Ncoa4 (nuclear receptor coactivator 4) - Rat Genome Database

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Gene: Ncoa4 (nuclear receptor coactivator 4) Rattus norvegicus
Analyze
Symbol: Ncoa4
Name: nuclear receptor coactivator 4
RGD ID: 1563014
Description: Predicted to enable transcription coactivator activity. Involved in response to hormone. Predicted to be located in autolysosome. Orthologous to human NCOA4 (nuclear receptor coactivator 4); PARTICIPATES IN iron homeostasis pathway; thyroid cancer pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC72479
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8167,395,502 - 7,415,846 (+)NCBIGRCr8
mRatBN7.2167,389,222 - 7,409,564 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl167,366,542 - 7,409,556 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl167,366,542 - 7,409,641 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx167,401,738 - 7,422,128 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0168,546,594 - 8,566,985 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0167,399,986 - 7,420,330 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0168,302,950 - 8,323,294 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl168,302,950 - 8,323,293 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0168,219,983 - 8,240,326 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4167,642,116 - 7,662,460 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera167,789,196 - 7,809,198 (-)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ncoa4Ratinvasive ductal carcinoma  ISONCOA4 (Homo sapiens)2293536protein:decreased expression:breastRGD 
Ncoa4Ratovarian carcinoma  ISONCOA4 (Homo sapiens)2293537mRNA:increased expression:ovaryRGD 
Ncoa4Ratpolycystic ovary syndrome  ISONCOA4 (Homo sapiens)2293533protein:increased expression:endometriumRGD 
Ncoa4Ratprostate cancer  ISONCOA4 (Homo sapiens)2293535mRNA:decreased expression:prostate glandRGD 
Ncoa4Ratprostate cancer severityISONCOA4 (Homo sapiens)2293534protein:increased expression:prostate glandRGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ncoa4RatCockayne syndrome B  ISONCOA4 (Homo sapiens)8554872ClinVar Annotator: match by term: Cockayne Syndrome and Type IIClinVarPMID:25741868 and PMID:38177409
Ncoa4Ratmegacolon  ISONCOA4 (Homo sapiens)8554872ClinVar Annotator: match by term: MegacolonClinVarPMID:21681106
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ncoa4RatThyroid Neoplasms  ISONCOA4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23811263

1 to 20 of 151 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ncoa4Rat1,2-dichloroethane increases expressionISONcoa4 (Mus musculus)6480464ethylene dichloride results in increased expression of NCOA4 mRNACTDPMID:28960355
Ncoa4Rat1,2-dimethylhydrazine multiple interactionsISONcoa4 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of NCOA4 mRNACTDPMID:22206623
Ncoa4Rat1,2-dimethylhydrazine affects expressionISONcoa4 (Mus musculus)64804641 and 2-Dimethylhydrazine affects the expression of NCOA4 mRNACTDPMID:22206623
Ncoa4Rat17alpha-ethynylestradiol affects expressionISONcoa4 (Mus musculus)6480464Ethinyl Estradiol affects the expression of NCOA4 mRNACTDPMID:17555576
Ncoa4Rat17alpha-ethynylestradiol multiple interactionsISONcoa4 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NCOA4 mRNACTDPMID:17942748
Ncoa4Rat17alpha-ethynylestradiol increases expressionISONcoa4 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of NCOA4 mRNACTDPMID:17942748
Ncoa4Rat17beta-estradiol increases expressionISONCOA4 (Homo sapiens)6480464Estradiol results in increased expression of NCOA4 mRNACTDPMID:23019147
Ncoa4Rat17beta-estradiol decreases expressionISONcoa4 (Mus musculus)6480464Estradiol results in decreased expression of NCOA4 mRNACTDPMID:39298647
Ncoa4Rat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of NCOA4 mRNACTDPMID:32145629
Ncoa4Rat17beta-hydroxy-5alpha-androstan-3-one multiple interactionsISONCOA4 (Homo sapiens)6480464NCOA4 promotes the reaction [Dihydrotestosterone results in increased activity of AR protein] and NCOA4 protein promotes the reaction [Dihydrotestosterone results in increased activity of AR protein]CTDPMID:11751618 and PMID:19815066
Ncoa4Rat2,3',4,4',5-Pentachlorobiphenyl increases expressionISONcoa4 (Mus musculus)64804642 more ...CTDPMID:31388691
Ncoa4Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISONcoa4 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NCOA4 mRNACTDPMID:17942748
Ncoa4Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of NCOA4 mRNACTDPMID:34747641
Ncoa4Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISONcoa4 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of NCOA4 mRNACTDPMID:19770486
Ncoa4Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISONcoa4 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of NCOA4 mRNACTDPMID:17942748
Ncoa4Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of NCOA4 mRNACTDPMID:21346803
Ncoa4Rat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of NCOA4 mRNACTDPMID:21346803
Ncoa4Rat25-hydroxycholesterol increases expressionISONCOA4 (Homo sapiens)648046425-hydroxycholesterol results in increased expression of NCOA4 proteinCTDPMID:39197811
Ncoa4Rat3-methyladenine multiple interactionsISONcoa4 (Mus musculus)64804643-methyladenine inhibits the reaction [Busulfan results in increased expression of NCOA4 protein]CTDPMID:38220133
Ncoa4Rat3-methyladenine multiple interactionsEXP 64804643-methyladenine inhibits the reaction [erastin results in decreased expression of NCOA4 protein]CTDPMID:32937103

