Mvp (major vault protein) - Rat Genome Database

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Gene: Mvp (major vault protein) Rattus norvegicus
Analyze
Symbol: Mvp
Name: major vault protein
RGD ID: 70932
Description: Predicted to enable identical protein binding activity; protein kinase binding activity; and protein phosphatase binding activity. Predicted to be involved in several processes, including negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of protein autophosphorylation; and protein activation cascade. Predicted to be located in cytoskeleton; cytosol; and perinuclear region of cytoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human MVP (major vault protein); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,025,259 - 191,052,866 (-)NCBIGRCr8
mRatBN7.21181,594,734 - 181,622,336 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,594,734 - 181,622,380 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,946,088 - 189,973,678 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01197,132,171 - 197,159,761 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01189,799,632 - 189,827,156 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01198,420,813 - 198,448,612 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1198,420,806 - 198,450,047 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01205,401,190 - 205,428,854 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,164,811 - 186,192,802 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,314,691 - 186,342,683 (-)NCBI
Celera1179,249,451 - 179,276,973 (-)NCBICelera
Cytogenetic Map1q37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
3,7-dihydropurine-6-thione  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
Aflatoxin B2 alpha  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
diclofenac  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
hydroxychloroquine  (ISO)
inulin  (ISO)
iron dichloride  (ISO)
ivermectin  (ISO)
kojic acid  (EXP)
lipopolysaccharide  (ISO)
mercaptopurine  (ISO)
methyl methanesulfonate  (ISO)
methylphenidate  (ISO)
metiram  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
niclosamide  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
purine-6-thiol  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
venlafaxine hydrochloride  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
cytoskeleton  (IEA,ISO)
cytosol  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
perinuclear region of cytoplasm  (IEA,ISO)
ribonucleoprotein complex  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Major vault protein is a substrate of endogenous protein kinases in CHO and PC12 cells. Ehrnsperger C and Volknandt W, Biol Chem 2001 Oct;382(10):1463-71.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Proteomic identification of glucocorticoid receptor interacting proteins. Hedman E, etal., Proteomics. 2006 May;6(10):3114-26.
4. The sequence of a cDNA encoding the major vault protein from Rattus norvegicus. Kickhoefer VA and Rome LH, Gene 1994 Dec 30;151(1-2):257-60.
5. Gene Data Set MGD Curation, June 12, 2002
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:10551828   PMID:15133037   PMID:15489334   PMID:16441665   PMID:19056867   PMID:19150846   PMID:19199708   PMID:19946888   PMID:20458337   PMID:21362503   PMID:21988832   PMID:23376485  
PMID:24722188   PMID:25416956   PMID:26316108   PMID:29093465   PMID:35352799  


Genomics

Comparative Map Data
Mvp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,025,259 - 191,052,866 (-)NCBIGRCr8
mRatBN7.21181,594,734 - 181,622,336 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,594,734 - 181,622,380 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,946,088 - 189,973,678 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01197,132,171 - 197,159,761 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01189,799,632 - 189,827,156 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01198,420,813 - 198,448,612 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1198,420,806 - 198,450,047 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01205,401,190 - 205,428,854 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,164,811 - 186,192,802 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,314,691 - 186,342,683 (-)NCBI
Celera1179,249,451 - 179,276,973 (-)NCBICelera
Cytogenetic Map1q37NCBI
MVP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381629,820,394 - 29,848,039 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1629,820,394 - 29,848,039 (+)EnsemblGRCh38hg38GRCh38
GRCh371629,831,715 - 29,859,360 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361629,731,591 - 29,766,842 (+)NCBINCBI36Build 36hg18NCBI36
Build 341629,739,288 - 29,766,843NCBI
Celera1672,936,886 - 72,964,474 (-)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1627,492,353 - 27,519,952 (+)NCBIHuRef
CHM1_11631,047,524 - 31,075,150 (+)NCBICHM1_1
T2T-CHM13v2.01630,102,554 - 30,130,675 (+)NCBIT2T-CHM13v2.0
Mvp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397126,586,036 - 126,613,729 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7126,586,032 - 126,613,793 (-)EnsemblGRCm39 Ensembl
GRCm387126,986,860 - 127,014,594 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7126,986,860 - 127,014,621 (-)EnsemblGRCm38mm10GRCm38
MGSCv377134,130,374 - 134,158,108 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367126,778,014 - 126,805,742 (-)NCBIMGSCv36mm8
Celera7126,835,060 - 126,862,722 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.26NCBI
Mvp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554937,113,319 - 7,143,582 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554937,113,194 - 7,141,944 (-)NCBIChiLan1.0ChiLan1.0
MVP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21830,569,361 - 30,597,756 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11635,628,134 - 35,656,003 (-)NCBINHGRI_mPanPan1
PanPan1.11630,190,929 - 30,217,971 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1630,190,090 - 30,219,070 (+)Ensemblpanpan1.1panPan2
MVP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1617,879,687 - 17,903,184 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl617,873,521 - 17,903,184 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha619,456,681 - 19,479,984 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0618,013,316 - 18,036,825 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl618,013,502 - 18,036,825 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1617,813,002 - 17,836,311 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0617,728,697 - 17,751,998 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0618,043,991 - 18,067,316 (+)NCBIUU_Cfam_GSD_1.0
Mvp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344124,501,044 - 124,512,454 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650112,599,036 - 12,655,910 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650112,598,907 - 12,610,306 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MVP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl318,057,177 - 18,081,155 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1318,056,548 - 18,081,169 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2318,509,107 - 18,534,192 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MVP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1526,805,070 - 26,833,043 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl526,801,753 - 26,833,199 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660682,694,565 - 2,723,262 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mvp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478213,363,000 - 13,387,086 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478213,363,121 - 13,386,961 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mvp
147 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:74
Count of miRNA genes:69
Interacting mature miRNAs:70
Transcripts:ENSRNOT00000027360
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1166532971191278129Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169112897197261052Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
61326Eae6Experimental allergic encephalomyelitis QTL 65.3body mass (VT:0001259)change in body weight (CMO:0002045)1172949660181830018Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1174133260196383668Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
2325725Eae31Experimental allergic encephalomyelitis QTL 31nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1178810256188377506Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat

