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Gene: Nphp4 (nephrocystin 4) Rattus norvegicus

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Symbol:

Nphp4

Name:

nephrocystin 4

RGD ID:

1560172

Description:

Predicted to be involved in negative regulation of canonical Wnt signaling pathway; positive regulation of bicellular tight junction assembly; and protein localization to ciliary transition zone. Predicted to act upstream of or within several processes, including flagellated sperm motility; photoreceptor cell maintenance; and photoreceptor cell outer segment organization. Located in ciliary basal body. Human ortholog(s) of this gene implicated in Joubert syndrome 4; Senior-Loken syndrome; congenital heart disease; nephronophthisis; and nephronophthisis 4. Orthologous to human NPHP4 (nephrocystin 4); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC313749; MGC125230; nephrocystin-4; nephronophthisis 4; nephronophthisis 4 (juvenile) homolog; nephronophthisis 4 (juvenile) homolog (human); similar to mKIAA0673 protein

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NPHP4 (nephrocystin 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Nphp4 (nephronophthisis 4 (juvenile) homolog (human))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Nphp4 (nephrocystin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NPHP4 (nephrocystin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NPHP4 (nephrocystin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Nphp4 (nephrocystin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NPHP4 (nephrocystin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NPHP4 (nephrocystin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Nphp4 (nephrocystin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	NPHP4 (nephrocystin 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Nphp4 (nephronophthisis 4 (juvenile) homolog (human))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	nphp4 (nephronophthisis 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	nphp-4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	nphp4.2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	168,270,522 - 168,356,393 (+)	NCBI		GRCr8
mRatBN7.2	5	162,986,157 - 163,073,708 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	162,988,370 - 163,073,706 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	165,691,473 - 165,776,590 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	167,513,074 - 167,598,197 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	167,475,281 - 167,560,405 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	169,647,581 - 169,744,662 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	169,659,188 - 169,744,660 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	173,201,362 - 173,298,422 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	169,711,038 - 169,797,486 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	5	161,218,067 - 161,302,859 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Nphp4	Rat	congenital heart disease		ISO	RGD:1351118	11537354	DNA:missense mutations: :multiple	RGD
Nphp4	Rat	Joubert syndrome 4		ISO	RGD:1351118	11068164	DNA:mutations:exon, intron:multiple	RGD
Nphp4	Rat	nephronophthisis		ISO	RGD:1351118	11065524	DNA:deletion, missense mutations, splice-site mutation:cds, intron:multiple	RGD
Nphp4	Rat	nephronophthisis 4		ISO	RGD:1351118	11537355	DNA:missense mutations, nonsense mutations, splice-site mutations:exon, intron:multiple	RGD
Nphp4	Rat	nephronophthisis 4		ISO	RGD:1351118	11537341	DNA:nonsense mutations, duplications:exon:multiple	RGD
Nphp4	Rat	nephronophthisis 4		ISO	RGD:1351118	11537342	DNA:nonsense mutation: :3272del (human)	RGD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Nphp4	Rat	atypical hemolytic-uremic syndrome		ISO	RGD:1351118	8554872	ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome	ClinVar	PMID:25741868\|PMID:28492532
Nphp4	Rat	Bardet-Biedl syndrome		ISO	RGD:1351118	8554872	ClinVar Annotator: match by term: Bardet-Biedl syndrome	ClinVar	PMID:15776426\|PMID:25741868\|PMID:28492532\|PMID:37431782
Nphp4	Rat	CAKUT		ISO	RGD:1351118	8554872	ClinVar Annotator: match by term: Congenital anomalies of kidney and urinary tract	ClinVar	PMID:28492532\|PMID:30143558
Nphp4	Rat	cholestasis		ISO	RGD:1351118	8554872	ClinVar Annotator: match by term: Cholestasis	ClinVar	PMID:15776426\|PMID:22550138\|PMID:25741868\|PMID:28492532\|PMID:28700940
Nphp4	Rat	chromosome 1p36 deletion syndrome		ISO	RGD:1351118	8554872	ClinVar Annotator: match by term: Chromosome 1p36 deletion syndrome	ClinVar
Nphp4	Rat	focal segmental glomerulosclerosis		ISO	RGD:1351118	8554872	ClinVar Annotator: match by term: Focal segmental glomerulosclerosis	ClinVar	PMID:25741868\|PMID:28492532
Nphp4	Rat	fundus dystrophy		ISO	RGD:1351118	8554872	ClinVar Annotator: match by term: Retinal dystrophy	ClinVar	PMID:12205563\|PMID:15776426\|PMID:16199547\|PMID:21068128\|PMID:21546380\|PMID:23559409\|PMID:25741868\|PMID:27004616\|PMID:27124789\|PMID:28492532\|PMID:30120289\|PMID:30586318\|PMID:31589614\|PMID:31964843\|PMID:34216551\|PMID:34426522
Nphp4	Rat	genetic disease		ISO	RGD:1351118	8554872	ClinVar Annotator: match by term: Hereditary disease \| ClinVar Annotator: match by term: Inborn genetic more ...	ClinVar	PMID:25741868\|PMID:28492532\|PMID:36090483
Nphp4	Rat	infertility		ISO	RGD:1351118	8554872	ClinVar Annotator: match by term: Infertility	ClinVar	PMID:11920287\|PMID:12205563\|PMID:12244321\|PMID:23559409\|PMID:23574405\|PMID:25558065\|PMID:25741868\|PMID:28492532
Nphp4	Rat	kidney disease		ISO	RGD:1351118	8554872	ClinVar Annotator: match by term: renal disease	ClinVar	PMID:12205563\|PMID:15776426\|PMID:16199547\|PMID:21546380\|PMID:22550138\|PMID:22773737\|PMID:23217326\|PMID:23559409\|PMID:25741868\|PMID:28492532\|PMID:28700940\|PMID:29127258
Nphp4	Rat	Leber congenital amaurosis		ISO	RGD:1351118	8554872	ClinVar Annotator: match by term: Leber congenital amaurosis	ClinVar	PMID:25445212\|PMID:25741868\|PMID:26920127\|PMID:28492532\|PMID:36090483
Nphp4	Rat	Lynch syndrome 1		ISO	RGD:1351118	8554872	ClinVar Annotator: match by term: Colorectal cancer, hereditary, nonpolyposis, type 1	ClinVar	PMID:25741868\|PMID:28492532
Nphp4	Rat	nephronophthisis		ISO	RGD:1351118	8554872	ClinVar Annotator: match by term: Nephronophthisis \| ClinVar Annotator: match by term: Nephronophthisis 8	ClinVar	PMID:11920287\|PMID:12205563\|PMID:12244321\|PMID:1248184\|PMID:15776426\|PMID:16199547\|PMID:16339905\|PMID:17558407\|PMID:17576681\|PMID:17855640\|PMID:17954299\|PMID:18076122\|PMID:21068128\|PMID:21546380\|PMID:21866095\|PMID:22550138\|PMID:22773737\|PMID:23167750\|PMID:23188109\|PMID:23217326\|PMID:23559409\|PMID:24033266\|PMID:25445212\|PMID:25472526\|PMID:25558065\|PMID:25741868\|PMID:26346198\|PMID:26489029\|PMID:26920127\|PMID:27004616\|PMID:27491411\|PMID:28492532\|PMID:28700940\|PMID:29127258\|PMID:30143558\|PMID:31810733\|PMID:32865313\|PMID:34295353\|PMID:6837691\|PMID:9536098
Nphp4	Rat	nephronophthisis		ISO	RGD:1351118	8554872	ClinVar Annotator: match by term: Nephronophthisis \| ClinVar Annotator: match by term: Nephronophthisis 8	ClinVar	PMID:11920287\|PMID:12205563\|PMID:12244321\|PMID:1248184\|PMID:15776426\|PMID:16199547\|PMID:16339905\|PMID:17558407\|PMID:17576681\|PMID:17855640\|PMID:17954299\|PMID:18076122\|PMID:21068128\|PMID:21546380\|PMID:21866095\|PMID:22550138\|PMID:22773737\|PMID:23167750\|PMID:23188109\|PMID:23217326\|PMID:23559409\|PMID:24033266\|PMID:24154662\|PMID:25445212\|PMID:25472526\|PMID:25558065\|PMID:25741868\|PMID:25741916\|PMID:26346198\|PMID:26489029\|PMID:26920127\|PMID:27004616\|PMID:27491411\|PMID:28492532\|PMID:28700940\|PMID:29127258\|PMID:30143558\|PMID:31810733\|PMID:32865313\|PMID:34295353\|PMID:34850017\|PMID:36090483\|PMID:6837691\|PMID:9536098
Nphp4	Rat	nephronophthisis		ISO	RGD:1351118	8554872	ClinVar Annotator: match by term: Nephronophthisis \| ClinVar Annotator: match by term: Nephronophthisis 8	ClinVar	PMID:11920287\|PMID:12205563\|PMID:12244321\|PMID:1248184\|PMID:15776426\|PMID:16199547\|PMID:16339905\|PMID:17558407\|PMID:17576681\|PMID:17855640\|PMID:17954299\|PMID:18076122\|PMID:21068128\|PMID:21546380\|PMID:21866095\|PMID:22550138\|PMID:22773737\|PMID:23167750\|PMID:23188109\|PMID:23217326\|PMID:23559409\|PMID:24033266\|PMID:25445212\|PMID:25472526\|PMID:25558065\|PMID:25741868\|PMID:26346198\|PMID:26920127\|PMID:27004616\|PMID:27491411\|PMID:28492532\|PMID:29127258\|PMID:30143558\|PMID:6837691\|PMID:9536098
