Acat2 (acetyl-CoA acetyltransferase 2) - Rat Genome Database

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Gene: Acat2 (acetyl-CoA acetyltransferase 2) Rattus norvegicus
Analyze
Symbol: Acat2
Name: acetyl-CoA acetyltransferase 2
RGD ID: 1359366
Description: Enables acetyl-CoA C-acetyltransferase activity. Involved in several processes, including cellular response to fatty acid; ketone body catabolic process; and liver development. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human ACAT2 (acetyl-CoA acetyltransferase 2); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; INTERACTS WITH 1-(3-(trifluoromethyl)phenyl)piperazine; 1-benzylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ab2-076; Acat3; acetyl-CoA acetyltransferase, cytosolic; acetyl-Coenzyme A acetyltransferase 2; acetyl-Coenzyme A acetyltransferase 3; cytosolic acetoacetyl-CoA thiolase; LOC678796; MGC95138; similar to acetyl CoA transferase-like; similar to acetyl-Coenzyme A acetyltransferase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,100,840 - 50,118,886 (+)NCBIGRCr8
mRatBN7.2147,695,833 - 47,713,879 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl147,695,788 - 47,752,821 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx148,244,680 - 48,262,723 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,232,698 - 54,250,748 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0148,320,196 - 48,338,239 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0147,972,399 - 47,992,654 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl147,972,399 - 47,992,653 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,757,961 - 51,776,935 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4141,922,020 - 41,940,074 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1141,924,964 - 41,943,018 (+)NCBI
Celera143,380,977 - 43,399,019 (+)NCBICelera
Cytogenetic Map1q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Acat2Ratarteriosclerosis  ISOAcat2 (Mus musculus)1601111 RGD 
Acat2Ratcoronary artery disease susceptibilityISOACAT2 (Homo sapiens)1601112DNA:polymorphisms: :41A>G more ...RGD 
Acat2RatHypercholesterolemia  ISOAcat2 (Mus musculus)1556516 RGD 
Acat2RatMetabolic Syndrome susceptibilityISOACAT2 (Homo sapiens)1581921DNA:polymorphismRGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Acat2Rat3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome  ISOACAT2 (Homo sapiens)8554872ClinVar Annotator: match by term: 3-methylglutaconic aciduria with deafness more ...ClinVarPMID:15220921 more ...
Acat2Ratbeta-ketothiolase deficiency  ISOACAT2 (Homo sapiens)8554872ClinVar Annotator: match by term: Deficiency of acetyl-CoA acetyltransferaseClinVarPMID:25741868 and PMID:31268215
Acat2RatCytosolic Acetoacetyl-CoA Thiolase Deficiency  ISOACAT2 (Homo sapiens)8554872ClinVar Annotator: match by term: Acetyl-CoA acetyltransferase-2 deficiencyClinVarPMID:25741868
Object Symbol
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Evidence
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Reference
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Original Reference(s)
Acat2RatCytosolic Acetoacetyl-CoA Thiolase Deficiency  ISOACAT2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Object Symbol
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Term
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Reference
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Original Reference(s)
Acat2RatCytosolic Acetoacetyl-CoA Thiolase Deficiency  ISOACAT2 (Homo sapiens)7240710 OMIM 

