Fanca (FA complementation group A) - Rat Genome Database

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Gene: Fanca (FA complementation group A) Rattus norvegicus
Analyze
Symbol: Fanca
Name: FA complementation group A
RGD ID: 1311380
Description: Predicted to be involved in regulation of regulatory T cell differentiation. Predicted to act upstream of or within several processes, including gonad development; regulation of CD40 signaling pathway; and regulation of germ cell proliferation. Predicted to be located in nucleoplasm. Predicted to be part of Fanconi anaemia nuclear complex and chromatin. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia (multiple); cervical cancer; esophagus squamous cell carcinoma; ovarian disease (multiple); and skin melanoma. Orthologous to human FANCA (FA complementation group A); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fanconi anemia group A protein homolog; Fanconi anemia, complementation group A; LOC103690042; LOC361435
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81968,210,562 - 68,271,080 (-)NCBIGRCr8
mRatBN7.21951,304,126 - 51,362,586 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1951,304,021 - 51,362,527 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1958,099,010 - 58,156,795 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01958,779,050 - 58,837,262 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01960,997,616 - 61,055,403 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01956,067,548 - 56,126,075 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1956,067,548 - 56,126,063 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01967,115,679 - 67,132,939 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01966,772,525 - 66,837,134 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41953,587,849 - 53,647,780 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11953,592,974 - 53,652,636 (-)NCBI
Celera1950,539,880 - 50,598,370 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
furan  (EXP)
hydrogen peroxide  (ISO)
L-methionine  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
methimazole  (EXP)
monocrotaline  (ISO)
N(4)-hydroxycytidine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
resveratrol  (EXP,ISO)
riddelliine  (ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Mutations in Fanconi anemia genes and the risk of esophageal cancer. Akbari MR, etal., Hum Genet. 2011 May;129(5):573-82. doi: 10.1007/s00439-011-0951-7. Epub 2011 Jan 30.
2. Fanconi anemia in Tunisia: high prevalence of group A and identification of new FANCA mutations. Bouchlaka C, etal., J Hum Genet. 2003;48(7):352-61. Epub 2003 Jun 24.
3. Mice with a targeted disruption of the Fanconi anemia homolog Fanca. Cheng NC, etal., Hum Mol Genet. 2000 Jul 22;9(12):1805-11.
4. Association of complementation group and mutation type with clinical outcome in fanconi anemia. European Fanconi Anemia Research Group. Faivre L, etal., Blood. 2000 Dec 15;96(13):4064-70.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Evaluation of Fanconi anaemia genes FANCA, FANCC and FANCL in cervical cancer susceptibility. Juko-Pecirep I, etal., Gynecol Oncol. 2011 Aug;122(2):377-81. doi: 10.1016/j.ygyno.2011.04.014. Epub 2011 May 4.
8. Fanconi anemia links reactive oxygen species to insulin resistance and obesity. Li J, etal., Antioxid Redox Signal. 2012 Oct 15;17(8):1083-98. doi: 10.1089/ars.2011.4417. Epub 2012 Jun 25.
9. Polymorphic variations in the FANCA gene in high-risk non-BRCA1/2 breast cancer individuals from the French Canadian population. Litim N, etal., Mol Oncol. 2013 Feb;7(1):85-100. doi: 10.1016/j.molonc.2012.08.002. Epub 2012 Sep 11.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. Michiels S, etal., Carcinogenesis. 2009 May;30(5):763-8. doi: 10.1093/carcin/bgp046. Epub 2009 Feb 23.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. Polymorphisms within the FANCA gene associate with premature ovarian failure in Korean women. Pyun JA, etal., Menopause. 2014 May;21(5):530-3. doi: 10.1097/GME.0b013e3182a4323e.
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
17. Genetics of the FANCA gene in familial pancreatic cancer. Rogers CD, etal., J Med Genet. 2004 Dec;41(12):e126.
18. A novel duplication polymorphism in the FANCA promoter and its association with breast and ovarian cancer. Thompson E, etal., BMC Cancer. 2005 Apr 29;5:43.
19. Deletion and reduced expression of the Fanconi anemia FANCA gene in sporadic acute myeloid leukemia. Tischkowitz MD, etal., Leukemia. 2004 Mar;18(3):420-5.
20. Common variants in immune and DNA repair genes and risk for human papillomavirus persistence and progression to cervical cancer. Wang SS, etal., J Infect Dis. 2009 Jan 1;199(1):20-30. doi: 10.1086/595563.
21. Identification and characterization of novel mutations of the major Fanconi anemia gene FANCA in the Japanese population. Yagasaki H, etal., Hum Mutat. 2004 Dec;24(6):481-90.