Nphp4	Rat	nephronophthisis		ISO	RGD:1351118	8554872	ClinVar Annotator: match by term: Nephronophthisis \| ClinVar Annotator: match by term: Nephronophthisis 8	ClinVar	PMID:11920287\|PMID:12205563\|PMID:12244321\|PMID:1248184\|PMID:15776426\|PMID:16199547\|PMID:16339905\|PMID:17558407\|PMID:17576681\|PMID:17855640\|PMID:17954299\|PMID:18076122\|PMID:21068128\|PMID:21546380\|PMID:21866095\|PMID:22550138\|PMID:22773737\|PMID:23167750\|PMID:23188109\|PMID:23217326\|PMID:23559409\|PMID:23574405\|PMID:24033266\|PMID:24154662\|PMID:25445212\|PMID:25472526\|PMID:25558065\|PMID:25640679\|PMID:25741868\|PMID:26346198\|PMID:26489029\|PMID:26920127\|PMID:27004616\|PMID:27124789\|PMID:27491411\|PMID:28492532\|PMID:28700940\|PMID:29127258\|PMID:30120289\|PMID:30143558\|PMID:30586318\|PMID:31589614\|PMID:31810733\|PMID:31964843\|PMID:32865313\|PMID:33946315\|PMID:34216551\|PMID:34295353\|PMID:34426522\|PMID:34850017\|PMID:36090483\|PMID:36474027\|PMID:36938085\|PMID:36990420\|PMID:37431782\|PMID:6837691\|PMID:9536098
Nphp4	Rat	nephronophthisis		ISO	RGD:1351118	8554872	ClinVar Annotator: match by term: Nephronophthisis \| ClinVar Annotator: match by term: Nephronophthisis 8	ClinVar	PMID:11920287\|PMID:12205563\|PMID:12244321\|PMID:1248184\|PMID:15776426\|PMID:16199547\|PMID:16339905\|PMID:17558407\|PMID:17576681\|PMID:17855640\|PMID:17954299\|PMID:18076122\|PMID:21068128\|PMID:21546380\|PMID:21866095\|PMID:22550138\|PMID:22773737\|PMID:23167750\|PMID:23188109\|PMID:23217326\|PMID:23559409\|PMID:24033266\|PMID:24154662\|PMID:25445212\|PMID:25472526\|PMID:25558065\|PMID:25741868\|PMID:26346198\|PMID:26489029\|PMID:26920127\|PMID:27004616\|PMID:27491411\|PMID:28492532\|PMID:28700940\|PMID:29127258\|PMID:30143558\|PMID:31810733\|PMID:32865313\|PMID:34295353\|PMID:34850017\|PMID:36090483\|PMID:6837691\|PMID:9536098
Nphp4	Rat	nephronophthisis		ISO	RGD:1351118	8554872	ClinVar Annotator: match by term: Nephronophthisis \| ClinVar Annotator: match by term: Nephronophthisis 8	ClinVar	PMID:11920287\|PMID:12205563\|PMID:12244321\|PMID:1248184\|PMID:15776426\|PMID:16199547\|PMID:16339905\|PMID:17558407\|PMID:17576681\|PMID:17855640\|PMID:17954299\|PMID:18076122\|PMID:21068128\|PMID:21546380\|PMID:21866095\|PMID:22550138\|PMID:22773737\|PMID:23167750\|PMID:23188109\|PMID:23217326\|PMID:23559409\|PMID:24033266\|PMID:24154662\|PMID:25445212\|PMID:25472526\|PMID:25558065\|PMID:25741868\|PMID:26346198\|PMID:26489029\|PMID:26920127\|PMID:27004616\|PMID:27491411\|PMID:27854218\|PMID:28492532\|PMID:28700940\|PMID:29127258\|PMID:30143558\|PMID:31810733\|PMID:32865313\|PMID:34295353\|PMID:34850017\|PMID:36090483\|PMID:6837691\|PMID:9536098
Nphp4	Rat	nephronophthisis 1		ISO	RGD:1351118	8554872	ClinVar Annotator: match by term: Juvenile Nephronophthisis \| ClinVar Annotator: match by term: juvenile nephronophthisis	ClinVar	PMID:11920287\|PMID:12205563\|PMID:12244321\|PMID:15776426\|PMID:16199547\|PMID:17576681\|PMID:21068128\|PMID:21546380\|PMID:21866095\|PMID:22550138\|PMID:22773737\|PMID:23167750\|PMID:23217326\|PMID:23559409\|PMID:23574405\|PMID:24033266\|PMID:25558065\|PMID:25741868\|PMID:26346198\|PMID:27004616\|PMID:27124789\|PMID:28492532\|PMID:28700940\|PMID:29127258\|PMID:30120289\|PMID:30143558\|PMID:30586318\|PMID:31589614\|PMID:31964843\|PMID:32865313\|PMID:34216551\|PMID:34426522\|PMID:36090483\|PMID:36990420\|PMID:37431782\|PMID:9536098
Nphp4	Rat	nephronophthisis 1		ISO	RGD:1351118	8554872	ClinVar Annotator: match by term: Nephronophthisis familial juvenile \| ClinVar Annotator: match by term: juvenile more ...	ClinVar	PMID:11920287\|PMID:12205563\|PMID:12244321\|PMID:15776426\|PMID:17576681\|PMID:21068128\|PMID:21546380\|PMID:21866095\|PMID:22550138\|PMID:22773737\|PMID:23167750\|PMID:23217326\|PMID:23559409\|PMID:23574405\|PMID:24033266\|PMID:25558065\|PMID:25741868\|PMID:26346198\|PMID:27004616\|PMID:27124789\|PMID:28492532\|PMID:28700940\|PMID:29127258\|PMID:30120289\|PMID:30143558\|PMID:30586318\|PMID:31589614\|PMID:31964843\|PMID:32865313\|PMID:34216551\|PMID:34426522\|PMID:9536098
Nphp4	Rat	nephronophthisis 1		ISO	RGD:1351118	8554872	ClinVar Annotator: match by term: juvenile nephronophthisis	ClinVar	PMID:11920287\|PMID:12205563\|PMID:12244321\|PMID:15776426\|PMID:17576681\|PMID:21068128\|PMID:21546380\|PMID:21866095\|PMID:22550138\|PMID:22773737\|PMID:23167750\|PMID:23217326\|PMID:23559409\|PMID:23574405\|PMID:24033266\|PMID:25558065\|PMID:25741868\|PMID:26346198\|PMID:27004616\|PMID:28492532\|PMID:28700940\|PMID:29127258\|PMID:30143558\|PMID:32865313\|PMID:9536098
Nphp4	Rat	nephronophthisis 1		ISO	RGD:1351118	8554872	ClinVar Annotator: match by term: juvenile nephronophthisis	ClinVar	PMID:11920287\|PMID:12205563\|PMID:12244321\|PMID:15776426\|PMID:17576681\|PMID:21068128\|PMID:21546380\|PMID:21866095\|PMID:22550138\|PMID:22773737\|PMID:23167750\|PMID:23217326\|PMID:23559409\|PMID:23574405\|PMID:25558065\|PMID:25741868\|PMID:26346198\|PMID:27004616\|PMID:28492532\|PMID:28700940\|PMID:29127258\|PMID:30143558\|PMID:9536098
Nphp4	Rat	nephronophthisis 4		ISO	RGD:1351118	8554872	ClinVar Annotator: match by term: NPHP4-related condition \| ClinVar Annotator: match by term: Nephronophthisis 4	ClinVar	PMID:11920287\|PMID:12205563\|PMID:12244321\|PMID:1248184\|PMID:15776426\|PMID:16199547\|PMID:16339905\|PMID:17558407\|PMID:17576681\|PMID:17855640\|PMID:17954299\|PMID:21068128\|PMID:21546380\|PMID:21866095\|PMID:22550138\|PMID:22773737\|PMID:23167750\|PMID:23188109\|PMID:23217326\|PMID:23559409\|PMID:23574405\|PMID:24033266\|PMID:24154662\|PMID:25445212\|PMID:25472526\|PMID:25558065\|PMID:25741868\|PMID:26346198\|PMID:26489029\|PMID:26920127\|PMID:27004616\|PMID:27124789\|PMID:27491411\|PMID:28492532\|PMID:28700940\|PMID:29127258\|PMID:30120289\|PMID:30143558\|PMID:30586318\|PMID:31589614\|PMID:31810733\|PMID:31964843\|PMID:32865313\|PMID:33532864\|PMID:34216551\|PMID:34295353\|PMID:34426522\|PMID:36090483\|PMID:36474027\|PMID:36938085\|PMID:36990420\|PMID:37431782\|PMID:9536098
Nphp4	Rat	nephronophthisis 4		ISO	RGD:1351118	8554872	ClinVar Annotator: match by term: Nephronophthisis 4	ClinVar	PMID:12205563\|PMID:12244321\|PMID:1248184\|PMID:15776426\|PMID:16199547\|PMID:16339905\|PMID:17558407\|PMID:17576681\|PMID:17855640\|PMID:17954299\|PMID:21068128\|PMID:21546380\|PMID:21866095\|PMID:22550138\|PMID:22773737\|PMID:23167750\|PMID:23188109\|PMID:23217326\|PMID:23559409\|PMID:24033266\|PMID:25326637\|PMID:25445212\|PMID:25472526\|PMID:25558065\|PMID:25741868\|PMID:26346198\|PMID:26489029\|PMID:26920127\|PMID:27004616\|PMID:27491411\|PMID:28492532\|PMID:28700940\|PMID:29127258\|PMID:30143558\|PMID:31810733\|PMID:32865313\|PMID:33532864\|PMID:34295353\|PMID:9536098
Nphp4	Rat	Neurodevelopmental Disorders		ISO	RGD:1351118	8554872	ClinVar Annotator: match by term: Neurodevelopmental disorder	ClinVar	PMID:25741868
Nphp4	Rat	optic atrophy		ISO	RGD:1351118	8554872	ClinVar Annotator: match by term: Optic atrophy	ClinVar	PMID:25741868\|PMID:28492532
Nphp4	Rat	retinitis pigmentosa		ISO	RGD:1351118	8554872	ClinVar Annotator: match by term: Retinitis pigmentosa	ClinVar	PMID:25741868\|PMID:34906470
Nphp4	Rat	Senior-Loken syndrome		ISO	RGD:1351118	8554872	ClinVar Annotator: match by term: Renal dysplasia and retinal aplasia	ClinVar	PMID:25741868\|PMID:28492532
Nphp4	Rat	Senior-Loken Syndrome 4		ISO	RGD:1351118	8554872	ClinVar Annotator: match by term: Senior-Loken syndrome 4	ClinVar	PMID:11920287\|PMID:12205563\|PMID:12244321\|PMID:1248184\|PMID:15776426\|PMID:16199547\|PMID:16339905\|PMID:17558407\|PMID:17576681\|PMID:17855640\|PMID:21068128\|PMID:21546380\|PMID:21866095\|PMID:22550138\|PMID:22773737\|PMID:23167750\|PMID:23188109\|PMID:23559409\|PMID:24033266\|PMID:24154662\|PMID:25445212\|PMID:25472526\|PMID:25741868\|PMID:26346198\|PMID:26920127\|PMID:27004616\|PMID:27124789\|PMID:27491411\|PMID:28492532\|PMID:28700940\|PMID:29127258\|PMID:30120289\|PMID:30586318\|PMID:31589614\|PMID:31964843\|PMID:32865313\|PMID:34216551\|PMID:34295353\|PMID:34426522\|PMID:36090483\|PMID:36474027\|PMID:36990420\|PMID:37431782\|PMID:6837691\|PMID:9536098

