Symbol:
Shb
Name:
SH2 domain containing adaptor protein B
RGD ID:
1565350
Description:
Predicted to enable phosphotyrosine residue binding activity and signaling receptor complex adaptor activity. Predicted to act upstream of or within several processes, including hematopoietic stem cell proliferation; negative regulation of oocyte maturation; and positive regulation of immune response. Predicted to be located in cytoplasmic ribonucleoprotein granule; cytosol; and nucleoplasm. Orthologous to human SHB (SH2 domain containing adaptor protein B); PARTICIPATES IN platelet-derived growth factor signaling pathway; vascular endothelial growth factor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
LOC362513; RGD1565350; SH2 domain-containing adapter protein B; similar to Shb protein; Src homology 2 domain containing adaptor protein B
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 5 64,473,694 - 64,581,072 (-) NCBI GRCr8 mRatBN7.2 5 59,678,066 - 59,785,443 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 5 59,678,216 - 59,785,538 (-) Ensembl mRatBN7.2 Ensembl Rnor_6.0 5 60,970,650 - 61,077,881 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 5 60,971,257 - 61,077,627 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 5 65,479,290 - 65,587,205 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 5 61,983,643 - 62,090,620 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 Celera 5 58,246,193 - 58,353,269 (-) NCBI Celera Cytogenetic Map 5 q22 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Only show annotations with direct experimental evidence (0 objects hidden)
Shb Rat (1->4)-beta-D-glucan multiple interactions ISO RGD:1558467 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of SHB mRNA CTD PMID:36331819 Shb Rat 1,2-dichloroethane decreases expression ISO RGD:1558467 6480464 ethylene dichloride results in decreased expression of SHB mRNA CTD PMID:28960355 Shb Rat 1,2-dimethylhydrazine increases expression ISO RGD:1558467 6480464 1,2-Dimethylhydrazine results in increased expression of SHB mRNA CTD PMID:22206623 Shb Rat 17beta-estradiol increases expression ISO RGD:1350494 6480464 Estradiol results in increased expression of SHB mRNA CTD PMID:12154049|PMID:31614463 Shb Rat 17beta-estradiol decreases expression ISO RGD:1558467 6480464 Estradiol results in decreased expression of SHB mRNA CTD PMID:39298647 Shb Rat 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1558467 6480464 [Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of SHB mRNA CTD PMID:16214954 Shb Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of SHB mRNA CTD PMID:33387578 Shb Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of SHB mRNA CTD PMID:32109520 Shb Rat 2,3,7,8-Tetrachlorodibenzofuran decreases expression EXP 6480464 2,3,7,8-tetrachlorodibenzofuran results in decreased expression of SHB mRNA CTD PMID:32109520 Shb Rat 3,3',4,4'-tetrachlorobiphenyl multiple interactions ISO RGD:1558467 6480464 3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of SHB mRNA] CTD PMID:19467301 Shb Rat 4,4'-sulfonyldiphenol affects expression ISO RGD:1558467 6480464 bisphenol S affects the expression of SHB mRNA CTD PMID:39298647 Shb Rat 4,4'-sulfonyldiphenol decreases methylation ISO RGD:1350494 6480464 bisphenol S results in decreased methylation of SHB gene CTD PMID:31601247 Shb Rat 4-hydroxyphenyl retinamide increases expression ISO RGD:1558467 6480464 Fenretinide results in increased expression of SHB mRNA