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Gene: Efhb (EF hand domain family, member B) Rattus norvegicus

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Symbol:

Efhb

Name:

EF hand domain family, member B

RGD ID:

1566407

Description:

Predicted to enable calcium ion sensor activity. Predicted to be involved in flagellated sperm motility; regulation of calcineurin-NFAT signaling cascade; and regulation of store-operated calcium entry. Predicted to be located in axonemal microtubule. Predicted to be active in axonemal A tubule inner sheath and sperm flagellum. Orthologous to human EFHB (EF-hand domain family member B); INTERACTS WITH amphetamine; Cuprizon; ketamine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

EF-hand domain-containing family member B; LOC301168; RGD1566407; similar to hypothetical protein 4921525D22

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	EFHB (EF-hand domain family member B)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Efhb (EF hand domain family, member B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Efhb (EF-hand domain family member B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	EFHB (EF-hand domain family member B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	EFHB (EF-hand domain family member B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Efhb (EF-hand domain family member B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	EFHB (EF-hand domain family member B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	EFHB (EF-hand domain family member B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Efhb (EF-hand domain family member B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	EFHB (EF-hand domain family member B)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Efhb (EF hand domain family, member B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	efhb (EF-hand domain family, member B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG32086	Alliance	DIOPT (Hieranoid\|InParanoid\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG33490	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG33489	Alliance	DIOPT (Hieranoid\|InParanoid\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	efhb	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	6,608,791 - 6,680,104 (-)	NCBI		GRCr8
mRatBN7.2	9	6,372,191 - 6,441,678 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	6,372,194 - 6,441,919 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	7,524,938 - 7,587,963 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	12,682,486 - 12,745,498 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	11,846,203 - 11,909,734 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	47,988 - 120,800 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	47,724 - 120,799 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	42,285 - 114,389 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	1,563,384 - 1,635,269	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Cytogenetic Map	9	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Efhb	Rat	3p deletion syndrome		ISO	EFHB (Homo sapiens)	8554872	ClinVar Annotator: match by term: 3p- syndrome	ClinVar	PMID:31690835

