Phex (phosphate regulating endopeptidase X-linked) - Rat Genome Database

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Gene: Phex (phosphate regulating endopeptidase X-linked) Rattus norvegicus
Analyze
Symbol: Phex
Name: phosphate regulating endopeptidase X-linked
RGD ID: 3323
Description: Predicted to enable metalloendopeptidase activity. Involved in several processes, including cellular response to parathyroid hormone stimulus; cellular response to vitamin D; and response to insulin-like growth factor stimulus. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and perinuclear region of cytoplasm. Predicted to be active in plasma membrane. Biomarker of kidney failure. Human ortholog(s) of this gene implicated in X-linked dominant hypophosphatemic rickets. Orthologous to human PHEX (phosphate regulating endopeptidase X-linked); INTERACTS WITH acrylamide; alachlor; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC102554012; metalloendopeptidase homolog PEX; metalloendopeptidase homolog PEX-like; PEX; phosphate regulating endopeptidase homolog, X-linked; phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets); Phosphate regulating neutral endopeptidase on the X chromosome (X-linked hypophosphatemia XLH); phosphate-regulating neutral endopeptidase; phosphate-regulating neutral endopeptidase PHEX
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X41,422,561 - 41,671,226 (+)NCBIGRCr8
mRatBN7.2X37,607,553 - 37,856,183 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX37,610,760 - 37,854,469 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX38,808,427 - 39,046,002 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X42,275,631 - 42,513,220 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X39,960,325 - 40,197,897 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X40,460,047 - 40,717,982 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX40,460,047 - 40,717,982 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X40,772,810 - 41,031,710 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X58,911,144 - 59,168,857 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X58,964,612 - 59,222,310 (+)NCBI
CeleraX38,233,227 - 38,472,933 (+)NCBICelera
Cytogenetic MapXq21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(2E,4E)-hexa-2,4-dienoic acid  (ISO)
1,4-dioxane  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-diaminotoluene  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
3-methylcholanthrene  (ISO)
7,12-dimethyltetraphene  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aflatoxin M1  (ISO)
alachlor  (EXP)
all-trans-retinoic acid  (ISO)
aluminium oxide  (ISO)
ammonium chloride  (EXP)
anthracene-1,8,9-triol  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
biphenyl-2-ol  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (EXP,ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
D-mannitol  (EXP)
DDT  (EXP)
dextran sulfate  (ISO)
dibutyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
erythrosin B  (ISO)
fenvalerate  (EXP)
glycerol 2-phosphate  (ISO)
iron dichloride  (ISO)
iron trichloride  (ISO)
levamisole  (ISO)
Mezerein  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nitrofen  (EXP)
oxaliplatin  (EXP)
paraquat  (EXP)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphonoformic acid  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
propionic acid  (ISO)
saccharin  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (EXP)
styrene oxide  (ISO)
thyroxine  (ISO)
tin(II) chloride (anhydrous)  (ISO)
topotecan  (EXP)
tributylstannane  (ISO)
trichloroethene  (EXP)
vinclozolin  (EXP)
XL147  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Differential regulation of PHEX expression in bone and parathyroid gland by chronic renal insufficiency and 1,25-dihydroxyvitamin D3. Brewer AJ, etal., Am J Physiol Renal Physiol. 2004 Apr;286(4):F739-48. Epub 2003 Dec 23.
2. Genomic organization of the human PEX gene mutated in X-linked dominant hypophosphatemic rickets. Francis F, etal., Genome Res 1997 Jun;7(6):573-85.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. 1,25-dihydroxyvitamin D3 down-regulation of PHEX gene expression is mediated by apparent repression of a 110 kDa transfactor that binds to a polyadenine element in the promoter. Hines ER, etal., J Biol Chem. 2004 Nov 5;279(45):46406-14. Epub 2004 Aug 25.
