Kdm2a (lysine demethylase 2A) - Rat Genome Database

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Gene: Kdm2a (lysine demethylase 2A) Rattus norvegicus
Analyze
Symbol: Kdm2a
Name: lysine demethylase 2A
RGD ID: 1309419
Description: Predicted to enable several functions, including histone H3K36 demethylase activity; unmethylated CpG binding activity; and zinc ion binding activity. Predicted to be involved in double-strand break repair via nonhomologous end joining; regulation of circadian rhythm; and regulation of gene expression. Predicted to act upstream of or within several processes, including epithelial tube morphogenesis; neuroepithelial cell differentiation; and regulation of gene expression. Predicted to be located in chromatin and nucleoplasm. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human KDM2A (lysine demethylase 2A); PARTICIPATES IN DNA modification pathway; histone modification pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: F-box and leucine-rich repeat protein 11; Fbxl11; LOC361700; lysine (K)-specific demethylase 2A; lysine-specific demethylase 2A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81211,041,859 - 211,125,749 (-)NCBIGRCr8
mRatBN7.21201,612,427 - 201,682,359 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1201,612,453 - 201,680,787 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1209,964,511 - 210,033,280 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01217,057,845 - 217,126,197 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01209,748,863 - 209,817,220 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,566,130 - 219,642,294 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,566,156 - 219,640,294 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01226,436,243 - 226,509,594 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41206,903,426 - 206,972,100 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11207,057,263 - 207,125,981 (-)NCBI
Celera1199,156,169 - 199,224,605 (-)NCBICelera
Cytogenetic Map1q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
Kdm2aRatcongestive heart failure  ISOKdm2a (Mus musculus)9588275protein:altered localization:promoter (mouse)RGD 
Kdm2aRatlung non-small cell carcinoma severityISOKDM2A (Homo sapiens)9588263mRNA:increased expression:stomach (human)RGD 
Kdm2aRatlung non-small cell carcinoma  ISOKDM2A (Homo sapiens)9588265human gene in a mouse modelRGD 
Object Symbol
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Reference
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Original Reference(s)
Kdm2aRatAicardi-Goutieres Syndrome 3  ISOKDM2A (Homo sapiens)8554872ClinVar Annotator: match by term: Aicardi-Goutieres syndrome 3ClinVarPMID:28492532
Kdm2aRatimmunodeficiency 90  ISOKDM2A (Homo sapiens)8554872ClinVar Annotator: match by term: Infections more ...ClinVarPMID:28492532
Kdm2aRatintellectual disability  ISOKDM2A (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
Kdm2aRatNeurodevelopmental Disorders  ISOKDM2A (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868 and PMID:38060137
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Kdm2aRatColorectal Neoplasms  ISOKDM2A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25944804
Kdm2aRatFamilial Prostate Cancer  ISOKDM2A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29892016

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Original Reference(s)
Kdm2aRat(1->4)-beta-D-glucan multiple interactionsISOKdm2a (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of KDM2A mRNACTDPMID:36331819
Kdm2aRat1,2-dichloroethane affects expressionISOKdm2a (Mus musculus)6480464ethylene dichloride affects the expression of KDM2A mRNACTDPMID:28960355
Kdm2aRat17alpha-ethynylestradiol multiple interactionsISOKdm2a (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KDM2A mRNACTDPMID:17942748
Kdm2aRat17beta-estradiol increases expressionISOKdm2a (Mus musculus)6480464Estradiol results in increased expression of KDM2A mRNACTDPMID:39298647
Kdm2aRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOKdm2a (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KDM2A mRNACTDPMID:17942748
Kdm2aRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of KDM2A mRNACTDPMID:33387578
Kdm2aRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of KDM2A mRNACTDPMID:34747641
Kdm2aRat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of KDM2A mRNACTDPMID:21346803
Kdm2aRat4,4'-sulfonyldiphenol decreases expressionISOKdm2a (Mus musculus)6480464bisphenol S results in decreased expression of KDM2A mRNACTDPMID:39298647
Kdm2aRat4,4'-sulfonyldiphenol multiple interactionsISOKDM2A (Homo sapiens)6480464[KDM2A protein co-treated with bisphenol S] results in decreased expression of and results in decreased activity of TET2 protein more ...CTDPMID:37315367
Kdm2aRat4,4'-sulfonyldiphenol increases expressionISOKDM2A (Homo sapiens)6480464bisphenol S results in increased expression of KDM2A mRNA and bisphenol S results in increased expression of KDM2A proteinCTDPMID:37315367
Kdm2aRatacrolein multiple interactionsISOKDM2A (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of KDM2A mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of KDM2A mRNACTDPMID:32699268
Kdm2aRatacrylamide increases expressionISOKDM2A (Homo sapiens)6480464Acrylamide results in increased expression of KDM2A mRNACTDPMID:32763439
Kdm2aRataflatoxin B1 increases expressionISOKdm2a (Mus musculus)6480464Aflatoxin B1 results in increased expression of KDM2A mRNACTDPMID:19770486
Kdm2aRatall-trans-retinoic acid increases expressionISOKDM2A (Homo sapiens)6480464Tretinoin results in increased expression of KDM2A mRNACTDPMID:33167477
Kdm2aRatalpha-pinene multiple interactionsISOKDM2A (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of KDM2A mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of KDM2A mRNACTDPMID:32699268
Kdm2aRatantirheumatic drug decreases expressionISOKDM2A (Homo sapiens)6480464Antirheumatic Agents results in decreased expression of KDM2A mRNACTDPMID:24449571
Kdm2aRatarsane multiple interactionsISOKDM2A (Homo sapiens)6480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of KDM2A mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of KDM2A mRNACTDPMID:39836092
Kdm2aRatarsenic atom multiple interactionsISOKDM2A (Homo sapiens)6480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of KDM2A mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of KDM2A mRNACTDPMID:39836092
Kdm2aRatarsenous acid increases expressionISOKDM2A (Homo sapiens)6480464Arsenic Trioxide results in increased expression of KDM2A mRNACTDPMID:20458559