1 to 20 of 151 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ncoa4Ratintracellular iron ion homeostasis involved_inIEAInterPro:IPR0399471600115GO_REF:0000002InterProGO_REF:0000002
Ncoa4Ratintracellular iron ion homeostasis acts_upstream_of_or_withinISONcoa4 (Mus musculus)1624291 PMID:25327288RGDPMID:25327288
Ncoa4Ratintracellular iron ion homeostasis acts_upstream_of_or_withinIEAUniProtKB:Q5U4H9 and ensembl:ENSMUSP000001260711600115GO_REF:0000107EnsemblGO_REF:0000107
Ncoa4Ratpositive regulation of DNA-templated transcription involved_inIEAGO:00037131600115GO_REF:0000108GOCGO_REF:0000108
Ncoa4Ratprotein targeting to lysosome acts_upstream_of_or_withinISONCOA4 (Homo sapiens)1624291 PMID:25327288RGDPMID:25327288
Ncoa4Ratresponse to hormone involved_inIBAPANTHER:PTN001048343 and Ncoa4 (Rattus norvegicus)1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ncoa4Ratresponse to hormone  IEP 2293538 RGD 

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ncoa4Ratautolysosome located_inISONCOA4 (Homo sapiens)1624291 PMID:25327288RGDPMID:25327288

Molecular Function

  

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ncoa4Ratiron homeostasis pathway   ISONCOA4 (Homo sapiens)11554199 RGD 
Ncoa4Ratiron homeostasis pathway   ISONCOA4 (Homo sapiens)11556274 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ncoa4Ratthyroid cancer pathway  IEA 6907045 KEGGrno:05216