Markers in Region
RH133765  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21181,622,875 - 181,623,082 (+)MAPPERmRatBN7.2
Rnor_6.01198,448,958 - 198,449,164NCBIRnor6.0
Rnor_5.01205,429,394 - 205,429,600UniSTSRnor5.0
RGSC_v3.41186,193,342 - 186,193,548UniSTSRGSC3.4
Celera1179,277,543 - 179,277,749UniSTS
Cytogenetic Map1q36UniSTS
RH134264  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21181,594,771 - 181,594,951 (+)MAPPERmRatBN7.2
Rnor_6.01198,420,859 - 198,421,038NCBIRnor6.0
Rnor_5.01205,401,228 - 205,401,407UniSTSRnor5.0
RGSC_v3.41186,164,849 - 186,165,028UniSTSRGSC3.4
Celera1179,249,489 - 179,249,668UniSTS
Cytogenetic Map1q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 55 39 19 39 8 11 20 35 38 11 8
Low 2 2 2 54 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000027360   ⟹   ENSRNOP00000027360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1181,594,734 - 181,610,670 (-)Ensembl
Rnor_6.0 Ensembl1198,420,806 - 198,450,047 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096594   ⟹   ENSRNOP00000089790
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1181,594,735 - 181,622,380 (-)Ensembl
RefSeq Acc Id: NM_022715   ⟹   NP_073206
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,025,267 - 191,052,866 (-)NCBI
mRatBN7.21181,594,734 - 181,622,336 (-)NCBI
Rnor_6.01198,420,821 - 198,448,418 (-)NCBI
Rnor_5.01205,401,190 - 205,428,854 (-)NCBI
RGSC_v3.41186,164,811 - 186,192,802 (-)RGD
Celera1179,249,451 - 179,276,973 (-)RGD
Sequence:
RefSeq Acc Id: XM_063272808   ⟹   XP_063128878
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,025,259 - 191,046,586 (-)NCBI
Protein Sequences
Protein RefSeqs NP_073206 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128878 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52161 (Get FASTA)   NCBI Sequence Viewer  
  AAH71174 (Get FASTA)   NCBI Sequence Viewer  
  EDM17332 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000027360.5
  ENSRNOP00000089790
  ENSRNOP00000089790.1
GenBank Protein Q62667 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_073206   ⟸   NM_022715
- UniProtKB: Q62667 (UniProtKB/Swiss-Prot),   A0A140TAE0 (UniProtKB/TrEMBL),   A6I9J8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000027360   ⟸   ENSRNOT00000027360
RefSeq Acc Id: ENSRNOP00000089790   ⟸   ENSRNOT00000096594
RefSeq Acc Id: XP_063128878   ⟸   XM_063272808
- Peptide Label: isoform X1
- UniProtKB: Q62667 (UniProtKB/Swiss-Prot)
Protein Domains
Major vault protein repeat   Major vault protein shoulder

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62667-F1-model_v2 AlphaFold Q62667 1-861 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690420
Promoter ID:EPDNEW_R944
Type:multiple initiation site
Name:Mvp_1
Description:major vault protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01198,448,428 - 198,448,488EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70932 AgrOrtholog
BioCyc Gene G2FUF-57400 BioCyc
Ensembl Genes ENSRNOG00000020182 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027360.6 UniProtKB/TrEMBL
  ENSRNOT00000096594 ENTREZGENE
  ENSRNOT00000096594.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.30.550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.30.560 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.30.570 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.30.620 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.479.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.720 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.20.380.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7099451 IMAGE-MGC_LOAD
InterPro Band_7/SPFH_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MVP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MVP_rep_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MVP_rep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MVP_shoulder UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vault_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vault_2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vault_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vault_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vault_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64681 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91677 IMAGE-MGC_LOAD
NCBI Gene 64681 ENTREZGENE
PANTHER MAJOR VAULT PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR14165 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MVP_shoulder UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vault UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vault_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vault_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vault_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mvp PhenoGen
PROSITE MVP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020182 RatGTEx
UniProt A0A140TAE0 ENTREZGENE, UniProtKB/TrEMBL
  A6I9J8 ENTREZGENE, UniProtKB/TrEMBL
  MVP_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Mvp  major vault protein      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein 104 kDa protein 70795
gene_regulation phosphorylated by casein kinase II 727331