Tnnt1 (troponin T1, slow skeletal type) - Rat Genome Database

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Gene: Tnnt1 (troponin T1, slow skeletal type) Rattus norvegicus
Analyze
Symbol: Tnnt1
Name: troponin T1, slow skeletal type
RGD ID: 621852
Description: Enables troponin T binding activity. Involved in slow-twitch skeletal muscle fiber contraction. Part of troponin complex. Human ortholog(s) of this gene implicated in nemaline myopathy 5A; nemaline myopathy 5B; and nemaline myopathy 5C. Orthologous to human TNNT1 (troponin T1, slow skeletal type); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fang2; slow skeletal muscle troponin T; sTnT; tnTs; troponin T type 1 (skeletal, slow); troponin T, slow skeletal muscle; troponin T1, skeletal, slow
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,349,035 - 78,359,394 (+)NCBIGRCr8
mRatBN7.2169,306,362 - 69,316,721 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,306,362 - 69,316,721 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx174,665,281 - 74,675,640 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0183,229,594 - 83,239,953 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,379,084 - 76,389,599 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0172,889,270 - 72,899,629 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl172,889,270 - 72,899,659 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0175,652,123 - 75,662,339 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4168,036,411 - 68,045,142 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1168,114,521 - 68,123,253 (+)NCBI
Celera167,811,420 - 67,821,558 (-)NCBICelera
Cytogenetic Map1q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
Tnnt1Ratnemaline myopathy 5A  ISOTNNT1 (Homo sapiens)737736DNA:nonsense mutation:exon:p.E180X (human)RGD 
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Original Reference(s)
Tnnt1Ratcardiomyopathy  ISOTNNT1 (Homo sapiens)8554872ClinVar Annotator: match by term: CardiomyopathiesClinVarPMID:24033266 more ...
Tnnt1Ratdilated cardiomyopathy  ISOTNNT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Dilated Cardiomyopathy and RecessiveClinVarPMID:18414213 more ...
Tnnt1Ratdilated cardiomyopathy  ISOTNNT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Dilated Cardiomyopathy and RecessiveClinVarPMID:18414213 more ...
Tnnt1Ratdilated cardiomyopathy 2A  ISOTNNT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Dilated cardiomyopathy 2AClinVarPMID:24033266 more ...
Tnnt1Ratfamilial hypertrophic cardiomyopathy  ISOTNNT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Primary familial hypertrophic cardiomyopathyClinVarPMID:24033266 more ...
Tnnt1Ratfamilial restrictive cardiomyopathy 1  ISOTNNT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Cardiomyopathy more ...ClinVarPMID:24033266 more ...
Tnnt1Ratgenetic disease  ISOTNNT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:10952871 more ...
Tnnt1Rathypertrophic cardiomyopathy  ISOTNNT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hypertrophic cardiomyopathyClinVarPMID:18414213 more ...
Tnnt1Rathypertrophic cardiomyopathy 7  ISOTNNT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hypertrophic cardiomyopathy 7ClinVarPMID:24033266 more ...
Tnnt1Ratmyopathy  ISOTNNT1 (Homo sapiens)8554872ClinVar Annotator: match by term: MyopathyClinVar 
Tnnt1Ratnemaline myopathy  ISOTNNT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Nemaline Myopathy and RecessiveClinVarPMID:24033266 more ...
Tnnt1Ratnemaline myopathy 5A  ISOTNNT1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10952871 more ...
Tnnt1Ratnemaline myopathy 5A  ISOTNNT1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10952871 more ...
Tnnt1Ratnemaline myopathy 5B  ISOTNNT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Nemaline myopathy 5B more ...ClinVarPMID:25741868 more ...
Tnnt1Ratnemaline myopathy 5C  ISOTNNT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Nemaline myopathy 5C and autosomal dominantClinVarPMID:14315666 more ...