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Object Symbol
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Qualifier
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Reference
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Original Reference(s)
Acat2Rat(-)-epigallocatechin 3-gallate increases expressionISOACAT2 (Homo sapiens)6480464epigallocatechin gallate results in increased expression of ACAT2 mRNACTDPMID:32512070
Acat2Rat1,2-dimethylhydrazine multiple interactionsISOAcat2 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of ACAT2 mRNACTDPMID:22206623
Acat2Rat1-(3-(trifluoromethyl)phenyl)piperazine increases expressionEXP 64804641-(3-trifluoromethylphenyl)piperazine results in increased expression of ACAT2 mRNACTDPMID:26821219
Acat2Rat1-benzylpiperazine increases expressionEXP 6480464N-benzylpiperazine results in increased expression of ACAT2 mRNACTDPMID:26821219
Acat2Rat1-chloro-2,4-dinitrobenzene affects bindingISOACAT2 (Homo sapiens)6480464Dinitrochlorobenzene binds to ACAT2 proteinCTDPMID:32991956
Acat2Rat1-naphthyl isothiocyanate affects expressionISOAcat2 (Mus musculus)64804641-Naphthylisothiocyanate affects the expression of ACAT2 mRNACTDPMID:28549656
Acat2Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of ACAT2 mRNACTDPMID:30723492
Acat2Rat1-naphthyl isothiocyanate multiple interactionsISOAcat2 (Mus musculus)648046418alpha-glycyrrhetinic acid affects the reaction [1-Naphthylisothiocyanate affects the expression of ACAT2 mRNA] and Glycyrrhizic Acid affects the reaction [1-Naphthylisothiocyanate affects the expression of ACAT2 mRNA]CTDPMID:28549656
Acat2Rat17alpha-ethynylestradiol affects expressionISOAcat2 (Mus musculus)6480464Ethinyl Estradiol affects the expression of ACAT2 mRNACTDPMID:17555576
Acat2Rat17alpha-ethynylestradiol multiple interactionsISOAcat2 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACAT2 mRNACTDPMID:17942748
Acat2Rat17alpha-ethynylestradiol affects expressionEXP 6480464Ethinyl Estradiol affects the expression of ACAT2 mRNACTDPMID:17351261
Acat2Rat17alpha-ethynylestradiol increases expressionISOAcat2 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of ACAT2 mRNACTDPMID:17942748
Acat2Rat17beta-estradiol affects expressionEXP 6480464Estradiol affects the expression of ACAT2 mRNACTDPMID:32145629
Acat2Rat17beta-estradiol increases expressionISOAcat2 (Mus musculus)6480464Estradiol results in increased expression of ACAT2 mRNACTDPMID:39298647
Acat2Rat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISOAcat2 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with 2 more ...CTDPMID:28433925
Acat2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOAcat2 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of ACAT2 mRNACTDPMID:21570461
Acat2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of ACAT2 mRNACTDPMID:33387578
Acat2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of ACAT2 mRNACTDPMID:32109520
Acat2Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOAcat2 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with 2 more ...CTDPMID:17942748 and PMID:28433925
Acat2Rat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642 more ...CTDPMID:32109520

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Biological Process

  
Object Symbol
Species
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Reference
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Source
Original Reference(s)
Acat2Ratcellular response to fatty acid  IEP 1598704fish oil chylomicron remnantsRGD 
Acat2Ratcellular response to nutrient  IEP 1598705N-acetylcysteineRGD 
Acat2Ratcholesterol biosynthetic process involved_inTAS 2326086PMID:10806397UniProt 
Acat2Ratdolichol biosynthetic process involved_inTAS 2326086PMID:10806397UniProt 
Acat2Ratfatty acid metabolic process involved_inIEAUniPathway:UPA001991600115GO_REF:0000041UniProtGO_REF:0000041
Acat2Ratketone body catabolic process  IEP 2326095 RGD 
Acat2Ratliver development  IEP 2326169 RGD 
Acat2Ratpositive regulation of intestinal cholesterol absorption involved_inISOAcat2 (Mus musculus)1624291 PMID:22045928RGDPMID:22045928

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Acat2Ratcytoplasm located_inIEAARBA:ARBA000269711600115GO_REF:0000117UniProtGO_REF:0000117
Acat2Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Acat2Ratcytoplasm located_inISOACAT2 (Homo sapiens)1624291 PMID:7911016RGDPMID:7911016
Acat2Ratcytosol located_inIEAUniProtKB-SubCell:SL-00911600115GO_REF:0000044UniProtGO_REF:0000044
Acat2Ratintracellular membrane-bounded organelle located_inIEAARBA:ARBA000290851600115GO_REF:0000117UniProtGO_REF:0000117
Acat2Ratperoxisome located_inTAS 2326086PMID:10806397UniProt 