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Biological Process
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Original Reference(s)
Kdm2aRatchromatin organization involved_inIEAUniProtKB-KW:KW-01561600115GO_REF:0000043UniProtGO_REF:0000043
Kdm2aRatchromatin remodeling involved_inIBAMGI:1338034 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Kdm2aRatchromatin remodeling involved_inIEAARBA:ARBA000279941600115GO_REF:0000117UniProtGO_REF:0000117
Kdm2aRatcircadian regulation of gene expression involved_inISOKDM2A (Homo sapiens)1624291 PMID:26037310RGDPMID:26037310
Kdm2aRatcircadian regulation of gene expression involved_inIEAUniProtKB:Q9Y2K7 and ensembl:ENSP000004327861600115GO_REF:0000107EnsemblGO_REF:0000107
Kdm2aRatdouble-strand break repair via nonhomologous end joining involved_inISOKDM2A (Homo sapiens)1624291 PMID:21187428RGDPMID:21187428
Kdm2aRatdouble-strand break repair via nonhomologous end joining involved_inIEAUniProtKB:Q9Y2K7 and ensembl:ENSP000004327861600115GO_REF:0000107EnsemblGO_REF:0000107
Kdm2aRatheart looping acts_upstream_of_or_withinISOKdm2a (Mus musculus)1624291 PMID:25463925RGDPMID:25463925
Kdm2aRatin utero embryonic development acts_upstream_of_or_withinISOKdm2a (Mus musculus)1624291 PMID:25463925RGDPMID:25463925
Kdm2aRatmulticellular organism growth acts_upstream_of_or_withinISOKdm2a (Mus musculus)1624291 PMID:25463925RGDPMID:25463925
Kdm2aRatnegative regulation of apoptotic process acts_upstream_of_or_withinISOKdm2a (Mus musculus)1624291 PMID:25463925RGDPMID:25463925
Kdm2aRatnegative regulation of gene expression acts_upstream_of_or_withinISOKdm2a (Mus musculus)1624291 PMID:25463925RGDPMID:25463925
Kdm2aRatnegative regulation of transcription by competitive promoter binding involved_inISOKDM2A (Homo sapiens)1624291 PMID:26037310RGDPMID:26037310
Kdm2aRatnegative regulation of transcription by competitive promoter binding involved_inIEAUniProtKB:Q9Y2K7 and ensembl:ENSP000004327861600115GO_REF:0000107EnsemblGO_REF:0000107
Kdm2aRatneural tube closure acts_upstream_of_or_withinISOKdm2a (Mus musculus)1624291 PMID:25463925RGDPMID:25463925
Kdm2aRatneuroepithelial cell differentiation acts_upstream_of_or_withinISOKdm2a (Mus musculus)1624291 PMID:25463925RGDPMID:25463925
Kdm2aRatneuron differentiation acts_upstream_of_or_withinISOKdm2a (Mus musculus)1624291 PMID:25463925RGDPMID:25463925
Kdm2aRatpositive regulation of gene expression acts_upstream_of_or_withinISOKdm2a (Mus musculus)1624291 PMID:25463925RGDPMID:25463925
Kdm2aRatregulation of circadian rhythm involved_inISOKDM2A (Homo sapiens)1624291 PMID:26037310RGDPMID:26037310
Kdm2aRatregulation of circadian rhythm involved_inIEAUniProtKB:Q9Y2K7 and ensembl:ENSP000004327861600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component