Tnnt1Ratprimary ciliary dyskinesia  ISOTNNT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Primary ciliary dyskinesiaClinVarPMID:22387996 more ...
Tnnt1Ratrestrictive cardiomyopathy  ISOTNNT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial restrictive cardiomyopathyClinVarPMID:18414213 more ...
Tnnt1RatWolff-Parkinson-White syndrome  ISOTNNT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial Hypertrophic Cardiomyopathy with Wolff-Parkinson-White SyndromeClinVarPMID:18414213 more ...
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Original Reference(s)
Tnnt1Ratnemaline myopathy 5A  ISOTNNT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
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Original Reference(s)
Tnnt1Ratnemaline myopathy 5A  ISSTnnt1 (Mus musculus)13592920OMIM:605355MouseDO 
Object Symbol
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Original Reference(s)
Tnnt1Ratnemaline myopathy 5A  ISOTNNT1 (Homo sapiens)7240710 OMIM 
Tnnt1Ratnemaline myopathy 5B  ISOTNNT1 (Homo sapiens)7240710 OMIM 
Tnnt1Ratnemaline myopathy 5C  ISOTNNT1 (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Tnnt1Rat1,2-dimethylhydrazine increases expressionISOTnnt1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of TNNT1 mRNACTDPMID:22206623
Tnnt1Rat17beta-estradiol affects expressionISOTnnt1 (Mus musculus)6480464Estradiol affects the expression of TNNT1 mRNACTDPMID:19484750
Tnnt1Rat17beta-estradiol multiple interactionsISOTNNT1 (Homo sapiens)6480464[Estradiol co-treated with TGFB1 protein] results in increased expression of TNNT1 mRNACTDPMID:30165855
Tnnt1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOTnnt1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of TNNT1 mRNACTDPMID:26377647
Tnnt1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of TNNT1 mRNACTDPMID:32109520
Tnnt1Rat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642 more ...CTDPMID:32109520
Tnnt1Rat2-hydroxypropanoic acid decreases expressionISOTNNT1 (Homo sapiens)6480464Lactic Acid results in decreased expression of TNNT1 mRNACTDPMID:30851411
Tnnt1Rat4,4'-sulfonyldiphenol affects expressionISOTnnt1 (Mus musculus)6480464bisphenol S affects the expression of TNNT1 mRNACTDPMID:30951980
Tnnt1Rat5-aza-2'-deoxycytidine affects expressionISOTNNT1 (Homo sapiens)6480464Decitabine affects the expression of TNNT1 mRNACTDPMID:17145863
Tnnt1Rat5-fluorouracil decreases expressionISOTNNT1 (Homo sapiens)6480464Fluorouracil results in decreased expression of TNNT1 proteinCTDPMID:15352031
Tnnt1Rat5-fluorouracil affects response to substanceISOTNNT1 (Homo sapiens)6480464TNNT1 protein affects the susceptibility to FluorouracilCTDPMID:15352031
Tnnt1Rat5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid increases expressionISOTNNT1 (Homo sapiens)6480464acipimox results in increased expression of TNNT1 mRNACTDPMID:25352640
Tnnt1Rat6-propyl-2-thiouracil multiple interactionsISOTnnt1 (Mus musculus)6480464[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of TNNT1 mRNACTDPMID:36706583
Tnnt1Ratacetamide increases expressionEXP 6480464acetamide results in increased expression of TNNT1 mRNACTDPMID:31881176
Tnnt1Rataflatoxin B1 decreases methylationISOTNNT1 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of TNNT1 intronCTDPMID:30157460
Tnnt1Ratall-trans-retinoic acid increases expressionISOTNNT1 (Homo sapiens)6480464Tretinoin results in increased expression of TNNT1 proteinCTDPMID:16283617
Tnnt1Ratall-trans-retinoic acid multiple interactionsISOTnnt1 (Mus musculus)6480464[mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in increased expression of TNNT1 mRNACTDPMID:36189433
Tnnt1Ratall-trans-retinoic acid decreases expressionISOTNNT1 (Homo sapiens)6480464Tretinoin results in decreased expression of TNNT1 mRNACTDPMID:21934132 and PMID:23724009
Tnnt1Ratalpha-Zearalanol decreases expressionEXP 6480464Zeranol results in decreased expression of TNNT1 mRNACTDPMID:35163327
Tnnt1Ratalpha-Zearalanol multiple interactionsEXP 6480464[Zeranol co-treated with perfluorooctanoic acid] affects the expression of TNNT1 mRNACTDPMID:35163327

