Ppp1r18 (protein phosphatase 1, regulatory subunit 18) - Rat Genome Database

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Gene: Ppp1r18 (protein phosphatase 1, regulatory subunit 18) Rattus norvegicus
Analyze
Symbol: Ppp1r18
Name: protein phosphatase 1, regulatory subunit 18
RGD ID: 1309543
Description: Predicted to enable phosphatase binding activity. Orthologous to human PPP1R18 (protein phosphatase 1 regulatory subunit 18); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Kiaa1949; LOC361790; phostensin; RGD1309543; similar to 2310014H01Rik protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8202,882,370 - 2,892,329 (-)NCBIGRCr8
mRatBN7.2202,877,567 - 2,887,526 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl202,877,567 - 2,891,802 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx202,929,329 - 2,939,012 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0202,934,300 - 2,943,985 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0202,960,463 - 2,970,126 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0203,372,412 - 3,397,351 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl203,372,413 - 3,397,039 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0205,469,936 - 5,494,453 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,013,902 - 3,034,973 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1203,025,916 - 3,035,199 (-)NCBI
Celera20303,632 - 313,449 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15060004  


Genomics

Comparative Map Data
Ppp1r18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8202,882,370 - 2,892,329 (-)NCBIGRCr8
mRatBN7.2202,877,567 - 2,887,526 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl202,877,567 - 2,891,802 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx202,929,329 - 2,939,012 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0202,934,300 - 2,943,985 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0202,960,463 - 2,970,126 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0203,372,412 - 3,397,351 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl203,372,413 - 3,397,039 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0205,469,936 - 5,494,453 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,013,902 - 3,034,973 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1203,025,916 - 3,035,199 (-)NCBI
Celera20303,632 - 313,449 (-)NCBICelera
Cytogenetic Map20p12NCBI
PPP1R18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38630,676,389 - 30,688,391 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl630,676,389 - 30,687,895 (-)EnsemblGRCh38hg38GRCh38
GRCh37630,644,166 - 30,654,984 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36630,752,145 - 30,761,963 (-)NCBINCBI36Build 36hg18NCBI36
Build 34630,752,146 - 30,761,804NCBI
Celera632,242,303 - 32,253,809 (-)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef630,444,133 - 30,455,610 (-)NCBIHuRef
CHM1_1630,646,276 - 30,657,779 (-)NCBICHM1_1
T2T-CHM13v2.0630,540,595 - 30,552,089 (-)NCBIT2T-CHM13v2.0
Ppp1r18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391736,176,483 - 36,186,488 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1736,176,485 - 36,186,488 (+)EnsemblGRCm39 Ensembl
GRCm381735,865,593 - 35,875,596 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,865,593 - 35,875,596 (+)EnsemblGRCm38mm10GRCm38
MGSCv371736,002,540 - 36,012,541 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361735,474,136 - 35,483,649 (+)NCBIMGSCv36mm8
MGSCv361734,955,011 - 34,964,657 (+)NCBIMGSCv36mm8
Celera1739,375,419 - 39,385,004 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.72NCBI
Ppp1r18
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955583673,393 - 680,836 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955583673,634 - 681,439 (-)NCBIChiLan1.0ChiLan1.0
PPP1R18
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2545,236,579 - 45,248,063 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1641,199,780 - 41,210,720 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0630,421,134 - 30,431,964 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1631,290,562 - 31,301,566 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl631,290,562 - 31,301,566 (-)Ensemblpanpan1.1panPan2
NRM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.112490,298 - 493,195 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl12490,298 - 493,145 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha12627,598 - 630,516 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.012633,443 - 636,365 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl12634,020 - 636,290 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.112490,793 - 493,925 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.012560,292 - 563,213 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.012628,875 - 631,801 (-)NCBIUU_Cfam_GSD_1.0
Ppp1r18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494633,980,319 - 33,991,274 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936837345,570 - 355,058 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936837345,578 - 356,175 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1R18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl723,211,808 - 23,221,384 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1723,211,806 - 23,222,295 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2726,933,736 - 26,944,155 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1R18
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11741,765,854 - 41,777,697 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1741,766,517 - 41,778,265 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604430,373,563 - 30,385,064 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp1r18
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475425,027,792 - 25,034,842 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppp1r18
80 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:365
Count of miRNA genes:196
Interacting mature miRNAs:227
Transcripts:ENSRNOT00000001084
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724519Bp144Blood pressure QTL 1440.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2013624629Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2026463954597031Rat
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2026463954597031Rat

