Casp4 (caspase 4) - Rat Genome Database

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Gene: Casp4 (caspase 4) Rattus norvegicus
Analyze
Symbol: Casp4
Name: caspase 4
RGD ID: 621757
Description: Enables scaffold protein binding activity. Predicted to be involved in several processes, including cellular response to amyloid-beta; positive regulation of signal transduction; and response to bacterium. Predicted to act upstream of or within ectopic germ cell programmed cell death; positive regulation of cytokine production; and pyroptotic inflammatory response. Located in neuronal cell body. Part of protein-containing complex. Orthologous to several human genes including CASP4 (caspase 4); INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2,4-trimethylbenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Casp11; caspase 11; caspase 4, apoptosis-related cysteine peptidase; MGC124949
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8810,883,817 - 10,919,978 (+)NCBIGRCr8
mRatBN7.282,599,017 - 2,635,097 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl82,598,876 - 2,635,092 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx86,570,604 - 6,598,288 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.084,868,372 - 4,896,060 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.082,851,833 - 2,886,754 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.082,616,391 - 2,651,682 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl82,635,851 - 2,651,652 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.082,638,624 - 2,673,915 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.482,038,626 - 2,075,722 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.182,038,610 - 2,075,144 (+)NCBI
Celera84,218,310 - 4,234,223 (+)NCBICelera
Cytogenetic Map8q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Casp4RatCOVID-19  ISOCASP4 (Homo sapiens)9068941mRNA:increased expression:bronchoalveolar lavage (human)RGDPMID:32407669 and REF_RGD_ID:30296672
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Casp4Ratataxia telangiectasia  ISOCASP4 (Homo sapiens)8554872ClinVar Annotator: match by term: Ataxia-telangiectasia syndromeClinVarPMID:23807571 more ...
Casp4Ratchromosome 11 partial duplication syndrome  ISOCASP4 (Homo sapiens)8554872ClinVar Annotator: match by term: Distal trisomy 11qClinVarPMID:25741868
Casp4Ratintellectual disability  ISOCASP4 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Casp4RatExperimental Liver Cirrhosis  ISOCASP4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25380136
Casp4Ratschizophrenia  ISOCASP4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21743468

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Casp4Rat(+)-dexrazoxane multiple interactionsISOCasp4 (Mus musculus)6480464[Doxorubicin co-treated with Dexrazoxane] results in decreased expression of CASP4 mRNACTDPMID:26873546
Casp4Rat(1->4)-beta-D-glucan multiple interactionsISOCasp4 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of CASP4 mRNACTDPMID:36331819
Casp4Rat1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane multiple interactionsEXP 64804642 more ...CTDPMID:19414516
Casp4Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expressionEXP 6480464o and p'-DDT results in increased expression of CASP4 mRNACTDPMID:22937105
Casp4Rat1,1-dichloroethene increases expressionISOCasp4 (Mus musculus)6480464vinylidene chloride results in increased expression of CASP4 mRNACTDPMID:26682919
Casp4Rat1,2,4-trimethylbenzene decreases expressionEXP 6480464pseudocumene results in decreased expression of CASP4 proteinCTDPMID:17337753
Casp4Rat1,2-dimethylhydrazine decreases expressionEXP 64804641 and 2-Dimethylhydrazine results in decreased expression of CASP4 mRNACTDPMID:32387197