Molecular Function
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RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Acat2Ratcholesterol biosynthetic pathway   ISOACAT2 (Homo sapiens)2316857 RGD 
Acat2Ratketone bodies metabolic pathway   ISOACAT2 (Homo sapiens)2326093 RGD 

Imported Annotations - SMPDB

1 to 20 of 27 rows
Object Symbol
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Qualifier
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Reference
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Source
Original Reference(s)
Acat2Ratalendronate pharmacodynamics pathway  ISOACAT2 (Homo sapiens)10402751 SMPDBSMP:00095
Acat2Ratcholesterol biosynthetic pathway   ISOACAT2 (Homo sapiens)10402751 SMPDBSMP:00023
Acat2Ratcholesterol ester storage disease pathway  ISOACAT2 (Homo sapiens)10402751 SMPDBSMP:00508
Acat2Ratcongenital hemidysplasia with ichthyosiform erythroderma and limb defects pathway  ISOACAT2 (Homo sapiens)10402751 SMPDBSMP:00387
Acat2Ratdesmosterolosis pathway  ISOACAT2 (Homo sapiens)10402751 SMPDBSMP:00386
Acat2Rathypercholesterolemia pathway  ISOACAT2 (Homo sapiens)10402751 SMPDBSMP:00209
Acat2Ratibandronate pharmacodynamics pathway  ISOACAT2 (Homo sapiens)10402751 SMPDBSMP:00079
Acat2Ratmevalonic aciduria pathway  ISOACAT2 (Homo sapiens)10402751 SMPDBSMP:00509
Acat2Ratmevalonic aciduria pathway  ISOACAT2 (Homo sapiens)10402751 SMPDBSMP:00510
Acat2Ratnitrogenous bisphosphonate pharmacodynamics pathway  ISOACAT2 (Homo sapiens)10402751 SMPDBSMP:00117
Acat2Ratnitrogenous bisphosphonate pharmacodynamics pathway  ISOACAT2 (Homo sapiens)10402751 SMPDBSMP:00095
Acat2Ratnitrogenous bisphosphonate pharmacodynamics pathway  ISOACAT2 (Homo sapiens)10402751 SMPDBSMP:00079
Acat2Ratnitrogenous bisphosphonate pharmacodynamics pathway  ISOACAT2 (Homo sapiens)10402751 SMPDBSMP:00112
Acat2Ratpamidronate pharmacodynamics pathway  ISOACAT2 (Homo sapiens)10402751 SMPDBSMP:00117
Acat2Ratrisedronate pharmacodynamics pathway  ISOACAT2 (Homo sapiens)10402751 SMPDBSMP:00112
Acat2RatSmith-Lemli-Opitz Syndrome pathway  ISOACAT2 (Homo sapiens)10402751 SMPDBSMP:00389
Acat2Ratstatin pharmacodynamics pathway   ISOACAT2 (Homo sapiens)10402751 SMPDBSMP:00092
Acat2Ratstatin pharmacodynamics pathway   ISOACAT2 (Homo sapiens)10402751 SMPDBSMP:00089
Acat2Ratstatin pharmacodynamics pathway   ISOACAT2 (Homo sapiens)10402751 SMPDBSMP:00131
Acat2Ratstatin pharmacodynamics pathway   ISOACAT2 (Homo sapiens)10402751 SMPDBSMP:00119
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Imported Annotations - KEGG (archival)