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Efhb	Rat	1,2-dimethylhydrazine	decreases expression	ISO	Efhb (Mus musculus)	6480464	1 and 2-Dimethylhydrazine results in decreased expression of EFHB mRNA	CTD	PMID:22206623
Efhb	Rat	17beta-estradiol	increases expression	ISO	Efhb (Mus musculus)	6480464	Estradiol results in increased expression of EFHB mRNA	CTD	PMID:19484750
Efhb	Rat	acrylamide	increases expression	ISO	EFHB (Homo sapiens)	6480464	Acrylamide results in increased expression of EFHB mRNA	CTD	PMID:32763439
Efhb	Rat	amphetamine	increases expression	EXP		6480464	Amphetamine results in increased expression of EFHB mRNA	CTD	PMID:30779732
Efhb	Rat	aristolochic acid A	decreases expression	ISO	EFHB (Homo sapiens)	6480464	aristolochic acid I results in decreased expression of EFHB mRNA	CTD	PMID:33212167
Efhb	Rat	atrazine	increases expression	ISO	EFHB (Homo sapiens)	6480464	Atrazine results in increased expression of EFHB mRNA	CTD	PMID:22378314
Efhb	Rat	bis(2-ethylhexyl) phthalate	decreases expression	ISO	EFHB (Homo sapiens)	6480464	Diethylhexyl Phthalate results in decreased expression of EFHB mRNA	CTD	PMID:31163220
Efhb	Rat	bis(2-ethylhexyl) phthalate	increases expression	ISO	Efhb (Mus musculus)	6480464	Diethylhexyl Phthalate results in increased expression of EFHB mRNA	CTD	PMID:34319233
Efhb	Rat	bisphenol A	multiple interactions	ISO	EFHB (Homo sapiens)	6480464	[bisphenol A co-treated with Fulvestrant] results in decreased methylation of EFHB gene	CTD	PMID:31601247
Efhb	Rat	cadmium dichloride	decreases expression	ISO	EFHB (Homo sapiens)	6480464	Cadmium Chloride results in decreased expression of EFHB mRNA	CTD	PMID:38382870
Efhb	Rat	carbon nanotube	decreases expression	ISO	Efhb (Mus musculus)	6480464	Nanotubes more ...	CTD	PMID:25554681
Efhb	Rat	copper(II) sulfate	decreases expression	ISO	EFHB (Homo sapiens)	6480464	Copper Sulfate results in decreased expression of EFHB mRNA	CTD	PMID:19549813
Efhb	Rat	CU-O LINKAGE	decreases expression	ISO	EFHB (Homo sapiens)	6480464	cupric oxide results in decreased expression of EFHB mRNA	CTD	PMID:22077320
Efhb	Rat	Cuprizon	increases expression	EXP		6480464	Cuprizone results in increased expression of EFHB mRNA	CTD	PMID:26577399
Efhb	Rat	dioxygen	increases expression	ISO	EFHB (Homo sapiens)	6480464	Oxygen deficiency results in increased expression of EFHB mRNA	CTD	PMID:26516004
Efhb	Rat	dorsomorphin	multiple interactions	ISO	EFHB (Homo sapiens)	6480464	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ...	CTD	PMID:27188386
Efhb	Rat	entinostat	multiple interactions	ISO	EFHB (Homo sapiens)	6480464	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EFHB mRNA	CTD	PMID:27188386
Efhb	Rat	entinostat	decreases expression	ISO	EFHB (Homo sapiens)	6480464	entinostat results in decreased expression of EFHB mRNA	CTD	PMID:26272509
Efhb	Rat	fulvestrant	multiple interactions	ISO	EFHB (Homo sapiens)	6480464	[bisphenol A co-treated with Fulvestrant] results in decreased methylation of EFHB gene	CTD	PMID:31601247
Efhb	Rat	fulvestrant	increases methylation	ISO	EFHB (Homo sapiens)	6480464	Fulvestrant results in increased methylation of EFHB gene	CTD	PMID:31601247
Efhb	Rat	hydralazine	multiple interactions	ISO	EFHB (Homo sapiens)	6480464	[Hydralazine co-treated with Valproic Acid] results in increased expression of EFHB mRNA	CTD	PMID:17183730
Efhb	Rat	ketamine	increases expression	EXP		6480464	Ketamine results in increased expression of EFHB mRNA	CTD	PMID:20080153
Efhb	Rat	lipopolysaccharide	multiple interactions	ISO	EFHB (Homo sapiens)	6480464	[S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of EFHB mRNA	CTD	PMID:35811015
Efhb	Rat	methylmercury chloride	decreases expression	ISO	EFHB (Homo sapiens)	6480464	methylmercuric chloride results in decreased expression of EFHB mRNA	CTD	PMID:28001369
Efhb	Rat	nickel atom	decreases expression	ISO	EFHB (Homo sapiens)	6480464	Nickel results in decreased expression of EFHB mRNA	CTD	PMID:25583101
Efhb	Rat	p-chloromercuribenzoic acid	increases expression	ISO	EFHB (Homo sapiens)	6480464	p-Chloromercuribenzoic Acid results in increased expression of EFHB mRNA	CTD	PMID:26272509
Efhb	Rat	p-chloromercuribenzoic acid	multiple interactions	ISO	EFHB (Homo sapiens)	6480464	[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EFHB mRNA	CTD	PMID:27188386
Efhb	Rat	pravastatin	increases expression	ISO	Efhb (Mus musculus)	6480464	Pravastatin results in increased expression of EFHB mRNA	CTD	PMID:27225895
Efhb	Rat	pravastatin	increases expression	EXP		6480464	Pravastatin results in increased expression of EFHB mRNA	CTD	PMID:27225895
Efhb	Rat	S-(1,2-dichlorovinyl)-L-cysteine	multiple interactions	ISO	EFHB (Homo sapiens)	6480464	[S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of EFHB mRNA	CTD	PMID:35811015
Efhb	Rat	SB 431542	multiple interactions	ISO	EFHB (Homo sapiens)	6480464	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ...	CTD	PMID:27188386
Efhb	Rat	sodium fluoride	increases expression	ISO	Efhb (Mus musculus)	6480464	Sodium Fluoride results in increased expression of EFHB protein	CTD	PMID:28918527
Efhb	Rat	temozolomide	decreases expression	ISO	EFHB (Homo sapiens)	6480464	Temozolomide results in decreased expression of EFHB mRNA	CTD	PMID:31758290
Efhb	Rat	tetraphene	increases expression	ISO	Efhb (Mus musculus)	6480464	benz(a)anthracene results in increased expression of EFHB mRNA	CTD	PMID:26377693
Efhb	Rat	titanium dioxide	affects expression	ISO	Efhb (Mus musculus)	6480464	titanium dioxide affects the expression of EFHB mRNA	CTD	PMID:23557971
Efhb	Rat	trichostatin A	decreases expression	ISO	EFHB (Homo sapiens)	6480464	trichostatin A results in decreased expression of EFHB mRNA	CTD	PMID:24935251
Efhb	Rat	valproic acid	multiple interactions	ISO	EFHB (Homo sapiens)	6480464	[Hydralazine co-treated with Valproic Acid] results in increased expression of EFHB mRNA	CTD	PMID:17183730
Efhb	Rat	valproic acid	decreases expression	ISO	EFHB (Homo sapiens)	6480464	Valproic Acid results in decreased expression of EFHB mRNA	CTD	PMID:23179753
Efhb	Rat	valproic acid	increases expression	ISO	EFHB (Homo sapiens)	6480464	Valproic Acid results in increased expression of EFHB mRNA	CTD	PMID:28001369

