NCOA4 (nuclear receptor coactivator 4) - Rat Genome Database

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Gene: NCOA4 (nuclear receptor coactivator 4) Pan paniscus
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Symbol: NCOA4
Name: nuclear receptor coactivator 4
RGD ID: 11765393
Description: ENCODES a protein that exhibits transcription coactivator activity (inferred); INVOLVED IN intracellular iron ion homeostasis (ortholog); response to hormone (ortholog); PARTICIPATES IN iron homeostasis pathway; ASSOCIATED WITH Cockayne syndrome B (ortholog); invasive ductal carcinoma (ortholog); megacolon (ortholog); FOUND IN autolysosome (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2858,884,053 - 58,909,606 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11058,889,371 - 58,914,924 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01043,159,014 - 43,184,558 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11046,420,952 - 46,446,479 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1046,420,952 - 46,443,223 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NCOA4Bonoboinvasive ductal carcinoma  ISORGD:13484009068941protein:decreased expression:breastRGDPMID:11561770|REF_RGD_ID:2293536
NCOA4Bonoboovarian carcinoma  ISORGD:13484009068941mRNA:increased expression:ovaryRGDPMID:11161850|REF_RGD_ID:2293537
NCOA4Bonobopolycystic ovary syndrome  ISORGD:13484009068941protein:increased expression:endometriumRGDPMID:16580389|REF_RGD_ID:2293533
NCOA4Bonoboprostate cancer severityISORGD:13484009068941protein:increased expression:prostate glandRGDPMID:15166229|REF_RGD_ID:2293534
NCOA4Bonoboprostate cancer  ISORGD:13484009068941mRNA:decreased expression:prostate glandRGDPMID:12368219|REF_RGD_ID:2293535
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NCOA4BonoboCockayne syndrome B  ISORGD:13484008554872ClinVar Annotator: match by term: Cockayne Syndrome, Type IIClinVarPMID:25741868|PMID:38177409
NCOA4Bonobomegacolon  ISORGD:13484008554872ClinVar Annotator: match by term: MegacolonClinVarPMID:21681106
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NCOA4BonoboThyroid Neoplasms  ISORGD:13484009068941CTD Direct Evidence: marker/mechanismCTDPMID:23811263


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NCOA4Bonobointracellular iron ion homeostasis involved_inIEAInterPro:IPR039947150520179 InterProGO_REF:0000002
NCOA4Bonobointracellular iron ion homeostasis acts_upstream_of_or_withinISORGD:16159369068941 PMID:25327288MGIPMID:25327288
NCOA4Bonobopositive regulation of DNA-templated transcription involved_inIEAGO:0003713150520179 GOCGO_REF:0000108
NCOA4Bonoboprotein targeting to lysosome acts_upstream_of_or_withinIEAUniProtKB:Q13772|ensembl:ENSP00000462943150520179 EnsemblGO_REF:0000107
NCOA4Bonoboresponse to hormone  ISORGD:15630149068941 RGDPMID:17412801|REF_RGD_ID:2293538
NCOA4Bonoboresponse to hormone involved_inIEAPANTHER:PTN000424886150520179 TreeGrafterGO_REF:0000118

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NCOA4Bonoboautolysosome located_inIEAUniProtKB:Q13772|ensembl:ENSP00000462943150520179 EnsemblGO_REF:0000107

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NCOA4Bonoboprotein binding enablesISOUniProtKB:Q9UJV3-29068941 PMID:32296183IntActPMID:32296183
NCOA4Bonoboprotein binding enablesISOUniProtKB:P21333-2|UniProtKB:Q8WXH2|UniProtKB:Q99700-5|UniProtKB:Q9UBB49068941 PMID:32814053IntActPMID:32814053
NCOA4Bonoboprotein binding enablesISOUniProtKB:P027929068941 PMID:28514442, PMID:33961781IntActPMID:28514442|PMID:33961781
NCOA4Bonobotranscription coactivator activity enablesIEAInterPro:IPR039947150520179 InterProGO_REF:0000002

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NCOA4Bonoboiron homeostasis pathway   ISORGD:13484009068941 RGDPMID:25661197|PMID:26725301|REF_RGD_ID:11554199|REF_RGD_ID:11556274
PMID:30032202  



