Efhb (EF-hand domain family member B) - Rat Genome Database

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Gene: Efhb (EF-hand domain family member B) Heterocephalus glaber
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Symbol: Efhb
Name: EF-hand domain family member B
RGD ID: 18926550
Description: ENCODES a protein that exhibits calcium ion sensor activity (ortholog); INVOLVED IN flagellated sperm motility (ortholog); regulation of calcineurin-NFAT signaling cascade (ortholog); regulation of store-operated calcium entry (ortholog); ASSOCIATED WITH 3p deletion syndrome (ortholog); FOUND IN axonemal A tubule inner sheath (ortholog); sperm flagellum (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: EF-hand domain-containing family member B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248215,216,624 - 5,269,433 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248215,215,680 - 5,269,500 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Efhb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248215,216,624 - 5,269,433 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248215,215,680 - 5,269,500 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
EFHB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38319,879,472 - 19,946,983 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl319,879,472 - 19,947,025 (-)EnsemblGRCh38hg38GRCh38
GRCh37319,920,964 - 19,988,475 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36319,895,968 - 19,950,710 (-)NCBINCBI36Build 36hg18NCBI36
Build 34319,895,971 - 19,950,676NCBI
Celera319,861,484 - 19,916,233 (-)NCBICelera
Cytogenetic Map3p24.3NCBI
HuRef319,861,347 - 19,916,080 (-)NCBIHuRef
CHM1_1319,873,136 - 19,927,880 (-)NCBICHM1_1
T2T-CHM13v2.0319,883,550 - 19,951,207 (-)NCBIT2T-CHM13v2.0
Efhb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391753,705,077 - 53,770,362 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1753,705,917 - 53,770,349 (-)EnsemblGRCm39 Ensembl
GRCm381753,398,044 - 53,463,334 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1753,398,889 - 53,463,321 (-)EnsemblGRCm38mm10GRCm38
MGSCv371753,538,214 - 53,602,646 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361752,863,818 - 52,928,250 (-)NCBIMGSCv36mm8
Celera1756,844,691 - 56,909,168 (-)NCBICelera
Cytogenetic Map17CNCBI
cM Map1727.78NCBI
Efhb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr896,608,791 - 6,680,104 (-)NCBIGRCr8
mRatBN7.296,372,191 - 6,441,678 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl96,372,194 - 6,441,919 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx97,524,938 - 7,587,963 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0912,682,486 - 12,745,498 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0911,846,203 - 11,909,734 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0947,988 - 120,800 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl947,724 - 120,799 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0942,285 - 114,389 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.491,563,384 - 1,635,269NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic Map9q11NCBI
Efhb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543011,932,296 - 11,987,845 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543011,932,753 - 11,986,985 (-)NCBIChiLan1.0ChiLan1.0
EFHB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2219,840,935 - 19,903,938 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1319,845,702 - 19,908,709 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0319,798,204 - 19,855,338 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1320,130,063 - 20,184,718 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl320,128,668 - 20,184,718 (-)Ensemblpanpan1.1panPan2
EFHB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12323,337,293 - 23,384,362 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2323,335,956 - 23,384,193 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2323,362,527 - 23,410,153 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02323,824,176 - 23,871,987 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2323,822,838 - 23,871,409 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12323,536,377 - 23,583,894 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02323,601,798 - 23,649,332 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02323,847,939 - 23,895,522 (+)NCBIUU_Cfam_GSD_1.0
Efhb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118179,041,162 - 179,093,637 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493647312,179,950 - 12,232,093 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EFHB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl136,824,503 - 6,898,764 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1136,826,023 - 6,898,763 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2137,728,118 - 7,798,299 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EFHB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11564,608,440 - 64,679,276 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1564,608,604 - 64,661,298 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604137,634,448 - 37,700,575 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000004936   ⟹   ENSHGLP00000004872
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248215,216,624 - 5,269,433 (-)Ensembl
RefSeq Acc Id: XM_004864290   ⟹   XP_004864347
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248215,215,680 - 5,269,500 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004864347 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000004872
  ENSHGLP00000040313
GenBank Protein JAN98063 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004864347   ⟸   XM_004864290
- UniProtKB: A0A0P6K252 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000004872   ⟸   ENSHGLT00000004936


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000003576 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000004936 ENTREZGENE
  ENSHGLT00000062060 UniProtKB/TrEMBL
Gene3D-CATH EF-hand UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  EFHC1/EFHC2/EFHB UniProtKB/TrEMBL
NCBI Gene Efhb ENTREZGENE
PANTHER EF-HAND DOMAIN-CONTAINING FAMILY MEMBER B UniProtKB/TrEMBL
  PTHR12086 UniProtKB/TrEMBL
Pfam EF-hand_7 UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
SMART EFh UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt A0A0P6K252 ENTREZGENE, UniProtKB/TrEMBL