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Efhb	Rat	flagellated sperm motility	involved_in	ISO	Efhb (Mus musculus)	1624291	PMID:37295417 more ...	RGD	PMID:37295417 more ...
Efhb	Rat	regulation of calcineurin-NFAT signaling cascade	involved_in	ISO	EFHB (Homo sapiens)	1624291	PMID:30481768	RGD	PMID:30481768
Efhb	Rat	regulation of calcineurin-NFAT signaling cascade	involved_in	IEA	UniProtKB:Q8N7U6 and ensembl:ENSP00000295824	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Efhb	Rat	regulation of store-operated calcium entry	involved_in	ISO	EFHB (Homo sapiens)	1624291	PMID:30481768	RGD	PMID:30481768
Efhb	Rat	regulation of store-operated calcium entry	involved_in	IEA	UniProtKB:Q8N7U6 and ensembl:ENSP00000295824	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Efhb	Rat	axonemal A tubule inner sheath	is_active_in	ISO	Efhb (Mus musculus)	1624291	PMID:37295417 more ...	RGD	PMID:37295417 more ...
Efhb	Rat	axonemal microtubule	located_in	ISO	EFHB (Homo sapiens)	1624291	PMID:36191189	RGD	PMID:36191189
Efhb	Rat	axonemal microtubule	located_in	IEA	ARBA:ARBA00044867	1600115	GO_REF:0000117	UniProt	GO_REF:0000117
Efhb	Rat	axonemal microtubule	located_in	IEA	UniProtKB:Q8N7U6 and ensembl:ENSP00000295824	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Efhb	Rat	cell projection	located_in	IEA	UniProtKB-KW:KW-0966	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Efhb	Rat	cilium	located_in	IEA	UniProtKB-KW:KW-0969	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Efhb	Rat	cytoskeleton	located_in	IEA	UniProtKB-KW:KW-0206	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Efhb	Rat	motile cilium	located_in	IEA	UniProtKB-KW:KW-0282	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Efhb	Rat	sperm flagellum	is_active_in	ISO	Efhb (Mus musculus)	1624291	PMID:37295417 more ...	RGD	PMID:37295417 more ...

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Efhb	Rat	calcium ion binding	enables	IEA	InterPro:IPR002048	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Efhb	Rat	calcium ion sensor activity	enables	ISO	EFHB (Homo sapiens)	1624291	PMID:30481768	RGD	PMID:30481768
Efhb	Rat	calcium ion sensor activity	enables	IEA	UniProtKB:Q8N7U6 and ensembl:ENSP00000295824	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Efhb	Rat	metal ion binding	enables	IEA	UniProtKB-KW:KW-0479	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Efhb	Rat	protein binding	enables	ISO	EFHB (Homo sapiens)	1624291	UniProtKB:Q13586 more ...	RGD	PMID:30481768

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

PMID:12477932	PMID:30481768

Efhb
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	6,608,791 - 6,680,104 (-)	NCBI		GRCr8
mRatBN7.2	9	6,372,191 - 6,441,678 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	6,372,194 - 6,441,919 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	7,524,938 - 7,587,963 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	12,682,486 - 12,745,498 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	11,846,203 - 11,909,734 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	47,988 - 120,800 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	47,724 - 120,799 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	42,285 - 114,389 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	1,563,384 - 1,635,269	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Cytogenetic Map	9	q11	NCBI