CTD PMID:28973697 Shb Rat 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of SHB mRNA CTD PMID:24780913 Shb Rat afimoxifene increases expression ISO RGD:1350494 6480464 afimoxifene results in increased expression of SHB mRNA CTD PMID:12154049 Shb Rat aflatoxin B1 increases methylation ISO RGD:1350494 6480464 Aflatoxin B1 results in increased methylation of SHB intron CTD PMID:30157460 Shb Rat antimycin A increases expression ISO RGD:1350494 6480464 Antimycin A results in increased expression of SHB mRNA CTD PMID:33512557 Shb Rat atrazine increases expression ISO RGD:1350494 6480464 Atrazine results in increased expression of SHB mRNA CTD PMID:22378314 Shb Rat azathioprine increases expression ISO RGD:1350494 6480464 Azathioprine results in increased expression of SHB mRNA CTD PMID:22623647 Shb Rat benzo[a]pyrene increases expression ISO RGD:1350494 6480464 Benzo(a)pyrene results in increased expression of SHB mRNA CTD PMID:26238291 Shb Rat benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1350494 6480464 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SHB mRNA CTD PMID:19150397 Shb Rat benzo[e]pyrene decreases methylation ISO RGD:1350494 6480464 benzo(e)pyrene results in decreased methylation of SHB intron CTD PMID:30157460 Shb Rat bisphenol A multiple interactions ISO RGD:1350494 6480464 [bisphenol A co-treated with Fulvestrant] results in increased methylation of SHB gene CTD PMID:31601247 Shb Rat bisphenol A increases expression ISO RGD:1558467 6480464 bisphenol A results in increased expression of SHB mRNA CTD PMID:32156529 Shb Rat bisphenol A affects methylation ISO RGD:1350494 6480464 bisphenol A affects the methylation of SHB gene CTD PMID:31601247 Shb Rat bisphenol F multiple interactions ISO RGD:1350494 6480464 [bisphenol F co-treated with Fulvestrant] results in increased methylation of SHB gene CTD PMID:31601247 Shb Rat cadmium dichloride decreases expression ISO RGD:1350494 6480464 Cadmium Chloride results in decreased expression of SHB mRNA CTD PMID:12760830 Shb Rat caffeine affects phosphorylation ISO RGD:1350494 6480464 Caffeine affects the phosphorylation of SHB protein CTD PMID:35688186 Shb Rat carbon nanotube increases expression ISO RGD:1558467 6480464 Nanotubes, Carbon results in increased expression of SHB mRNA CTD PMID:25620056 Shb Rat CGP 52608 multiple interactions ISO RGD:1350494 6480464 CGP 52608 promotes the reaction [RORA protein binds to SHB gene] CTD PMID:28238834 Shb Rat chlorpyrifos increases expression ISO RGD:1558467 6480464 Chlorpyrifos results in increased expression of SHB mRNA CTD PMID:37019170 Shb Rat crocidolite asbestos decreases expression ISO RGD:1558467 6480464 Asbestos, Crocidolite results in decreased expression of SHB mRNA CTD PMID:29279043 Shb Rat cyclosporin A increases expression ISO RGD:1350494 6480464 Cyclosporine results in increased expression of SHB mRNA CTD PMID:20106945|PMID:25562108 Shb Rat decabromodiphenyl ether increases expression EXP 6480464 decabromobiphenyl ether results in increased expression of SHB mRNA CTD PMID:23640034 Shb Rat diazinon increases methylation ISO RGD:1350494 6480464 Diazinon results in increased methylation of SHB gene CTD PMID:22964155 Shb Rat dioxygen multiple interactions ISO RGD:1558467 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of SHB mRNA CTD PMID:30529165 Shb Rat dorsomorphin multiple interactions ISO RGD:1350494 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression more ... CTD