Casp4Rat1,2-dimethylhydrazine multiple interactionsISOCasp4 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of CASP4 mRNACTDPMID:22206623
Casp4Rat1,2-dimethylhydrazine decreases expressionISOCasp4 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of CASP4 mRNACTDPMID:22206623
Casp4Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of CASP4 mRNACTDPMID:25380136
Casp4Rat17beta-estradiol affects expressionISOCASP4 (Homo sapiens)6480464Estradiol affects the expression of CASP4 mRNACTDPMID:22574217
Casp4Rat17beta-estradiol multiple interactionsISOCASP4 (Homo sapiens)6480464[Estradiol co-treated with TGFB1 protein] results in decreased expression of CASP4 mRNACTDPMID:30165855
Casp4Rat17beta-estradiol increases expressionISOCASP4 (Homo sapiens)6480464Estradiol results in increased expression of CASP4 mRNACTDPMID:23373633 and PMID:24481588
Casp4Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionISOCASP4 (Homo sapiens)64804642 more ...CTDPMID:27589474
Casp4Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOCASP4 (Homo sapiens)6480464Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CASP4 mRNA]CTDPMID:11007951
Casp4Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of CASP4 mRNACTDPMID:33387578
Casp4Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of CASP4 mRNACTDPMID:32109520
Casp4Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOCasp4 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of CASP4 mRNACTDPMID:21570461
Casp4Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of CASP4 mRNACTDPMID:22298810
Casp4Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOCasp4 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of CASP4 mRNACTDPMID:12167310

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Biological Process
1 to 20 of 33 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Casp4Ratanimal organ development involved_inIEAARBA:ARBA000292471600115GO_REF:0000117UniProtGO_REF:0000117
Casp4Ratcellular response to amyloid-beta involved_inISOCASP4 (Homo sapiens)1624291 PMID:15123740RGDPMID:15123740
Casp4Ratdefense response to bacterium involved_inISOCasp4 (Mus musculus)1624291 PMID:23348507 more ...RGDPMID:23348507 more ...
Casp4Ratdefense response to bacterium involved_inISOCASP4 (Homo sapiens)1624291 PMID:25119034 more ...RGDPMID:25119034 more ...
Casp4Ratdefense response to Gram-positive bacterium involved_inISOCASP4 (Homo sapiens)1624291 PMID:33377178RGDPMID:33377178
Casp4Ratdefense response to Gram-positive bacterium involved_inISOCasp4 (Mus musculus)1624291 PMID:30392956RGDPMID:30392956
Casp4Ratdetection of lipopolysaccharide involved_inISOCasp4 (Mus musculus)1624291 PMID:23887873 more ...RGDPMID:23887873 more ...
Casp4Ratectopic germ cell programmed cell death acts_upstream_of_or_withinISOCasp4 (Mus musculus)1624291MGI:2159366 more ...RGDPMID:11536012
Casp4Ratintrinsic apoptotic signaling pathway involved_inISOCASP4 (Homo sapiens)1624291 PMID:15123740RGDPMID:15123740
Casp4Ratintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress involved_inISOCASP4 (Homo sapiens)1624291 PMID:15123740RGDPMID:15123740
Casp4Ratnon-canonical inflammasome complex assembly involved_inISOCASP4 (Homo sapiens)1624291 PMID:25119034 more ...RGDPMID:25119034 more ...
Casp4Ratnon-canonical inflammasome complex assembly involved_inISOCasp4 (Mus musculus)1624291 PMID:22895188 more ...RGDPMID:22895188 more ...
Casp4Ratpositive regulation of apoptotic process involved_inIEAARBA:ARBA000277451600115GO_REF:0000117UniProtGO_REF:0000117
Casp4Ratpositive regulation of inflammatory response involved_inISOCasp4 (Mus musculus)1624291 PMID:23348507 more ...RGDPMID:23348507 more ...
Casp4Ratpositive regulation of inflammatory response involved_inISOCASP4 (Homo sapiens)1624291 PMID:33377178 more ...RGDPMID:33377178 more ...