Markers in Region
D20Rat71  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2202,883,677 - 2,883,902 (+)MAPPERmRatBN7.2
Rnor_6.020100,252 - 100,476NCBIRnor6.0
Rnor_6.0203,393,191 - 3,393,415NCBIRnor6.0
Rnor_5.0205,490,294 - 5,490,518UniSTSRnor5.0
Rnor_5.020101,389 - 101,613UniSTSRnor5.0
RGSC_v3.4203,031,125 - 3,031,349UniSTSRGSC3.4
RGSC_v3.4203,031,124 - 3,031,349RGDRGSC3.4
RGSC_v3.1203,031,351 - 3,031,576RGD
Celera20309,601 - 309,825UniSTS
SHRSP x BN Map200.0UniSTS
SHRSP x BN Map200.0RGD
Cytogenetic Map20p12UniSTS
AI450394  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2202,877,814 - 2,877,908 (+)MAPPERmRatBN7.2
Rnor_6.0203,372,661 - 3,372,754NCBIRnor6.0
Rnor_5.0205,470,184 - 5,470,277UniSTSRnor5.0
Celera20303,880 - 303,973UniSTS
Cytogenetic Map20p12UniSTS
RH139928  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2202,889,011 - 2,889,198 (+)MAPPERmRatBN7.2
Rnor_6.0203,398,525 - 3,398,711NCBIRnor6.0
Rnor_5.0205,495,628 - 5,495,814UniSTSRnor5.0
RGSC_v3.4203,036,459 - 3,036,645UniSTSRGSC3.4
Celera20314,935 - 315,121UniSTS
RH 3.4 Map2052.1UniSTS
Cytogenetic Map20p12UniSTS
AI236751  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2202,888,651 - 2,888,773 (+)MAPPERmRatBN7.2
Rnor_6.0203,398,165 - 3,398,286NCBIRnor6.0
Rnor_5.0205,495,268 - 5,495,389UniSTSRnor5.0
RGSC_v3.4203,036,099 - 3,036,220UniSTSRGSC3.4
Celera20314,575 - 314,696UniSTS
RH 3.4 Map2015.8UniSTS
Cytogenetic Map20p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 33 21 6 19 6 53 21 34 11
Low 1 10 36 35 35 8 11 21 14 7 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000001084   ⟹   ENSRNOP00000001084
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl203,372,413 - 3,397,039 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000082999   ⟹   ENSRNOP00000069345
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl203,372,413 - 3,374,344 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085259   ⟹   ENSRNOP00000074541
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl203,394,425 - 3,397,039 (-)Ensembl
RefSeq Acc Id: NM_001126287   ⟹   NP_001119759
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8202,882,370 - 2,892,329 (-)NCBI
mRatBN7.2202,877,567 - 2,887,526 (-)NCBI
Rnor_6.0203,372,413 - 3,397,039 (-)NCBI
Rnor_5.0205,469,936 - 5,494,453 (-)NCBI
RGSC_v3.4203,013,902 - 3,034,973 (-)RGD
Celera20303,632 - 313,449 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001119759 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI61960 (Get FASTA)   NCBI Sequence Viewer  
  EDL86736 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001084
  ENSRNOP00000001084.5
  ENSRNOP00000080259.1
Reference Protein Sequences
RefSeq Acc Id: NP_001119759   ⟸   NM_001126287
- UniProtKB: G3V629 (UniProtKB/TrEMBL),   B1WC08 (UniProtKB/TrEMBL),   A6KT82 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069345   ⟸   ENSRNOT00000082999
RefSeq Acc Id: ENSRNOP00000074541   ⟸   ENSRNOT00000085259
RefSeq Acc Id: ENSRNOP00000001084   ⟸   ENSRNOT00000001084
Protein Domains
Phostensin/Taperin N-terminal   Phostensin/Taperin PP1-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V629-F1-model_v2 AlphaFold G3V629 1-597 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701298
Promoter ID:EPDNEW_R11822
Type:multiple initiation site
Name:Ppp1r18_1
Description:protein phosphatase 1, regulatory subunit 18
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0203,397,047 - 3,397,107EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309543 AgrOrtholog
BioCyc Gene G2FUF-4782 BioCyc
Ensembl Genes ENSRNOG00000000816 Ensembl
  ENSRNOG00000000818 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001084 ENTREZGENE
  ENSRNOT00000001084.8 UniProtKB/TrEMBL
  ENSRNOT00000081611.2 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9027646 IMAGE-MGC_LOAD
InterPro Phostensin/Taperin_N_dom UniProtKB/TrEMBL
  Phostensin/Taperin_PP1-bd_dom UniProtKB/TrEMBL
  PPP1R18/Tprn UniProtKB/TrEMBL
KEGG Report rno:361790 UniProtKB/TrEMBL
MGC_CLONE MGC:187762 IMAGE-MGC_LOAD
NCBI Gene 361790 ENTREZGENE
PANTHER PHOSTENSIN UniProtKB/TrEMBL
  PTHR21685 UniProtKB/TrEMBL
Pfam Phostensin UniProtKB/TrEMBL
  Phostensin_N UniProtKB/TrEMBL
PhenoGen Ppp1r18 PhenoGen
RatGTEx ENSRNOG00000000816 RatGTEx
  ENSRNOG00000000818 RatGTEx
UniProt A0A8I5ZP80_RAT UniProtKB/TrEMBL
  A6KT82 ENTREZGENE, UniProtKB/TrEMBL
  B1WC08 ENTREZGENE
  G3V629 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B1WC08 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-10-21 Ppp1r18  protein phosphatase 1, regulatory subunit 18  RGD1309543  similar to 2310014H01Rik protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1309543  similar to 2310014H01Rik protein   RGD1309543_predicted  similar to 2310014H01Rik protein (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1309543_predicted  similar to 2310014H01Rik protein (predicted)  LOC361790_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC361790_predicted  similar to 2310014H01Rik protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL