Tpi1 (triosephosphate isomerase 1) - Rat Genome Database

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Gene: Tpi1 (triosephosphate isomerase 1) Rattus norvegicus
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Symbol: Tpi1 (Ensembl: Tpi1l2)
Name: triosephosphate isomerase 1 (Ensembl:triosephosphate isomerase 1 like 2)
RGD ID: 3896
Description: Enables triose-phosphate isomerase activity. Predicted to be involved in several processes, including glucose metabolic process; glyceraldehyde-3-phosphate biosynthetic process; and methylglyoxal biosynthetic process. Predicted to act upstream of or within glucose metabolic process. Predicted to be active in cytosol. Biomarker of ocular hypertension. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and triosephosphate isomerase deficiency. Orthologous to human TPI1 (triosephosphate isomerase 1); PARTICIPATES IN Fanconi syndrome pathway; fructose and mannose metabolic pathway; fructose-1,6-bisphosphatase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC100911515; methylglyoxal synthase; MGC156639; TIM; Tpi; triose-phosphate isomerase; triosephosphate isomerase; triosephosphate isomerase-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: LOC681129  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,301,558 - 159,305,088 (-)NCBIGRCr8
mRatBN7.24157,615,283 - 157,618,813 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,615,386 - 157,619,541 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4163,843,450 - 163,846,958 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04159,626,360 - 159,629,868 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,261,966 - 158,265,490 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,328,375 - 157,331,905 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04224,345,971 - 224,349,501 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44160,933,341 - 160,936,871 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14161,178,382 - 161,181,807 (-)NCBI
Celera4146,353,273 - 146,356,791 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
Tpi1Ratcarbohydrate metabolic disorder  ISOTPI1 (Homo sapiens)1599584triosephosphate isomerase deficiencyRGD 
Tpi1RatCOVID-19  ISOTPI1 (Homo sapiens)9068941mRNA:increased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226 and REF_RGD_ID:28912744
Tpi1RatExperimental Diabetes Mellitus  IEP 5147874protein:decreased expression:retinaRGD 
Tpi1Ratocular hypertension  IEP 2303613protein:decreased expression:retinaRGD 
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Original Reference(s)
Tpi1Ratdevelopmental and epileptic encephalopathy 21  ISOTPI1 (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathy and 21ClinVarPMID:28492532
Tpi1Ratgenetic disease  ISOTPI1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
Tpi1RatHyperphosphatemic Familial Tumoral Calcinosis 1  ISOTPI1 (Homo sapiens)8554872ClinVar Annotator: match by term: Tumoral calcinosis more ...ClinVarPMID:25378588 and PMID:29389098
Tpi1RatKlippel-Feil syndrome 3  ISOTPI1 (Homo sapiens)8554872ClinVar Annotator: match by term: Klippel-Feil syndrome 3 and autosomal dominantClinVarPMID:28492532
Tpi1Ratlymphoproliferative syndrome 2  ISOTPI1 (Homo sapiens)8554872ClinVar Annotator: match by term: Lymphoproliferative syndrome 2ClinVarPMID:28492532
Tpi1Ratperoxisome biogenesis disorder 2B  ISOTPI1 (Homo sapiens)8554872ClinVar Annotator: match by term: Peroxisome biogenesis disorder 2BClinVarPMID:28492532
Tpi1RatTemtamy syndrome  ISOTPI1 (Homo sapiens)8554872ClinVar Annotator: match by term: Temtamy syndromeClinVarPMID:28492532
Tpi1Rattriosephosphate isomerase deficiency  ISOTPI1 (Homo sapiens)8554872ClinVar Annotator: match by term: Triosephosphate isomerase deficiencyClinVarPMID:10209987 more ...
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Original Reference(s)
Tpi1RatAlzheimer's disease  ISOTPI1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19374891
Tpi1RatAnimal Disease Models  ISOTPI1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27602772
Tpi1Ratcongenital nonspherocytic hemolytic anemia  ISOTPI1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:8503454
Tpi1Ratesophagus squamous cell carcinoma  ISOTPI1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21517111
Tpi1Rathemolytic anemia  ISOTPI1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:2876430
Tpi1Ratinherited metabolic disorder  ISOTPI1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:2876430 and PMID:8503454
Tpi1Ratlung adenocarcinoma  ISOTPI1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27602772
Tpi1RatMouth Neoplasms  ISOTPI1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15274141
Tpi1Ratneuromuscular disease  ISOTPI1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:8503454
Tpi1RatNeuromuscular Manifestations  ISOTPI1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:2876430 and PMID:8503454
Tpi1Ratosteoporosis  ISOTPI1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18924182
Tpi1Ratsquamous cell carcinoma  ISOTPI1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15274141
Tpi1Rattriosephosphate isomerase deficiency  ISOTPI1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
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Tpi1Rattriosephosphate isomerase deficiency  ISSTpi1 (Mus musculus)13592920OMIM:615512MouseDO 
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Tpi1Rattriosephosphate isomerase deficiency  ISOTPI1 (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Tpi1Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of TPI1 mRNA]CTDPMID:31150632
Tpi1Rat1,2,4-trimethylbenzene decreases expressionEXP 6480464pseudocumene results in decreased expression of TPI1 proteinCTDPMID:17337753
Tpi1Rat1,2-dimethylhydrazine multiple interactionsISOTpi1 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of TPI1 mRNACTDPMID:22206623
Tpi1Rat1,3-dinitrobenzene decreases expressionEXP 64804643-dinitrobenzene results in decreased expression of TPI1 proteinCTDPMID:24140754
Tpi1Rat1-bromopropane increases expressionEXP 64804641-bromopropane results in increased expression of TPI1 proteinCTDPMID:21925529
Tpi1Rat1-bromopropane decreases expressionEXP 64804641-bromopropane results in decreased expression of TPI1 proteinCTDPMID:21925529
Tpi1Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of TPI1 mRNACTDPMID:12075121 and PMID:15576828
Tpi1Rat17alpha-ethynylestradiol affects expressionISOTpi1 (Mus musculus)6480464Ethinyl Estradiol affects the expression of TPI1 mRNACTDPMID:17555576
Tpi1Rat17beta-estradiol multiple interactionsISOTPI1 (Homo sapiens)6480464[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of TPI1 mRNACTDPMID:20823114
Tpi1Rat17beta-estradiol increases expressionISOTpi1 (Mus musculus)6480464Estradiol results in increased expression of TPI1 mRNACTDPMID:39298647
Tpi1Rat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of TPI1 mRNACTDPMID:32145629
Tpi1Rat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISOTpi1 (Mus musculus)6480464[2 more ...CTDPMID:23457121
Tpi1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOTPI1 (Homo sapiens)64804642-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of TPI1 mRNA] and alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of TPI1 mRNA]CTDPMID:23152189
Tpi1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of TPI1 mRNACTDPMID:32109520 and PMID:33387578
Tpi1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOTpi1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of TPI1 mRNACTDPMID:21570461
Tpi1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOTPI1 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in decreased expression of TPI1 mRNACTDPMID:23152189
Tpi1Rat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642 more ...CTDPMID:32109520
Tpi1Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether increases expressionEXP 64804642 more ...CTDPMID:19954255
Tpi1Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOTpi1 (Mus musculus)64804642 more ...CTDPMID:38648751
Tpi1Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of TPI1 mRNACTDPMID:21346803