Casp4Ratpositive regulation of interleukin-1 beta production acts_upstream_of_or_withinISOCasp4 (Mus musculus)1624291MGI:1931465 more ...RGDPMID:22002608
Casp4Ratpositive regulation of interleukin-18-mediated signaling pathway involved_inISOCasp4 (Mus musculus)1624291 PMID:30392956RGDPMID:30392956
Casp4Ratpositive regulation of interleukin-18-mediated signaling pathway involved_inISOCASP4 (Homo sapiens)1624291 PMID:33377178RGDPMID:33377178
Casp4Ratpositive regulation of macrophage cytokine production acts_upstream_of_or_withinISOCasp4 (Mus musculus)1624291MGI:1931465 more ...RGDPMID:22002608
Casp4Ratpositive regulation of NLRP3 inflammasome complex assembly involved_inISOCasp4 (Mus musculus)1624291 PMID:26173909RGDPMID:26173909
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Cellular Component
1 to 15 of 15 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Casp4RatAIM2 inflammasome complex part_ofIBAPANTHER:PTN008720309 and UniProtKB:P294661600115GO_REF:0000033GO_CentralGO_REF:0000033
Casp4Ratcytoplasm is_active_inISOCasp4 (Mus musculus)1624291 PMID:16670335RGDPMID:16670335
Casp4Ratcytosol is_active_inISOCASP4 (Homo sapiens)1624291 PMID:23661706RGDPMID:23661706
Casp4Ratcytosol is_active_inISOCasp4 (Mus musculus)1624291 PMID:16670335RGDPMID:16670335
Casp4Ratcytosol located_inISOCASP4 (Homo sapiens) and UniProtKB:P49662-11624291 RGDGO_REF:0000052
Casp4Ratendoplasmic reticulum located_inISOCASP4 (Homo sapiens)1624291 PMID:15123740RGDPMID:15123740
Casp4RatIPAF inflammasome complex part_ofIBAMGI:96544 and PANTHER:PTN0087203091600115GO_REF:0000033GO_CentralGO_REF:0000033
Casp4Ratmitochondrion located_inISOCASP4 (Homo sapiens)1624291 PMID:15123740RGDPMID:15123740
Casp4Ratneuronal cell body  IDA 5491174 RGD 
Casp4RatNLRP3 inflammasome complex part_ofIBAPANTHER:PTN008720309 and UniProtKB:P294661600115GO_REF:0000033GO_CentralGO_REF:0000033
Casp4Ratnon-canonical inflammasome complex part_ofISOCASP4 (Homo sapiens)1624291 PMID:25119034 and PMID:31268602RGDPMID:25119034 and PMID:31268602
Casp4Ratnon-canonical inflammasome complex part_ofISOCasp4 (Mus musculus)1624291 PMID:23887873 and PMID:30135078RGDPMID:23887873 and PMID:30135078
Casp4Ratplasma membrane located_inISOCASP4 (Homo sapiens) and UniProtKB:P49662-11624291 RGDGO_REF:0000052
Casp4Ratprotein-containing complex  IDA 5491011 RGD 
Casp4Ratprotein-containing complex part_ofISOCASP4 (Homo sapiens)1624291 PMID:16920334RGDPMID:16920334
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#
Reference Title
Reference Citation
1. Therapeutic neutralization of the NLRP1 inflammasome reduces the innate immune response and improves histopathology after traumatic brain injury. de Rivero Vaccari JP, etal., J Cereb Blood Flow Metab. 2009 Jul;29(7):1251-61. Epub 2009 Apr 29.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Induction of caspase-11 by inflammatory stimuli in rat astrocytes: lipopolysaccharide induction through p38 mitogen-activated protein kinase pathway. Hur J, etal., FEBS Lett 2001 Oct 26;507(2):157-62.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. The pannexin 1 channel activates the inflammasome in neurons and astrocytes. Silverman WR, etal., J Biol Chem. 2009 Jul 3;284(27):18143-51. Epub 2009 May 5.