22. Genetic variants in fanconi anemia pathway genes BRCA2 and FANCA predict melanoma survival. Yin J, etal., J Invest Dermatol. 2015 Feb;135(2):542-50. doi: 10.1038/jid.2014.416. Epub 2014 Sep 22.
Additional References at PubMed
PMID:11726552   PMID:12913077   PMID:20347428   PMID:22266823   PMID:22343915   PMID:22705371   PMID:24501220  


Genomics

Comparative Map Data
Fanca
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81968,210,562 - 68,271,080 (-)NCBIGRCr8
mRatBN7.21951,304,126 - 51,362,586 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1951,304,021 - 51,362,527 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1958,099,010 - 58,156,795 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01958,779,050 - 58,837,262 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01960,997,616 - 61,055,403 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01956,067,548 - 56,126,075 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1956,067,548 - 56,126,063 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01967,115,679 - 67,132,939 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01966,772,525 - 66,837,134 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41953,587,849 - 53,647,780 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11953,592,974 - 53,652,636 (-)NCBI
Celera1950,539,880 - 50,598,370 (-)NCBICelera
Cytogenetic Map19q12NCBI
FANCA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381689,737,549 - 89,816,647 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1689,726,683 - 89,816,977 (-)EnsemblGRCh38hg38GRCh38
GRCh371689,803,957 - 89,883,055 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361688,331,460 - 88,410,566 (-)NCBINCBI36Build 36hg18NCBI36
Build 341688,331,459 - 88,410,555NCBI
Celera1674,868,202 - 74,947,293 (-)NCBICelera
Cytogenetic Map16q24.3NCBI
HuRef1675,499,171 - 75,578,023 (-)NCBIHuRef
CHM1_11691,215,162 - 91,294,341 (-)NCBICHM1_1
T2T-CHM13v2.01695,822,301 - 95,901,198 (-)NCBIT2T-CHM13v2.0
Fanca
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398123,993,033 - 124,045,390 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8123,995,039 - 124,045,315 (-)EnsemblGRCm39 Ensembl
GRCm388123,266,294 - 123,318,651 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8123,268,300 - 123,318,576 (-)EnsemblGRCm38mm10GRCm38
MGSCv378125,792,144 - 125,842,476 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368126,154,390 - 126,204,666 (-)NCBIMGSCv36mm8
Celera8127,507,685 - 127,559,921 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map872.1NCBI
Fanca
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555413,273,022 - 3,320,052 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555413,272,936 - 3,320,229 (-)NCBIChiLan1.0ChiLan1.0
FANCA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21899,585,370 - 99,668,686 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan116105,473,180 - 105,555,774 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01670,495,310 - 70,579,275 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11690,162,900 - 90,245,190 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1690,163,950 - 90,245,147 (-)Ensemblpanpan1.1panPan2
FANCA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1563,778,149 - 63,838,869 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl563,778,212 - 63,838,823 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha563,791,001 - 63,853,152 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0564,006,193 - 64,068,100 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl564,006,249 - 64,066,477 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1564,026,242 - 64,086,986 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0563,863,551 - 63,925,841 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0564,270,126 - 64,332,344 (+)NCBIUU_Cfam_GSD_1.0
Fanca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934924,527,532 - 24,567,237 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936641281,073 - 324,053 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936641281,119 - 319,796 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FANCA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6253,207 - 300,152 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16253,207 - 300,159 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26378,761 - 425,687 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FANCA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1575,073,161 - 75,149,110 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl575,073,358 - 75,148,591 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666047286,358 - 422,323 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fanca
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624746215,193 - 252,569 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624746206,069 - 253,473 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fanca
549 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:81
Interacting mature miRNAs:84
Transcripts:ENSRNOT00000022658