PMID:27188386 Shb Rat elemental selenium increases expression ISO RGD:1350494 6480464 Selenium results in increased expression of SHB mRNA CTD PMID:19244175 Shb Rat endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of SHB mRNA CTD PMID:29391264 Shb Rat entinostat increases expression ISO RGD:1350494 6480464 entinostat results in increased expression of SHB mRNA CTD PMID:26272509 Shb Rat entinostat multiple interactions ISO RGD:1350494 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression more ... CTD PMID:27188386 Shb Rat ethyl methanesulfonate decreases expression ISO RGD:1350494 6480464 Ethyl Methanesulfonate results in decreased expression of SHB mRNA CTD PMID:23649840 Shb Rat ethylparaben increases expression ISO RGD:1350494 6480464 ethyl-p-hydroxybenzoate results in increased expression of SHB mRNA CTD PMID:37690743 Shb Rat FR900359 affects phosphorylation ISO RGD:1350494 6480464 FR900359 affects the phosphorylation of SHB protein CTD PMID:37730182 Shb Rat fulvestrant multiple interactions ISO RGD:1350494 6480464 [bisphenol A co-treated with Fulvestrant] results in increased methylation of SHB gene; [bisphenol F co-treated more ... CTD PMID:31601247 Shb Rat glyphosate affects methylation EXP 6480464 Glyphosate affects the methylation of SHB gene CTD PMID:35440735 Shb Rat leflunomide decreases expression EXP 6480464 leflunomide results in decreased expression of SHB mRNA CTD PMID:24136188 Shb Rat leflunomide increases expression ISO RGD:1350494 6480464 leflunomide results in increased expression of SHB mRNA CTD PMID:28988120 Shb Rat methapyrilene decreases methylation ISO RGD:1350494 6480464 Methapyrilene results in decreased methylation of SHB intron CTD PMID:30157460 Shb Rat methotrexate decreases expression ISO RGD:1350494 6480464 Methotrexate results in decreased expression of SHB mRNA CTD PMID:24449571 Shb Rat methoxychlor affects methylation EXP 6480464 Methoxychlor affects the methylation of SHB gene CTD PMID:35440735 Shb Rat methyl methanesulfonate decreases expression ISO RGD:1350494 6480464 Methyl Methanesulfonate results in decreased expression of SHB mRNA CTD PMID:23649840 Shb Rat methylmercury chloride increases expression ISO RGD:1350494 6480464 methylmercuric chloride results in increased expression of SHB mRNA CTD PMID:28001369 Shb Rat okadaic acid increases expression ISO RGD:1350494 6480464 Okadaic Acid results in increased expression of SHB mRNA CTD PMID:38832940 Shb Rat panobinostat multiple interactions ISO RGD:1350494 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression more ... CTD PMID:27188386 Shb Rat panobinostat increases expression ISO RGD:1350494 6480464 panobinostat results in increased expression of SHB mRNA CTD PMID:26272509 Shb Rat paracetamol increases expression ISO RGD:1350494 6480464 Acetaminophen results in increased expression of SHB mRNA CTD PMID:29067470 Shb Rat paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of SHB mRNA CTD PMID:33387578 Shb Rat pentachlorophenol increases expression ISO RGD:1558467 6480464 Pentachlorophenol results in increased expression of SHB mRNA CTD PMID:23892564 Shb Rat perfluorooctane-1-sulfonic acid multiple interactions ISO RGD:1558467 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of SHB mRNA CTD PMID:36331819 Shb Rat phenylmercury acetate increases expression ISO RGD:1350494 6480464 Phenylmercuric Acetate results in increased expression of SHB mRNA CTD PMID:26272509 Shb Rat phenylmercury acetate