6. Mutational analysis of the PEX gene in patients with X-linked hypophosphatemic rickets. Holm IA, etal., Am J Hum Genet. 1997 Apr;60(4):790-7.
7. New intragenic deletions in the Phex gene clarify X-linked hypophosphatemia-related abnormalities in mice. Lorenz-Depiereux B, etal., Mamm Genome. 2004 Mar;15(3):151-61.
8. A compilation of partial sequences of randomly selected cDNA clones from the rat incisor. Matsuki Y, etal., J Dent Res 1995 Jan;74(1):307-12.
9. A mouse model with postnatal endolymphatic hydrops and hearing loss. Megerian CA, etal., Hear Res. 2008 Mar;237(1-2):90-105. doi: 10.1016/j.heares.2008.01.002. Epub 2008 Jan 15.
10. MRNA expression of Phex in mice and rats: the effect of low phosphate diet. Meyer MH and Meyer RA Jr, Endocrine. 2000 Aug;13(1):81-7.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. A gene (PEX) with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets. The HYP Consortium. NO_AUTHOR Nat Genet. 1995 Oct;11(2):130-6.
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. A novel Phex mutation in a new mouse model of hypophosphatemic rickets. Owen C, etal., J Cell Biochem. 2012 Jul;113(7):2432-41. doi: 10.1002/jcb.24115.
16. PTHrP(1-34)-mediated repression of the PHEX gene in osteoblastic cells involves the transcriptional repressor E4BP4. Pellicelli M, etal., J Cell Physiol. 2012 Jun;227(6):2378-87. doi: 10.1002/jcp.22973.
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Comprehensive gene review and curation RGD comprehensive gene curation
21. Pex gene deletions in Gy and Hyp mice provide mouse models for X-linked hypophosphatemia. Strom TM, etal., Hum Mol Genet. 1997 Feb;6(2):165-71.
22. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
23. The role of tumor necrosis factor alpha in down-regulation of osteoblast Phex gene expression in experimental murine colitis. Uno JK, etal., Gastroenterology. 2006 Aug;131(2):497-509.
24. IGF-I and GH stimulate Phex mRNA expression in lungs and bones and 1,25-dihydroxyvitamin D(3) production in hypophysectomized rats. Zoidis E, etal., Eur J Endocrinol 2002 Jan;146(1):97-105.
25. Phex cDNA cloning from rat bone and studies on phex mRNA expression: tissue-specificity, age-dependency, and regulation by insulin-like growth factor (IGF) I in vivo. Zoidis E, etal., Mol Cell Endocrinol. 2000 Oct 25;168(1-2):41-51.
Additional References at PubMed
PMID:11409890   PMID:11811562   PMID:15843468   PMID:22206666   PMID:23174213   PMID:38116308  


Genomics

Comparative Map Data
Phex
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X41,422,561 - 41,671,226 (+)NCBIGRCr8
mRatBN7.2X37,607,553 - 37,856,183 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX37,610,760 - 37,854,469 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX38,808,427 - 39,046,002 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X42,275,631 - 42,513,220 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X39,960,325 - 40,197,897 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X40,460,047 - 40,717,982 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX40,460,047 - 40,717,982 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X40,772,810 - 41,031,710 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X58,911,144 - 59,168,857 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X58,964,612 - 59,222,310 (+)NCBI
CeleraX38,233,227 - 38,472,933 (+)NCBICelera
Cytogenetic MapXq21NCBI
PHEX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X22,032,325 - 22,251,310 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX22,032,325 - 22,494,713 (+)EnsemblGRCh38hg38GRCh38
GRCh37X22,050,443 - 22,269,427 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X21,960,842 - 22,176,399 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X21,810,215 - 22,025,985NCBI
CeleraX26,171,770 - 26,387,304 (+)NCBICelera
Cytogenetic MapXp22.11NCBI
HuRefX19,791,354 - 20,006,299 (+)NCBIHuRef
CHM1_1X22,081,373 - 22,297,157 (+)NCBICHM1_1
T2T-CHM13v2.0X21,615,666 - 21,834,723 (+)NCBIT2T-CHM13v2.0
Phex