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Biological Process
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Cellular Component

  
Object Symbol
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Original Reference(s)
Tnnt1Ratsarcomere located_inIEAARBA:ARBA000282611600115GO_REF:0000117UniProtGO_REF:0000117
Tnnt1Rattroponin complex  IDA 1599030 RGD 
Tnnt1Rattroponin complex part_ofIEAUniProtKB:P13805 and ensembl:ENSP000004671761600115GO_REF:0000107EnsemblGO_REF:0000107
Tnnt1Rattroponin complex part_ofIBAFB:FBgn0004169 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tnnt1Rattroponin complex part_ofISOTNNT1 (Homo sapiens)1624291 PMID:15665378 and PMID:18032382RGDPMID:15665378 and PMID:18032382
Tnnt1Rattroponin complex part_ofIEAInterPro:IPR001978 and InterPro:IPR0277071600115GO_REF:0000002InterProGO_REF:0000002
Tnnt1Rattroponin complex  IDA 1599482 RGD 

Molecular Function

  

Imported Annotations - SMPDB

1 to 20 of 38 rows
Object Symbol
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Original Reference(s)
Tnnt1Ratacebutolol pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)10402751 SMPDBSMP:00296
Tnnt1Ratadrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway   ISOTNNT1 (Homo sapiens)10402751 SMPDBSMP:00296
Tnnt1Ratamiodarone pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)10402751 SMPDBSMP:00665
Tnnt1Ratamlodipine pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)10402751 SMPDBSMP:00376
Tnnt1Ratatenolol pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)10402751 SMPDBSMP:00298
Tnnt1Ratbetaxolol pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)10402751 SMPDBSMP:00299
Tnnt1Ratbisoprolol pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)10402751 SMPDBSMP:00300
Tnnt1Ratbupranolol drug pathway  ISOTNNT1 (Homo sapiens)10402751 SMPDBSMP:00670
Tnnt1Ratbupranolol pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)10402751 SMPDBSMP:00670
Tnnt1Ratcarvedilol pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)10402751 SMPDBSMP:00367
Tnnt1Ratdiltiazem pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)10402751 SMPDBSMP:00359
Tnnt1Ratdisopyramide pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)10402751 SMPDBSMP:00325
Tnnt1Ratdobutamine pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)10402751 SMPDBSMP:00662
Tnnt1Ratesmolol pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)10402751 SMPDBSMP:00301
Tnnt1Ratflecainde pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)10402751 SMPDBSMP:00331
Tnnt1Ratfosphenytoin pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)10402751 SMPDBSMP:00326
Tnnt1Ratibutilide pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)10402751 SMPDBSMP:00332
Tnnt1Ratisoprenaline pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)10402751 SMPDBSMP:00663
Tnnt1Ratisradipine pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)10402751 SMPDBSMP:00378
Tnnt1Ratlevobunolol pharmacodynamics pathway  ISOTNNT1 (Homo sapiens)10402751 SMPDBSMP:00666
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Reference Title
Reference Citation
1. Coupled expression of troponin T and troponin I isoforms in single skeletal muscle fibers correlates with contractility. Brotto MA, etal., Am J Physiol Cell Physiol. 2006 Feb;290(2):C567-76. Epub 2005 Sep 28.
2. Alternative splicing generates variants in important functional domains of human slow skeletal troponin T. Gahlmann R, etal., J Biol Chem 1987 Nov 25;262(33):16122-6.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. A novel nemaline myopathy in the Amish caused by a mutation in troponin T1. Johnston JJ, etal., Am J Hum Genet 2000 Oct;67(4):814-21. Epub 2000 Aug 21.
6. Expression and functional properties of four slow skeletal troponin T isoforms in rat muscles. Kischel P, etal., Am J Physiol Cell Physiol. 2005 Aug;289(2):C437-43. Epub 2005 Mar 23.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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PMID:15665378   PMID:18032382   PMID:18978355  