multiple interactions ISO RGD:1350494 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... CTD PMID:27188386 Shb Rat pirinixic acid decreases expression ISO RGD:1558467 6480464 pirinixic acid results in decreased expression of SHB mRNA CTD PMID:23811191 Shb Rat pregnenolone 16alpha-carbonitrile increases expression ISO RGD:1558467 6480464 Pregnenolone Carbonitrile results in increased expression of SHB mRNA CTD PMID:28903501 Shb Rat raloxifene affects expression ISO RGD:1350494 6480464 Raloxifene Hydrochloride affects the expression of SHB mRNA CTD PMID:14699072 Shb Rat resveratrol increases expression ISO RGD:1350494 6480464 resveratrol results in increased expression of SHB mRNA CTD PMID:12154049 Shb Rat resveratrol multiple interactions ISO RGD:1350494 6480464 [Plant Extracts co-treated with Resveratrol] results in decreased expression of SHB mRNA CTD PMID:23557933 Shb Rat SB 431542 multiple interactions ISO RGD:1350494 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression more ... CTD PMID:27188386 Shb Rat selenium atom increases expression ISO RGD:1350494 6480464 Selenium results in increased expression of SHB mRNA CTD PMID:19244175 Shb Rat sodium arsenite increases expression ISO RGD:1350494 6480464 sodium arsenite results in increased expression of SHB mRNA CTD PMID:12760830 Shb Rat tamoxifen affects expression ISO RGD:1350494 6480464 Tamoxifen affects the expression of SHB mRNA CTD PMID:14699072 Shb Rat tetrachloromethane increases expression ISO RGD:1558467 6480464 Carbon Tetrachloride results in increased expression of SHB mRNA CTD PMID:31919559 Shb Rat thapsigargin decreases expression ISO RGD:1350494 6480464 Thapsigargin results in decreased expression of SHB mRNA CTD PMID:22378314 Shb Rat thiram increases expression ISO RGD:1350494 6480464 Thiram results in increased expression of SHB mRNA CTD PMID:38568856 Shb Rat titanium dioxide increases methylation ISO RGD:1558467 6480464 titanium dioxide results in increased methylation of SHB gene CTD PMID:35295148 Shb Rat trichostatin A increases expression ISO RGD:1350494 6480464 trichostatin A results in increased expression of SHB mRNA CTD PMID:24935251 Shb Rat triclosan increases expression ISO RGD:1350494 6480464 Triclosan results in increased expression of SHB mRNA CTD PMID:30510588 Shb Rat triptonide increases expression ISO RGD:1558467 6480464 triptonide results in increased expression of SHB mRNA CTD PMID:33045310 Shb Rat urethane increases expression ISO RGD:1350494 6480464 Urethane results in increased expression of SHB mRNA CTD PMID:28818685 Shb Rat valproic acid increases methylation ISO RGD:1350494 6480464 Valproic Acid results in increased methylation of SHB gene CTD PMID:29154799 Shb Rat valproic acid increases expression ISO RGD:1350494 6480464 Valproic Acid results in increased expression of SHB mRNA CTD PMID:23179753|PMID:24935251|PMID:27188386 Shb Rat vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of SHB mRNA CTD PMID:23034163 Shb Rat vinclozolin increases methylation EXP 6480464 vinclozolin results in increased methylation of SHB gene CTD PMID:31682807 Shb Rat zinc atom multiple interactions ISO RGD:1350494 6480464 [PCI 5002 co-treated with Zinc] results in increased expression of SHB mRNA CTD PMID:18593933 Shb Rat zinc(0) multiple interactions ISO RGD:1350494 6480464 [PCI 5002 co-treated with Zinc] results in increased expression of SHB mRNA CTD PMID:18593933
Imported Annotations - PID (archival)