1 to 15 of 15 rows
#
Reference Title
Reference Citation
1. Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease. Bogdan AR, etal., Trends Biochem Sci. 2016 Mar;41(3):274-86. doi: 10.1016/j.tibs.2015.11.012. Epub 2015 Dec 23.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer. Hu YC, etal., J Biol Chem. 2004 Aug 6;279(32):33438-46. Epub 2004 May 27.
4. Loss of androgen receptor associated protein 70 (ARA70) expression in a subset of HER2-positive breast cancers. Kollara A, etal., Breast Cancer Res Treat. 2001 Jun;67(3):245-53.
5. Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Lane DJ, etal., Biochim Biophys Acta. 2015 May;1853(5):1130-44. doi: 10.1016/j.bbamcr.2015.01.021. Epub 2015 Feb 4.
6. Heterogeneous expression and functions of androgen receptor co-factors in primary prostate cancer. Li P, etal., Am J Pathol. 2002 Oct;161(4):1467-74.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. Evaluation of steroid receptors, coregulators, and molecules associated with uterine receptivity in secretory endometria from untreated women with polycystic ovary syndrome. Quezada S, etal., Fertil Steril. 2006 Apr;85(4):1017-26. Epub 2006 Mar 9.
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Activation of androgen receptor-associated protein 70 (ARA70) mRNA expression in ovarian cancer. Shaw PA, etal., Gynecol Oncol. 2001 Feb;80(2):132-8.
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15. Direct regulation of androgen receptor-associated protein 70 by thyroid hormone and its receptors. Tai PJ, etal., Endocrinology. 2007 Jul;148(7):3485-95. Epub 2007 Apr 5.
1 to 15 of 15 rows
PMID:8889548   PMID:18614015   PMID:25327288   PMID:38465865  



Ncoa4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8167,395,502 - 7,415,846 (+)NCBIGRCr8
mRatBN7.2167,389,222 - 7,409,564 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl167,366,542 - 7,409,556 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl167,366,542 - 7,409,641 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx167,401,738 - 7,422,128 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0168,546,594 - 8,566,985 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0167,399,986 - 7,420,330 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0168,302,950 - 8,323,294 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl168,302,950 - 8,323,293 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0168,219,983 - 8,240,326 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4167,642,116 - 7,662,460 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera167,789,196 - 7,809,198 (-)NCBICelera
Cytogenetic Map16p16NCBI
NCOA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381046,005,088 - 46,030,623 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1046,005,088 - 46,030,623 (-)EnsemblGRCh38hg38GRCh38
GRCh371051,565,199 - 51,590,734 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361051,242,373 - 51,260,738 (+)NCBINCBI36Build 36hg18NCBI36
Build 341051,242,372 - 51,260,738NCBI
Celera1042,865,707 - 42,891,332 (+)NCBICelera
Cytogenetic Map10q11.22NCBI
HuRef1045,675,105 - 45,698,057 (+)NCBIHuRef
CHM1_11051,847,046 - 51,872,689 (+)NCBICHM1_1
T2T-CHM13v2.01046,885,972 - 46,911,498 (-)NCBIT2T-CHM13v2.0
Ncoa4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391431,881,884 - 31,901,210 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1431,881,822 - 31,901,812 (+)EnsemblGRCm39 Ensembl
GRCm381432,159,879 - 32,179,855 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1432,159,865 - 32,179,855 (+)EnsemblGRCm38mm10GRCm38
MGSCv371432,973,078 - 32,992,549 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361430,988,901 - 31,008,372 (+)NCBIMGSCv36mm8
Celera1428,418,721 - 28,438,204 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1419.4NCBI
Ncoa4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955556392,398 - 412,166 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955556392,412 - 413,643 (+)NCBIChiLan1.0ChiLan1.0
NCOA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2858,884,053 - 58,909,606 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11058,889,371 - 58,914,924 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01043,159,014 - 43,184,558 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11046,420,952 - 46,446,479 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1046,420,952 - 46,443,223 (-)Ensemblpanpan1.1panPan2
NCOA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1281,801,655 - 1,867,705 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl281,802,678 - 1,825,020 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha282,036,132 - 2,102,171 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0281,979,010 - 2,045,152 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl281,979,034 - 2,044,626 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1281,776,104 - 1,842,163 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0281,812,773 - 1,879,059 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0281,945,148 - 2,011,231 (-)NCBIUU_Cfam_GSD_1.0
Ncoa4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721379,174,126 - 79,199,709 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936728376,852 - 402,539 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936728376,915 - 402,539 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NCOA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1490,505,110 - 90,531,118 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11490,505,614 - 90,531,302 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21498,548,146 - 98,573,846 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NCOA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1941,813,018 - 41,836,974 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl941,826,320 - 41,837,505 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660481,522,166 - 1,546,119 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ncoa4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462492818,148 - 30,594 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249286,298 - 32,051 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Ncoa4
132 total Variants