PMID:11536012   PMID:12477932   PMID:15123740   PMID:16920334   PMID:19890920   PMID:22002608   PMID:32617860   PMID:35988500   PMID:35990672   PMID:38864370  



Casp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8810,883,817 - 10,919,978 (+)NCBIGRCr8
mRatBN7.282,599,017 - 2,635,097 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl82,598,876 - 2,635,092 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx86,570,604 - 6,598,288 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.084,868,372 - 4,896,060 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.082,851,833 - 2,886,754 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.082,616,391 - 2,651,682 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl82,635,851 - 2,651,652 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.082,638,624 - 2,673,915 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.482,038,626 - 2,075,722 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.182,038,610 - 2,075,144 (+)NCBI
Celera84,218,310 - 4,234,223 (+)NCBICelera
Cytogenetic Map8q11NCBI
CASP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811104,942,866 - 104,968,574 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11104,942,866 - 104,969,366 (-)EnsemblGRCh38hg38GRCh38
GRCh3711104,813,593 - 104,839,301 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611104,318,804 - 104,344,535 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411104,318,804 - 104,344,503NCBI
Celera11101,977,781 - 102,003,518 (-)NCBICelera
Cytogenetic Map11q22.3NCBI
HuRef11100,744,534 - 100,770,269 (-)NCBIHuRef
CHM1_111104,696,522 - 104,722,254 (-)NCBICHM1_1
T2T-CHM13v2.011104,946,956 - 104,972,673 (-)NCBIT2T-CHM13v2.0
Casp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3995,308,816 - 5,336,791 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl95,308,828 - 5,336,783 (+)EnsemblGRCm39 Ensembl
GRCm3895,308,849 - 5,336,791 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl95,308,828 - 5,336,783 (+)EnsemblGRCm38mm10GRCm38
MGSCv3795,308,860 - 5,336,791 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3695,308,874 - 5,336,717 (+)NCBIMGSCv36mm8
Celera3117,367,159 - 117,395,096 (-)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
CASP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29105,734,010 - 105,759,789 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111106,822,318 - 106,848,104 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01199,883,353 - 99,909,185 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111103,366,138 - 103,391,849 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11103,366,138 - 103,391,824 (-)Ensemblpanpan1.1panPan2
CASP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1527,133,778 - 27,147,954 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl527,132,565 - 27,149,736 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha527,064,601 - 27,078,777 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0527,170,519 - 27,184,696 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl527,169,891 - 27,186,517 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1527,212,077 - 27,226,245 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0527,098,364 - 27,112,532 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0527,257,464 - 27,271,644 (+)NCBIUU_Cfam_GSD_1.0
LOC100522887
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1935,167,567 - 35,185,791 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2939,189,534 - 39,208,073 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103248367
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1196,315,781 - 96,342,057 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl196,315,569 - 96,342,016 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604329,555,456 - 29,581,392 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Casp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624918145,661 - 187,006 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Casp4
298 total Variants

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:68
Interacting mature miRNAs:73
Transcripts:ENSRNOT00000061973
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)813402289Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000061973   ⟹   ENSRNOP00000058685
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl82,598,876 - 2,635,092 (+)Ensembl