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Biological Process
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Original Reference(s)
Tpi1Ratcanonical glycolysis involved_inISOTpi1 (Mus musculus)1624291MGI:3780541 PMID:30174313RGDPMID:30174313
Tpi1Ratgluconeogenesis involved_inIEAUniPathway:UPA001381600115GO_REF:0000041UniProtGO_REF:0000041
Tpi1Ratgluconeogenesis involved_inISOTpi1 (Mus musculus)1624291 PMID:31891762RGDPMID:31891762
Tpi1Ratgluconeogenesis involved_inIBAMGI:98797 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tpi1Ratgluconeogenesis involved_inIEAUniProtKB-KW:KW-03121600115GO_REF:0000043UniProtGO_REF:0000043
Tpi1Ratglucose metabolic process acts_upstream_of_or_withinISOTpi1 (Mus musculus)1624291 PMID:2693209RGDPMID:2693209
Tpi1Ratglyceraldehyde-3-phosphate biosynthetic process involved_inISSUniProtKB:P009391600115GO_REF:0000024UniProtGO_REF:0000024
Tpi1Ratglyceraldehyde-3-phosphate biosynthetic process involved_inIBAPANTHER:PTN000474559 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tpi1Ratglyceraldehyde-3-phosphate biosynthetic process involved_inISOTPI1 (Homo sapiens)1624291 PMID:18562316RGDPMID:18562316
Tpi1Ratglyceraldehyde-3-phosphate metabolic process involved_inISOTpi1 (Mus musculus)1624291 PMID:15155459RGDPMID:15155459
Tpi1Ratglycerol catabolic process involved_inIBAPANTHER:PTN000474559 and TAIR:locus:20470721600115GO_REF:0000033GO_CentralGO_REF:0000033
Tpi1Ratglycolytic process  TAS 1599585 RGD 
Tpi1Ratglycolytic process involved_inIBAFB:FBgn0086355 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tpi1Ratglycolytic process involved_inIEAUniProtKB-KW:KW-03241600115GO_REF:0000043UniProtGO_REF:0000043
Tpi1Ratglycolytic process involved_inIEAInterPro:IPR0228961600115GO_REF:0000002InterProGO_REF:0000002
Tpi1Ratglycolytic process involved_inIEAUniPathway:UPA001091600115GO_REF:0000041UniProtGO_REF:0000041
Tpi1Ratmethylglyoxal biosynthetic process involved_inISSUniProtKB:P009391600115GO_REF:0000024UniProtGO_REF:0000024
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Cellular Component