(1->4)-beta-D-glucan (ISO) 1,2-dichloroethane (ISO) 1,2-dimethylhydrazine (ISO) 17beta-estradiol (ISO) 2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO) 2,3,7,8-Tetrachlorodibenzofuran (EXP) 3,3',4,4'-tetrachlorobiphenyl (ISO) 4,4'-sulfonyldiphenol (ISO) 4-hydroxyphenyl retinamide (ISO) 6-propyl-2-thiouracil (EXP) afimoxifene (ISO) aflatoxin B1 (ISO) antimycin A (ISO) atrazine (ISO) azathioprine (ISO) benzo[a]pyrene (ISO) benzo[a]pyrene diol epoxide I (ISO) benzo[e]pyrene (ISO) bisphenol A (ISO) bisphenol F (ISO) cadmium dichloride (ISO) caffeine (ISO) carbon nanotube (ISO) CGP 52608 (ISO) chlorpyrifos (ISO) crocidolite asbestos (ISO) cyclosporin A (ISO) decabromodiphenyl ether (EXP) diazinon (ISO) dioxygen (ISO) dorsomorphin (ISO) elemental selenium (ISO) endosulfan (EXP) entinostat (ISO) ethyl methanesulfonate (ISO) ethylparaben (ISO) FR900359 (ISO) fulvestrant (ISO) glyphosate (EXP) leflunomide (EXP,ISO) methapyrilene (ISO) methotrexate (ISO) methoxychlor (EXP) methyl methanesulfonate (ISO) methylmercury chloride (ISO) okadaic acid (ISO) panobinostat (ISO) paracetamol (EXP,ISO) pentachlorophenol (ISO) perfluorooctane-1-sulfonic acid (ISO) phenylmercury acetate (ISO) pirinixic acid (ISO) pregnenolone 16alpha-carbonitrile (ISO) raloxifene (ISO) resveratrol (ISO) SB 431542 (ISO) selenium atom (ISO) sodium arsenite (ISO) tamoxifen (ISO) tetrachloromethane (ISO) thapsigargin (ISO) thiram (ISO) titanium dioxide (ISO) trichostatin A (ISO) triclosan (ISO) triptonide (ISO) urethane (ISO) valproic acid (ISO) vinclozolin (EXP) zinc atom (ISO) zinc(0) (ISO)
Shb Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 5 64,473,694 - 64,581,072 (-) NCBI GRCr8 mRatBN7.2 5 59,678,066 - 59,785,443 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 5 59,678,216 - 59,785,538 (-) Ensembl mRatBN7.2 Ensembl Rnor_6.0 5 60,970,650 - 61,077,881 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 5 60,971,257 - 61,077,627 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 5 65,479,290 - 65,587,205 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 5 61,983,643 - 62,090,620 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 Celera 5 58,246,193 - 58,353,269 (-) NCBI Celera Cytogenetic Map 5 q22 NCBI
SHB Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 9 37,915,898 - 38,069,227 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl 9 37,915,898 - 38,069,227 (-) Ensembl GRCh38 hg38 GRCh38 GRCh37 9 37,915,895 - 38,069,224 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 9 37,905,895 - 38,059,210 (-) NCBI NCBI36 Build 36 hg18 NCBI36 Build 34 9 37,909,613 - 38,059,208 NCBI Celera 9 37,849,067 - 38,002,380 (-) NCBI Celera Cytogenetic Map 9 p13.1 NCBI HuRef 9 37,868,289 - 38,021,594 (-) NCBI HuRef CHM1_1 9 37,917,509 - 38,070,825 (-) NCBI CHM1_1 T2T-CHM13v2.0 9 37,939,809 - 38,093,156 (-) NCBI T2T-CHM13v2.0
Shb Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 4 45,423,278 - 45,530,804 (-) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 4 45,423,278 - 45,532,470 (-) Ensembl GRCm39 Ensembl GRCm38 4 45,423,276 - 45,530,828 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 4 45,423,278 - 45,532,470 (-) Ensembl GRCm38 mm10 GRCm38 MGSCv37 4 45,436,148 - 45,543,700 (-) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 4 45,444,376 - 45,551,862 (-) NCBI MGSCv36 mm8 MGSCv36 4 44,263,381 - 44,370,910 (-) NCBI MGSCv36 mm8 Celera 4 45,444,918 - 45,556,568 (-) NCBI Celera Cytogenetic Map 4 B1 NCBI cM Map 4 24.0 NCBI