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Nphp4	Rat	nephronophthisis 4		ISO	RGD:1351118	11554173	CTD Direct Evidence: marker/mechanism	CTD
Nphp4	Rat	Senior-Loken Syndrome 4		ISO	RGD:1351118	11554173	CTD Direct Evidence: marker/mechanism	CTD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Nphp4	Rat	nephronophthisis 4		ISS	RGD:1621253	13592920	OMIM:606966	MouseDO

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Nphp4	Rat	nephronophthisis 4		ISO	RGD:1351118	7240710		OMIM
Nphp4	Rat	Senior-Loken Syndrome 4		ISO	RGD:1351118	7240710		OMIM

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Nphp4	Rat	1,2-dimethylhydrazine	multiple interactions	EXP		6480464	[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of NPHP4 mRNA	CTD	PMID:27840820
Nphp4	Rat	1,2-dimethylhydrazine	increases expression	ISO	RGD:1621253	6480464	1,2-Dimethylhydrazine results in increased expression of NPHP4 mRNA	CTD	PMID:22206623
Nphp4	Rat	17beta-estradiol	decreases expression	ISO	RGD:1621253	6480464	Estradiol results in decreased expression of NPHP4 mRNA	CTD	PMID:19484750
Nphp4	Rat	2,3,7,8-tetrachlorodibenzodioxine	multiple interactions	ISO	RGD:1621253	6480464	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to NPHP4 promoter]	CTD	PMID:19654925
Nphp4	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	EXP		6480464	Tetrachlorodibenzodioxin results in increased expression of NPHP4 mRNA	CTD	PMID:33387578
Nphp4	Rat	4,4'-sulfonyldiphenol	increases methylation	ISO	RGD:1621253	6480464	bisphenol S results in increased methylation of NPHP4 exon	CTD	PMID:33297965
Nphp4	Rat	6-propyl-2-thiouracil	decreases expression	EXP		6480464	Propylthiouracil results in decreased expression of NPHP4 mRNA	CTD	PMID:24780913
Nphp4	Rat	acrylamide	increases expression	ISO	RGD:1621253	6480464	Acrylamide results in increased expression of NPHP4 mRNA	CTD	PMID:30807115
Nphp4	Rat	acrylamide	decreases expression	ISO	RGD:1351118	6480464	Acrylamide results in decreased expression of NPHP4 mRNA	CTD	PMID:32763439
Nphp4	Rat	aflatoxin B1	decreases methylation	ISO	RGD:1351118	6480464	Aflatoxin B1 results in decreased methylation of NPHP4 intron	CTD	PMID:30157460
Nphp4	Rat	Aflatoxin B2 alpha	increases methylation	ISO	RGD:1351118	6480464	aflatoxin B2 results in increased methylation of NPHP4 exon; aflatoxin B2 results in increased methylation more ...	CTD	PMID:30157460
Nphp4	Rat	all-trans-retinoic acid	increases expression	ISO	RGD:1621253	6480464	Tretinoin results in increased expression of NPHP4 mRNA	CTD	PMID:16788091
Nphp4	Rat	all-trans-retinoic acid	decreases expression	ISO	RGD:1351118	6480464	Tretinoin results in decreased expression of NPHP4 mRNA	CTD	PMID:33167477
Nphp4	Rat	arsane	affects methylation	ISO	RGD:1351118	6480464	Arsenic affects the methylation of NPHP4 gene	CTD	PMID:25304211
Nphp4	Rat	arsenic atom	affects methylation	ISO	RGD:1351118	6480464	Arsenic affects the methylation of NPHP4 gene	CTD	PMID:25304211
Nphp4	Rat	arsenous acid	multiple interactions	ISO	RGD:1351118	6480464	Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to NPHP4 protein]	CTD	PMID:26598702
Nphp4	Rat	atrazine	affects methylation	EXP		6480464	Atrazine affects the methylation of NPHP4 gene	CTD	PMID:28931070\|PMID:35440735
Nphp4	Rat	benzo[a]pyrene	decreases expression	ISO	RGD:1621253	6480464	Benzo(a)pyrene results in decreased expression of NPHP4 mRNA	CTD	PMID:22228805
Nphp4	Rat	benzo[a]pyrene	affects methylation	ISO	RGD:1351118	6480464	Benzo(a)pyrene affects the methylation of NPHP4 intron	CTD	PMID:30157460
Nphp4	Rat	benzo[e]pyrene	increases methylation	ISO	RGD:1351118	6480464	benzo(e)pyrene results in increased methylation of NPHP4 exon	CTD	PMID:30157460
Nphp4	Rat	bisphenol A	affects expression	EXP		6480464	bisphenol A affects the expression of NPHP4 mRNA	CTD	PMID:25181051
Nphp4	Rat	bisphenol A	decreases methylation	ISO	RGD:1351118	6480464	bisphenol A results in decreased methylation of NPHP4 gene	CTD	PMID:31601247
Nphp4	Rat	bisphenol A	increases methylation	EXP		6480464	bisphenol A results in increased methylation of NPHP4 gene	CTD	PMID:28505145
Nphp4	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of NPHP4 mRNA	CTD	PMID:30816183
Nphp4	Rat	butanal	decreases expression	ISO	RGD:1351118	6480464	butyraldehyde results in decreased expression of NPHP4 mRNA	CTD	PMID:26079696
Nphp4	Rat	C60 fullerene	increases expression	EXP		6480464	fullerene C60 results in increased expression of NPHP4 mRNA	CTD	PMID:19167457
Nphp4	Rat	caffeine	affects phosphorylation	ISO	RGD:1351118	6480464	Caffeine affects the phosphorylation of NPHP4 protein	CTD	PMID:35688186
Nphp4	Rat	carbon nanotube	decreases expression	ISO	RGD:1621253	6480464	Nanotubes, Carbon results in decreased expression of NPHP4 mRNA	CTD	PMID:25554681
Nphp4	Rat	CGP 52608	multiple interactions	ISO	RGD:1351118	6480464	CGP 52608 promotes the reaction [RORA protein binds to NPHP4 gene]	CTD	PMID:28238834
Nphp4	Rat	choline	multiple interactions	ISO	RGD:1621253	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ...	CTD	PMID:20938992
Nphp4	Rat	cisplatin	decreases expression	ISO	RGD:1351118	6480464	Cisplatin results in decreased expression of NPHP4 mRNA	CTD	PMID:27392435
Nphp4	Rat	coumarin	decreases phosphorylation	ISO	RGD:1351118	6480464	coumarin results in decreased phosphorylation of NPHP4 protein	CTD	PMID:35688186
Nphp4	Rat	Cuprizon	increases expression	EXP		6480464	Cuprizone results in increased expression of NPHP4 mRNA	CTD	PMID:27523638
Nphp4	Rat	decabromodiphenyl ether	decreases expression	EXP		6480464	decabromobiphenyl ether results in decreased expression of NPHP4 mRNA	CTD	PMID:23914054
Nphp4	Rat	diarsenic trioxide	multiple interactions	ISO	RGD:1351118	6480464	Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to NPHP4 protein]	CTD	PMID:26598702
Nphp4	Rat	Dibutyl phosphate	affects expression	ISO	RGD:1351118	6480464	di-n-butylphosphoric acid affects the expression of NPHP4 mRNA	CTD	PMID:37042841
Nphp4	Rat	dorsomorphin	multiple interactions	ISO	RGD:1351118	6480464	[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ...	CTD	PMID:27188386
Nphp4	Rat	endosulfan	decreases expression	EXP		6480464	Endosulfan results in decreased expression of NPHP4 mRNA	CTD	PMID:29391264
Nphp4	Rat	ethanol	affects expression	ISO	RGD:1621253	6480464	Ethanol affects the expression of NPHP4 mRNA	CTD	PMID:30319688
Nphp4	Rat	folic acid	multiple interactions	ISO	RGD:1621253	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ...	CTD	PMID:20938992
Nphp4	Rat	FR900359	affects phosphorylation	ISO	RGD:1351118	6480464	FR900359 affects the phosphorylation of NPHP4 protein	CTD	PMID:37730182
Nphp4	Rat	gentamycin	increases expression	EXP		6480464	Gentamicins results in increased expression of NPHP4 mRNA	CTD	PMID:33387578
Nphp4	Rat	glycidol	increases expression	EXP		6480464	glycidol results in increased expression of NPHP4 mRNA	CTD	PMID:24915197
Nphp4	Rat	hydralazine	multiple interactions	ISO	RGD:1351118	6480464	[Hydralazine co-treated with Valproic Acid] results in increased expression of NPHP4 mRNA	CTD	PMID:17183730
Nphp4	Rat	L-methionine	multiple interactions	ISO	RGD:1621253	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ...	CTD	PMID:20938992
Nphp4	Rat	mercury dibromide	decreases expression	ISO	RGD:1351118	6480464	mercuric bromide results in decreased expression of NPHP4 mRNA	CTD	PMID:26272509
Nphp4	Rat	mercury dibromide	multiple interactions	ISO	RGD:1351118	6480464	[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ...	CTD	PMID:27188386
Nphp4	Rat	methapyrilene	increases methylation	ISO	RGD:1351118	6480464	Methapyrilene results in increased methylation of NPHP4 exon	CTD	PMID:30157460
Nphp4	Rat	methoxychlor	affects methylation	EXP		6480464	Methoxychlor affects the methylation of NPHP4 gene	CTD	PMID:35440735
Nphp4	Rat	methylmercury chloride	decreases expression	ISO	RGD:1351118	6480464	methylmercuric chloride results in decreased expression of NPHP4 mRNA	CTD	PMID:28001369
Nphp4	Rat	mono(2-ethylhexyl) phthalate	increases expression	ISO	RGD:1621253	6480464	mono-(2-ethylhexyl)phthalate results in increased expression of NPHP4 mRNA	CTD	PMID:22401849
Nphp4	Rat	N,N-diethyl-m-toluamide	multiple interactions	EXP		6480464	[Permethrin co-treated with DEET] results in decreased methylation of NPHP4 gene	CTD	PMID:33148267
Nphp4	Rat	ozone	multiple interactions	ISO	RGD:1621253	6480464	[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased more ...	CTD	PMID:34911549
Nphp4	Rat	p-chloromercuribenzoic acid	decreases expression	ISO	RGD:1351118	6480464	p-Chloromercuribenzoic Acid results in decreased expression of NPHP4 mRNA	CTD	PMID:26272509
Nphp4	Rat	p-chloromercuribenzoic acid	multiple interactions	ISO	RGD:1351118	6480464	[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ...	CTD	PMID:27188386
Nphp4	Rat	paracetamol	increases expression	EXP		6480464	Acetaminophen results in increased expression of NPHP4 mRNA	CTD	PMID:33387578
Nphp4	Rat	permethrin	multiple interactions	EXP		6480464	[Permethrin co-treated with DEET] results in decreased methylation of NPHP4 gene	CTD	PMID:33148267
Nphp4	Rat	pirinixic acid	multiple interactions	ISO	RGD:1621253	6480464	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in more ...	CTD	PMID:19710929
Nphp4	Rat	SB 431542	multiple interactions	ISO	RGD:1351118	6480464	[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ...	CTD	PMID:27188386
Nphp4	Rat	sodium arsenite	decreases expression	ISO	RGD:1351118	6480464	sodium arsenite results in decreased expression of NPHP4 mRNA	CTD	PMID:38568856
Nphp4	Rat	sodium arsenite	increases expression	ISO	RGD:1351118	6480464	sodium arsenite results in increased expression of NPHP4 mRNA	CTD	PMID:34032870
Nphp4	Rat	sunitinib	decreases expression	ISO	RGD:1351118	6480464	Sunitinib results in decreased expression of NPHP4 mRNA	CTD	PMID:31533062
Nphp4	Rat	tert-butyl hydroperoxide	decreases expression	ISO	RGD:1351118	6480464	tert-Butylhydroperoxide results in decreased expression of NPHP4 mRNA	CTD	PMID:15336504
Nphp4	Rat	thioacetamide	increases expression	EXP		6480464	Thioacetamide results in increased expression of NPHP4 mRNA	CTD	PMID:34492290
Nphp4	Rat	titanium dioxide	affects expression	ISO	RGD:1621253	6480464	titanium dioxide affects the expression of NPHP4 mRNA	CTD	PMID:23557971
Nphp4	Rat	titanium dioxide	decreases methylation	ISO	RGD:1621253	6480464	titanium dioxide results in decreased methylation of NPHP4 gene	CTD	PMID:35295148
Nphp4	Rat	trichloroethene	increases expression	EXP		6480464	Trichloroethylene results in increased expression of NPHP4 mRNA	CTD	PMID:33387578
Nphp4	Rat	trimellitic anhydride	increases expression	ISO	RGD:1621253	6480464	trimellitic anhydride results in increased expression of NPHP4 mRNA	CTD	PMID:19042947
Nphp4	Rat	triphenyl phosphate	affects expression	ISO	RGD:1351118	6480464	triphenyl phosphate affects the expression of NPHP4 mRNA	CTD	PMID:37042841
Nphp4	Rat	triptonide	increases expression	ISO	RGD:1621253	6480464	triptonide results in increased expression of NPHP4 mRNA	CTD	PMID:33045310
Nphp4	Rat	trovafloxacin	decreases expression	ISO	RGD:1621253	6480464	trovafloxacin results in decreased expression of NPHP4 mRNA	CTD	PMID:35537566
Nphp4	Rat	valproic acid	multiple interactions	ISO	RGD:1351118	6480464	[Hydralazine co-treated with Valproic Acid] results in increased expression of NPHP4 mRNA	CTD	PMID:17183730
Nphp4	Rat	valproic acid	decreases expression	ISO	RGD:1621253	6480464	Valproic Acid analog results in decreased expression of NPHP4 mRNA	CTD	PMID:21427059
Nphp4	Rat	valproic acid	increases expression	ISO	RGD:1621253	6480464	Valproic Acid results in increased expression of NPHP4 mRNA	CTD	PMID:21427059