  
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Tpi1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Tpi1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Tpi1Ratcytosol is_active_inIBAMGI:98797 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tpi1Ratcytosol is_active_inISOTpi1 (Mus musculus)1624291 PMID:12581871 and PMID:23665338RGDPMID:12581871 and PMID:23665338

Molecular Function
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Original Reference(s)
Tpi1Ratisomerase activity enablesIEAUniProtKB-KW:KW-04131600115GO_REF:0000043UniProtGO_REF:0000043
Tpi1Ratisomerase activity enablesISOTpi1 (Mus musculus)1624291 PMID:566475RGDPMID:566475
Tpi1Ratlyase activity enablesIEAUniProtKB-KW:KW-04561600115GO_REF:0000043UniProtGO_REF:0000043
Tpi1Ratmethylglyoxal synthase activity enablesIEAEC:4.2.3.31600115GO_REF:0000003UniProtGO_REF:0000003
Tpi1Ratmethylglyoxal synthase activity enablesIEARHEA:179371600115GO_REF:0000116RHEAGO_REF:0000116
Tpi1Ratmethylglyoxal synthase activity enablesISSUniProtKB:P009391600115GO_REF:0000024UniProtGO_REF:0000024
Tpi1Ratprotein binding  IPIKcnj11 (Mus musculus)1599585 RGD 
Tpi1Ratprotein binding enablesISOTpi1 (Mus musculus)1624291UniProtKB:Q9CPW0 and PMID:25707359RGDPMID:25707359
Tpi1Ratprotein binding enablesISOTPI1 (Homo sapiens)1624291UniProtKB:P12004 more ...RGDPMID:20849852 more ...
Tpi1Ratprotein homodimerization activity enablesISSUniProtKB:P601741600115GO_REF:0000024UniProtGO_REF:0000024
Tpi1Ratprotein homodimerization activity enablesISOTPI1 (Homo sapiens)1624291 PMID:18562316RGDPMID:18562316
Tpi1Rattriose-phosphate isomerase activity  IDA 1599371 RGD 
Tpi1Rattriose-phosphate isomerase activity enablesIEARHEA:185851600115GO_REF:0000116RHEAGO_REF:0000116
Tpi1Rattriose-phosphate isomerase activity enablesIEAEC:5.3.1.11600115GO_REF:0000003UniProtGO_REF:0000003
Tpi1Rattriose-phosphate isomerase activity enablesISOTpi1 (Mus musculus)1624291MGI:2183489 PMID:15155459 more ...RGDMGI:62142 more ...
Tpi1Rattriose-phosphate isomerase activity enablesIBAFB:FBgn0086355 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tpi1Rattriose-phosphate isomerase activity enablesISOTPI1 (Homo sapiens)1624291 PMID:18562316RGDPMID:18562316
Tpi1Rattriose-phosphate isomerase activity enablesIEAInterPro:IPR000652 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Tpi1Ratubiquitin protein ligase binding enablesISOTPI1 (Homo sapiens)1624291UniProtKB:O60260 and PMID:19725078RGDPMID:19725078
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Imported Annotations - KEGG (archival)