Shb Chinchilla Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChiLan1.0 Ensembl NW_004955419 28,421,354 - 28,558,823 (+) Ensembl ChiLan1.0 ChiLan1.0 NW_004955419 28,423,354 - 28,555,948 (+) NCBI ChiLan1.0 ChiLan1.0
SHB Bonobo Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl NHGRI_mPanPan1-v2 11 86,515,564 - 86,730,162 (+) NCBI NHGRI_mPanPan1-v2 NHGRI_mPanPan1 9 86,522,079 - 86,673,682 (+) NCBI NHGRI_mPanPan1 Mhudiblu_PPA_v0 9 37,768,566 - 37,921,897 (-) NCBI Mhudiblu_PPA_v0 Mhudiblu_PPA_v0 panPan3 PanPan1.1 9 38,694,980 - 38,843,827 (-) NCBI panpan1.1 PanPan1.1 panPan2
SHB Dog Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl CanFam3.1 11 54,189,580 - 54,329,004 (-) NCBI CanFam3.1 CanFam3.1 canFam3 CanFam3.1 CanFam3.1 Ensembl 11 54,189,843 - 54,329,325 (-) Ensembl CanFam3.1 canFam3 CanFam3.1 Dog10K_Boxer_Tasha 11 52,615,325 - 52,754,488 (-) NCBI Dog10K_Boxer_Tasha ROS_Cfam_1.0 11 55,298,243 - 55,437,485 (-) NCBI ROS_Cfam_1.0 ROS_Cfam_1.0 Ensembl 11 55,298,508 - 55,438,186 (-) Ensembl ROS_Cfam_1.0 Ensembl UMICH_Zoey_3.1 11 53,796,294 - 53,935,436 (-) NCBI UMICH_Zoey_3.1 UNSW_CanFamBas_1.0 11 53,826,088 - 53,965,258 (-) NCBI UNSW_CanFamBas_1.0 UU_Cfam_GSD_1.0 11 54,522,809 - 54,661,888 (-) NCBI UU_Cfam_GSD_1.0
Shb Squirrel Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl HiC_Itri_2 NW_024404947 169,150,521 - 169,284,871 (-) NCBI HiC_Itri_2 SpeTri2.0 Ensembl NW_004936524 5,701,566 - 5,834,539 (-) Ensembl SpeTri2.0 SpeTri2.0 Ensembl SpeTri2.0 NW_004936524 5,698,101 - 5,832,801 (-) NCBI SpeTri2.0 SpeTri2.0 SpeTri2.0
SHB Pig Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Sscrofa11.1 Ensembl 1 238,681,194 - 238,826,429 (-) Ensembl Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa11.1 1 238,680,804 - 238,826,424 (-) NCBI Sscrofa11.1 Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa10.2 1 266,638,474 - 266,670,709 (+) NCBI Sscrofa10.2 Sscrofa10.2 susScr3
SHB Green Monkey Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChlSab1.1 12 42,520,803 - 42,669,892 (+) NCBI ChlSab1.1 ChlSab1.1 chlSab2 ChlSab1.1 Ensembl 12 42,520,905 - 42,669,211 (+) Ensembl ChlSab1.1 ChlSab1.1 Ensembl chlSab2 Vero_WHO_p1.0 NW_023666038 39,581,717 - 39,730,643 (+) NCBI Vero_WHO_p1.0 Vero_WHO_p1.0
Shb
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Predicted Target Of
Count of predictions: 199 Count of miRNA genes: 149 Interacting mature miRNAs: 165 Transcripts: ENSRNOT00000015338, ENSRNOT00000067955 Prediction methods: Microtar, Miranda, Rnahybrid, Targetscan Result types: miRGate_prediction
1578776 Stresp18 Stress response QTL 18 2.9 thymus mass (VT:0004954) thymus wet weight (CMO:0000855) 5 27955440 72955440 Rat 1298067 Scl15 Serum cholesterol level QTL 15 4.8 0.001 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) 5 33215665 78215665 Rat 1300115 Hrtrt7 Heart rate QTL 7 2.76 heart pumping trait (VT:2000009) heart rate (CMO:0000002) 5 47869062 90099692 Rat 1549845 Scl44 Serum cholesterol level QTL 44 6 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) 5 40128307 148607290 Rat 70212 Niddm25 Non-insulin dependent diabetes mellitus QTL 25 3.54 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 5 1 131345958 Rat 1358353 Srcrtb2 Stress Responsive Cort Basal QTL 2 3.48 0.003 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 5 18873947 74251464 Rat 634305 Mamtr1 Mammary tumor resistance QTL 1 0.0001 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) 5 12789751 113558310 Rat 1598868 