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194997648153225766Rat

Markers in Region
D19Got113  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21951,344,675 - 51,344,847 (+)MAPPERmRatBN7.2
Rnor_6.01956,403,073 - 56,403,260NCBIRnor6.0
Rnor_6.01956,108,196 - 56,108,383NCBIRnor6.0
Rnor_5.01966,818,965 - 66,819,152UniSTSRnor5.0
Rnor_5.01967,115,072 - 67,115,259UniSTSRnor5.0
RGSC_v3.41953,629,913 - 53,630,100UniSTSRGSC3.4
Celera1950,580,443 - 50,580,615UniSTS
Cytogenetic Map19q12UniSTS
UniSTS:238171  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21951,304,339 - 51,305,154 (+)MAPPERmRatBN7.2
Rnor_6.01956,067,867 - 56,068,681NCBIRnor6.0
Rnor_5.01966,772,739 - 66,773,553UniSTSRnor5.0
RGSC_v3.41953,588,168 - 53,588,982UniSTSRGSC3.4
Celera1950,540,199 - 50,541,013UniSTS
Cytogenetic Map19q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 10 10 1 10 30 16 23
Low 3 24 44 28 18 28 8 11 44 19 18 11 8
Below cutoff 13 3 3 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000022658   ⟹   ENSRNOP00000022659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1951,304,021 - 51,362,527 (-)Ensembl
Rnor_6.0 Ensembl1956,067,548 - 56,126,063 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101339   ⟹   ENSRNOP00000083808
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1951,344,934 - 51,362,527 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000107501   ⟹   ENSRNOP00000092075
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1951,304,021 - 51,362,527 (-)Ensembl
RefSeq Acc Id: NM_001401252   ⟹   NP_001388181
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81968,212,643 - 68,271,019 (-)NCBI
mRatBN7.21951,304,126 - 51,362,509 (-)NCBI
RefSeq Acc Id: XM_039097888   ⟹   XP_038953816
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81968,213,297 - 68,271,079 (-)NCBI
mRatBN7.21951,304,776 - 51,362,573 (-)NCBI
RefSeq Acc Id: XM_039097889   ⟹   XP_038953817
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81968,210,562 - 68,269,117 (-)NCBI
mRatBN7.21951,304,126 - 51,360,278 (-)NCBI
RefSeq Acc Id: XM_039097892   ⟹   XP_038953820
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81968,215,626 - 68,271,079 (-)NCBI
mRatBN7.21951,307,476 - 51,362,576 (-)NCBI
RefSeq Acc Id: XM_063278163   ⟹   XP_063134233
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81968,210,562 - 68,246,542 (-)NCBI
RefSeq Acc Id: XR_005496676
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81968,229,943 - 68,271,080 (-)NCBI
mRatBN7.21951,321,425 - 51,362,582 (-)NCBI
RefSeq Acc Id: XR_010060017
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81968,232,008 - 68,271,080 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000022659   ⟸   ENSRNOT00000022658
RefSeq Acc Id: XP_038953817   ⟸   XM_039097889
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AGX8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953816   ⟸   XM_039097888
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AGX8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953820   ⟸   XM_039097892
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AGX8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000083808   ⟸   ENSRNOT00000101339
RefSeq Acc Id: ENSRNOP00000092075   ⟸   ENSRNOT00000107501
RefSeq Acc Id: NP_001388181   ⟸   NM_001401252
RefSeq Acc Id: XP_063134233   ⟸   XM_063278163
- Peptide Label: isoform X4
Protein Domains
Fanconi anaemia group A protein N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZQL0-F1-model_v2 AlphaFold D3ZQL0 1-1190 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311380 AgrOrtholog
BioCyc Gene G2FUF-5331 BioCyc
Ensembl Genes ENSRNOG00000016706 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022658.8 UniProtKB/TrEMBL
  ENSRNOT00000101339.1 UniProtKB/TrEMBL
  ENSRNOT00000107501 ENTREZGENE
  ENSRNOT00000107501.1 UniProtKB/TrEMBL
InterPro Fanconi_A_N UniProtKB/TrEMBL
  Fanconia UniProtKB/TrEMBL
KEGG Report rno:361435 UniProtKB/TrEMBL
NCBI Gene 361435 ENTREZGENE
PANTHER FANCONI ANEMIA GROUP A PROTEIN UniProtKB/TrEMBL
  PTHR12047 UniProtKB/TrEMBL
Pfam Fanconi_A UniProtKB/TrEMBL
  Fanconi_A_N UniProtKB/TrEMBL
PhenoGen Fanca PhenoGen
PRINTS FANCONIAGENE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016706 RatGTEx
UniProt A0A8I5ZXD8_RAT UniProtKB/TrEMBL
  A0A8I6AGX8 ENTREZGENE, UniProtKB/TrEMBL
  A6IZX7_RAT UniProtKB/TrEMBL
  D3ZQL0_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Fanca  FA complementation group A  LOC103690042  Fanconi anemia group A protein homolog  Data merged from RGD:9109459 737654 PROVISIONAL
2018-05-25 Fanca  FA complementation group A  Fanca  Fanconi anemia, complementation group A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103690042  Fanconi anemia group A protein homolog      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Fanca  Fanconi anemia, complementation group A   Fanca_predicted  Fanconi anemia, complementation group A (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Fanca_predicted  Fanconi anemia, complementation group A (predicted)      Symbol and Name status set to approved 70820 APPROVED