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Nphp4	Rat	biological_process		ND		1598407	09/2016: no relevant rat data	RGD
Nphp4	Rat	flagellated sperm motility	acts_upstream_of_or_within	IEA	UniProtKB:P59240\|ensembl:ENSMUSP00000080128	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Nphp4	Rat	flagellated sperm motility	acts_upstream_of_or_within	ISO	RGD:1621253	1624291	MGI:3032515 PMID:21078623	RGD	PMID:21078623
Nphp4	Rat	negative regulation of canonical Wnt signaling pathway	involved_in	ISO	RGD:1351118	1624291	PMID:22654112	RGD	PMID:22654112
Nphp4	Rat	negative regulation of canonical Wnt signaling pathway	involved_in	IBA	PANTHER:PTN001287074\|UniProtKB:A0A8M9PS59\|UniProtKB:O75161	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Nphp4	Rat	negative regulation of canonical Wnt signaling pathway	involved_in	IEA	InterPro:IPR029775	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Nphp4	Rat	negative regulation of canonical Wnt signaling pathway	involved_in	IEA	UniProtKB:O75161\|ensembl:ENSP00000367398	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Nphp4	Rat	photoreceptor cell maintenance	acts_upstream_of_or_within	ISO	RGD:1621253	1624291	MGI:3032515 PMID:21078623	RGD	PMID:21078623
Nphp4	Rat	photoreceptor cell maintenance	acts_upstream_of_or_within	IEA	UniProtKB:P59240\|ensembl:ENSMUSP00000080128	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Nphp4	Rat	photoreceptor cell outer segment organization	acts_upstream_of_or_within	IEA	UniProtKB:P59240\|ensembl:ENSMUSP00000080128	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Nphp4	Rat	photoreceptor cell outer segment organization	acts_upstream_of_or_within	ISO	RGD:1621253	1624291	MGI:3032515 PMID:21078623	RGD	PMID:21078623
Nphp4	Rat	positive regulation of bicellular tight junction assembly	involved_in	ISO	RGD:1351118	1624291	PMID:19755384	RGD	PMID:19755384
Nphp4	Rat	positive regulation of bicellular tight junction assembly	involved_in	IEA	UniProtKB:O75161\|ensembl:ENSP00000367398	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Nphp4	Rat	protein localization to ciliary transition zone	involved_in	IBA	PANTHER:PTN001287074\|WB:WBGene00011261	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Nphp4	Rat	retina development in camera-type eye	acts_upstream_of_or_within	ISO	RGD:1621253	1624291	PMID:21052544	RGD	PMID:21052544
Nphp4	Rat	retina development in camera-type eye	acts_upstream_of_or_within	IEA	UniProtKB:P59240\|ensembl:ENSMUSP00000080128	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Nphp4	Rat	cell-cell junction	located_in	ISO	RGD:1351118	1624291	PMID:21565611	RGD	PMID:21565611
Nphp4	Rat	cell-cell junction	located_in	IEA	UniProtKB:O75161\|ensembl:ENSP00000367398	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Nphp4	Rat	centriole	located_in	ISO	RGD:1621253	1624291	PMID:29038301	RGD	PMID:29038301
Nphp4	Rat	centriole	located_in	IEA	UniProtKB:P59240\|ensembl:ENSMUSP00000080128	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Nphp4	Rat	centrosome	located_in	ISO	RGD:1351118	1624291	PMID:21399614	RGD	PMID:21399614
Nphp4	Rat	centrosome	located_in	IEA	UniProtKB:O75161\|ensembl:ENSP00000367398	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Nphp4	Rat	ciliary basal body		IDA		11537356		RGD
Nphp4	Rat	ciliary basal body	is_active_in	IBA	PANTHER:PTN001287074\|RGD:1560172\|WB:WBGene00011261	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Nphp4	Rat	ciliary base	located_in	IEA	UniProtKB:P59240\|ensembl:ENSMUSP00000080128	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Nphp4	Rat	ciliary base	is_active_in	IBA	MGI:2384210\|PANTHER:PTN001287074	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Nphp4	Rat	ciliary base	located_in	ISO	RGD:1621253	1624291	PMID:20169535	RGD	PMID:20169535
Nphp4	Rat	ciliary transition zone	is_active_in	IBA	MGI:2384210\|PANTHER:PTN001287074\|WB:WBGene00011261	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Nphp4	Rat	ciliary transition zone	located_in	IEA	UniProtKB:P59240\|ensembl:ENSMUSP00000080128	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Nphp4	Rat	ciliary transition zone	located_in	ISO	RGD:1621253	1624291	PMID:20169535	RGD	PMID:20169535
Nphp4	Rat	cytoplasm	located_in	ISO	RGD:1621253	1624291	PMID:21565611	RGD	PMID:21565611
Nphp4	Rat	cytoplasm	part_of	IEA	UniProtKB:P59240\|ensembl:ENSMUSP00000080128	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Nphp4	Rat	cytoskeleton	located_in	IEA	InterPro:IPR029775	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Nphp4	Rat	cytosol	located_in	ISO	RGD:1351118\|UniProtKB:O75161-1\|UniProtKB:O75161-2	1624291		RGD	GO_REF:0000052
Nphp4	Rat	cytosol	located_in	IEA	UniProtKB:O75161\|ensembl:ENSP00000367398	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Nphp4	Rat	non-motile cilium	is_active_in	IBA	MGI:2384210\|PANTHER:PTN001287074\|WB:WBGene00011261	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Nphp4	Rat	non-motile cilium	located_in	IEA	InterPro:IPR029775	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Nphp4	Rat	nuclear body	located_in	IEA	UniProtKB:O75161\|ensembl:ENSP00000367398	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Nphp4	Rat	nuclear body	located_in	ISO	RGD:1351118\|UniProtKB:O75161-1\|UniProtKB:O75161-2	1624291		RGD	GO_REF:0000052
Nphp4	Rat	nucleoplasm	located_in	ISO	RGD:1351118\|UniProtKB:O75161-1\|UniProtKB:O75161-2	1624291		RGD	GO_REF:0000052
Nphp4	Rat	nucleoplasm	located_in	IEA	UniProtKB:O75161\|ensembl:ENSP00000367398	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Nphp4	Rat	photoreceptor connecting cilium	located_in	ISO	RGD:1621253	1624291	PMID:21078623	RGD	PMID:21078623
Nphp4	Rat	photoreceptor connecting cilium	located_in	IEA	UniProtKB:P59240\|ensembl:ENSMUSP00000080128	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Nphp4	Rat	photoreceptor distal connecting cilium	located_in	IEA	UniProtKB:P59240\|ensembl:ENSMUSP00000080128	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Nphp4	Rat	photoreceptor distal connecting cilium	located_in	ISO	RGD:1621253	1624291	PMID:29899041	RGD	PMID:29899041
Nphp4	Rat	ribbon synapse	located_in	ISO	RGD:1621253	1624291	PMID:21078623	RGD	PMID:21078623
Nphp4	Rat	ribbon synapse	located_in	IEA	UniProtKB:P59240\|ensembl:ENSMUSP00000080128	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Nphp4	Rat	protein binding	enables	ISO	RGD:1351118	1624291	UniProtKB:O15259\|UniProtKB:Q14289\|UniProtKB:Q15051\|UniProtKB:Q68CZ1\|UniProtKB:Q68CZ1-2\|UniProtKB:Q6IE81\|UniProtKB:Q92834\|UniProtKB:Q96KN7\|UniProtKB:Q9ULD6\|UniProtKB:Q9UPV0\|UniProtKB:Q9Y265 PMID:12244321, PMID:15661758, PMID:17558407, PMID:20664800, PMID:21224891, PMID:21357692, PMID:21565611, PMID:22654112, PMID:22863007, PMID:26638075, PMID:26644512, PMID:27173435, PMID:29959317, more ...	RGD	PMID:12244321\|PMID:15661758\|PMID:17558407\|PMID:20664800\|PMID:21224891\|PMID:21357692\|PMID:21565611\|PMID:22654112\|PMID:22863007\|PMID:26638075\|PMID:26644512\|PMID:27173435\|PMID:29959317\|PMID:33961781
Nphp4	Rat	protein binding	enables	ISO	RGD:1621253	1624291	MGI:2144877\|PR:Q9R0X5\|UniProtKB:Q8CG73\|UniProtKB:Q9QY53 PMID:20664800, PMID:21565611, PMID:29899041	RGD	PMID:20664800\|PMID:21565611\|PMID:29899041
Nphp4	Rat	protein binding	enables	ISO	RGD:1351118,UniProtKB:O75161-1	1624291	UniProtKB:Q96KN7-1 PMID:16339905	RGD	PMID:16339905

#	Reference Title	Reference Citation
1.	Mutations in the gene encoding the basal body protein RPGRIP1L, a nephrocystin-4 interactor, cause Joubert syndrome.	Arts HH, etal., Nat Genet. 2007 Jul;39(7):882-8. Epub 2007 Jun 10.
2.	NPHP4 variants are associated with pleiotropic heart malformations.	French VM, etal., Circ Res. 2012 Jun 8;110(12):1564-74. doi: 10.1161/CIRCRESAHA.112.269795. Epub 2012 May 1.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Clinical and histological presentation of 3 siblings with mutations in the NPHP4 gene.	Hoefele J, etal., Am J Kidney Dis. 2004 Feb;43(2):358-64.
5.	Mutational analysis of the NPHP4 gene in 250 patients with nephronophthisis.	Hoefele J, etal., Hum Mutat. 2005 Apr;25(4):411.
6.	Evidence of oligogenic inheritance in nephronophthisis.	Hoefele J, etal., J Am Soc Nephrol. 2007 Oct;18(10):2789-95. Epub 2007 Sep 12.
7.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
8.	A gene mutated in nephronophthisis and retinitis pigmentosa encodes a novel protein, nephroretinin, conserved in evolution.	Otto E, etal., Am J Hum Genet. 2002 Nov;71(5):1161-7. Epub 2002 Aug 29.
9.	Mutation analysis in nephronophthisis using a combined approach of homozygosity mapping, CEL I endonuclease cleavage, and direct sequencing.	Otto EA, etal., Hum Mutat. 2008 Mar;29(3):418-26.
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Comprehensive gene review and curation	RGD comprehensive gene curation
13.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

PMID:19755384	PMID:20169535	PMID:21052544	PMID:21078623	PMID:21399614	PMID:21565611	PMID:22654112	PMID:29899041

Nphp4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	168,270,522 - 168,356,393 (+)	NCBI		GRCr8
mRatBN7.2	5	162,986,157 - 163,073,708 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	162,988,370 - 163,073,706 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	165,691,473 - 165,776,590 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	167,513,074 - 167,598,197 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	167,475,281 - 167,560,405 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	169,647,581 - 169,744,662 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	169,659,188 - 169,744,660 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	173,201,362 - 173,298,422 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	169,711,038 - 169,797,486 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	5	161,218,067 - 161,302,859 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

NPHP4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	5,862,811 - 5,992,425 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	5,862,811 - 5,992,473 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	5,922,871 - 6,052,485 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	5,845,457 - 5,975,118 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	5,857,135 - 5,986,797	NCBI
Celera	1	5,037,702 - 5,167,377 (-)	NCBI		Celera
Cytogenetic Map	1	p36.31	NCBI
HuRef	1	5,071,502 - 5,201,940 (-)	NCBI		HuRef
CHM1_1	1	5,911,568 - 6,041,216 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	5,387,041 - 5,518,608 (-)	NCBI		T2T-CHM13v2.0

Nphp4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	152,561,163 - 152,647,641 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	152,561,163 - 152,647,640 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	152,476,706 - 152,563,184 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	152,476,706 - 152,563,183 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	151,852,251 - 151,937,293 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	151,321,942 - 151,406,934 (+)	NCBI		MGSCv36	mm8
Celera	4	154,764,281 - 154,849,333 (+)	NCBI		Celera
Cytogenetic Map	4	E2	NCBI
cM Map	4	83.14	NCBI

Nphp4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955486	6,448,442 - 6,547,488 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955486	6,442,058 - 6,547,451 (+)	NCBI	ChiLan1.0	ChiLan1.0

NPHP4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	222,234,457 - 222,370,369 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	220,876,170 - 221,012,339 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	4,620,593 - 4,756,363 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	5,878,739 - 6,012,869 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	5,878,739 - 6,012,864 (-)	Ensembl	panpan1.1		panPan2

NPHP4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	59,819,236 - 59,936,220 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	59,814,274 - 59,929,386 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	59,830,501 - 59,946,241 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	60,022,493 - 60,152,631 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	60,035,558 - 60,152,688 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	60,035,853 - 60,151,600 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	59,902,253 - 60,018,001 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	60,303,659 - 60,419,425 (-)	NCBI		UU_Cfam_GSD_1.0

Nphp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	30,316,914 - 30,418,643 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936623	802,152 - 904,198 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NPHP4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	66,815,281 - 66,928,146 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	66,815,282 - 66,928,245 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	61,821,151 - 61,829,018 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NPHP4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	125,739,075 - 125,878,088 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	125,744,295 - 125,874,482 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666054	29,894,007 - 30,031,596 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nphp4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624818	5,327,038 - 5,432,901 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624818	5,325,946 - 5,432,290 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Nphp4
397 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	54
Count of miRNA genes:	46
Interacting mature miRNAs:	54
Transcripts:	ENSRNOT00000066623
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	124965598	166875058	Rat
631272	Lanf1	Left ventricular atrial natriuretic factor QTL 1	12		heart left ventricle natriuretic peptide A amount (VT:0010596)	heart left ventricle natriuretic peptide A level (CMO:0002165)	5	151113452	166875058	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
631562	Apr2	Acute phase response QTL 2	3.7		blood murinoglobulin 1 amount (VT:0010597)	plasma murinoglobulin 1 level (CMO:0001931)	5	135927956	166875058	Rat
634349	Bp139	Blood pressure QTL 139		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	128924607	166875058	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	135929696	166875058	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	126424772	166875058	Rat
1549904	Neuinf1	Neuroinflammation QTL 1	3	0	nervous system integrity trait (VT:0010566)	blood T lymphocyte count (CMO:0000110)	5	154828214	166875058	Rat
738018	Anxrr4	Anxiety related response QTL 4	5.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	5	130130159	166875058	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	128506074	166875058	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	131345754	166875058	Rat
1354631	Swd2	Spike wave discharge measurement QTL 2	3.64	0.0002	brain electrophysiology trait (VT:0010557)	brain total spike-and-wave discharge duration (CMO:0001740)	5	151113452	164465185	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	82394392	166664054	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	127798274	166875058	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	132717196	165560427	Rat
1641920	Colcs1	Colorectal carcinoma susceptibility QTL 1	2.99	0.0055	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	5	121846814	166846814	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	127798274	166875058	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	128506074	166875058	Rat
1331721	Bp210	Blood pressure QTL 210	3.413		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	143069996	166846814	Rat