EFHB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	19,879,472 - 19,946,983 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	19,879,472 - 19,947,025 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	19,920,964 - 19,988,475 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	19,895,968 - 19,950,710 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	19,895,971 - 19,950,676	NCBI
Celera	3	19,861,484 - 19,916,233 (-)	NCBI		Celera
Cytogenetic Map	3	p24.3	NCBI
HuRef	3	19,861,347 - 19,916,080 (-)	NCBI		HuRef
CHM1_1	3	19,873,136 - 19,927,880 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	19,883,550 - 19,951,207 (-)	NCBI		T2T-CHM13v2.0

Efhb
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	53,705,077 - 53,770,362 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	53,705,917 - 53,770,349 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	53,398,044 - 53,463,334 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	53,398,889 - 53,463,321 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	53,538,214 - 53,602,646 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	52,863,818 - 52,928,250 (-)	NCBI		MGSCv36	mm8
Celera	17	56,844,691 - 56,909,168 (-)	NCBI		Celera
Cytogenetic Map	17	C	NCBI
cM Map	17	27.78	NCBI

Efhb
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955430	11,932,296 - 11,987,845 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955430	11,932,753 - 11,986,985 (-)	NCBI	ChiLan1.0	ChiLan1.0

EFHB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	19,840,935 - 19,903,938 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	19,845,702 - 19,908,709 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	19,798,204 - 19,855,338 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	20,130,063 - 20,184,718 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	20,128,668 - 20,184,718 (-)	Ensembl	panpan1.1		panPan2

EFHB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	23,337,293 - 23,384,362 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	23	23,335,956 - 23,384,193 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	23,362,527 - 23,410,153 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	23,824,176 - 23,871,987 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	23	23,822,838 - 23,871,409 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	23	23,536,377 - 23,583,894 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	23,601,798 - 23,649,332 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	23,847,939 - 23,895,522 (+)	NCBI		UU_Cfam_GSD_1.0

Efhb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	179,041,162 - 179,093,637 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936473	12,179,950 - 12,232,093 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EFHB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	6,824,503 - 6,898,764 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	6,826,023 - 6,898,763 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	7,728,118 - 7,798,299 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

EFHB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	64,608,440 - 64,679,276 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	64,608,604 - 64,661,298 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	37,634,448 - 37,700,575 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Efhb
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624821	5,216,624 - 5,269,433 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624821	5,215,680 - 5,269,500 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Efhb
529 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	164
Count of miRNA genes:	122
Interacting mature miRNAs:	127
Transcripts:	ENSRNOT00000016911, ENSRNOT00000066582
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631211	Bw4	Body weight QTL4	5.31		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	9	5109826	50109826	Rat
10054141	Gmadr4	Adrenal mass QTL 4	2.45	0.0074	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	9	1	14209783	Rat
2303559	Gluco54	Glucose level QTL 54	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	9	1254084	46254084	Rat
1578675	Bss17	Bone structure and strength QTL 17	3.8		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	9	3368652	13533896	Rat
9589055	Scfw5	Subcutaneous fat weight QTL 5	5.55	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	9	1	37999212	Rat
1641911	Alcrsp13	Alcohol response QTL 13			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	1	43718459	Rat
1354650	Despr5	Despair related QTL 5	4.01	0.0017	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	9	1254084	46254084	Rat
1300124	Cm4	Cardiac mass QTL 4	3.55		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	9	1	40594091	Rat
61425	Cia15	Collagen induced arthritis QTL 15	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	9	5109826	42921101	Rat
70226	Eae4	Experimental allergic encephalomyelitis QTL 4			nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	9	1	25661317	Rat
9589158	Gluco65	Glucose level QTL 65	6.82	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	9	1	37999212	Rat
10054125	Srcrt7	Stress Responsive Cort QTL 7	3.33	0.0011	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	9	1	87073594	Rat
7411592	Foco8	Food consumption QTL 8	7.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	1	37999212	Rat
1331757	Cdexp1	CD45RC expression in CD8 T cells QTL 1	4.3		CD8-positive T cell quantity (VT:0008077)	blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)	9	1024537	67509080	Rat
1298088	Edpm11	Estrogen-dependent pituitary mass QTL 11	2.5		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	9	1	43718459	Rat

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
7	3	11	96	27	38	13	19	13	6	70	34	88	13	60	25


RefSeq Transcripts	NM_001106879	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039083161	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039083162	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063266838	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063266839	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC166482	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474184	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000016911 ⟹ ENSRNOP00000016911