Predicted Target Of
Summary Value
Count of predictions:310
Count of miRNA genes:113
Interacting mature miRNAs:141
Transcripts:ENSRNOT00000026803, ENSRNOT00000066062
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 30 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1619639137Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat

1 to 10 of 30 rows
D12Got38  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2167,396,808 - 7,396,980 (+)MAPPERmRatBN7.2
Rnor_6.0168,310,539 - 8,310,710NCBIRnor6.0
Rnor_5.0168,227,571 - 8,227,742UniSTSRnor5.0
RGSC_v3.4167,649,704 - 7,649,876RGDRGSC3.4
RGSC_v3.4167,649,705 - 7,649,876UniSTSRGSC3.4
RGSC_v3.1167,649,702 - 7,649,874RGD
Celera167,801,780 - 7,801,951UniSTS
Cytogenetic Map16p16UniSTS
RH132366  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8167,411,540 - 7,411,754 (+)Marker Load Pipeline
mRatBN7.2167,405,258 - 7,405,472 (+)MAPPERmRatBN7.2
Rnor_6.0168,318,989 - 8,319,202NCBIRnor6.0
Rnor_5.0168,236,021 - 8,236,234UniSTSRnor5.0
RGSC_v3.4167,658,155 - 7,658,368UniSTSRGSC3.4
Celera167,793,288 - 7,793,501UniSTS
RH 3.4 Map1665.3UniSTS
Cytogenetic Map16p16UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 25 of 25 rows
RefSeq Transcripts NM_001034007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001034008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006252660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC129637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI031008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI112421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC160817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB758330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB806310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV119475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV795771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 25 of 25 rows