D5Rat244

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	163,026,006 - 163,026,191 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	169,696,938 - 169,697,122	NCBI	Rnor6.0
Rnor_5.0	5	173,250,700 - 173,250,884	UniSTS	Rnor5.0
RGSC_v3.4	5	169,748,820 - 169,749,004	UniSTS	RGSC3.4
Celera	5	161,255,576 - 161,255,760	UniSTS
SHRSP x BN Map	5	97.9299	UniSTS
SHRSP x BN Map	5	97.9299	RGD
Cytogenetic Map	5	q36	UniSTS

RH94672

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	162,987,799 - 162,987,983 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	169,658,618 - 169,658,801	NCBI	Rnor6.0
Rnor_5.0	5	173,212,381 - 173,212,564	UniSTS	Rnor5.0
RGSC_v3.4	5	169,710,468 - 169,710,651	UniSTS	RGSC3.4
Celera	5	161,217,497 - 161,217,680	UniSTS
RH 3.4 Map	5	1140.7	UniSTS
Cytogenetic Map	5	q36	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31


RefSeq Transcripts	NM_001037650	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001436895	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001436896	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006239464	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006239465	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006239467	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017593432	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017593433	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017593434	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017593435	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017593436	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039110104	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039110105	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC097926	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC107905	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000066623 ⟹ ENSRNOP00000063188

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	162,988,370 - 163,073,706 (+)	Ensembl
Rnor_6.0 Ensembl	5	169,659,188 - 169,744,660 (+)	Ensembl

RefSeq Acc Id:

NM_001037650 ⟹ NP_001032739

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	168,271,073 - 168,356,393 (+)	NCBI
mRatBN7.2	5	162,988,370 - 163,073,706 (+)	NCBI
Rnor_6.0	5	169,659,188 - 169,744,660 (+)	NCBI
Rnor_5.0	5	173,201,362 - 173,298,422 (+)	NCBI
RGSC_v3.4	5	169,711,038 - 169,797,486 (+)	RGD
Celera	5	161,218,067 - 161,302,859 (+)	RGD

Sequence:

show sequence

GGTTGCCAGCTGAAGTTCGGCTGCTGGGATTCCTTCGGTTAGTCTACTGACCCTGTGTGCGCAGCCGTCCGGGGCTGAAACCGATGCTGTGAGCTCGCCAGAGCCTTGAAGATGCTCACAGTCTGGTG
TACGCGCCTCTATCCCAGCCCTAGGCCGTGCAGCTCTCTTAGGCCCCTGCGGCCCTCGATGCACTGTGAGGCCCTTGGCCCAGTCCAAGTCCAGCCCTCGGGGCGCAGGGCTGACCTCCTCCTCCACT
GCTCGGAATTGCAACCCACACTGCTGTCCGGGTTCCCAATGGTGCAGGGAGTCCCGGAGACCCACGTGAGGTTGGACAGGCAGCATGGATGACTGGCACAGAGCCTTCACCCAGAACACACTGGTCCC
TCCCCACCCGCAGAGAGCGCGGCAGTTTGGGAAGGAGTCCACGGCGTTCCAGTGCATCCTGAAGTGGCTTGATGGGCCACTCATTAAGCAGGGAATCCTAGACATGCTGTCTGAGCTTGAATGCCACC
TGCGAGTGTCTCTCTTCGACGTCACCTACAAACATTTCTTCGGGAGGACGTGGAAAACCACAGTGAAGCCCACCAATCAGCTCTCTAAGCAGCCACCCAGGATCCTCTTCAATGAGCCCTTGTACTTC
CACACAACCTTGAGCCACCCCAGCATCGTGGCTGTAATAGAAGTGGTCGCTGAAGGCAGGAAGAGGGACGGTGCCCTGCAGGTGCTGTCCTGTGGGTTTGGAATTCTTCGAATTTTTGGCAATAAGCC
GGAATCTCCCACCTCTGCAGGCCAGGACAAACGGTTGAGGCTGTATCATGGTACCCCCAGAGCCCTTCTGCACCCACTTCTCCAGGATCCCATAGAACAGAACAGGTACATGACAATGATGGAAAACT
GTAGCCTGCAGTATACCCTGAAGCCACACCCGCCCCTGGAGCCCGCCTTCCACCTGCTCCCCGAGAACTTCCTGATCTCCGGTCTCCAGCAGATCCCTGGCCTCCTCCCACCTCATGGAGACACGGGT
GATGCCCTGAGGAAGCCTCGCTTCCAGAAGCCCACCACATTGCACCTAGATGACCTCTTCTTCACCCTGTACCCCTCCCTGGAGAAGTTTGAGGAGGAACTTGTGCAGCTGCTCATCAGCGACCACTT
CCGGGAGGGGGTTGGCCTGCTAGATAGCGGCACCCTAGAGGTCTTGGAGCGGCGCCTGCATGTCTGTGTCCACAACGGTCTGGGCTTCGTGCACAGGCCACAGGTGGTTGTGCTTGTACCTGAGATGG
ACATGACCTTGACGCGCTCGGCCAGCTTCAGCAGGAGAATCACTGCCTCTTCTAAGAGCAGCTCTGGAAATCAGGCTCTGGTTTTGAGAAGCCACCTGAGACTCCCGGAGATGGTCAATCACCCATCG
TTTGCCATCGTCTTCCAGCTGGAGTACGTGTTCAACAGCCCCTCAGGAGCGGACGGCAGTGCCAGCTCATCCACCTCTCTGTCCAGCTTGGCGTGCATGCACATGGTTCGATGGGCTGTTTGGAACCC
CGATCTGGAAGCAGGCCCGGGAAAGGTGACGCTGCCTCTTCAGGGTGGGGTACAGCACAACCCCTCACGATGTCTGGTCTATAAGGTGCCTTCGGCTAGCATGAGCTCTGAGGAGGTGAAGCAGGTGG
AATCCGGAACCATCCAGTTCCACTTCTCACTGAGCTCAGATGCCCTTACAGAGCATGCCAACGGCCCCAGGGCAGGGCGGCGCTCCACCAGAAAGGCACTAACGTCCCCTTCAGGCACACCAGCACTG
GCAGCCCGGGATCTTGCTGCGATACAGGACTCTCCTGTGGGCCCAGGGCTCTCGCTCTCCCAGCTGGCGGCCTCCCCACAGTCTCTGGCCTCACAAAGATCTTTCAAGCCTCCTCCTCAGCCCCTGGA
TGGCTCTCAGTCCCCAGAGGGTCCCCAGCTCCAAGCAGGATCTGTATTAGAGAGCAGGATCTCTCATCTGGAAGCTGACCTGAGCCAGCCGCCCTTCTCGGTGCAGGGGACGCCCACTGTAGAACACC
TACAGGAACTTCCCTTCACTCCTTTGCATGCCCCCATTGTGGTGGGAGCCCAGACCAGGAGCTCCAGAAGCCAGCTCTCCAGAGCTGCCATGGTCCTCCTGCAGTCTTCCGGCTTCCCTGAGATCCTT
GATGCCAGGCAGCAGCCGGTGGAGGCCGTCAATCCCATGGATCCTGTGAGGTTCAACCCTCAGAAGGAGGAGTCAGACTGCCTTCTAGGGAATGAGATCGTGCTGCAGTTTCTTGCCTTCAGCAGAGC
GGCCCAGGACTGCCCGGGAGCGCCGTGGCCACAGACTGTGTATTTCACCTTCCAGTTCTACCGTTTCCCACCCGAGACCACGCCACGCCTGCAGCTGGTCAAACTGGACAGGACAGGCAAGAACGGCT
CTGCCTCCCTGTCTCACATCCTGGTCCACATCAATAAAGACGGCTCCTTTGACGCTGGCTCCCCTGGCTTCCAGCTGAGGTACATGGTGGATCCCGGGTTCCTGAAGCCAGGAGAGCAGCGCTGGTTC
GCCCAGTACCTGGCCGCTCAGACGCTGCAAGTCGACGTCTGGGATGGAGACTCCTTGCTCCTCATTGGGTCTGCCGGCATCCAGATGAAGCACCTCCTCCGCCAAGGGCGGCCAGCTGTTCAGGTCTC
ACATGAACTGGAGGTCGTGGCCACTGAGTACGAACAGGAAATGATGGTGGTGAGCGGCGACGTGGCGGGCTTCGGCAGCGTCAAGCCCATCGGAGTCCACACGGTCGTGAAGGGCCGGCTGCACCTGA
CCTTGGCCAACGTGGGTCACGAGTGTGAACCGAGAGCAAGAGGTTCCAACGCGCTGCCACCATCCAGGTCCCGGGTCATCTCAAATAATGGAGCCAGCTTCTTCTCTGGGGGAAGCCTCCTCATACCA
GGAGGCCCCAAGCGAAAGCGTGTGGTTCAAGCCCAGAAGCTGGCTGATGTGGACAGTGAGCTGGCCGCCATGCTGCTGACCCACACTCGAGCTGGCCAGGGGCCCCAGGCTGTGGGCCAGGAGGCAGA
CGCTGTGCACAGGCGCAAGCTGGAAAGGATGCGGCTGGTGCGCCTGCAGGAGGCCGGAGGGGACTCTGACAGTCGCAGGATCAGCGTGCTGGCCCGACACAGTGTCCGTGCACAGCACTCACGGGACC
TGCAGGTCATCGACGCCTACCGGGAACGGACCAAGGCTGAGAACATTGCCAGCGTGTTGAGCCAGGCCATCACCACACACCACACACTGTATGCCACGCTGGGCACGGCTGAGTTCTTCGAGTTTGCA
CTTAAAAACCCACACAACACTCAGCACACGGTGGCCATCGAGATTGACAGCCCTGAGCTCAGCATCATCCTGGACAGCCAGGAGTGGAGGTACTTCAAGGAGGCCACTGGCCTGCTCACACCCCTGGA
GGAGGACATGTTCCACCTGCGTGGGAGCCTGGCACCCCAGCTCTACCTGCGGCCCCGGGAGACTGCCCACATCCCCTTCAAGTTCCAGAACTTCTCTGTGGGCCCACCTGCTCCGACACAGGCCCCTG
CGGAGGTGATCTCAGAGAAGGATGCAGAGTCTGGACCCCATTGGAAGTGCAGTGCCATGCCTACCAAACACGCCAAGGTCCTTTTCCGGGTGGAGACCGGCCAGCTCATTGCTGTGCTCTGCCTGACC
GTGGAGCCCCAGCCCCACGTGGTGGACCAGGTTTTCCGTTTCTACCACCCAGAACTCACCTTCCTGAAGAAGGCCATCCGCCTGCCGCCCTGGCACACGCTTCCAGGTGCTCCCGTGGGGATGCCTGG
CGAGGACCCCCCAGTCCACGTTCGATGCAGCGACCCGAATGTCATCTGCGAGGCCCAGAACGTGGGCCTTGGTGAGCCGAGGGACGTGTTCCTTAAGGTGGCCAGCGGTCCAAGCCCGGAGATCAAAG
ACTTCTTTGTCGTCATCTATGCGGATCGCTGGCTGGCGGTGCCCGTGCAGACATGGCAGGTCTGCCTCCACTCCCTGCAGCGCGTGGATGTCTCCTGTGTCGCAGGGCAGATGACCCGTCTGTCCCTC
GTCCTACGGGGGACGCAGACCGTTAGGAAAGTGAGAGCTTTCACCTCCCACCCTCAGGAGCTGAAGACAGACCCCGCTGGTGTCTTTGTGTTACCACCTCACGGGGTGCAGGACCTGCATGTGGGCGT
GAGGCCAAGGAGGGCGGGCAGCCGCTTCATCCATCTCAACCTGGTGGACGTCGACTACCACCAGCTGGTCGCGTCGTGGCTCGTGTGCCTGTCCTGCCGCCAGCCCCTCATTTCCAAGGCCTTCGAGA
TCACCATGGCAGCAGGCGAAGGGAAGGGTGCCAACAAGCGGATCACCTACACCAACCCCTACCCTTCTCGGAGGACCTACCGTCTGCACAGTGACCGGCCAGACCTGCTGCATTTCAAGGAGGACTCC
TTCCAGGTGGCCGGAGGGGAGACCTACACCATCGGGCTGCGGTTCTTGCCGAGTGGCAGCGCCGGGCAGGAGGAGATCCTGATCTACATCAATGACCAGGACGACAAGAATGAAGAGACATTCTGTGT
GAAGGTCCTCTACCAGTGAGGGGATGGCTGTGAGGCCAGCGCCCCTTCCAGAGTGCCCCTCCCTGCAGACATCACTGTGACTCCAGGACTGGTCTGCGTAGCCCATGGAGCTGACTGAGTGCAGGGAG
ACAAAGGCTACCCTCGCCATGGTGTAGCATAATCCCATGAGCGAATGTGACCTCCGGGGTCACGGCAGTGGCTCACTCTGCCTATGGCACTCACAAGGTTGTGTCACACCCCATGACTCTCAGGCTGT
CACCGTCTAGAACAAACTGTTTTATAAATCATTTCCAATGACAAAATTATGTTTTTCTTTCTAGATTTTTAAAAAATGAACACAATATATTTTCATTTGCTATGTATTTTATACTGGAATTCCCTTGT
ATATATATTTTTTAAGTTATTGAATGAAGCACCTCACTTCGGCTG

hide sequence

RefSeq Acc Id:

XM_006239465 ⟹ XP_006239527

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	168,270,522 - 168,356,391 (+)	NCBI
mRatBN7.2	5	162,988,008 - 163,073,705 (+)	NCBI
Rnor_6.0	5	169,658,875 - 169,744,662 (+)	NCBI
Rnor_5.0	5	173,201,362 - 173,298,422 (+)	NCBI

Sequence:

show sequence

CCTCGGGTTCCGCTGGGCACCGGCAGCCCGATCGCTGGATCCACGGTGCGGGACCTGTTCCGTA
GCGTGGATCTCGTGCCCGTCTCCTAGATGGTGCAGGGAGTCCCGGAGACCCACGTGAGGTTGGACAGGCAGCATGGATGACTGGCACAGAGCCTTCACCCAGAACACACTGGTCCCTCCCCACCCGCA
GAGAGCGCGGCAGTTTGGGAAGGAGTCCACGGCGTTCCAGTGCATCCTGAAGTGGCTTGATGGGCCACTCATTAAGCAGGGAATCCTAGACATGCTGTCTGAGCTTGAATGCCACCTGCGAGTGTCTC
TCTTCGACGTCACCTACAAACATTTCTTCGGGAGGACGTGGAAAACCACAGTGAAGCCCACCAATCAGCTCTCTAAGCAGCCACCCAGGATCCTCTTCAATGAGCCCTTGTACTTCCACACAACCTTG
AGCCACCCCAGCATCGTGGCTGTAATAGAAGTGGTCGCTGAAGGCAGGAAGAGGGACGGTGCCCTGCAGGTGCTGTCCTGTGGGTTTGGAATTCTTCGAATTTTTGGCAATAAGCCGGAATCTCCCAC
CTCTGCAGGCCAGGACAAACGGTTGAGGCTGTATCATGGTACCCCCAGAGCCCTTCTGCACCCACTTCTCCAGGATCCCATAGAACAGAACAGGTACATGACAATGATGGAAAACTGTAGCCTGCAGT
ATACCCTGAAGCCACACCCGCCCCTGGAGCCCGCCTTCCACCTGCTCCCCGAGAACTTCCTGATCTCCGGTCTCCAGCAGATCCCTGGCCTCCTCCCACCTCATGGAGACACGGGTGATGCCCTGAGG
AAGCCTCGCTTCCAGAAGCCCACCACATTGCACCTAGATGACCTCTTCTTCACCCTGTACCCCTCCCTGGAGAAGTTTGAGGAGGAACTTGTGCAGCTGCTCATCAGCGACCACTTCCGGGAGGGGGT
TGGCCTGCTAGATAGCGGCACCCTAGAGGTCTTGGAGCGGCGCCTGCATGTCTGTGTCCACAACGGTCTGGGCTTCGTGCACAGGCCACAGGTGGTTGTGCTTGTACCTGAGATGGACATGACCTTGA
CGCGCTCGGCCAGCTTCAGCAGGAGAATCACTGCCTCTTCTAAGAGCAGCTCTGGAAATCAGGCTCTGGTTTTGAGAAGCCACCTGAGACTCCCGGAGATGGTCAATCACCCATCGTTTGCCATCGTC
TTCCAGCTGGAGTACGTGTTCAACAGCCCCTCAGGAGCGGACGGCAGTGCCAGCTCATCCACCTCTCTGTCCAGCTTGGCGTGCATGCACATGGTTCGATGGGCTGTTTGGAACCCCGATCTGGAAGC
AGGCCCGGGAAAGGTGACGCTGCCTCTTCAGGGTGGGGTACAGCACAACCCCTCACGATGTCTGGTCTATAAGGTGCCTTCGGCTAGCATGAGCTCTGAGGAGGTGAAGCAGGTGGAATCCGGAACCA
TCCAGTTCCACTTCTCACTGAGCTCAGATGCCCTTACAGAGCATGCCAACGGCCCCAGGGCAGGGCGGCGCTCCACCAGAAAGGCACTAACGTCCCCTTCAGGCACACCAGCACTGGCAGCCCGGGAT
CTTGCTGCGATACAGGACTCTCCTGTGGGCCCAGGGCTCTCGCTCTCCCAGCTGGCGGCCTCCCCACAGTCTCTGGCCTCACAAAGATCTTTCAAGCCTCCTCCTCAGCCCCTGGATGGCTCTCAGTC
CCCAGAGGGTCCCCAGCTCCAAGCAGGATCTGTATTAGAGAGCAGGATCTCTCATCTGGAAGCTGACCTGAGCCAGCCGCCCTTCTCGGTGCAGGGGACGCCCACTGTAGAACACCTACAGGAACTTC
CCTTCACTCCTTTGCATGCCCCCATTGTGGTGGGAGCCCAGACCAGGAGCTCCAGAAGCCAGCTCTCCAGAGCTGCCATGGTCCTCCTGCAGTCTTCCGGCTTCCCTGAGATCCTTGATGCCAGGCAG
CAGCCGGTGGAGGCCGTCAATCCCATGGATCCTGTGAGGTTCAACCCTCAGAAGGAGGAGTCAGACTGCCTTCTAGGGAATGAGATCGTGCTGCAGTTTCTTGCCTTCAGCAGAGCGGCCCAGGACTG
CCCGGGAGCGCCGTGGCCACAGACTGTGTATTTCACCTTCCAGTTCTACCGTTTCCCACCCGAGACCACGCCACGCCTGCAGCTGGTCAAACTGGACAGGACAGGCAAGAACGGCTCTGCCTCCCTGT
CTCACATCCTGGTCCACATCAATAAAGACGGCTCCTTTGACGCTGAATTAATGATCGCGCTTCCTCAGGAAGATGAAGGCAGAGGCCGCAGTCTGGCTACCATGTTAGTCAGCTCGATGGGCTCCCCT
GGCTTCCAGCTGAGGTACATGGTGGATCCCGGGTTCCTGAAGCCAGGAGAGCAGCGCTGGTTCGCCCAGTACCTGGCCGCTCAGACGCTGCAAGTCGACGTCTGGGATGGAGACTCCTTGCTCCTCAT
TGGGTCTGCCGGCATCCAGATGAAGCACCTCCTCCGCCAAGGGCGGCCAGCTGTTCAGGTCTCACATGAACTGGAGGTCGTGGCCACTGAGTACGAACAGGAAATGATGGTGGTGAGCGGCGACGTGG
CGGGCTTCGGCAGCGTCAAGCCCATCGGAGTCCACACGGTCGTGAAGGGCCGGCTGCACCTGACCTTGGCCAACGTGGGTCACGAGTGTGAACCGAGAGCAAGAGGTTCCAACGCGCTGCCACCATCC
AGGTCCCGGGTCATCTCAAATAATGGAGCCAGCTTCTTCTCTGGGGGAAGCCTCCTCATACCAGGAGGCCCCAAGCGAAAGCGTGTGGTTCAAGCCCAGAAGCTGGCTGATGTGGACAGTGAGCTGGC
CGCCATGCTGCTGACCCACACTCGAGCTGGCCAGGGGCCCCAGGCTGTGGGCCAGGAGGCAGACGCTGTGCACAGGCGCAAGCTGGAAAGGATGCGGCTGGTGCGCCTGCAGGAGGCCGGAGGGGACT
CTGACAGTCGCAGGATCAGCGTGCTGGCCCGACACAGTGTCCGTGCACAGCACTCACGGGACCTGCAGGTCATCGACGCCTACCGGGAACGGACCAAGGCTGAGAACATTGCCAGCGTGTTGAGCCAG
GCCATCACCACACACCACACACTGTATGCCACGCTGGGCACGGCTGAGTTCTTCGAGTTTGCACTTAAAAACCCACACAACACTCAGCACACGGTGGCCATCGAGATTGACAGCCCTGAGCTCAGCAT
CATCCTGGACAGCCAGGAGTGGAGGTACTTCAAGGAGGCCACTGGCCTGCTCACACCCCTGGAGGAGGACATGTTCCACCTGCGTGGGAGCCTGGCACCCCAGCTCTACCTGCGGCCCCGGGAGACTG
CCCACATCCCCTTCAAGTTCCAGAACTTCTCTGTGGGCCCACCTGCTCCGACACAGGCCCCTGCGGAGGTGATCTCAGAGAAGGATGCAGAGTCTGGACCCCATTGGAAGTGCAGTGCCATGCCTACC
AAACACGCCAAGGTCCTTTTCCGGGTGGAGACCGGCCAGCTCATTGCTGTGCTCTGCCTGACCGTGGAGCCCCAGCCCCACGTGGTGGACCAGGTTTTCCGTTTCTACCACCCAGAACTCACCTTCCT
GAAGAAGGCCATCCGCCTGCCGCCCTGGCACACGCTTCCAGGTGCTCCCGTGGGGATGCCTGGCGAGGACCCCCCAGTCCACGTTCGATGCAGCGACCCGAATGTCATCTGCGAGGCCCAGAACGTGG
GCCTTGGTGAGCCGAGGGACGTGTTCCTTAAGGTGGCCAGCGGTCCAAGCCCGGAGATCAAAGACTTCTTTGTCGTCATCTATGCGGATCGCTGGCTGGCGGTGCCCGTGCAGACATGGCAGGTCTGC
CTCCACTCCCTGCAGCGCGTGGATGTCTCCTGTGTCGCAGGGCAGATGACCCGTCTGTCCCTCGTCCTACGGGGGACGCAGACCGTTAGGAAAGTGAGAGCTTTCACCTCCCACCCTCAGGAGCTGAA
GACAGACCCCGCTGGTGTCTTTGTGTTACCACCTCACGGGGTGCAGGACCTGCATGTGGGCGTGAGGCCAAGGAGGGCGGGCAGCCGCTTCATCCATCTCAACCTGGTGGACGTCGACTACCACCAGC
TGGTCGCGTCGTGGCTCGTGTGCCTGTCCTGCCGCCAGCCCCTCATTTCCAAGGCCTTCGAGATCACCATGGCAGCAGGCGAAGGGAAGGGTGCCAACAAGCGGATCACCTACACCAACCCCTACCCT
TCTCGGAGGACCTACCGTCTGCACAGTGACCGGCCAGACCTGCTGCATTTCAAGGAGGACTCCTTCCAGGTGGCCGGAGGGGAGACCTACACCATCGGGCTGCGGTTCTTGCCGAGTGGCAGCGCCGG
GCAGGAGGAGATCCTGATCTACATCAATGACCAGGACGACAAGAATGAAGAGACATTCTGTGTGAAGGTCCTCTACCAGTGAGGGGATGGCTGTGAGGCCAGCGCCCCTTCCAGAGTGCCCCTCCCTG
CAGACATCACTGTGACTCCAGGACTGGTCTGCGTAGCCCATGGAGCTGACTGAGTGCAGGGAGACAAAGGCTACCCTCGCCATGGTGTAGCATAATCCCATGAGCGAATGTGACCTCCGGGGTCACGG
CAGTGGCTCACTCTGCCTATGGCACTCACAAGGTTGTGTCACACCCCATGACTCTCAGGCTGTCACCGTCTAGAACAAACTGTTTTATAAATCATTTCCAATGACAAAATTATGTTTTTCTTTCTAGA
TTTTTAAAAAATGAACACAATATATTTTCATTTGCTATGTATTTTATACTGGAATTCCCTTGTATATATATTTTTTAAGTTATTGAATGAAGCACCTCACTTCGGCTGTT

hide sequence

RefSeq Acc Id:

