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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1589867
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Spen
Name: spen family transcriptional repressor
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Spendecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of SPEN mRNAPMID:32145629
Spenincreases expressionEXP 6480464CTDbisphenol A results in increased expression of SPEN mRNAPMID:30816183 PMID:32528016 PMID:34947998
Spenaffects methylationISOSpen (Mus musculus)6480464CTDbisphenol A affects the methylation of SPEN promoterPMID:27334623
Spendecreases expressionISOSpen (Mus musculus)6480464CTDbisphenol A results in decreased expression of SPEN mRNAPMID:38074096
Spendecreases methylationISOSpen (Mus musculus)6480464CTDbisphenol A results in decreased methylation of SPEN promoterPMID:27312807
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