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#
Reference Title
Reference Citation
1. Identification, purification and characterization of an acetoacetyl-CoA thiolase from rat liver peroxisomes. Antonenkov VD, etal., Eur J Biochem. 2000 May;267(10):2981-90.
2. Liver-specific inhibition of acyl-coenzyme a:cholesterol acyltransferase 2 with antisense oligonucleotides limits atherosclerosis development in apolipoprotein B100-only low-density lipoprotein receptor-/- mice. Bell TA 3rd, etal., Arterioscler Thromb Vasc Biol. 2006 Aug;26(8):1814-20. Epub 2006 May 4.
3. The influence of chylomicron remnants on cholesteryl ester metabolism in cultured rat hepatocytes: comparison of the effects of particles enriched in n-3 or n-6 polyunsaturated fatty acids. Botham KM, etal., Biochim Biophys Acta. 2001 Dec 30;1534(2-3):96-109.
4. The effects of dietary n-3 polyunsaturated fatty acids delivered in chylomicron remnants on the transcription of genes regulating synthesis and secretion of very-low-density lipoprotein by the liver: modulation by cellular oxidative state. Botham KM, etal., Exp Biol Med (Maywood). 2003 Feb;228(2):143-51.
5. Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice. Buhman KK, etal., Nat Med 2000 Dec;6(12):1341-7.
6. Impaired VLDL assembly: a novel mechanism contributing to hepatic lipid accumulation following ovariectomy and high-fat/high-cholesterol diets? Côté I, etal., Br J Nutr. 2014 Nov 28;112(10):1592-600. doi: 10.1017/S0007114514002517. Epub 2014 Sep 29.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Acyl-CoA: cholesterol acyltransferase-2 gene polymorphisms and their association with plasma lipids and coronary artery disease risks. He X, etal., Hum Genet. 2005 Dec;118(3-4):393-403. Epub 2005 Sep 30.
9. ACAT2 contributes cholesteryl esters to newly secreted VLDL, whereas LCAT adds cholesteryl ester to LDL in mice. Lee RG, etal., J Lipid Res 2005 Jun;46(6):1205-12. Epub 2005 Apr 1.
10. Dual action of neutral sphingomyelinase on rat hepatocytes: activation of cholesteryl ester metabolism and biliary cholesterol secretion and inhibition of VLDL secretion. Liza M, etal., Lipids. 2003 Jan;38(1):53-63.
11. The course of ketosis and the activity of key enzymes of ketogenesis and ketone-body utilization during development of the postnatal rat. Lockwood EA and Bailey E, Biochem J. 1971 Aug;124(1):249-54.
12. Evidence for substantial effect modification by gender in a large-scale genetic association study of the metabolic syndrome among coronary heart disease patients. McCarthy JJ, etal., Hum Genet. 2003 Dec;114(1):87-98. Epub 2003 Oct 14.
13. The acetoacetyl-coenzyme A thiolases of rat brain and their relative activities during postnatal development. Middleton B Biochem J. 1973 Apr;132(4):731-7.
14. Cerebral ketone body metabolism. Morris AA J Inherit Metab Dis. 2005;28(2):109-21.
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. Activities of enzymes of ketone-body utilization in brain and other tissues of suckling rats. Page MA, etal., Biochem J. 1971 Jan;121(1):49-53.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
19. GOA pipeline RGD automated data pipeline
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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PMID:7911016   PMID:15489334   PMID:18614015   PMID:23533145   PMID:27809850   PMID:31647302  