XM_017593435 ⟹ XP_017448924

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	168,270,738 - 168,356,391 (+)	NCBI
mRatBN7.2	5	162,988,035 - 163,073,705 (+)	NCBI
Rnor_6.0	5	169,658,903 - 169,744,662 (+)	NCBI

Sequence:

show sequence

CGATCGCTGGATCCACGGTGCGGGACCTGTTCCGTAGCGTGGATCTCGTGCCCGTCTCCTAGGTAACGCGCCAGCGGTGGACTGAACCAAATGGTGCAGGGAGTCCCGGAGACCCACGTGAGGTTGGA
CAGGCAGCATGGATGACTGGCACAGAGCCTTCACCCAGAACACACTGGTCCCTCCCCACCCGCAGAGAGCGCGGCAGTTTGGGAAGGAGTCCACGGCGTTCCAGTGCATCCTGAAGTGGCTTGATGGG
CCACTCATTAAGCAGGGAATCCTAGACATGCTGTCTGAGCTTGAATGCCACCTGCGAGTGTCTCTCTTCGACGTCACCTACAAACATTTCTTCGGGAGGACGTGGAAAACCACAGTGAAGCCCACCAA
TCAGCTCTCTAAGCAGCCACCCAGGATCCTCTTCAATGAGCCCTTGTACTTCCACACAACCTTGAGCCACCCCAGCATCGTGGCTGTAATAGAAGTGGTCGCTGAAGGCAGGAAGAGGGACGGTGCCC
TGCAGGTGCTGTCCTGTGGGTTTGGAATTCTTCGAATTTTTGGCAATAAGCCGGAATCTCCCACCTCTGCAGGCCAGGACAAACGGTTGAGGCTGTATCATGGTACCCCCAGAGCCCTTCTGCACCCA
CTTCTCCAGGATCCCATAGAACAGAACAGGTACATGACAATGATGGAAAACTGTAGCCTGCAGTATACCCTGAAGCCACACCCGCCCCTGGAGCCCGCCTTCCACCTGCTCCCCGAGAACTTCCTGAT
CTCCGGTCTCCAGCAGATCCCTGGCCTCCTCCCACCTCATGGAGACACGGGTGATGCCCTGAGGAAGCCTCGCTTCCAGAAGCCCACCACATTGCACCTAGATGACCTCTTCTTCACCCTGTACCCCT
CCCTGGAGAAGTTTGAGGAGGAACTTGTGCAGCTGCTCATCAGCGACCACTTCCGGGAGGGGGTTGGCCTGCTAGATAGCGGCACCCTAGAGGTCTTGGAGCGGCGCCTGCATGTCTGTGTCCACAAC
GGTCTGGGCTTCGTGCACAGGCCACAGGTGGTTGTGCTTGTACCTGAGATGGACATGACCTTGACGCGCTCGGCCAGCTTCAGCAGGAGAATCACTGCCTCTTCTAAGAGCAGCTCTGGAAATCAGGC
TCTGGTTTTGAGAAGCCACCTGAGACTCCCGGAGATGGTCAATCACCCATCGTTTGCCATCGTCTTCCAGCTGGAGTACGTGTTCAACAGCCCCTCAGGAGCGGACGGCAGTGCCAGCTCATCCACCT
CTCTGTCCAGCTTGGCGTGCATGCACATGGTTCGATGGGCTGTTTGGAACCCCGATCTGGAAGCAGGCCCGGGAAAGGTGACGCTGCCTCTTCAGGGTGGGGTACAGCACAACCCCTCACGATGTCTG
GTCTATAAGGTGCCTTCGGCTAGCATGAGCTCTGAGGAGGTGAAGCAGGTGGAATCCGGAACCATCCAGTTCCACTTCTCACTGAGCTCAGATGCCCTTACAGAGCATGCCAACGGCCCCAGGGCAGG
GCGGCGCTCCACCAGAAAGGCACTAACGTCCCCTTCAGGCACACCAGCACTGGCAGCCCGGGATCTTGCTGCGATACAGGACTCTCCTGTGGGCCCAGGGCTCTCGCTCTCCCAGCTGGCGGCCTCCC
CACAGTCTCTGGCCTCACAAAGATCTTTCAAGCCTCCTCCTCAGCCCCTGGATGGCTCTCAGTCCCCAGAGGGTCCCCAGCTCCAAGCAGGATCTGTATTAGAGAGCAGGATCTCTCATCTGGAAGCT
GACCTGAGCCAGCCGCCCTTCTCGGTGCAGGGGACGCCCACTGTAGAACACCTACAGGAACTTCCCTTCACTCCTTTGCATGCCCCCATTGTGGTGGGAGCCCAGACCAGGAGCTCCAGAAGCCAGCT
CTCCAGAGCTGCCATGGTCCTCCTGCAGTCTTCCGGCTTCCCTGAGATCCTTGATGCCAGGCAGCAGCCGGTGGAGGCCGTCAATCCCATGGATCCTGTGAGGTTCAACCCTCAGAAGGAGGAGTCAG
ACTGCCTTCTAGGGAATGAGATCGTGCTGCAGTTTCTTGCCTTCAGCAGAGCGGCCCAGGACTGCCCGGGAGCGCCGTGGCCACAGACTGTGTATTTCACCTTCCAGTTCTACCGTTTCCCACCCGAG
ACCACGCCACGCCTGCAGCTGGTCAAACTGGACAGGACAGGCAAGAACGGCTCTGCCTCCCTGTCTCACATCCTGGTCCACATCAATAAAGACGGCTCCTTTGACGCTGAATTAATGATCGCGCTTCC
TCAGGAAGATGAAGGCAGAGGCCGCAGTCTGGCTACCATGTTAGTCAGCTCGATGGGCTCCCCTGGCTTCCAGCTGAGGTACATGGTGGATCCCGGGTTCCTGAAGCCAGGAGAGCAGCGCTGGTTCG
CCCAGTACCTGGCCGCTCAGACGCTGCAAGTCGACGTCTGGGATGGAGACTCCTTGCTCCTCATTGGGTCTGCCGGCATCCAGATGAAGCACCTCCTCCGCCAAGGGCGGCCAGCTGTTCAGGTCTCA
CATGAACTGGAGGTCGTGGCCACTGAGTACGAACAGGAAATGATGGTGGTGAGCGGCGACGTGGCGGGCTTCGGCAGCGTCAAGCCCATCGGAGTCCACACGGTCGTGAAGGGCCGGCTGCACCTGAC
CTTGGCCAACGTGGGTCACGAGTGTGAACCGAGAGCAAGAGGTTCCAACGCGCTGCCACCATCCAGGTCCCGGGTCATCTCAAATAATGGAGCCAGCTTCTTCTCTGGGGGAAGCCTCCTCATACCAG
GAGGCCCCAAGCGAAAGCGTGTGGTTCAAGCCCAGAAGCTGGCTGATGTGGACAGTGAGCTGGCCGCCATGCTGCTGACCCACACTCGAGCTGGCCAGGGGCCCCAGGCTGTGGGCCAGGAGGCAGAC
GCTGTGCACAGGCGCAAGCTGGAAAGGATGCGGCTGGTGCGCCTGCAGGAGGCCGGAGGGGACTCTGACAGTCGCAGGATCAGCGTGCTGGCCCGACACAGTGTCCGTGCACAGCACTCACGGGACCT
GCAGGTCATCGACGCCTACCGGGAACGGACCAAGGCTGAGAACATTGCCAGCGTGTTGAGCCAGGCCATCACCACACACCACACACTGTATGCCACGCTGGGCACGGCTGAGTTCTTCGAGTTTGCAC
TTAAAAACCCACACAACACTCAGCACACGGTGGCCATCGAGATTGACAGCCCTGAGCTCAGCATCATCCTGGACAGCCAGGAGTGGAGGTACTTCAAGGAGGCCACTGGCCTGCTCACACCCCTGGAG
GAGGACATGTTCCACCTGCGTGGGAGCCTGGCACCCCAGCTCTACCTGCGGCCCCGGGAGACTGCCCACATCCCCTTCAAGTTCCAGAACTTCTCTGTGGGCCCACCTGCTCCGACACAGGCCCCTGC
GGAGGTGATCTCAGAGAAGGATGCAGAGTCTGGACCCCATTGGAAGTGCAGTGCCATGCCTACCAAACACGCCAAGGTCCTTTTCCGGGTGGAGACCGGCCAGCTCATTGCTGTGCTCTGCCTGACCG
TGGAGCCCCAGCCCCACGTGGTGGACCAGGTTTTCCGTTTCTACCACCCAGAACTCACCTTCCTGAAGAAGGCCATCCGCCTGCCGCCCTGGCACACGCTTCCAGGTGCTCCCGTGGGGATGCCTGGC
GAGGACCCCCCAGTCCACGTTCGATGCAGCGACCCGAATGTCATCTGCGAGGCCCAGAACGTGGGCCTTGGTGAGCCGAGGGACGTGTTCCTTAAGGTGGCCAGCGGTCCAAGCCCGGAGATCAAAGA
CTTCTTTGTCGTCATCTATGCGGATCGCTGGCTGGCGGTGCCCGTGCAGACATGGCAGGTCTGCCTCCACTCCCTGCAGCGCGTGGATGTCTCCTGTGTCGCAGGGCAGATGACCCGTCTGTCCCTCG
TCCTACGGGGGACGCAGACCGTTAGGAAAGTGAGAGCTTTCACCTCCCACCCTCAGGAGCTGAAGACAGACCCCGCTGGTGTCTTTGTGTTACCACCTCACGGGGTGCAGGACCTGCATGTGGGCGTG
AGGCCAAGGAGGGCGGGCAGCCGCTTCATCCATCTCAACCTGGTGGACGTCGACTACCACCAGCTGGTCGCGTCGTGGCTCGTGTGCCTGTCCTGCCGCCAGCCCCTCATTTCCAAGGCCTTCGAGAT
CACCATGGCAGCAGGCGAAGGGAAGGGTGCCAACAAGCGGATCACCTACACCAACCCCTACCCTTCTCGGAGGACCTACCGTCTGCACAGTGACCGGCCAGACCTGCTGCATTTCAAGGAGGACTCCT
TCCAGGTGGCCGGAGGGGAGACCTACACCATCGGGCTGCGGTTCTTGCCGAGTGGCAGCGCCGGGCAGGAGGAGATCCTGATCTACATCAATGACCAGGACGACAAGAATGAAGAGACATTCTGTGTG
AAGGTCCTCTACCAGTGAGGGGATGGCTGTGAGGCCAGCGCCCCTTCCAGAGTGCCCCTCCCTGCAGACATCACTGTGACTCCAGGACTGGTCTGCGTAGCCCATGGAGCTGACTGAGTGCAGGGAGA
CAAAGGCTACCCTCGCCATGGTGTAGCATAATCCCATGAGCGAATGTGACCTCCGGGGTCACGGCAGTGGCTCACTCTGCCTATGGCACTCACAAGGTTGTGTCACACCCCATGACTCTCAGGCTGTC
ACCGTCTAGAACAAACTGTTTTATAAATCATTTCCAATGACAAAATTATGTTTTTCTTTCTAGATTTTTAAAAAATGAACACAATATATTTTCATTTGCTATGTATTTTATACTGGAATTCCCTTGTA
TATATATTTTTTAAGTTATTGAATGAAGCACCTCACTTCGGCTGTT

hide sequence

RefSeq Acc Id:

XM_039110104 ⟹ XP_038966032

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	168,270,914 - 168,356,391 (+)	NCBI
mRatBN7.2	5	162,988,206 - 163,073,708 (+)	NCBI

RefSeq Acc Id:

XM_039110105 ⟹ XP_038966033

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	168,270,522 - 168,356,391 (+)	NCBI
mRatBN7.2	5	162,988,008 - 163,073,697 (+)	NCBI


Protein RefSeqs	NP_001032739	(Get FASTA)	NCBI Sequence Viewer
	NP_001423824	(Get FASTA)	NCBI Sequence Viewer
	NP_001423825	(Get FASTA)	NCBI Sequence Viewer
	XP_006239527	(Get FASTA)	NCBI Sequence Viewer
	XP_017448924	(Get FASTA)	NCBI Sequence Viewer
	XP_038966032	(Get FASTA)	NCBI Sequence Viewer
	XP_038966033	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI07906	(Get FASTA)	NCBI Sequence Viewer
	EDL81239	(Get FASTA)	NCBI Sequence Viewer
	EDL81242	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000063188
	ENSRNOP00000063188.1

