Spen (spen family transcriptional repressor) - Rat Genome Database

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Gene: Spen (spen family transcriptional repressor) Rattus norvegicus
Analyze
Symbol: Spen
Name: spen family transcriptional repressor
RGD ID: 1589867
Description: Predicted to enable several functions, including DNA-binding transcription factor activity; single-stranded DNA binding activity; and transcription corepressor activity. Predicted to be involved in heterochromatin formation; negative regulation of transcription by RNA polymerase II; and positive regulation of neurogenesis. Predicted to act upstream of or within negative regulation of DNA-templated transcription and positive regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma. Orthologous to human SPEN (spen family transcriptional repressor); PARTICIPATES IN Notch signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC298604; LOC690911; rCG30673-like; RGD1564662; similar to Msx-2 interacting nuclear target protein; similar to Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein); SPEN homolog, transcriptional regulator; spen homolog, transcriptional regulator (Drosophila); uncharacterized protein LOC690911
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85159,058,258 - 159,131,789 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5159,058,258 - 159,165,934 (-)EnsemblGRCr8
mRatBN7.25153,775,287 - 153,848,677 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5153,776,234 - 153,848,811 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5156,462,638 - 156,532,813 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05158,235,926 - 158,306,102 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05158,225,101 - 158,295,288 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd5158,674,174 - 158,744,343 (-)NCBI
Lyon_Normotensive5160,664,436 - 160,734,617 (-)NCBI
Lyon_Hypertensive5159,839,931 - 159,910,120 (-)NCBI
F344_StmMcwi5153,408,717 - 153,478,881 (-)NCBI
Rnor_6.05160,015,573 - 160,070,915 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5160,015,454 - 160,070,965 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.05163,735,389 - 163,790,132 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45160,359,738 - 160,414,311 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5152,134,833 - 152,205,318 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3',5'-cyclic UMP  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
aflatoxin B1  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzalutamide  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenthion  (ISO)
florfenicol  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
inulin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
picoxystrobin  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
rotenone  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
temozolomide  (ISO)
testosterone enanthate  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
transcription repressor complex  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. SPEN induces miR-4652-3p to target HIPK2 in nasopharyngeal carcinoma. Li Y, etal., Cell Death Dis. 2020 Jul 2;11(7):509. doi: 10.1038/s41419-020-2699-2.
3. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Mutational Characterization and Potential Prognostic Biomarkers of Chinese Patients with Esophageal Squamous Cell Carcinoma. Zhang N, etal., Onco Targets Ther. 2020 Dec 14;13:12797-12809. doi: 10.2147/OTT.S275688. eCollection 2020.
Additional References at PubMed
PMID:10451362   PMID:12477932   PMID:15778499   PMID:16129689   PMID:16287852   PMID:19056867   PMID:22658674   PMID:22681889  


Genomics

Comparative Map Data
Spen
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85159,058,258 - 159,131,789 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5159,058,258 - 159,165,934 (-)EnsemblGRCr8
mRatBN7.25153,775,287 - 153,848,677 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5153,776,234 - 153,848,811 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5156,462,638 - 156,532,813 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05158,235,926 - 158,306,102 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05158,225,101 - 158,295,288 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd5158,674,174 - 158,744,343 (-)NCBI
Lyon_Normotensive5160,664,436 - 160,734,617 (-)NCBI
Lyon_Hypertensive5159,839,931 - 159,910,120 (-)NCBI
F344_StmMcwi5153,408,717 - 153,478,881 (-)NCBI
Rnor_6.05160,015,573 - 160,070,915 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5160,015,454 - 160,070,965 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.05163,735,389 - 163,790,132 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45160,359,738 - 160,414,311 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5152,134,833 - 152,205,318 (-)NCBICelera
Cytogenetic Map5q36NCBI
SPEN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38115,847,707 - 15,940,456 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl115,836,095 - 15,940,456 (+)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh37116,174,202 - 16,266,951 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36116,046,946 - 16,139,537 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34115,919,664 - 16,012,256NCBI
Celera114,654,230 - 14,746,824 (+)NCBICelera
Cytogenetic Map1p36.21-p36.13NCBI
HuRef114,692,961 - 14,785,958 (+)NCBIHuRef
CHM1_1115,972,883 - 16,065,485 (+)NCBICHM1_1
T2T-CHM13v2.0115,288,973 - 15,381,736 (+)NCBIT2T-CHM13v2.0
Spen
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394141,195,199 - 141,265,955 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4141,195,199 - 141,265,997 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm384141,467,885 - 141,538,644 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4141,467,890 - 141,538,597 (-)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv374141,023,805 - 141,094,512 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364140,740,934 - 140,794,407 (-)NCBIMGSCv36mm8
Celera4143,285,155 - 143,361,424 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map474.26NCBI
Spen
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555272,280,459 - 2,343,262 (-)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_0049555272,279,438 - 2,343,263 (-)NCBIChiLan1.0ChiLan1.0
SPEN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21210,978,987 - 211,071,078 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11210,227,594 - 210,319,647 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0114,987,415 - 15,079,477 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1116,004,908 - 16,072,585 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl116,004,473 - 16,072,585 (+)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
SPEN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1281,683,824 - 81,775,904 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,220,017 - 78,313,915 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0282,329,704 - 82,424,151 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl282,329,709 - 82,424,332 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1279,082,956 - 79,177,612 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0280,101,457 - 80,195,821 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0281,167,341 - 81,261,911 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Spen
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap11110,399,203 - 10,481,923 (+)NCBImIctTri1.hap1
HiC_Itri_2NW_02440505837,619,001 - 37,710,867 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364743,473,901 - 3,534,628 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364743,473,892 - 3,535,307 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPEN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl675,015,521 - 75,107,033 (+)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.1675,015,565 - 75,107,468 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SPEN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap120120,998,889 - 121,097,730 (-)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_02366605419,886,901 - 19,987,389 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.120116,359,981 - 116,458,156 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20116,361,008 - 116,458,064 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Spen
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247642,058,689 - 2,144,640 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_0046247642,058,773 - 2,143,640 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl732,095,684 - 32,181,379 (-)Ensembl
Spen
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1116,608,272 - 16,678,285 (+)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1