Ensembl Acc Id: ENSRNOT00000026803   ⟹   ENSRNOP00000026803
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl167,366,542 - 7,409,556 (+)Ensembl
Rnor_6.0 Ensembl168,309,239 - 8,323,293 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000066062   ⟹   ENSRNOP00000061299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl167,366,542 - 7,409,556 (+)Ensembl
Rnor_6.0 Ensembl168,302,950 - 8,323,293 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095475   ⟹   ENSRNOP00000085149
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl167,398,798 - 7,409,641 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117357   ⟹   ENSRNOP00000085575
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl167,395,642 - 7,409,556 (+)Ensembl
RefSeq Acc Id: NM_001034007   ⟹   NP_001029179
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8167,401,791 - 7,415,846 (+)NCBI
mRatBN7.2167,395,509 - 7,409,564 (+)NCBI
Rnor_6.0168,309,239 - 8,323,294 (+)NCBI
Rnor_5.0168,219,983 - 8,240,326 (+)NCBI
RGSC_v3.4167,642,116 - 7,662,460 (+)RGD
Celera167,789,196 - 7,803,251 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001034008   ⟹   NP_001029180
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8167,395,502 - 7,415,846 (+)NCBI
mRatBN7.2167,389,222 - 7,409,564 (+)NCBI
Rnor_6.0168,302,950 - 8,323,294 (+)NCBI
Rnor_5.0168,219,983 - 8,240,326 (+)NCBI
RGSC_v3.4167,642,116 - 7,662,460 (+)RGD
Celera167,789,196 - 7,809,198 (-)RGD
Sequence:
RefSeq Acc Id: XM_006252660   ⟹   XP_006252722
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8167,401,806 - 7,415,841 (+)NCBI
mRatBN7.2167,395,590 - 7,409,564 (+)NCBI
Rnor_6.0168,309,306 - 8,323,289 (+)NCBI
Rnor_5.0168,219,983 - 8,240,326 (+)NCBI
Sequence:
1 to 12 of 12 rows
Protein RefSeqs NP_001029179 (Get FASTA)   NCBI Sequence Viewer  
  NP_001029180 (Get FASTA)   NCBI Sequence Viewer  
  XP_006252722 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI60817 (Get FASTA)   NCBI Sequence Viewer  
  EDL88925 (Get FASTA)   NCBI Sequence Viewer  
  EDL88926 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026803
  ENSRNOP00000026803.4
  ENSRNOP00000061299
  ENSRNOP00000061299.1
  ENSRNOP00000085149.1
  ENSRNOP00000085575.1
1 to 12 of 12 rows
RefSeq Acc Id: NP_001029180   ⟸   NM_001034008
- UniProtKB: B1H215 (UniProtKB/TrEMBL),   A6KFW8 (UniProtKB/TrEMBL),   A0A8I6A3B1 (UniProtKB/TrEMBL),   F7FLG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001029179   ⟸   NM_001034007
- UniProtKB: B1H215 (UniProtKB/TrEMBL),   A6KFW8 (UniProtKB/TrEMBL),   A0A8I6A3B1 (UniProtKB/TrEMBL),   F7FLG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252722   ⟸   XM_006252660
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A1Q3 (UniProtKB/TrEMBL),   A0A8I6A3B1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026803   ⟸   ENSRNOT00000026803
Ensembl Acc Id: ENSRNOP00000061299   ⟸   ENSRNOT00000066062
Name Modeler Protein Id AA Range Protein Structure
AF-B1H215-F1-model_v2 AlphaFold B1H215 1-622 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699938
Promoter ID:EPDNEW_R10461
Type:initiation region
Name:Ncoa4_1
Description:nuclear receptor coactivator 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10462  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0168,303,011 - 8,303,071EPDNEW
RGD ID:13699939
Promoter ID:EPDNEW_R10462
Type:single initiation site
Name:Ncoa4_2
Description:nuclear receptor coactivator 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10461  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0168,309,251 - 8,309,311EPDNEW


1 to 27 of 27 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-12118 BioCyc
Ensembl Genes ENSRNOG00000019768 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000063221 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026803 ENTREZGENE
  ENSRNOT00000026803.6 UniProtKB/TrEMBL
  ENSRNOT00000066062 ENTREZGENE
  ENSRNOT00000066062.4 UniProtKB/TrEMBL
  ENSRNOT00000095475.1 UniProtKB/TrEMBL
  ENSRNOT00000117357.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7454028 IMAGE-MGC_LOAD
InterPro ARA70 UniProtKB/TrEMBL
  NCoA-4 UniProtKB/TrEMBL
KEGG Report rno:619385 UniProtKB/TrEMBL
MGC_CLONE MGC:187270 IMAGE-MGC_LOAD
NCBI Gene 619385 ENTREZGENE
PANTHER NUCLEAR RECEPTOR COACTIVATOR 4 UniProtKB/TrEMBL
  PTHR17085 UniProtKB/TrEMBL
Pfam ARA70 UniProtKB/TrEMBL
PhenoGen Ncoa4 PhenoGen
RatGTEx ENSRNOG00000019768 RatGTEx
  ENSRNOG00000063221 RatGTEx
UniProt A0A8I6A1Q3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A3B1 ENTREZGENE, UniProtKB/TrEMBL
  A6KFW8 ENTREZGENE
  B1H215 ENTREZGENE, UniProtKB/TrEMBL
  F7FLG1 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A6KFW8 UniProtKB/TrEMBL
1 to 27 of 27 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Ncoa4  nuclear receptor coactivator 4   Ncoa4_predicted  nuclear receptor coactivator 4 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 Ncoa4_predicted  nuclear receptor coactivator 4 (predicted)  Ncoa4  nuclear receptor coactivator 4  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 Ncoa4  nuclear receptor coactivator 4      Symbol and Name status set to provisional 70820 PROVISIONAL