RefSeq Acc Id:

NP_001032739 ⟸ NM_001037650

- UniProtKB:

G3V9Y6 (UniProtKB/TrEMBL), A6IUI8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDDWHRAFTQNTLVPPHPQRARQFGKESTAFQCILKWLDGPLIKQGILDMLSELECHLRVSLFDVTYKHFFGRTWKTTVKPTNQLSKQPPRILFNEPLYFHTTLSHPSIVAVIEVVAEGRKRDGALQV
LSCGFGILRIFGNKPESPTSAGQDKRLRLYHGTPRALLHPLLQDPIEQNRYMTMMENCSLQYTLKPHPPLEPAFHLLPENFLISGLQQIPGLLPPHGDTGDALRKPRFQKPTTLHLDDLFFTLYPSLE
KFEEELVQLLISDHFREGVGLLDSGTLEVLERRLHVCVHNGLGFVHRPQVVVLVPEMDMTLTRSASFSRRITASSKSSSGNQALVLRSHLRLPEMVNHPSFAIVFQLEYVFNSPSGADGSASSSTSLS
SLACMHMVRWAVWNPDLEAGPGKVTLPLQGGVQHNPSRCLVYKVPSASMSSEEVKQVESGTIQFHFSLSSDALTEHANGPRAGRRSTRKALTSPSGTPALAARDLAAIQDSPVGPGLSLSQLAASPQS
LASQRSFKPPPQPLDGSQSPEGPQLQAGSVLESRISHLEADLSQPPFSVQGTPTVEHLQELPFTPLHAPIVVGAQTRSSRSQLSRAAMVLLQSSGFPEILDARQQPVEAVNPMDPVRFNPQKEESDCL
LGNEIVLQFLAFSRAAQDCPGAPWPQTVYFTFQFYRFPPETTPRLQLVKLDRTGKNGSASLSHILVHINKDGSFDAGSPGFQLRYMVDPGFLKPGEQRWFAQYLAAQTLQVDVWDGDSLLLIGSAGIQ
MKHLLRQGRPAVQVSHELEVVATEYEQEMMVVSGDVAGFGSVKPIGVHTVVKGRLHLTLANVGHECEPRARGSNALPPSRSRVISNNGASFFSGGSLLIPGGPKRKRVVQAQKLADVDSELAAMLLTH
TRAGQGPQAVGQEADAVHRRKLERMRLVRLQEAGGDSDSRRISVLARHSVRAQHSRDLQVIDAYRERTKAENIASVLSQAITTHHTLYATLGTAEFFEFALKNPHNTQHTVAIEIDSPELSIILDSQE
WRYFKEATGLLTPLEEDMFHLRGSLAPQLYLRPRETAHIPFKFQNFSVGPPAPTQAPAEVISEKDAESGPHWKCSAMPTKHAKVLFRVETGQLIAVLCLTVEPQPHVVDQVFRFYHPELTFLKKAIRL
PPWHTLPGAPVGMPGEDPPVHVRCSDPNVICEAQNVGLGEPRDVFLKVASGPSPEIKDFFVVIYADRWLAVPVQTWQVCLHSLQRVDVSCVAGQMTRLSLVLRGTQTVRKVRAFTSHPQELKTDPAGV
FVLPPHGVQDLHVGVRPRRAGSRFIHLNLVDVDYHQLVASWLVCLSCRQPLISKAFEITMAAGEGKGANKRITYTNPYPSRRTYRLHSDRPDLLHFKEDSFQVAGGETYTIGLRFLPSGSAGQEEILI
YINDQDDKNEETFCVKVLYQ

hide sequence

RefSeq Acc Id:

XP_006239527 ⟸ XM_006239465

- Peptide Label:

isoform X1

- Sequence:

show sequence

MDDWHRAFTQNTLVPPHPQRARQFGKESTAFQCILKWLDGPLIKQGILDMLSELECHLRVSLFD
VTYKHFFGRTWKTTVKPTNQLSKQPPRILFNEPLYFHTTLSHPSIVAVIEVVAEGRKRDGALQVLSCGFGILRIFGNKPESPTSAGQDKRLRLYHGTPRALLHPLLQDPIEQNRYMTMMENCSLQYTL
KPHPPLEPAFHLLPENFLISGLQQIPGLLPPHGDTGDALRKPRFQKPTTLHLDDLFFTLYPSLEKFEEELVQLLISDHFREGVGLLDSGTLEVLERRLHVCVHNGLGFVHRPQVVVLVPEMDMTLTRS
ASFSRRITASSKSSSGNQALVLRSHLRLPEMVNHPSFAIVFQLEYVFNSPSGADGSASSSTSLSSLACMHMVRWAVWNPDLEAGPGKVTLPLQGGVQHNPSRCLVYKVPSASMSSEEVKQVESGTIQF
HFSLSSDALTEHANGPRAGRRSTRKALTSPSGTPALAARDLAAIQDSPVGPGLSLSQLAASPQSLASQRSFKPPPQPLDGSQSPEGPQLQAGSVLESRISHLEADLSQPPFSVQGTPTVEHLQELPFT
PLHAPIVVGAQTRSSRSQLSRAAMVLLQSSGFPEILDARQQPVEAVNPMDPVRFNPQKEESDCLLGNEIVLQFLAFSRAAQDCPGAPWPQTVYFTFQFYRFPPETTPRLQLVKLDRTGKNGSASLSHI
LVHINKDGSFDAELMIALPQEDEGRGRSLATMLVSSMGSPGFQLRYMVDPGFLKPGEQRWFAQYLAAQTLQVDVWDGDSLLLIGSAGIQMKHLLRQGRPAVQVSHELEVVATEYEQEMMVVSGDVAGF
GSVKPIGVHTVVKGRLHLTLANVGHECEPRARGSNALPPSRSRVISNNGASFFSGGSLLIPGGPKRKRVVQAQKLADVDSELAAMLLTHTRAGQGPQAVGQEADAVHRRKLERMRLVRLQEAGGDSDS
RRISVLARHSVRAQHSRDLQVIDAYRERTKAENIASVLSQAITTHHTLYATLGTAEFFEFALKNPHNTQHTVAIEIDSPELSIILDSQEWRYFKEATGLLTPLEEDMFHLRGSLAPQLYLRPRETAHI
PFKFQNFSVGPPAPTQAPAEVISEKDAESGPHWKCSAMPTKHAKVLFRVETGQLIAVLCLTVEPQPHVVDQVFRFYHPELTFLKKAIRLPPWHTLPGAPVGMPGEDPPVHVRCSDPNVICEAQNVGLG
EPRDVFLKVASGPSPEIKDFFVVIYADRWLAVPVQTWQVCLHSLQRVDVSCVAGQMTRLSLVLRGTQTVRKVRAFTSHPQELKTDPAGVFVLPPHGVQDLHVGVRPRRAGSRFIHLNLVDVDYHQLVA
SWLVCLSCRQPLISKAFEITMAAGEGKGANKRITYTNPYPSRRTYRLHSDRPDLLHFKEDSFQVAGGETYTIGLRFLPSGSAGQEEILIYINDQDDKNEETFCVKVLYQ

hide sequence

RefSeq Acc Id:

XP_017448924 ⟸ XM_017593435

- Peptide Label:

isoform X1

- Sequence:

show sequence

MDDWHRAFTQNTLVPPHPQRARQFGKESTAFQCILKWLDGPLIKQGILDMLSELECHLRVSLFDVTYKHFFGRTWKTTVKPTNQLSKQPPRILFNEPLYFHTTLSHPSIVAVIEVVAEGRKRDGALQV
LSCGFGILRIFGNKPESPTSAGQDKRLRLYHGTPRALLHPLLQDPIEQNRYMTMMENCSLQYTLKPHPPLEPAFHLLPENFLISGLQQIPGLLPPHGDTGDALRKPRFQKPTTLHLDDLFFTLYPSLE
KFEEELVQLLISDHFREGVGLLDSGTLEVLERRLHVCVHNGLGFVHRPQVVVLVPEMDMTLTRSASFSRRITASSKSSSGNQALVLRSHLRLPEMVNHPSFAIVFQLEYVFNSPSGADGSASSSTSLS
SLACMHMVRWAVWNPDLEAGPGKVTLPLQGGVQHNPSRCLVYKVPSASMSSEEVKQVESGTIQFHFSLSSDALTEHANGPRAGRRSTRKALTSPSGTPALAARDLAAIQDSPVGPGLSLSQLAASPQS
LASQRSFKPPPQPLDGSQSPEGPQLQAGSVLESRISHLEADLSQPPFSVQGTPTVEHLQELPFTPLHAPIVVGAQTRSSRSQLSRAAMVLLQSSGFPEILDARQQPVEAVNPMDPVRFNPQKEESDCL
LGNEIVLQFLAFSRAAQDCPGAPWPQTVYFTFQFYRFPPETTPRLQLVKLDRTGKNGSASLSHILVHINKDGSFDAELMIALPQEDEGRGRSLATMLVSSMGSPGFQLRYMVDPGFLKPGEQRWFAQY
LAAQTLQVDVWDGDSLLLIGSAGIQMKHLLRQGRPAVQVSHELEVVATEYEQEMMVVSGDVAGFGSVKPIGVHTVVKGRLHLTLANVGHECEPRARGSNALPPSRSRVISNNGASFFSGGSLLIPGGP
KRKRVVQAQKLADVDSELAAMLLTHTRAGQGPQAVGQEADAVHRRKLERMRLVRLQEAGGDSDSRRISVLARHSVRAQHSRDLQVIDAYRERTKAENIASVLSQAITTHHTLYATLGTAEFFEFALKN
PHNTQHTVAIEIDSPELSIILDSQEWRYFKEATGLLTPLEEDMFHLRGSLAPQLYLRPRETAHIPFKFQNFSVGPPAPTQAPAEVISEKDAESGPHWKCSAMPTKHAKVLFRVETGQLIAVLCLTVEP
QPHVVDQVFRFYHPELTFLKKAIRLPPWHTLPGAPVGMPGEDPPVHVRCSDPNVICEAQNVGLGEPRDVFLKVASGPSPEIKDFFVVIYADRWLAVPVQTWQVCLHSLQRVDVSCVAGQMTRLSLVLR
GTQTVRKVRAFTSHPQELKTDPAGVFVLPPHGVQDLHVGVRPRRAGSRFIHLNLVDVDYHQLVASWLVCLSCRQPLISKAFEITMAAGEGKGANKRITYTNPYPSRRTYRLHSDRPDLLHFKEDSFQV
AGGETYTIGLRFLPSGSAGQEEILIYINDQDDKNEETFCVKVLYQ

hide sequence

Ensembl Acc Id:

ENSRNOP00000063188 ⟸ ENSRNOT00000066623

RefSeq Acc Id:	XP_038966033 ⟸ XM_039110105
- Peptide Label:	isoform X2
- UniProtKB:	G3V9Y6 (UniProtKB/TrEMBL), A6IUI8 (UniProtKB/TrEMBL)

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V9Y6-F1-model_v2	AlphaFold	G3V9Y6	1-1428	view protein structure

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-39002	BioCyc
Ensembl Genes	ENSRNOG00000011967	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000066623	ENTREZGENE
	ENSRNOT00000066623.2	UniProtKB/TrEMBL
InterPro	NPHP4	UniProtKB/TrEMBL
KEGG Report	rno:313749	UniProtKB/TrEMBL
NCBI Gene	313749	ENTREZGENE
PANTHER	NEPHROCYSTIN-4	UniProtKB/TrEMBL
	PTHR31043	UniProtKB/TrEMBL
PhenoGen	Nphp4	PhenoGen
RatGTEx	ENSRNOG00000011967	RatGTEx
UniProt	A6IUI8	ENTREZGENE, UniProtKB/TrEMBL
	G3V9Y6	ENTREZGENE, UniProtKB/TrEMBL
	Q32Q04_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-29	Nphp4	nephrocystin 4	Nphp4	nephronophthisis 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-01-22	Nphp4	nephronophthisis 4	Nphp4	nephronophthisis 4 (juvenile) homolog (human)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-05-27	Nphp4	nephronophthisis 4 (juvenile) homolog (human)	Nphp4	nephronophthisis 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-05	Nphp4	nephronophthisis 4	LOC313749	similar to mKIAA0673 protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-02-09	LOC313749	similar to mKIAA0673 protein			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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