Mcs12 Mammary carcinoma susceptibility QTL 12 0.0001 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) 5 58973449 60051321 Rat 1331801 Rf33 Renal function QTL 33 4.149 kidney blood vessel physiology trait (VT:0100012) absolute change in renal vascular resistance (CMO:0001900) 5 43726656 129132602 Rat 1598807 Glom12 Glomerulus QTL 12 2.7 kidney glomerulus morphology trait (VT:0005325) index of glomerular damage (CMO:0001135) 5 33215665 78215665 Rat 1302786 Kidm8 Kidney mass QTL 8 28.15 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) 5 33215665 78215665 Rat 6903292 Stl28 Serum triglyceride level QTL 28 2.6 0.0073 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) 5 28515489 73515489 Rat 1578766 Tcas11 Tongue tumor susceptibility QTL 11 4.12 tongue integrity trait (VT:0010553) number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950) 5 46711509 161317411 Rat 1578767 Stresp17 Stress response QTL 17 4.3 0.01 blood aldosterone amount (VT:0005346) plasma aldosterone level (CMO:0000551) 5 27955440 72955440 Rat 7411561 Bw134 Body weight QTL 134 24 0.001 body mass (VT:0001259) body weight gain (CMO:0000420) 5 49463600 94463600 Rat 1641922 Alcrsp8 Alcohol response QTL 8 alcohol metabolism trait (VT:0015089) blood ethanol level (CMO:0000535) 5 35189153 68564008 Rat 2303615 Vencon7 Ventilatory control QTL 7 0.001 respiration trait (VT:0001943) respiration rate (CMO:0000289) 5 50983895 95983895 Rat 1576312 Emca8 Estrogen-induced mammary cancer QTL 8 4.1 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) 5 50328551 141643988 Rat 1641912 Alcrsp18 Alcohol response QTL 18 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) 5 35189153 141643988 Rat 1576314 Eutr1 Estrogen induced uterine response QTL 1 uterus integrity trait (VT:0010575) pyometritis severity score (CMO:0002009) 5 2138965 166875058 Rat 6903306 Scl35 Serum cholesterol QTL 35 2.6 0.0073 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) 5 28515489 73515489 Rat 1576317 Eutr2 Estrogen induced uterine response QTL 2 0.01 uterus integrity trait (VT:0010575) pyometritis severity score (CMO:0002009) 5 34730116 104251008 Rat 7394712 Emca13 Estrogen-induced mammary cancer QTL 13 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) 5 9823266 99753708 Rat 1331773 Scl26 Serum cholesterol level QTL 26 3.065 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) 5 43726656 86724018 Rat 70189 Mcs5 Mammary carcinoma susceptibility QTL 5 10.51 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) 5 55805606 132207589 Rat 1331771 Rf35 Renal function QTL 35 4.36965 kidney blood vessel physiology trait (VT:0100012) absolute change in renal blood flow rate (CMO:0001168) 5 729470 86724018 Rat 61359 Eaex Experimental allergic encephalomyelitis QTL x 3 nervous system integrity trait (VT:0010566) post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422) 5 55715622 100715622 Rat 8662454 Vetf3 Vascular elastic tissue fragility QTL 3 27.4 artery integrity trait (VT:0010639) number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562) 5 2282226 69540447 Rat 2290448 Scl54 Serum cholesterol level QTL 54 2.93 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) 5 31663789 131345958 Rat 9589025 Epfw7 Epididymal fat weight QTL 7 20.66 0.001 epididymal fat pad mass (VT:0010421) epididymal fat pad weight to body weight ratio (CMO:0000658) 5 49463600 94463600 Rat 2303574 Gluco42 Glucose level QTL 42 2 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 