Variants

.
Variants in Spen
658 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:233
Count of miRNA genes:84
Interacting mature miRNAs:88
Transcripts:ENSRNOT00000047339, ENSRNOT00000055791, ENSRNOT00000067517
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149642129171146538Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5156396728172190305Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5149805999162987697Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5156396728167181764Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5149661912166600247Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5156289283171137955Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat

Markers in Region
RH139365  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25153,775,316 - 153,775,444 (+)MAPPERmRatBN7.2
Rnor_6.05160,015,603 - 160,015,730NCBIRnor6.0
Rnor_5.05163,735,419 - 163,735,546UniSTSRnor5.0
RGSC_v3.45160,359,768 - 160,359,895UniSTSRGSC3.4
Celera5152,134,863 - 152,134,990UniSTS
RH 3.4 Map51053.7UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
275 155 730 1591 4063 997 1712 133 860 491 842 155 5376 2592 448 3977 38 1390 740 907 160 158

Sequence


Ensembl Acc Id: ENSRNOT00000055791   ⟹   ENSRNOP00000052647
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5159,058,258 - 159,131,861 (-)Ensembl
mRatBN7.2 Ensembl5153,776,234 - 153,848,811 (-)Ensembl
Rnor_6.0 Ensembl5160,015,454 - 160,070,965 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000067517   ⟹   ENSRNOP00000059120
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5160,015,573 - 160,070,916 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000127835   ⟹   ENSRNOP00000102912
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5159,058,258 - 159,131,743 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000144567   ⟹   ENSRNOP00000100325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5159,058,258 - 159,165,934 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000154197   ⟹   ENSRNOP00000098634
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5159,058,258 - 159,131,743 (-)Ensembl
RefSeq Acc Id: NM_001395101   ⟹   NP_001382030
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85159,058,258 - 159,131,743 (-)NCBI
mRatBN7.25153,775,287 - 153,848,677 (-)NCBI
Dahl_SR_JrHsd5158,674,174 - 158,744,343 (-)NCBI
Lyon_Normotensive5160,664,436 - 160,734,617 (-)NCBI
Lyon_Hypertensive5159,839,931 - 159,910,120 (-)NCBI
F344_StmMcwi5153,408,717 - 153,478,881 (-)NCBI
RefSeq Acc Id: XM_039110804   ⟹   XP_038966732
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85159,058,259 - 159,131,789 (-)NCBI
mRatBN7.25153,775,287 - 153,848,677 (-)NCBI
RefSeq Acc Id: XM_039110807   ⟹   XP_038966735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85159,058,259 - 159,131,789 (-)NCBI
mRatBN7.25153,775,287 - 153,848,677 (-)NCBI
RefSeq Acc Id: XM_039110809   ⟹   XP_038966737
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85159,058,259 - 159,115,274 (-)NCBI
mRatBN7.25153,775,287 - 153,832,278 (-)NCBI
RefSeq Acc Id: XM_063288446   ⟹   XP_063144516
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85159,058,259 - 159,113,008 (-)NCBI
Ensembl Acc Id: ENSRNOP00000052647   ⟸   ENSRNOT00000055791
Ensembl Acc Id: ENSRNOP00000059120   ⟸   ENSRNOT00000067517
RefSeq Acc Id: XP_038966735   ⟸   XM_039110807
- Peptide Label: isoform X2
- UniProtKB: A0ABK0LDA4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966732   ⟸   XM_039110804
- Peptide Label: isoform X1
- UniProtKB: A0ABK0LDA4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966737   ⟸   XM_039110809
- Peptide Label: isoform X3
- UniProtKB: A0ABK0LDA4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001382030   ⟸   NM_001395101
- UniProtKB: A0ABK0LDA4 (UniProtKB/TrEMBL),   A0ABK0LDP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144516   ⟸   XM_063288446
- Peptide Label: isoform X4
- UniProtKB: A0ABK0LJC1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000098634   ⟸   ENSRNOT00000154197
Ensembl Acc Id: ENSRNOP00000102912   ⟸   ENSRNOT00000127835
Ensembl Acc Id: ENSRNOP00000100325   ⟸   ENSRNOT00000144567
Protein Domains
RRM   SPOC