Acat2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,100,840 - 50,118,886 (+)NCBIGRCr8
mRatBN7.2147,695,833 - 47,713,879 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl147,695,788 - 47,752,821 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx148,244,680 - 48,262,723 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,232,698 - 54,250,748 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0148,320,196 - 48,338,239 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0147,972,399 - 47,992,654 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl147,972,399 - 47,992,653 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,757,961 - 51,776,935 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4141,922,020 - 41,940,074 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1141,924,964 - 41,943,018 (+)NCBI
Celera143,380,977 - 43,399,019 (+)NCBICelera
Cytogenetic Map1q11NCBI
ACAT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386159,762,045 - 159,779,112 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6159,762,045 - 159,779,112 (+)EnsemblGRCh38hg38GRCh38
GRCh376160,183,077 - 160,200,144 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366160,102,979 - 160,120,077 (+)NCBINCBI36Build 36hg18NCBI36
Build 346160,153,495 - 160,170,496NCBI
Celera6160,829,071 - 160,846,164 (+)NCBICelera
Cytogenetic Map6q25.3NCBI
HuRef6157,652,350 - 157,670,330 (+)NCBIHuRef
CHM1_16160,445,318 - 160,462,378 (+)NCBICHM1_1
T2T-CHM13v2.06161,007,676 - 161,024,729 (+)NCBIT2T-CHM13v2.0
Acat2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391713,161,929 - 13,179,612 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1713,161,777 - 13,179,634 (-)EnsemblGRCm39 Ensembl
GRCm381712,943,042 - 12,960,725 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1712,942,890 - 12,960,747 (-)EnsemblGRCm38mm10GRCm38
MGSCv371713,135,908 - 13,153,591 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361712,785,822 - 12,803,643 (-)NCBIMGSCv36mm8
Celera1712,974,572 - 12,992,259 (-)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.73NCBI
Acat2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543921,122,923 - 21,142,480 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543921,123,886 - 21,142,562 (-)NCBIChiLan1.0ChiLan1.0
ACAT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25179,860,401 - 179,877,462 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16177,765,362 - 177,782,416 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06157,644,894 - 157,661,965 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16162,656,497 - 162,673,606 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6162,656,497 - 162,673,606 (+)Ensemblpanpan1.1panPan2
ACAT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1149,011,665 - 49,029,368 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl149,011,706 - 49,029,327 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha149,853,633 - 49,871,344 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0149,196,147 - 49,214,069 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl149,196,175 - 49,214,050 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1149,078,510 - 49,096,406 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0148,949,606 - 48,967,503 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0149,564,773 - 49,582,676 (+)NCBIUU_Cfam_GSD_1.0
Acat2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946144,003,888 - 144,021,848 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648911,255,871 - 11,283,216 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648911,255,871 - 11,273,848 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACAT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl17,598,735 - 7,612,866 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.117,600,616 - 7,612,861 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.219,399,574 - 9,411,820 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACAT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11387,363,527 - 87,378,002 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604059,762,875 - 59,777,018 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acat2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248553,176,171 - 3,199,705 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248553,177,402 - 3,199,634 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Acat2
239 total Variants

Predicted Target Of
Summary Value
Count of predictions:217
Count of miRNA genes:151
Interacting mature miRNAs:170
Transcripts:ENSRNOT00000033408
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 45 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat

1 to 10 of 45 rows
D1Rat332  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2147,772,213 - 47,772,342 (-)MAPPERmRatBN7.2
mRatBN7.2147,746,929 - 47,747,057 (-)MAPPERmRatBN7.2
Rnor_6.0154,424,371 - 54,424,496NCBIRnor6.0
Rnor_5.0155,644,514 - 55,644,639UniSTSRnor5.0
RGSC_v3.1141,941,176 - 41,941,281RGD
Celera143,397,178 - 43,397,283UniSTS
SHRSP x BN Map124.95UniSTS
SHRSP x BN Map124.95RGD
Cytogenetic Map1q11UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000033408   ⟹   ENSRNOP00000059561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl147,695,788 - 47,713,873 (+)Ensembl
Rnor_6.0 Ensembl147,972,399 - 47,992,653 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076951   ⟹   ENSRNOP00000068312
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl147,695,788 - 47,752,821 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077707   ⟹   ENSRNOP00000069035
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl147,972,425 - 47,991,846 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111916   ⟹   ENSRNOP00000085078
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl147,695,788 - 47,730,867 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114086   ⟹   ENSRNOP00000083545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl147,695,810 - 47,724,428 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117522   ⟹   ENSRNOP00000087001
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl147,695,810 - 47,724,428 (+)Ensembl
RefSeq Acc Id: NM_001006995   ⟹   NP_001006996
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,100,840 - 50,118,886 (+)NCBI
mRatBN7.2147,695,833 - 47,713,879 (+)NCBI
Rnor_6.0147,972,399 - 47,992,654 (+)NCBI
Rnor_5.0151,757,961 - 51,776,935 (-)NCBI
RGSC_v3.4141,922,020 - 41,940,074 (+)RGD
Celera143,380,977 - 43,399,019 (+)RGD
Sequence:
Protein RefSeqs NP_001006996 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH83872 (Get FASTA)   NCBI Sequence Viewer  
  AAP92588 (Get FASTA)   NCBI Sequence Viewer  
  EDL83695 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000083545
  ENSRNOP00000083545.1
GenBank Protein Q5XI22 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001006996   ⟸   NM_001006995
- UniProtKB: Q5XI22 (UniProtKB/Swiss-Prot),   A6KP31 (UniProtKB/TrEMBL),   F1LS48 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000059561   ⟸   ENSRNOT00000033408
Ensembl Acc Id: ENSRNOP00000069035   ⟸   ENSRNOT00000077707
Ensembl Acc Id: ENSRNOP00000068312   ⟸   ENSRNOT00000076951
Ensembl Acc Id: ENSRNOP00000085078   ⟸   ENSRNOT00000111916
Thiolase C-terminal   Thiolase N-terminal

