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Gene: TPI1 (triosephosphate isomerase 1) Homo sapiens
Symbol: TPI1
Name: triosephosphate isomerase 1
RGD ID: 737023
Description: Exhibits protein homodimerization activity; triose-phosphate isomerase activity; and ubiquitin protein ligase binding activity. Involved in glyceraldehyde-3-phosphate biosynthetic process. Localizes to extracellular exosome and nucleus. Implicated in carbohydrate metabolic disorder and triosephosphate isomerase deficiency.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: epididymis secretory protein Li 49; HEL-S-49; methylglyoxal synthase; MGC88108; TIM; TPI; TPID; triose-phosphate isomerase; triosephosphate isomerase
Mus musculus (house mouse) : Tpi1 (triosephosphate isomerase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tpi1 (triosephosphate isomerase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tpi1 (triosephosphate isomerase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TPI1 (triosephosphate isomerase 1)
Canis lupus familiaris (dog) : TPI1 (triosephosphate isomerase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tpi1 (triosephosphate isomerase 1)
Sus scrofa (pig) : TPI1 (triosephosphate isomerase 1)
Chlorocebus sabaeus (African green monkey) : TPI1 (triosephosphate isomerase 1)
Heterocephalus glaber (naked mole-rat) : Tpi1 (triosephosphate isomerase 1)
more info ...
Related Pseudogenes: TPI1P1   TPI1P2   TPI1P3   TPI1P4  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl126,867,119 - 6,870,948 (+)EnsemblGRCh38hg38GRCh38
GRCh38126,866,834 - 6,870,948 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37126,976,288 - 6,980,110 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,846,967 - 6,850,253 (+)NCBINCBI36hg18NCBI36
Build 34126,846,966 - 6,850,253NCBI
Celera128,593,870 - 8,597,397 (+)NCBI
Cytogenetic Map12p13.31NCBI
HuRef126,830,312 - 6,833,839 (+)NCBIHuRef
CHM1_1126,975,582 - 6,979,109 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on TPI1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737023
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-10-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.