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1589867 AgrOrtholog
BioCyc Gene G2FUF-39341 BioCyc
Ensembl Genes ENSRNOG00000033556 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000055791.7 UniProtKB/TrEMBL
  ENSRNOT00000127835 ENTREZGENE
  ENSRNOT00000127835.1 UniProtKB/TrEMBL
  ENSRNOT00000144567.1 UniProtKB/TrEMBL
  ENSRNOT00000154197.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.290.10 UniProtKB/TrEMBL
  3.30.70.330 UniProtKB/TrEMBL
InterPro MINT_MID UniProtKB/TrEMBL
  MINT_RAM7 UniProtKB/TrEMBL
  MINT_RID UniProtKB/TrEMBL
  Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  RRM_dom UniProtKB/TrEMBL
  SHARP_RRM1 UniProtKB/TrEMBL
  SHARP_RRM2 UniProtKB/TrEMBL
  SHARP_RRM3 UniProtKB/TrEMBL
  SHARP_RRM4 UniProtKB/TrEMBL
  SPOC-like UniProtKB/TrEMBL
  SPOC_C UniProtKB/TrEMBL
  SPOC_met UniProtKB/TrEMBL
KEGG Report rno:690911 UniProtKB/TrEMBL
NCBI Gene 690911 ENTREZGENE
PANTHER RNA RECOGNITION MOTIF-CONTAINING UniProtKB/TrEMBL
Pfam MINT_MID UniProtKB/TrEMBL
  MINT_RAM7 UniProtKB/TrEMBL
  MINT_RID UniProtKB/TrEMBL
  RRM_1 UniProtKB/TrEMBL
  SPOC UniProtKB/TrEMBL
PhenoGen Spen PhenoGen
PROSITE RRM UniProtKB/TrEMBL
  SPOC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033556 RatGTEx
SMART RRM UniProtKB/TrEMBL
Superfamily-SCOP SPOC-like UniProtKB/TrEMBL
  SSF54928 UniProtKB/TrEMBL
UniProt A0ABK0LDA4 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LDP2 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LJC1 ENTREZGENE, UniProtKB/TrEMBL
  F1M816_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-11 Spen  spen family transcriptional repressor  Spen  spen homolog, transcriptional regulator (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 Spen  spen homolog, transcriptional regulator (Drosophila)  LOC100365546  rCG30673-like  Data merged from RGD:2318836 1643240 APPROVED
2012-10-02 Spen  spen homolog, transcriptional regulator (Drosophila)  LOC690911  similar to Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 LOC100365546  rCG30673-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-01-09 LOC690911  similar to Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein)  Spen_predicted  SPEN homolog, transcriptional regulator (Drosophila) (predicted)  Data merged from RGD:1564662 1643240 APPROVED
2006-11-20 LOC690911  similar to Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-30 Spen_predicted  SPEN homolog, transcriptional regulator (Drosophila) (predicted)  RGD1564662_predicted  similar to Msx-2 interacting nuclear target protein (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1564662_predicted  similar to Msx-2 interacting nuclear target protein (predicted)  LOC298604  similar to Msx-2 interacting nuclear target protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC298604  similar to Msx-2 interacting nuclear target protein      Symbol and Name status set to provisional 70820 PROVISIONAL