Rnor_6.0 Ensembl82,635,851 - 2,651,652 (+)Ensembl
RefSeq Acc Id: NM_053736   ⟹   NP_446188
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8810,884,045 - 10,919,978 (+)NCBI
mRatBN7.282,599,153 - 2,635,086 (+)NCBI
Rnor_6.082,616,391 - 2,651,682 (+)NCBI
Rnor_5.082,638,624 - 2,673,915 (+)NCBI
RGSC_v3.482,038,626 - 2,075,722 (+)RGD
Celera84,218,310 - 4,234,223 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063264773   ⟹   XP_063120843
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8810,883,960 - 10,919,978 (+)NCBI
RefSeq Acc Id: XM_063264774   ⟹   XP_063120844
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8810,883,960 - 10,919,404 (+)NCBI
RefSeq Acc Id: XM_063264775   ⟹   XP_063120845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8810,902,842 - 10,919,978 (+)NCBI
RefSeq Acc Id: XR_005487740
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8810,883,817 - 10,919,978 (+)NCBI
mRatBN7.282,599,017 - 2,635,097 (+)NCBI
RefSeq Acc Id: XR_010053917
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8810,883,960 - 10,919,978 (+)NCBI
Protein RefSeqs NP_001416199 (Get FASTA)   NCBI Sequence Viewer  
  NP_446188 (Get FASTA)   NCBI Sequence Viewer  
  XP_063120843 (Get FASTA)   NCBI Sequence Viewer  
  XP_063120844 (Get FASTA)   NCBI Sequence Viewer  
  XP_063120845 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI04721 (Get FASTA)   NCBI Sequence Viewer  
  AAK38735 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000058685.5
RefSeq Acc Id: NP_446188   ⟸   NM_053736
- UniProtKB: Q3MHS1 (UniProtKB/TrEMBL),   A6JN17 (UniProtKB/TrEMBL),   Q91XW7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000058685   ⟸   ENSRNOT00000061973
RefSeq Acc Id: XP_063120843   ⟸   XM_063264773
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063120844   ⟸   XM_063264774
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063120845   ⟸   XM_063264775
- Peptide Label: isoform X3
CARD   Caspase family p10   Caspase family p20

Name Modeler Protein Id AA Range Protein Structure
AF-E9PSM0-F1-model_v2 AlphaFold E9PSM0 1-356 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 40 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-31820 BioCyc
Ensembl Genes ENSRNOG00000033697 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000061973.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  3.40.50.1460 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7382967 IMAGE-MGC_LOAD
InterPro CARD UniProtKB/TrEMBL
  Caspase-like_dom UniProtKB/TrEMBL
  Caspase_cys_AS UniProtKB/TrEMBL
  DEATH-like UniProtKB/TrEMBL
  Pept_C14 UniProtKB/TrEMBL
  Pept_C14_caspase UniProtKB/TrEMBL
  Pept_C14_ICE_p20 UniProtKB/TrEMBL
  Pept_C14_ICE_p20_AS UniProtKB/TrEMBL
  Pept_C14_p10 UniProtKB/TrEMBL
  Pept_C14_p45_core UniProtKB/TrEMBL
KEGG Report rno:114555 UniProtKB/TrEMBL
MGC_CLONE MGC:124949 IMAGE-MGC_LOAD
NCBI Gene 114555 ENTREZGENE
PANTHER CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18 UniProtKB/TrEMBL
  CASPASE-1 UniProtKB/TrEMBL
Pfam CARD UniProtKB/TrEMBL
  Peptidase_C14 UniProtKB/TrEMBL
PhenoGen Casp4 PhenoGen
PIRSF Caspase_ICE UniProtKB/TrEMBL
PRINTS IL1BCENZYME UniProtKB/TrEMBL
PROSITE CARD UniProtKB/TrEMBL
  CASPASE_CYS UniProtKB/TrEMBL
  CASPASE_HIS UniProtKB/TrEMBL
  CASPASE_P10 UniProtKB/TrEMBL
  CASPASE_P20 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033697 RatGTEx
SMART CARD UniProtKB/TrEMBL
  CASc UniProtKB/TrEMBL
Superfamily-SCOP DEATH_like UniProtKB/TrEMBL
  SSF52129 UniProtKB/TrEMBL
UniProt A6JN17 ENTREZGENE, UniProtKB/TrEMBL
  E9PSM0_RAT UniProtKB/TrEMBL
  Q3MHS1 ENTREZGENE, UniProtKB/TrEMBL
  Q91XW7 ENTREZGENE, UniProtKB/TrEMBL
1 to 40 of 40 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-19 Casp4  caspase 4  Casp4  caspase 4, apoptosis-related cysteine peptidase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Casp4  caspase 4, apoptosis-related cysteine peptidase  Casp11  caspase 11  Symbol and Name updated 1299863 APPROVED
2005-01-28 Casp11    Casp4  caspase 11  Symbol updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2004-09-10 Casp4  caspase 11  Casp11    Symbol and Name updated 1299863 APPROVED
2002-08-07 Casp11  caspase 11      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_homology aa sequence shares 88.7% similarity to mouse Casp11 632459
gene_pathway inflammatory induction of Casp11 may be mediated through the p38 MAPK pathway 632459
gene_protein protein masses 43 kDa 632459