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Original Reference(s)
Tpi1Ratfructose and mannose metabolic pathway  IEA 6907045 KEGGrno:00051
Tpi1Ratgluconeogenesis pathway   IEA 6907045 KEGGrno:00010
Tpi1Ratglycolysis pathway   IEA 6907045 KEGGrno:00010
Tpi1Ratglycolysis/gluconeogenesis pathway  IEA 6907045 KEGGrno:00010
Tpi1Ratinositol phosphate metabolic pathway  IEA 6907045 KEGGrno:00562

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#
Reference Title
Reference Citation
1. Evidence for founder effect of the Glu104Asp substitution and identification of new mutations in triosephosphate isomerase deficiency. Arya R, etal., Hum Mutat. 1997;10(4):290-4.
2. Key enzymes of carbohydrate metabolism as targets of the 11.5-kDa Zn(2+)-binding protein (parathymosin). Brand IA and Heinickel A, J Biol Chem. 1991 Nov 5;266(31):20984-9.
3. The glycolytic enzymes, glyceraldehyde-3-phosphate dehydrogenase, triose-phosphate isomerase, and pyruvate kinase are components of the K(ATP) channel macromolecular complex and regulate its function. Dhar-Chowdhury P, etal., J Biol Chem. 2005 Nov 18;280(46):38464-70. Epub 2005 Sep 16.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Differences in expression of retinal proteins between diabetic and normal rats. Liu SQ, etal., World J Gastroenterol. 2007 Apr 14;13(14):2118-24.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Proteomic analysis of rat retina in a steroid-induced ocular hypertension model: potential vulnerability to oxidative stress. Miyara N, etal., Jpn J Ophthalmol. 2008 Mar-Apr;52(2):84-90. Epub 2008 Apr 30.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Information Derived from GenBank Report RGD, Sept. 2003
17. Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus. Shakib K, etal., Proteomics. 2005 Jul;5(11):2819-38.
18. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
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PMID:204065   PMID:566475   PMID:566476   PMID:2693209   PMID:3796661   PMID:6434534   PMID:8417789   PMID:15155459   PMID:15489334   PMID:15632090   PMID:16502470   PMID:16854843  
PMID:17023274   PMID:18562316   PMID:19056867   PMID:19182904   PMID:19725078   PMID:21630459   PMID:22420779   PMID:22664934   PMID:22871113   PMID:23376485   PMID:23533145   PMID:23580065  
PMID:26316108   PMID:26945066   PMID:29476059   PMID:33450132   PMID:35111160   PMID:35352799   PMID:36755387  