Name Modeler Protein Id AA Range Protein Structure
AF-Q5XI22-F1-model_v2 AlphaFold Q5XI22 1-397 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13689614
Promoter ID:EPDNEW_R138
Type:multiple initiation site
Name:Acat2_1
Description:acetyl-CoA acetyltransferase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0147,972,376 - 47,972,436EPDNEW


1 to 32 of 32 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-61592 BioCyc
Ensembl Genes ENSRNOG00000019189 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000114086 ENTREZGENE
  ENSRNOT00000114086.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.47.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7128564 IMAGE-MGC_LOAD
InterPro Thiolase UniProtKB/Swiss-Prot
  Thiolase-like UniProtKB/Swiss-Prot
  Thiolase_AS UniProtKB/Swiss-Prot
  Thiolase_C UniProtKB/Swiss-Prot
  Thiolase_CS UniProtKB/Swiss-Prot
  Thiolase_N UniProtKB/Swiss-Prot
KEGG Report rno:308100 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95138 IMAGE-MGC_LOAD
NCBI Gene 308100 ENTREZGENE
PANTHER ACETYL-COA ACETYLTRANSFERASE, CYTOSOLIC UniProtKB/Swiss-Prot
  ACETYL-COA C-ACYLTRANSFERASE UniProtKB/Swiss-Prot
Pfam Thiolase_C UniProtKB/Swiss-Prot
  Thiolase_N UniProtKB/Swiss-Prot
PharmGKB ACAT2 RGD
PhenoGen Acat2 PhenoGen
PIRSF Ac-CoA_Ac_transf UniProtKB/Swiss-Prot
PROSITE THIOLASE_2 UniProtKB/Swiss-Prot
  THIOLASE_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019189 RatGTEx
Superfamily-SCOP SSF53901 UniProtKB/Swiss-Prot
UniProt A0A096MJY8_RAT UniProtKB/TrEMBL
  A0A8I6A0J1_RAT UniProtKB/TrEMBL
  A0A8I6AFP7_RAT UniProtKB/TrEMBL
  A6KP31 ENTREZGENE, UniProtKB/TrEMBL
  F1LS48 ENTREZGENE, UniProtKB/TrEMBL
  Q5XI22 ENTREZGENE, UniProtKB/Swiss-Prot
1 to 32 of 32 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Acat2  acetyl-CoA acetyltransferase 2  LOC678796  similar to acetyl-Coenzyme A acetyltransferase 2  Data merged from RGD:1596891 737654 PROVISIONAL
2013-03-08 Acat2  acetyl-CoA acetyltransferase 2  Acat2  acetyl-Coenzyme A acetyltransferase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-03-07 Acat2  acetyl-Coenzyme A acetyltransferase 2  Acat3  acetyl-Coenzyme A acetyltransferase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC678796  similar to acetyl-Coenzyme A acetyltransferase 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-30 Acat2  acetyl-Coenzyme A acetyltransferase 2  MGC95138  similar to acetyl CoA transferase-like  Symbol and Name updated 1299863 APPROVED
2005-07-29 MGC95138  similar to acetyl CoA transferase-like      Symbol and Name status set to provisional 70820 PROVISIONAL