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X155,945,071 - 156,198,282 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX155,945,071 - 156,198,308 (-)EnsemblGRCm39 Ensembl
GRCm38X157,162,075 - 157,415,286 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX157,162,075 - 157,415,312 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X153,596,618 - 153,853,218 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X152,502,794 - 152,759,383 (-)NCBIMGSCv36mm8
CeleraX140,419,752 - 140,667,816 (-)NCBICelera
Cytogenetic MapXF4NCBI
cM MapX72.38NCBI
Phex
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555092,357,263 - 2,546,802 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555092,357,263 - 2,546,802 (+)NCBIChiLan1.0ChiLan1.0
PHEX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X23,841,047 - 24,060,334 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X23,844,437 - 24,063,724 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X14,663,847 - 14,859,294 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X22,017,678 - 22,235,560 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX22,017,681 - 22,232,501 (+)Ensemblpanpan1.1panPan2
PHEX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X17,830,714 - 18,038,755 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX17,829,158 - 18,035,775 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X17,788,714 - 17,997,786 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX17,788,830 - 17,994,811 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X17,822,506 - 18,032,213 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X17,844,194 - 18,054,186 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X17,904,817 - 18,114,749 (+)NCBIUU_Cfam_GSD_1.0
Phex
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X10,843,339 - 11,033,426 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366242,126,253 - 2,312,847 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366242,124,479 - 2,312,847 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PHEX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX18,203,174 - 18,418,004 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X18,199,396 - 18,420,985 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X19,362,855 - 19,605,399 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PHEX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X20,507,619 - 20,733,367 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX20,522,498 - 20,734,599 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605622,362,964 - 22,589,561 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Phex
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248296,960,904 - 7,151,752 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248296,960,740 - 7,151,752 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Phex
860 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:730
Count of miRNA genes:326
Interacting mature miRNAs:434
Transcripts:ENSRNOT00000010970
Prediction methods:Microtar, Miranda, Pita, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2099094741052531Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2099094741203591Rat

Markers in Region
DXMgh2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X37,797,731 - 37,797,874 (+)MAPPERmRatBN7.2
Rnor_6.0X40,653,281 - 40,653,423NCBIRnor6.0
Rnor_5.0X40,962,512 - 40,962,654UniSTSRnor5.0
RGSC_v3.4X59,112,160 - 59,112,303RGDRGSC3.4
RGSC_v3.4X59,112,161 - 59,112,303UniSTSRGSC3.4
RGSC_v3.1X59,165,629 - 59,165,772RGD
CeleraX38,416,332 - 38,416,474UniSTS
RH 2.0 Map21423.4RGD
Cytogenetic MapXq21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 6
Low 10 8 2 2 2 3 3 46 8 23 5 3
Below cutoff 30 21 11 15 11 5 5 28 24 13 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000010970   ⟹   ENSRNOP00000010970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX37,610,760 - 37,854,469 (+)Ensembl
Rnor_6.0 EnsemblX40,460,047 - 40,717,982 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000086990