Tpi1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,301,558 - 159,305,088 (-)NCBIGRCr8
mRatBN7.24157,615,283 - 157,618,813 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,615,386 - 157,619,541 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4163,843,450 - 163,846,958 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04159,626,360 - 159,629,868 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,261,966 - 158,265,490 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,328,375 - 157,331,905 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04224,345,971 - 224,349,501 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44160,933,341 - 160,936,871 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14161,178,382 - 161,181,807 (-)NCBI
Celera4146,353,273 - 146,356,791 (-)NCBICelera
Cytogenetic Map4q42NCBI
TPI1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,867,420 - 6,870,948 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,867,119 - 6,870,948 (+)EnsemblGRCh38hg38GRCh38
GRCh37126,976,584 - 6,980,112 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,846,967 - 6,850,253 (+)NCBINCBI36Build 36hg18NCBI36
Build 34126,846,966 - 6,850,253NCBI
Celera128,593,870 - 8,597,397 (+)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef126,830,312 - 6,833,839 (+)NCBIHuRef
CHM1_1126,975,582 - 6,979,109 (+)NCBICHM1_1
T2T-CHM13v2.0126,876,717 - 6,880,246 (+)NCBIT2T-CHM13v2.0
Tpi1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396124,787,549 - 124,791,121 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6124,787,549 - 124,791,259 (-)EnsemblGRCm39 Ensembl
GRCm386124,810,586 - 124,814,158 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6124,810,586 - 124,814,296 (-)EnsemblGRCm38mm10GRCm38
MGSCv376124,760,610 - 124,764,314 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366124,776,334 - 124,780,031 (-)NCBIMGSCv36mm8
Celera6126,486,721 - 126,490,425 (-)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.17NCBI
Tpi1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554134,467,566 - 4,471,177 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554134,467,615 - 4,471,594 (+)NCBIChiLan1.0ChiLan1.0
TPI1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21012,430,570 - 12,434,002 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11212,427,328 - 12,430,760 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0126,999,275 - 7,002,678 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1126,910,819 - 6,914,056 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl126,910,813 - 6,913,612 (+)Ensemblpanpan1.1panPan2
TPI1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,154,519 - 38,157,900 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,154,519 - 38,158,137 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,458,847 - 8,462,228 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02738,507,407 - 38,510,797 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2738,507,407 - 38,510,859 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12738,381,481 - 38,384,861 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02738,422,508 - 38,425,888 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0277,937,580 - 7,940,961 (+)NCBIUU_Cfam_GSD_1.0
Tpi1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,280,602 - 102,283,888 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936709945,201 - 951,441 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936709948,151 - 951,430 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPI1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl563,838,506 - 63,843,134 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1563,839,473 - 63,842,853 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2566,274,980 - 66,278,361 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TPI1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1116,900,762 - 6,904,188 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl116,900,787 - 6,906,787 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660631,319,371 - 1,323,379 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tpi1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248603,533,320 - 3,539,755 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248603,533,226 - 3,536,786 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Tpi1
11 total Variants

Predicted Target Of
Summary Value
Count of predictions:135
Count of miRNA genes:107
Interacting mature miRNAs:114
Transcripts:ENSRNOT00000020647
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 36 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat

1 to 10 of 36 rows
RH94523  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4q42UniSTS
RH129184  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4q42UniSTS
AI411387  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24157,619,843 - 157,620,056 (-)MAPPERmRatBN7.2
mRatBN7.24157,619,843 - 157,620,056 (+)MAPPERmRatBN7.2
Rnor_6.04157,332,936 - 157,333,148NCBIRnor6.0
Rnor_6.0920,212,509 - 20,212,721NCBIRnor6.0
Rnor_5.04224,350,532 - 224,350,744UniSTSRnor5.0
Rnor_5.0919,088,485 - 19,088,697UniSTSRnor5.0
RGSC_v3.44160,937,902 - 160,938,114UniSTSRGSC3.4
Celera4146,357,822 - 146,358,034UniSTS
RH 3.4 Map41005.8UniSTS
Cytogenetic Map4q42UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
18 22 98 221 173 174 113 46 113 12 423 186 185 90 115 61


1 to 28 of 28 rows
RefSeq Transcripts NM_022922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC115420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC126087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L36250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 28 of 28 rows

Ensembl Acc Id: ENSRNOT00000020647   ⟹   ENSRNOP00000020647
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4157,615,386 - 157,619,050 (-)Ensembl
Rnor_6.0 Ensembl4157,328,379 - 157,331,905 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000071439   ⟹   ENSRNOP00000067409
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4157,615,386 - 157,618,825 (-)Ensembl
Rnor_6.0 Ensembl920,213,776 - 20,216,608 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089341   ⟹   ENSRNOP00000069904
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl920,213,588 - 20,217,176 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117284   ⟹   ENSRNOP00000088185
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4157,615,386 - 157,619,541 (-)Ensembl
RefSeq Acc Id: NM_022922   ⟹   NP_075211
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84159,301,558 - 159,305,088 (-)NCBI
mRatBN7.24157,615,283 - 157,618,813 (-)NCBI
Rnor_6.04157,328,375 - 157,331,905 (-)NCBI
Rnor_5.04224,345,971 - 224,349,501 (-)NCBI
RGSC_v3.44160,933,341 - 160,936,871 (-)RGD
Celera4146,353,273 - 146,356,791 (-)RGD
Sequence:
1 to 10 of 10 rows
Protein RefSeqs NP_075211 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42278 (Get FASTA)   NCBI Sequence Viewer  
  AAH61781 (Get FASTA)   NCBI Sequence Viewer  
  AAI26088 (Get FASTA)   NCBI Sequence Viewer  
  EDM01923 (Get FASTA)   NCBI Sequence Viewer  
  EDM01924 (Get FASTA)   NCBI Sequence Viewer  
  EDM01925 (Get FASTA)   NCBI Sequence Viewer  
  EDM01926 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000020647
GenBank Protein P48500 (Get FASTA)   NCBI Sequence Viewer  
1 to 10 of 10 rows
RefSeq Acc Id: NP_075211   ⟸   NM_022922
- UniProtKB: A0JN18 (UniProtKB/Swiss-Prot),   Q6P793 (UniProtKB/Swiss-Prot),   P48500 (UniProtKB/Swiss-Prot),   A0A8L2R053 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020647   ⟸   ENSRNOT00000020647
Ensembl Acc Id: ENSRNOP00000067409   ⟸   ENSRNOT00000071439
Ensembl Acc Id: ENSRNOP00000069904   ⟸   ENSRNOT00000089341
Ensembl Acc Id: ENSRNOP00000088185   ⟸   ENSRNOT00000117284