  
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Original Reference(s)
Kdm2aRatchromatin located_inISOKdm2a (Mus musculus)1624291 PMID:20417597 and PMID:32584788RGDPMID:20417597 and PMID:32584788
Kdm2aRatnucleoplasm located_inIEAUniProtKB:Q9Y2K7 and ensembl:ENSP000004327861600115GO_REF:0000107EnsemblGO_REF:0000107
Kdm2aRatnucleoplasm located_inISOKDM2A (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Kdm2aRatnucleoplasm located_inIEAUniProtKB:I3VM53 and ensembl:ENSP000004327861600115GO_REF:0000107EnsemblGO_REF:0000107
Kdm2aRatnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Kdm2aRatnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043

Molecular Function
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Original Reference(s)
Kdm2aRatdioxygenase activity enablesIEAUniProtKB-KW:KW-02231600115GO_REF:0000043UniProtGO_REF:0000043
Kdm2aRatDNA binding enablesIEAInterPro:IPR0028571600115GO_REF:0000002InterProGO_REF:0000002
Kdm2aRathistone demethylase activity enablesIBAFB:FBgn0037659 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Kdm2aRathistone H3K36 demethylase activity enablesISOKDM2A (Homo sapiens)1624291 PMID:20417597 more ...RGDPMID:20417597 more ...
Kdm2aRathistone H3K36 demethylase activity enablesIEAUniProtKB:Q9Y2K7 and ensembl:ENSP000004327861600115GO_REF:0000107EnsemblGO_REF:0000107
Kdm2aRatmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Kdm2aRatoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
Kdm2aRatprotein binding enablesISOKDM2A (Homo sapiens)1624291UniProtKB:P63208 more ...RGDPMID:15070733 more ...
Kdm2aRattranscription coregulator activity enablesIBAPANTHER:PTN000564171 and UniProtKB:O751511600115GO_REF:0000033GO_CentralGO_REF:0000033
Kdm2aRatunmethylated CpG binding enablesISOKDM2A (Homo sapiens)1624291 PMID:29276034RGDPMID:29276034
Kdm2aRatunmethylated CpG binding enablesISOKdm2a (Mus musculus)1624291 PMID:20417597RGDPMID:20417597
Kdm2aRatunmethylated CpG binding enablesIEAUniProtKB:Q9Y2K7 and ensembl:ENSP000004327861600115GO_REF:0000107EnsemblGO_REF:0000107
Kdm2aRatzinc ion binding enablesISOKDM2A (Homo sapiens)1624291 PMID:29276034RGDPMID:29276034
Kdm2aRatzinc ion binding enablesIEAInterPro:IPR0028571600115GO_REF:0000002InterProGO_REF:0000002
Kdm2aRatzinc ion binding enablesIEAUniProtKB-KW:KW-08631600115GO_REF:0000043UniProtGO_REF:0000043
Kdm2aRatzinc ion binding enablesIEAUniProtKB:Q9Y2K7 and ensembl:ENSP000004327861600115GO_REF:0000107EnsemblGO_REF:0000107
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RGD Manual Annotations


  
Object Symbol
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Original Reference(s)
Kdm2aRatDNA modification pathway   ISOKDM2A (Homo sapiens)9479164 RGD 
Kdm2aRathistone modification pathway   ISOKDM2A (Homo sapiens)7242632 RGD 

#
Reference Title
Reference Citation
1. Epigenetic switch at atp2a2 and myh7 gene promoters in pressure overload-induced heart failure. Angrisano T, etal., PLoS One. 2014 Sep 2;9(9):e106024. doi: 10.1371/journal.pone.0106024. eCollection 2014.
2. Histone lysine methylation dynamics: establishment, regulation, and biological impact. Black JC, etal., Mol Cell. 2012 Nov 30;48(4):491-507. doi: 10.1016/j.molcel.2012.11.006.
3. Transcriptional repression of histone deacetylase 3 by the histone demethylase KDM2A is coupled to tumorigenicity of lung cancer cells. Dhar SS, etal., J Biol Chem. 2014 Mar 14;289(11):7483-96. doi: 10.1074/jbc.M113.521625. Epub 2014 Jan 30.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection. Long HK, etal., Biochem Soc Trans. 2013 Jun;41(3):727-40. doi: 10.1042/BST20130028.
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling. Wagner KW, etal., J Clin Invest. 2013 Dec 2;123(12):5231-46. doi: 10.1172/JCI68642. Epub 2013 Nov 8.
PMID:20417597   PMID:21187428   PMID:25463925   PMID:26037310   PMID:28262558   PMID:29276034   PMID:36723950  