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	6,372,194 - 6,441,919 (-)	Ensembl
Rnor_6.0 Ensembl	9	47,724 - 120,798 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000066582 ⟹ ENSRNOP00000060318

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	6,372,195 - 6,441,679 (-)	Ensembl
Rnor_6.0 Ensembl	9	47,987 - 120,799 (+)	Ensembl

RefSeq Acc Id:

NM_001106879 ⟹ NP_001100349

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	6,608,794 - 6,678,267 (-)	NCBI
mRatBN7.2	9	6,372,194 - 6,441,678 (-)	NCBI
Rnor_6.0	9	47,988 - 120,800 (+)	NCBI
Rnor_5.0	9	42,285 - 114,389 (+)	NCBI
RGSC_v3.4	9	1,563,384 - 1,635,269 (+)	RGD

Sequence:

show sequence

TACTCTCCGGCAGGAAGCAATCTGCAGGGAGTACCGGGAGCATGTGTTCATTTGTGAGATTGGGATCCCCCAAAGCTTTGCAAACTTCAGATTCTCCATTAGAGATGAGTTCCCTGAGAAGGACGAGA
GCACCTGAAATCTCGGAACTTGGACTCACCCAAGAACAAAAGGACGATATAAGAGACAGAGTAGGTAGGGAATCAAAATCTCCCACAGAGCTGGGGTTCGAATTGAGACTAGAACAAGATCGAAGATG
GAGGGAGAGGATGGCATCATCAGAACCAAAATCGCCACCTTACCATGCACTTGGAGTAGGATTAGAAAGACAGACTATTTCTGCGACGCCCACAGAGATGGGTAATTTAGGACTTCACAAGGGCTCTG
CTTTCCAAGGATCAAAACCTCTGGGTATGTTACCAGGAAGAGTGGGGTCAGAAAATAAGGGCCTCCCACCTTGCCTTCGCTATGGAGGAACACTACACCCTCCTTTGGGCACAGTCCATGCAAGTCCA
CAGGCCGCAGGGAGCACAAGGAGGCCTCTTCCCTGTGGTTCTGCCTGGACGGATGCTGTAGTGGAAAAGCAGCCTGTGGGTTTGGAACTGAGAAAAGAACTGGAAAAAGAGCCCACCTGTGTTATGGT
GAAACCCTACCCAGAGATACCCCCTAAGGAGGTAGATATTGGGTTGCCACAAACCCAGGATTCAGATGAAGCCAAGAATACAGAGCCTCTGATAGGTTTAGTAAGAGAACCTTATGAGTGTCCAATTG
CTCAACAACCAGAAGAGAAAAAGGAGCCTATCAGCACTGAACCCGGAGTGGAACCTCCAGGGAACATCAGACCCATATATTCAGGGAAATTCTTTGATCGAGCGCCTTCTTGGCCAACTGCCGGAAAA
GTTAAGCCGGTTGGATACAGAGTTGCAAATTGTTTGACTGAAAAGCTTCCCAGGCTTATGACTCCCCCAGAGGCAAAGAAGTATTTCAACTTCAGATATCCACCTCCGGGAGCAGAAAGAATATTTTA
TGGCAGAGCAAATGATCCCCAAATCGCACCTTATTTGACACATGGGATGAGACCTAAAGGTTTAGTAACGATGAGCTCATTGATAAACCCACAGCCCATTACCACGTTTCAACAGAAAGTTAAAGACA
AAAAAGAATCTATATACTTTAGCCATCAACGAGCACCATTGGGAAAATCTCATGATCAAACACCAGGATTGCCTAAAGGAATGGATGTGATCAACACAACATTAGGGACACCAACTATCAGAGAGCTG
TCTGTTCGTGACGTTGTGAATCCATCAAAATCCTTCGAAGATGTGTTTAAAGAAGGACAGGAAGGACATGATTTGTACACTATCTCTCACAATGATTATTTTGCAGGAGAAGCAAAGAACCGAAAGTA
TAACCCAGCAAGTTTCCATAGATTTAACTTGTATGGAGTCCCGACACCTCACTGTAATGATGGGCGCACCATGGCTAAAACTTTACATTGGCTCCATGAACTACAAATGGAAAGAGGAGCAAAAATTG
TATCCAAAAGAGCTGATGATTTTGAAGAAAAATTTCAACACAGACTTGGAAGAGTTTTAGACCCCATTGCTGAAACTATGAATGTTCCCCCAGGGCACACATTTGGAGCTTGCCTCCAGCCTGAAGAA
TATGGAGCTGGTGATCTCATCCATTACAGAGGCCCAGATGAATATCTCCGTGGGAAGGACCGCCAGAGAGCCCTGGTTGCGGCTGCTCGCCACCACTTGAAGAAATTTAATCACCAGCACTTTGACAC
TTTGCTGATGGCTTTCAGGCACTATGACAAGAAGGGAGATGGGGTAATTGACAGAGCAGAACTGCATGAAGCTTGTGTCCAGGCCAACCTGCATCTGGACAAGATGCTCCTGGACCATCTCTTTGACT
ACTGTGATGTGGATCAGGATGGCCTGATTAACTACCTGGAATTTGCCAATTTCCTTACCTGGAAAGACAGAATACCTCTCACCGAGTATGAGAAGAGGGTCGTCATTAAAGGTAAAAAAACAGACTGT
GAAAATGTTACGGAGACTAGTATCGTGGGAGAAACTGATCCGAGTCTTCTGGTAAATCCTGAAGACATTGTCCCCAAAGAACCAGGAAGTTCAGAAGAGATTGTCCGGACAATCCTGAGACCAGGTGA
CAAAGTTTCTGACCAGTATAAGACAACTTCTTCTGAGATCAATGCTGTTGTTGGAGCTGTTCCTTCTATATGTTACCCCATCTATGGTGTTCCAACCATTCGCTCTGACATCCCTGCTCCCCGTATTC
GTCGAGTCAGTGACATGAATAACTACGGTGAAGAAGGCAATGCCTACGCCTTGCTGCACCCCTCCATCTTCTCGCAGAAAGGTGTATTCGAGAGAGACTTCTTCAAAACCAGGTCCAAGGAAGAGATT
TCAGATATATTAACTAACATTGGAGTCAAGCTTACTGAAGAAGAATTCGAAAACGTATGGAATCTTGCTTCACAAAAACATCAGCAAGGAGAAGTTTGTGTTGAAACCATCAGGAATGTTCTAGATGA
ACTGCACGCAGACCTCTTTAAGTGTAAAACGGCCATGTGATATTTTTGGGAACTTACACATTTAAGCAAAAGAGATTAAATTTATATTCATGTA