Name Modeler Protein Id AA Range Protein Structure
AF-P48500-F1-model_v2 AlphaFold P48500 1-249 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693390
Promoter ID:EPDNEW_R3915
Type:multiple initiation site
Name:Tpi1_1
Description:triosephosphate isomerase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04157,331,917 - 157,331,977EPDNEW


1 to 40 of 40 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-43066 BioCyc
BioCyc Pathway ANAGLYCOLYSIS-PWY [glycolysis III (from glucose)] BioCyc
  PWY66-373 [sucrose degradation V (sucrose alpha-glucosidase)] BioCyc
  PWY66-399 [gluconeogenesis III] BioCyc
BioCyc Pathway Image ANAGLYCOLYSIS-PWY BioCyc
  PWY66-373 BioCyc
  PWY66-399 BioCyc
Ensembl Genes ENSRNOG00000015290 Ensembl, ENTREZGENE
  ENSRNOG00000050669 Ensembl
Ensembl Transcript ENSRNOT00000020647 ENTREZGENE
Gene3D-CATH 3.20.20.70 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5623367 IMAGE-MGC_LOAD
  IMAGE:8368624 IMAGE-MGC_LOAD
InterPro Aldolase_TIM UniProtKB/Swiss-Prot
  TIM_sf UniProtKB/Swiss-Prot
  TrioseP_Isoase_bac/euk UniProtKB/Swiss-Prot
  Triosephosphate_isomerase UniProtKB/Swiss-Prot
  Triosephosphate_isomerase_AS UniProtKB/Swiss-Prot
KEGG Report rno:24849 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156639 IMAGE-MGC_LOAD
  MGC:72436 IMAGE-MGC_LOAD
NCBI Gene 24849 ENTREZGENE
PANTHER PTHR21139 UniProtKB/Swiss-Prot
  TRIOSEPHOSPHATE ISOMERASE UniProtKB/Swiss-Prot
Pfam TIM UniProtKB/Swiss-Prot
PhenoGen Tpi1 PhenoGen
PROSITE TIM_1 UniProtKB/Swiss-Prot
  TIM_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015290 RatGTEx
  ENSRNOG00000050669 RatGTEx
Superfamily-SCOP SSF51351 UniProtKB/Swiss-Prot
UniProt A0A8I6A997_RAT UniProtKB/TrEMBL
  A0A8L2QAQ2_RAT UniProtKB/TrEMBL
  A0A8L2R053 ENTREZGENE, UniProtKB/TrEMBL
  A0JN18 ENTREZGENE
  P48500 ENTREZGENE
  Q6P793 ENTREZGENE
  TPIS_RAT UniProtKB/Swiss-Prot
UniProt Secondary A0JN18 UniProtKB/Swiss-Prot
  Q6P793 UniProtKB/Swiss-Prot
1 to 40 of 40 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Tpi1  triosephosphate isomerase 1  LOC100911515  triosephosphate isomerase-like  Data merged from RGD:6492323 737654 PROVISIONAL
2012-07-05 LOC100911515  triosephosphate isomerase-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2003-04-09 Tpi1  triosephosphate isomerase 1    Triosephosphate isomerase 1  Name updated 629478 APPROVED
2002-06-10 Tpi1  Triosephosphate isomerase 1      Symbol and Name status set to approved 70586 APPROVED