Tnnt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,349,035 - 78,359,394 (+)NCBIGRCr8
mRatBN7.2169,306,362 - 69,316,721 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,306,362 - 69,316,721 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx174,665,281 - 74,675,640 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0183,229,594 - 83,239,953 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,379,084 - 76,389,599 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0172,889,270 - 72,899,629 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl172,889,270 - 72,899,659 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0175,652,123 - 75,662,339 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4168,036,411 - 68,045,142 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1168,114,521 - 68,123,253 (+)NCBI
Celera167,811,420 - 67,821,558 (-)NCBICelera
Cytogenetic Map1q12NCBI
TNNT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381955,132,698 - 55,149,206 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1955,132,698 - 55,149,206 (-)EnsemblGRCh38hg38GRCh38
GRCh371955,644,066 - 55,660,574 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361960,336,009 - 60,352,386 (-)NCBINCBI36Build 36hg18NCBI36
Build 341960,336,008 - 60,352,386NCBI
Celera1952,683,099 - 52,701,800 (-)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1951,967,104 - 51,981,532 (-)NCBIHuRef
CHM1_11955,637,767 - 55,654,167 (-)NCBICHM1_1
T2T-CHM13v2.01958,226,372 - 58,243,170 (-)NCBIT2T-CHM13v2.0
Tnnt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3974,507,568 - 4,518,974 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl74,507,569 - 4,519,381 (-)EnsemblGRCm39 Ensembl
GRCm3874,504,569 - 4,515,975 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl74,504,570 - 4,516,382 (-)EnsemblGRCm38mm10GRCm38
MGSCv3774,456,265 - 4,467,577 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3674,107,750 - 4,119,062 (-)NCBIMGSCv36mm8
Celera74,249,175 - 4,260,487 (-)NCBICelera
Cytogenetic Map7A1NCBI
cM Map72.6NCBI
Tnnt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555671,043,026 - 1,055,039 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555671,039,625 - 1,050,581 (+)NCBIChiLan1.0ChiLan1.0
TNNT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22061,268,613 - 61,282,914 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11962,997,739 - 63,012,038 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01952,173,523 - 52,190,577 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11960,868,241 - 60,885,197 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1960,868,330 - 60,882,005 (-)Ensemblpanpan1.1panPan2
TNNT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11102,479,617 - 102,490,776 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1102,366,801 - 102,491,147 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1102,536,670 - 102,547,827 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01103,133,191 - 103,144,315 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1102,973,590 - 103,144,307 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11102,770,115 - 102,781,270 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01102,481,708 - 102,492,858 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01103,245,737 - 103,256,895 (+)NCBIUU_Cfam_GSD_1.0
Tnnt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093492,124,674 - 2,133,897 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936886425,438 - 435,500 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936886425,331 - 434,546 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNNT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl659,347,582 - 59,365,284 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1659,351,445 - 59,365,584 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2654,300,086 - 54,314,541 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TNNT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1647,726,049 - 47,743,465 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl647,726,002 - 47,743,404 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045282,217 - 298,212 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnnt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248322,094,903 - 2,100,560 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248322,093,852 - 2,100,647 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Tnnt1
50 total Variants

Predicted Target Of
Summary Value
Count of predictions:183
Count of miRNA genes:65
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000034957, ENSRNOT00000058843, ENSRNOT00000073491
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 46 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat

1 to 10 of 46 rows
RH131706  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2169,311,353 - 69,311,570 (+)MAPPERmRatBN7.2
Rnor_6.0172,894,262 - 72,894,478NCBIRnor6.0
Rnor_5.0175,657,130 - 75,657,346UniSTSRnor5.0
RGSC_v3.4168,039,654 - 68,039,870UniSTSRGSC3.4
Celera167,816,350 - 67,816,566UniSTS
Cytogenetic Map1q12UniSTS
RH140454  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8178,356,648 - 78,357,441 (+)Marker Load Pipeline
mRatBN7.2169,313,975 - 69,314,768 (+)MAPPERmRatBN7.2
Rnor_6.0172,896,884 - 72,897,676NCBIRnor6.0
Rnor_5.0175,654,076 - 75,654,868UniSTSRnor5.0
RGSC_v3.4168,042,409 - 68,043,201UniSTSRGSC3.4
Celera167,813,373 - 67,814,165UniSTS
Cytogenetic Map1q12UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 217 97 93 44 60 31


1 to 23 of 23 rows
RefSeq Transcripts NM_001277260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001277261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001277262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_134388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC141517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF399874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY334079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY334080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY334081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY334082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 23 of 23 rows

Ensembl Acc Id: ENSRNOT00000034957   ⟹   ENSRNOP00000038327
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl169,306,362 - 69,316,721 (+)Ensembl
Rnor_6.0 Ensembl172,889,278 - 72,899,659 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000058843   ⟹   ENSRNOP00000055633
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl169,306,362 - 69,316,721 (+)Ensembl
Rnor_6.0 Ensembl172,889,270 - 72,899,629 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101852   ⟹   ENSRNOP00000076828
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl169,306,363 - 69,316,715 (+)Ensembl
RefSeq Acc Id: NM_001277260   ⟹   NP_001264189
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,349,035 - 78,359,394 (+)NCBI
mRatBN7.2169,306,362 - 69,316,721 (+)NCBI
Rnor_6.0172,889,270 - 72,899,629 (+)NCBI
Rnor_5.0175,652,123 - 75,662,339 (-)NCBI
Celera167,811,420 - 67,821,558 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001277261   ⟹   NP_001264190
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,349,035 - 78,359,394 (+)NCBI
mRatBN7.2169,306,362 - 69,316,721 (+)NCBI
Rnor_6.0172,889,270 - 72,899,629 (+)NCBI
Rnor_5.0175,652,123 - 75,662,339 (-)NCBI
Celera167,811,420 - 67,821,558 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001277262   ⟹   NP_001264191
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,349,035 - 78,359,394 (+)NCBI
mRatBN7.2169,306,362 - 69,316,721 (+)NCBI
Rnor_6.0172,889,270 - 72,899,629 (+)NCBI
Rnor_5.0175,652,123 - 75,662,339 (-)NCBI
Celera167,811,420 - 67,821,558 (-)NCBI
Sequence:
RefSeq Acc Id: NM_134388   ⟹   NP_599215
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,349,035 - 78,359,394 (+)NCBI
mRatBN7.2169,306,362 - 69,316,721 (+)NCBI
Rnor_6.0172,889,270 - 72,899,629 (+)NCBI
Rnor_5.0175,652,123 - 75,662,339 (-)NCBI
RGSC_v3.4168,036,411 - 68,045,142 (+)RGD
Celera167,811,420 - 67,821,558 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063276629   ⟹   XP_063132699
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,349,040 - 78,359,388 (+)NCBI
RefSeq Acc Id: XM_063276664   ⟹   XP_063132734
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,350,812 - 78,359,388 (+)NCBI
RefSeq Acc Id: XM_063276683   ⟹   XP_063132753
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,349,040 - 78,359,388 (+)NCBI
RefSeq Acc Id: XM_063276702   ⟹   XP_063132772
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,349,040 - 78,359,388 (+)NCBI
RefSeq Acc Id: XM_063276722   ⟹   XP_063132792
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,349,040 - 78,359,388 (+)NCBI
RefSeq Acc Id: XM_063276740   ⟹   XP_063132810
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,349,040 - 78,359,388 (+)NCBI
RefSeq Acc Id: XM_063276768   ⟹   XP_063132838
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,350,773 - 78,359,388 (+)NCBI
RefSeq Acc Id: XM_063276789   ⟹   XP_063132859
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,350,773 - 78,359,388 (+)NCBI
RefSeq Acc Id: XM_063276811   ⟹   XP_063132881
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,350,812 - 78,359,388 (+)NCBI
RefSeq Acc Id: XM_063276839   ⟹   XP_063132909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,350,812 - 78,359,388 (+)NCBI
1 to 5 of 17 rows
1 to 5 of 17 rows
RefSeq Acc Id: NP_599215   ⟸   NM_134388
- Peptide Label: isoform 1
- UniProtKB: Q7TNB1 (UniProtKB/Swiss-Prot),   Q7TNB0 (UniProtKB/Swiss-Prot),   Q7TNA9 (UniProtKB/Swiss-Prot),   Q923S7 (UniProtKB/Swiss-Prot),   Q7TNB2 (UniProtKB/Swiss-Prot),   A6KNL6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001264190   ⟸   NM_001277261
- Peptide Label: isoform 3
- UniProtKB: A6KNL6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001264191   ⟸   NM_001277262
- Peptide Label: isoform 4
- UniProtKB: A6KNL6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001264189   ⟸   NM_001277260
- Peptide Label: isoform 2
- UniProtKB: A6KNL6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000055633   ⟸   ENSRNOT00000058843