NCOA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2858,884,053 - 58,909,606 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11058,889,371 - 58,914,924 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01043,159,014 - 43,184,558 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11046,420,952 - 46,446,479 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1046,420,952 - 46,443,223 (-)Ensemblpanpan1.1panPan2
NCOA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381046,005,088 - 46,030,623 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1046,005,088 - 46,030,623 (-)EnsemblGRCh38hg38GRCh38
GRCh371051,565,199 - 51,590,734 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361051,242,373 - 51,260,738 (+)NCBINCBI36Build 36hg18NCBI36
Build 341051,242,372 - 51,260,738NCBI
Celera1042,865,707 - 42,891,332 (+)NCBICelera
Cytogenetic Map10q11.22NCBI
HuRef1045,675,105 - 45,698,057 (+)NCBIHuRef
CHM1_11051,847,046 - 51,872,689 (+)NCBICHM1_1
T2T-CHM13v2.01046,885,972 - 46,911,498 (-)NCBIT2T-CHM13v2.0
Ncoa4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391431,881,884 - 31,901,210 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1431,881,822 - 31,901,812 (+)EnsemblGRCm39 Ensembl
GRCm381432,159,879 - 32,179,855 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1432,159,865 - 32,179,855 (+)EnsemblGRCm38mm10GRCm38
MGSCv371432,973,078 - 32,992,549 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361430,988,901 - 31,008,372 (+)NCBIMGSCv36mm8
Celera1428,418,721 - 28,438,204 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1419.4NCBI
Ncoa4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8167,395,502 - 7,415,846 (+)NCBIGRCr8
mRatBN7.2167,389,222 - 7,409,564 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl167,366,542 - 7,409,556 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl167,366,542 - 7,409,641 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx167,401,738 - 7,422,128 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0168,546,594 - 8,566,985 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0167,399,986 - 7,420,330 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0168,302,950 - 8,323,294 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl168,302,950 - 8,323,293 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0168,219,983 - 8,240,326 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4167,642,116 - 7,662,460 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera167,789,196 - 7,809,198 (-)NCBICelera
Cytogenetic Map16p16NCBI
Ncoa4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955556392,398 - 412,166 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955556392,412 - 413,643 (+)NCBIChiLan1.0ChiLan1.0
NCOA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1281,801,655 - 1,867,705 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl281,802,678 - 1,825,020 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha282,036,132 - 2,102,171 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0281,979,010 - 2,045,152 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl281,979,034 - 2,044,626 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1281,776,104 - 1,842,163 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0281,812,773 - 1,879,059 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0281,945,148 - 2,011,231 (-)NCBIUU_Cfam_GSD_1.0
Ncoa4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721379,174,126 - 79,199,709 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936728376,852 - 402,539 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936728376,915 - 402,539 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NCOA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1490,505,110 - 90,531,118 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11490,505,614 - 90,531,302 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21498,548,146 - 98,573,846 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NCOA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1941,813,018 - 41,836,974 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl941,826,320 - 41,837,505 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660481,522,166 - 1,546,119 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ncoa4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462492818,148 - 30,594 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249286,298 - 32,051 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.






Ensembl Acc Id: ENSPPAT00000032777   ⟹   ENSPPAP00000010130
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1046,420,952 - 46,435,308 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000032785   ⟹   ENSPPAP00000010138
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1046,422,452 - 46,430,990 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000032788   ⟹   ENSPPAP00000010141
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1046,424,985 - 46,443,223 (-)Ensembl
RefSeq Acc Id: XM_003811807   ⟹   XP_003811855
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2858,884,053 - 58,909,606 (-)NCBI
NHGRI_mPanPan11058,889,371 - 58,914,924 (-)NCBI
Mhudiblu_PPA_v01043,159,014 - 43,184,558 (-)NCBI
PanPan1.11046,420,952 - 46,446,479 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063607672   ⟹   XP_063463742
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2858,885,584 - 58,909,568 (-)NCBI
Protein RefSeqs XP_003811855 (Get FASTA)   NCBI Sequence Viewer  
  XP_063463742 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000010130.1
  ENSPPAP00000010138.1
  ENSPPAP00000010141.1
RefSeq Acc Id: XP_003811855   ⟸   XM_003811807
- Peptide Label: isoform X1
- UniProtKB: A0A2R9A4C1 (UniProtKB/TrEMBL),   A0A2R8ZYS5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000010130   ⟸   ENSPPAT00000032777
Ensembl Acc Id: ENSPPAP00000010141   ⟸   ENSPPAT00000032788
Ensembl Acc Id: ENSPPAP00000010138   ⟸   ENSPPAT00000032785
RefSeq Acc Id: XP_063463742   ⟸   XM_063607672
- Peptide Label: isoform X2
- UniProtKB: A0A2R8ZYS5 (UniProtKB/TrEMBL)


1 to 14 of 14 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSPPAG00000028269 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000032777.1 UniProtKB/TrEMBL
  ENSPPAT00000032785.1 UniProtKB/TrEMBL
  ENSPPAT00000032788.1 UniProtKB/TrEMBL
InterPro ARA70 UniProtKB/TrEMBL
  NCoA-4 UniProtKB/TrEMBL
KEGG Report pps:100995250 UniProtKB/TrEMBL
NCBI Gene NCOA4 ENTREZGENE
PANTHER NUCLEAR RECEPTOR COACTIVATOR 4 UniProtKB/TrEMBL
  PTHR17085 UniProtKB/TrEMBL
Pfam ARA70 UniProtKB/TrEMBL
UniProt A0A2R8ZYS5 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R8ZZX0_PANPA UniProtKB/TrEMBL
  A0A2R9A4C1 ENTREZGENE, UniProtKB/TrEMBL
1 to 14 of 14 rows