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3107,401,705 - 107,406,543 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108391   ⟹   ENSRNOP00000095059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX37,610,760 - 37,854,469 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119693   ⟹   ENSRNOP00000091346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX37,610,760 - 37,854,469 (+)Ensembl
RefSeq Acc Id: NM_013004   ⟹   NP_037136
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X41,425,804 - 41,669,529 (+)NCBI
mRatBN7.2X37,610,760 - 37,854,486 (+)NCBI
Rnor_6.0X40,460,047 - 40,717,982 (+)NCBI
Rnor_5.0X40,772,810 - 41,031,710 (+)NCBI
RGSC_v3.4X58,911,144 - 59,168,857 (+)RGD
CeleraX38,233,227 - 38,472,933 (+)RGD
Sequence:
RefSeq Acc Id: XM_039099503   ⟹   XP_038955431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X41,422,561 - 41,671,226 (+)NCBI
mRatBN7.2X37,607,553 - 37,856,183 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_037136   ⟸   NM_013004
- UniProtKB: G3V723 (UniProtKB/TrEMBL),   A6IPQ1 (UniProtKB/TrEMBL),   O35812 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000010970   ⟸   ENSRNOT00000010970
RefSeq Acc Id: XP_038955431   ⟸   XM_039099503
- Peptide Label: isoform X1
- UniProtKB: G3V723 (UniProtKB/TrEMBL),   A6IPQ1 (UniProtKB/TrEMBL),   O35812 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000095059   ⟸   ENSRNOT00000108391
RefSeq Acc Id: ENSRNOP00000091346   ⟸   ENSRNOT00000119693
Protein Domains
Peptidase M13 C-terminal   Peptidase M13 N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V723-F1-model_v2 AlphaFold G3V723 1-749 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3323 AgrOrtholog
BioCyc Gene G2FUF-2459 BioCyc
Ensembl Genes ENSRNOG00000023440 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000056480 Ensembl
Ensembl Transcript ENSRNOT00000010970 ENTREZGENE
  ENSRNOT00000010970.8 UniProtKB/TrEMBL
  ENSRNOT00000108391.1 UniProtKB/TrEMBL
  ENSRNOT00000119693.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1380.10 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
InterPro MetalloPept_cat_dom UniProtKB/TrEMBL
  Peptidase_M13 UniProtKB/TrEMBL
  Peptidase_M13_C UniProtKB/TrEMBL
  Peptidase_M13_dom_2 UniProtKB/TrEMBL
  Peptidase_M13_N UniProtKB/TrEMBL
KEGG Report rno:25512 UniProtKB/TrEMBL
NCBI Gene 25512 ENTREZGENE
PANTHER Peptidase_M13 UniProtKB/TrEMBL
  PHOSPHATE-REGULATING NEUTRAL ENDOPEPTIDASE PHEX UniProtKB/TrEMBL
Pfam Peptidase_M13 UniProtKB/TrEMBL
  Peptidase_M13_N UniProtKB/TrEMBL
PhenoGen Phex PhenoGen
PRINTS NEPRILYSIN UniProtKB/TrEMBL
PROSITE NEPRILYSIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000023440 RatGTEx
  ENSRNOG00000056480 RatGTEx
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
TIGR TC210957
UniProt A0A8I6ALX7_RAT UniProtKB/TrEMBL
  A0A8I6AQX5_RAT UniProtKB/TrEMBL
  A6IPQ1 ENTREZGENE, UniProtKB/TrEMBL
  A6IPQ2_RAT UniProtKB/TrEMBL
  G3V723 ENTREZGENE, UniProtKB/TrEMBL
  O35812 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-15 Phex  phosphate regulating endopeptidase X-linked  Phex  phosphate regulating endopeptidase homolog, X-linked  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2021-03-09 Phex  phosphate regulating endopeptidase homolog, X-linked  LOC102554012  metalloendopeptidase homolog PEX-like  Data merged from RGD:7701994 737654 PROVISIONAL
2013-12-18 LOC102554012  metalloendopeptidase homolog PEX-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2009-02-26 Phex  phosphate regulating endopeptidase homolog, X-linked  Phex  phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Phex  phosphate regulating gene with homologies to endopeptidases on the X chromosome     Phosphate regulating neutral endopeptidase on the X chromosome (X-linked hypophosphatemia XLH)  Name updated 629478 APPROVED
2002-06-10 Phex  Phosphate regulating neutral endopeptidase on the X chromosome (X-linked hypophosphatemia XLH)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed mainly in bones, teeth and lungs 724649
gene_regulation induced in lungs and bones by IGF-I and GH 724649