5 53496719 98496719 Rat 1331756 Rf34 Renal function QTL 34 4.16275 kidney blood vessel physiology trait (VT:0100012) absolute change in renal blood flow rate (CMO:0001168) 5 1 90450412 Rat 8552954 Pigfal14 Plasma insulin-like growth factor 1 level QTL 14 9 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) 5 21226744 66226744 Rat 1358895 Bp254 Blood pressure QTL 254 3.6 0.0003 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 5 58829236 128034027 Rat 2316959 Gluco59 Glucose level QTL 59 4.7 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 5 34944474 113558310 Rat 1600358 Mamtr5 Mammary tumor resistance QTL 5 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) 5 18873947 63873947 Rat
D5Mgh10
Rat Assembly Chr Position (strand) Source JBrowse GRCr8 5 64,589,016 - 64,589,145 (+) Marker Load Pipeline mRatBN7.2 5 59,793,399 - 59,793,528 (+) MAPPER mRatBN7.2 Rnor_6.0 5 61,086,525 - 61,086,653 NCBI Rnor6.0 Rnor_5.0 5 65,595,163 - 65,595,291 UniSTS Rnor5.0 RGSC_v3.4 5 62,098,646 - 62,098,775 RGD RGSC3.4 RGSC_v3.4 5 62,098,647 - 62,098,775 UniSTS RGSC3.4 RGSC_v3.1 5 62,098,825 - 62,098,954 RGD Celera 5 58,361,489 - 58,361,617 UniSTS SHRSP x BN Map 5 37.0299 RGD SHRSP x BN Map 5 37.0299 UniSTS Cytogenetic Map 5 q22 UniSTS
RH131997
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 5 59,905,869 - 59,906,064 (+) MAPPER mRatBN7.2 Rnor_6.0 5 61,225,560 - 61,225,754 NCBI Rnor6.0 Rnor_5.0 5 65,729,011 - 65,729,205 UniSTS Rnor5.0 RGSC_v3.4 5 62,153,496 - 62,153,690 UniSTS RGSC3.4 Celera 5 58,471,648 - 58,471,842 UniSTS RH 3.4 Map 5 378.2 UniSTS Cytogenetic Map 5 q22 UniSTS
Click on a value in the shaded box below the category label to view a detailed expression data table for that system.
alimentary part of gastrointestinal system
9
11
49
113
91
90
59
25
59
6
218
97
93
45
60
31
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Ensembl Acc Id:
ENSRNOT00000015338 ⟹ ENSRNOP00000015338
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 5 59,678,216 - 59,785,538 (-) Ensembl Rnor_6.0 Ensembl 5 60,971,257 - 61,077,627 (-) Ensembl
Ensembl Acc Id:
ENSRNOT00000116607 ⟹ ENSRNOP00000095708
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 5 59,684,479 - 59,785,538 (-) Ensembl
RefSeq Acc Id:
NM_001427398 ⟹ NP_001414327
RefSeq Status:
VALIDATED
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 5 64,473,694 - 64,581,072 (-) NCBI
Ensembl Acc Id:
ENSRNOP00000015338 ⟸ ENSRNOT00000015338
Ensembl Acc Id:
ENSRNOP00000095708 ⟸ ENSRNOT00000116607
RefSeq Acc Id:
NP_001414327 ⟸ NM_001427398
- UniProtKB:
A0A8I6ARZ3 (UniProtKB/TrEMBL), D3ZN31 (UniProtKB/TrEMBL)
Date
Current Symbol
Current Name
Previous Symbol
Previous Name
Description
Reference
Status
2016-04-20
Shb
SH2 domain containing adaptor protein B
Shb
Src homology 2 domain containing adaptor protein B
Nomenclature updated to reflect human and mouse nomenclature
1299863 APPROVED
2012-10-12
Shb
Src homology 2 domain containing adaptor protein B
RGD1565350
similar to Shb protein
Nomenclature updated to reflect human and mouse nomenclature
1299863 APPROVED
2008-04-30
RGD1565350
similar to Shb protein
RGD1565350_predicted
similar to Shb protein (predicted)
'predicted' is removed
2292626 APPROVED
2006-03-07
RGD1565350_predicted
similar to Shb protein (predicted)
LOC362513
similar to Shb protein
Symbol and Name status set to approved
1299863 APPROVED
2006-02-09
LOC362513
similar to Shb protein
Symbol and Name status set to provisional
70820 PROVISIONAL
