNA | CTD | PMID:25629700 | fulvestrant | multiple interactions | ISO | SPIN1 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of SPIN1 gene | CTD | PMID:31601247 | genistein | decreases expression | ISO | SPIN1 (Homo sapiens) | 6480464 | Genistein results in decreased expression of SPIN1 mRNA | CTD | PMID:16705744 | hydrogen peroxide | affects expression | ISO | SPIN1 (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of SPIN1 mRNA | CTD | PMID:21179406 | indometacin | multiple interactions | ISO | SPIN1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SPIN1 mRNA | CTD | PMID:28628672 | inulin | multiple interactions | ISO | Spin1 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of SPIN1 mRNA | CTD | PMID:36331819 | leflunomide | increases expression | EXP | | 6480464 | leflunomide results in increased expression of SPIN1 mRNA | CTD | PMID:24136188 | methapyrilene | increases methylation | ISO | SPIN1 (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of SPIN1 intron | CTD | PMID:30157460 | methidathion | increases expression | ISO | Spin1 (Mus musculus) | 6480464 | methidathion results in increased expression of SPIN1 mRNA | CTD | PMID:34813904 | ozone | multiple interactions | ISO | SPIN1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of SPIN1 mRNA more ... | CTD | PMID:32699268 | paracetamol | multiple interactions | ISO | Spin1 (Mus musculus) | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of SPIN1 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SPIN1 mRNA] | CTD | PMID:17585979 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of SPIN1 mRNA | CTD | PMID:33387578 | paracetamol | affects expression | ISO | Spin1 (Mus musculus) | 6480464 | Acetaminophen affects the expression of SPIN1 mRNA | CTD | PMID:17562736 | PCB138 | multiple interactions | ISO | Spin1 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | pentachlorophenol | increases expression | ISO | Spin1 (Mus musculus) | 6480464 | Pentachlorophenol results in increased expression of SPIN1 mRNA | CTD | PMID:23892564 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Spin1 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of SPIN1 mRNA and [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of SPIN1 mRNA | CTD | PMID:36331819 | rotenone | increases expression | EXP | | 6480464 | Rotenone results in increased expression of SPIN1 mRNA | CTD | PMID:28374803 | silver atom | decreases expression | ISO | Spin1 (Mus musculus) | 6480464 | Silver results in decreased expression of SPIN1 mRNA | CTD | PMID:27131904 | silver(0) | decreases expression | ISO | Spin1 (Mus musculus) | 6480464 | Silver results in decreased expression of SPIN1 mRNA | CTD | PMID:27131904 | tetrachloromethane | increases expression | ISO | Spin1 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of SPIN1 mRNA | CTD | PMID:31919559 | tetraphene | decreases expression | ISO | Spin1 (Mus musculus) | 6480464 | benz(a)anthracene results in decreased expression of SPIN1 mRNA | CTD | PMID:26377693 | tetraphene | multiple interactions | ISO | Spin1 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SPIN1 mRNA | CTD | PMID:27858113 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of SPIN1 mRNA | CTD | PMID:34492290 | valproic acid | affects expression | ISO | Spin1 (Mus musculus) | 6480464 | Valproic Acid affects the expression of SPIN1 mRNA | CTD | PMID:17292431 | valproic acid | decreases expression | ISO | Spin1 (Mus musculus) | 6480464 | Valproic Acid results in decreased expression of SPIN1 mRNA | CTD | PMID:21427059 | valproic acid | affects expression | ISO | SPIN1 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of SPIN1 mRNA | CTD | PMID:25979313 | vorinostat | decreases expression | ISO | SPIN1 (Homo sapiens) | 6480464 | vorinostat results in decreased expression of SPIN1 mRNA | CTD | PMID:27188386 | |