Name Modeler Protein Id AA Range Protein Structure
AF-Q7TNB2-F1-model_v2 AlphaFold Q7TNB2 1-261 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13689706
Promoter ID:EPDNEW_R231
Type:single initiation site
Name:Tnnt1_1
Description:troponin T1, slow skeletal type
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0172,889,270 - 72,889,330EPDNEW


1 to 33 of 33 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-60838 BioCyc
Ensembl Genes ENSRNOG00000028041 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000034957 ENTREZGENE
  ENSRNOT00000034957.7 UniProtKB/Swiss-Prot
  ENSRNOT00000058843 ENTREZGENE
  ENSRNOT00000058843.6 UniProtKB/Swiss-Prot
  ENSRNOT00000101852 ENTREZGENE
Gene3D-CATH 1.20.5.350 UniProtKB/Swiss-Prot
InterPro TNNT UniProtKB/Swiss-Prot
  Troponin UniProtKB/Swiss-Prot
  Troponin_sf UniProtKB/Swiss-Prot
KEGG Report rno:171409 UniProtKB/Swiss-Prot
NCBI Gene 171409 ENTREZGENE
PANTHER PTHR11521 UniProtKB/Swiss-Prot
  TROPONIN T, SLOW SKELETAL MUSCLE UniProtKB/Swiss-Prot
Pfam Troponin UniProtKB/Swiss-Prot
PhenoGen Tnnt1 PhenoGen
RatGTEx ENSRNOG00000028041 RatGTEx
Superfamily-SCOP SSF90250 UniProtKB/Swiss-Prot
UniProt A0A8I5YBH8_RAT UniProtKB/TrEMBL
  A6KNL6 ENTREZGENE, UniProtKB/TrEMBL
  A6KNL7 ENTREZGENE, UniProtKB/TrEMBL
  A6KNL8_RAT UniProtKB/TrEMBL
  Q7TNA9 ENTREZGENE
  Q7TNB0 ENTREZGENE
  Q7TNB1 ENTREZGENE
  Q7TNB2 ENTREZGENE
  Q923S7 ENTREZGENE
  TNNT1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q7TNA9 UniProtKB/Swiss-Prot
  Q7TNB0 UniProtKB/Swiss-Prot
  Q7TNB1 UniProtKB/Swiss-Prot
  Q923S7 UniProtKB/Swiss-Prot
1 to 33 of 33 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Tnnt1  troponin T1, slow skeletal type  Tnnt1  troponin T type 1 (skeletal, slow)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Tnnt1  troponin T type 1 (skeletal, slow)  Tnnt1  troponin T1, skeletal, slow  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Tnnt1  troponin T1, skeletal, slow      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Tnnt1  troponin T1, skeletal, slow      Symbol and Name status set to provisional 70820 PROVISIONAL