hide sequence

RefSeq Acc Id:

XM_039083161 ⟹ XP_038939089

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	6,608,791 - 6,677,517 (-)	NCBI
mRatBN7.2	9	6,372,191 - 6,440,928 (-)	NCBI

RefSeq Acc Id:

XM_039083162 ⟹ XP_038939090

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	6,608,791 - 6,677,517 (-)	NCBI
mRatBN7.2	9	6,372,191 - 6,440,928 (-)	NCBI

RefSeq Acc Id:

XM_063266838 ⟹ XP_063122908

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	6,619,606 - 6,678,578 (-)	NCBI

RefSeq Acc Id:

XM_063266839 ⟹ XP_063122909

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	6,608,791 - 6,680,104 (-)	NCBI


Protein RefSeqs	NP_001100349	(Get FASTA)	NCBI Sequence Viewer
	XP_038939089	(Get FASTA)	NCBI Sequence Viewer
	XP_038939090	(Get FASTA)	NCBI Sequence Viewer
	XP_063122908	(Get FASTA)	NCBI Sequence Viewer
	XP_063122909	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI66482	(Get FASTA)	NCBI Sequence Viewer
	EDL82847	(Get FASTA)	NCBI Sequence Viewer
	EDL82848	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000016911
	ENSRNOP00000016911.6
	ENSRNOP00000060318.1

RefSeq Acc Id:

NP_001100349 ⟸ NM_001106879

- UniProtKB:

A6KUI1 (UniProtKB/TrEMBL), A6KUI0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MCSFVRLGSPKALQTSDSPLEMSSLRRTRAPEISELGLTQEQKDDIRDRVGRESKSPTELGFELRLEQDRRWRERMASSEPKSPPYHALGVGLERQTISATPTEMGNLGLHKGSAFQGSKPLGMLPGR
VGSENKGLPPCLRYGGTLHPPLGTVHASPQAAGSTRRPLPCGSAWTDAVVEKQPVGLELRKELEKEPTCVMVKPYPEIPPKEVDIGLPQTQDSDEAKNTEPLIGLVREPYECPIAQQPEEKKEPISTE
PGVEPPGNIRPIYSGKFFDRAPSWPTAGKVKPVGYRVANCLTEKLPRLMTPPEAKKYFNFRYPPPGAERIFYGRANDPQIAPYLTHGMRPKGLVTMSSLINPQPITTFQQKVKDKKESIYFSHQRAPL
GKSHDQTPGLPKGMDVINTTLGTPTIRELSVRDVVNPSKSFEDVFKEGQEGHDLYTISHNDYFAGEAKNRKYNPASFHRFNLYGVPTPHCNDGRTMAKTLHWLHELQMERGAKIVSKRADDFEEKFQH
RLGRVLDPIAETMNVPPGHTFGACLQPEEYGAGDLIHYRGPDEYLRGKDRQRALVAAARHHLKKFNHQHFDTLLMAFRHYDKKGDGVIDRAELHEACVQANLHLDKMLLDHLFDYCDVDQDGLINYLE
FANFLTWKDRIPLTEYEKRVVIKGKKTDCENVTETSIVGETDPSLLVNPEDIVPKEPGSSEEIVRTILRPGDKVSDQYKTTSSEINAVVGAVPSICYPIYGVPTIRSDIPAPRIRRVSDMNNYGEEGN
AYALLHPSIFSQKGVFERDFFKTRSKEEISDILTNIGVKLTEEEFENVWNLASQKHQQGEVCVETIRNVLDELHADLFKCKTAM

hide sequence

Ensembl Acc Id:

ENSRNOP00000016911 ⟸ ENSRNOT00000016911

Ensembl Acc Id:

ENSRNOP00000060318 ⟸ ENSRNOT00000066582

RefSeq Acc Id:	XP_038939090 ⟸ XM_039083162
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038939089 ⟸ XM_039083161
- Peptide Label:	isoform X2

Protein Domains

EF-hand

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZTX5-F1-model_v2	AlphaFold	D3ZTX5	1-946	view protein structure

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

RGD ID:

13696421

Promoter ID:

EPDNEW_R6942

Type:

single initiation site

Name:

Efhb_1

Description:

EF hand domain family, member B

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	9	47,972 - 48,032	EPDNEW

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-28402	BioCyc
Ensembl Genes	ENSRNOG00000012618	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000016911	ENTREZGENE
	ENSRNOT00000016911.7	UniProtKB/TrEMBL
	ENSRNOT00000066582.3	UniProtKB/TrEMBL
Gene3D-CATH	EF-hand	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7098775	IMAGE-MGC_LOAD
InterPro	EF-hand-like_dom	UniProtKB/TrEMBL
	EF_Hand_1_Ca_BS	UniProtKB/TrEMBL
	EF_hand_Ca-bd	UniProtKB/TrEMBL
	EFHC1/EFHC2/EFHB	UniProtKB/TrEMBL
KEGG Report	rno:301168	UniProtKB/TrEMBL
MGC_CLONE	MGC:187959	IMAGE-MGC_LOAD
NCBI Gene	301168	ENTREZGENE
PANTHER	EF-HAND DOMAIN-CONTAINING FAMILY MEMBER B	UniProtKB/TrEMBL
	PTHR12086	UniProtKB/TrEMBL
Pfam	EF_hand_5	UniProtKB/TrEMBL
PhenoGen	Efhb	PhenoGen
PROSITE	EF_HAND_1	UniProtKB/TrEMBL
	EF_HAND_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000012618	RatGTEx
SMART	EFh	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47473	UniProtKB/TrEMBL
UniProt	A6KUI0	ENTREZGENE, UniProtKB/TrEMBL
	A6KUI1	ENTREZGENE, UniProtKB/TrEMBL
	B2GV10_RAT	UniProtKB/TrEMBL
	D3ZTX5	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Efhb	EF hand domain family, member B	Efhb_predicted	EF hand domain family, member B (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Efhb_predicted	EF hand domain family, member B (predicted)	RGD1566407_predicted	similar to hypothetical protein 4921525D22 (predicted)	Symbol and Name updated	1299863	APPROVED
2006-03-07	RGD1566407_predicted	similar to hypothetical protein 4921525D22 (predicted)	LOC301168	similar to hypothetical protein 4921525D22	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC301168	similar to hypothetical protein 4921525D22			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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Imported Disease Annotations - ClinVar