Kdm2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81211,041,859 - 211,125,749 (-)NCBIGRCr8
mRatBN7.21201,612,427 - 201,682,359 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1201,612,453 - 201,680,787 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1209,964,511 - 210,033,280 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01217,057,845 - 217,126,197 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01209,748,863 - 209,817,220 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,566,130 - 219,642,294 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,566,156 - 219,640,294 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01226,436,243 - 226,509,594 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41206,903,426 - 206,972,100 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11207,057,263 - 207,125,981 (-)NCBI
Celera1199,156,169 - 199,224,605 (-)NCBICelera
Cytogenetic Map1q43NCBI
KDM2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381167,119,263 - 67,258,082 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1167,119,263 - 67,258,082 (+)EnsemblGRCh38hg38GRCh38
GRCh371166,886,734 - 67,025,553 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361166,644,074 - 66,781,717 (+)NCBINCBI36Build 36hg18NCBI36
Build 341166,644,073 - 66,781,717NCBI
Celera1164,216,493 - 64,358,014 (+)NCBICelera
Cytogenetic Map11q13.2NCBI
HuRef1163,214,819 - 63,354,668 (+)NCBIHuRef
CHM1_11166,769,756 - 66,908,574 (+)NCBICHM1_1
T2T-CHM13v2.01167,110,939 - 67,252,047 (+)NCBIT2T-CHM13v2.0
Kdm2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39194,366,172 - 4,448,749 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl194,364,447 - 4,448,313 (-)EnsemblGRCm39 Ensembl
GRCm38194,316,144 - 4,398,721 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl194,314,419 - 4,398,285 (-)EnsemblGRCm38mm10GRCm38
MGSCv37194,316,144 - 4,397,077 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36194,317,806 - 4,398,266 (-)NCBIMGSCv36mm8
Celera194,187,040 - 4,267,780 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map194.01NCBI
Kdm2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542218,200,758 - 18,308,163 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542218,201,243 - 18,308,163 (-)NCBIChiLan1.0ChiLan1.0
KDM2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2968,339,000 - 68,484,737 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11169,381,707 - 69,527,213 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01162,470,549 - 62,616,135 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11165,793,464 - 65,930,509 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1165,793,464 - 65,930,498 (+)Ensemblpanpan1.1panPan2
KDM2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11850,178,511 - 50,294,097 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1850,181,024 - 50,291,127 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1848,788,733 - 48,940,137 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01851,127,518 - 51,280,575 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1851,127,518 - 51,241,565 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11850,313,570 - 50,464,719 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01849,888,074 - 50,039,414 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01850,682,691 - 50,834,402 (-)NCBIUU_Cfam_GSD_1.0
Kdm2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049476,024,717 - 6,134,274 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365992,466,214 - 2,576,623 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365992,466,427 - 2,576,623 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KDM2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl25,240,312 - 5,357,829 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.125,238,690 - 5,357,799 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.224,021,430 - 4,050,212 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.224,143,872 - 4,182,749 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KDM2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.117,004,109 - 7,152,072 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl17,003,784 - 7,082,720 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038104,292,429 - 104,442,261 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kdm2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476719,248,430 - 19,364,793 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476719,247,009 - 19,365,520 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Kdm2a
282 total Variants

Predicted Target Of
Summary Value
Count of predictions:413
Count of miRNA genes:218
Interacting mature miRNAs:287
Transcripts:ENSRNOT00000054850
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 85 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat

1 to 10 of 85 rows
RH129222  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21201,612,485 - 201,612,672 (+)MAPPERmRatBN7.2
Rnor_6.01219,566,189 - 219,566,375NCBIRnor6.0
Rnor_5.01226,436,302 - 226,436,488UniSTSRnor5.0
RGSC_v3.41206,903,483 - 206,903,669UniSTSRGSC3.4
Celera1199,156,226 - 199,156,412UniSTS
RH 3.4 Map11559.0UniSTS
Cytogenetic Map1q42UniSTS
AW536790  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21201,612,636 - 201,612,743 (+)MAPPERmRatBN7.2
Rnor_6.01219,566,340 - 219,566,446NCBIRnor6.0
Rnor_5.01226,436,453 - 226,436,559UniSTSRnor5.0
RGSC_v3.41206,903,634 - 206,903,740UniSTSRGSC3.4
Celera1199,156,377 - 199,156,483UniSTS
Cytogenetic Map1q42UniSTS
BF390516  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21201,637,567 - 201,637,749 (+)MAPPERmRatBN7.2
Rnor_6.01219,591,270 - 219,591,451NCBIRnor6.0
Rnor_5.01226,461,383 - 226,461,564UniSTSRnor5.0
RGSC_v3.41206,928,565 - 206,928,746UniSTSRGSC3.4
Celera1199,181,307 - 199,181,488UniSTS
RH 3.4 Map11558.4UniSTS
Cytogenetic Map1q42UniSTS
UniSTS:224510  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21201,614,169 - 201,614,339 (+)MAPPERmRatBN7.2
Rnor_6.01219,567,873 - 219,568,042NCBIRnor6.0
Rnor_5.01226,437,986 - 226,438,155UniSTSRnor5.0
RGSC_v3.41206,905,167 - 206,905,336UniSTSRGSC3.4
Celera1199,157,910 - 199,158,079UniSTS
Cytogenetic Map1q42UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000054850   ⟹   ENSRNOP00000051732
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1201,612,453 - 201,680,787 (-)Ensembl
Rnor_6.0 Ensembl1219,566,156 - 219,640,294 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098321   ⟹   ENSRNOP00000097302
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1201,612,453 - 201,655,048 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113561   ⟹   ENSRNOP00000096348
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1201,675,826 - 201,678,968 (-)Ensembl
RefSeq Acc Id: NM_001108515   ⟹   NP_001101985
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81211,041,861 - 211,110,215 (-)NCBI
mRatBN7.21201,612,429 - 201,680,787 (-)NCBI
Rnor_6.01219,566,132 - 219,640,294 (-)NCBI
Rnor_5.01226,436,243 - 226,509,594 (-)NCBI
RGSC_v3.41206,903,426 - 206,972,100 (-)RGD
Celera1199,156,169 - 199,224,605 (-)RGD
Sequence:
RefSeq Acc Id: XM_039083854   ⟹   XP_038939782
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81211,041,859 - 211,059,221 (-)NCBI
mRatBN7.21201,612,427 - 201,629,792 (-)NCBI
RefSeq Acc Id: XM_063268221   ⟹   XP_063124291
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81211,041,859 - 211,125,749 (-)NCBI
RefSeq Acc Id: XM_063268222   ⟹   XP_063124292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81211,041,859 - 211,110,878 (-)NCBI
RefSeq Acc Id: XM_063268223   ⟹   XP_063124293
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81211,041,859 - 211,116,765 (-)NCBI
1 to 10 of 10 rows
Protein RefSeqs NP_001101985 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939782 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124291 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124292 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124293 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM12402 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000051732.2
  ENSRNOP00000096348.1
  ENSRNOP00000097302
  ENSRNOP00000097302.1
1 to 10 of 10 rows
RefSeq Acc Id: NP_001101985   ⟸   NM_001108515
- UniProtKB: D3ZTJ7 (UniProtKB/TrEMBL),   A6HYX1 (UniProtKB/TrEMBL),   A0A8I6ARD6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000051732   ⟸   ENSRNOT00000054850
RefSeq Acc Id: XP_038939782   ⟸   XM_039083854
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000096348   ⟸   ENSRNOT00000113561
Ensembl Acc Id: ENSRNOP00000097302   ⟸   ENSRNOT00000098321
CXXC-type   JmjC   PHD-type

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZTJ7-F1-model_v2 AlphaFold D3ZTJ7 1-1161 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 46 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-56756 BioCyc
Ensembl Genes ENSRNOG00000019145 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000054850.3 UniProtKB/TrEMBL
  ENSRNOT00000098321 ENTREZGENE
  ENSRNOT00000098321.1 UniProtKB/TrEMBL
  ENSRNOT00000113561.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.1360 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
  6.10.280.250 UniProtKB/TrEMBL
  Cupin UniProtKB/TrEMBL
InterPro F-box_dom_cyclin-like UniProtKB/TrEMBL
  JHD UniProtKB/TrEMBL
  JHDM1_Histone_Demethylase UniProtKB/TrEMBL
  L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt_Cys-con_subtyp UniProtKB/TrEMBL
  TF_JmjC_AAH UniProtKB/TrEMBL
  Zinc_finger_PHD-type_CS UniProtKB/TrEMBL
  Znf_CXXC UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
  Znf_PHD UniProtKB/TrEMBL
  Znf_PHD-finger UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
KEGG Report rno:361700 UniProtKB/TrEMBL
NCBI Gene 361700 ENTREZGENE
PANTHER PHD/F-BOX CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam F-box-like UniProtKB/TrEMBL
  JHD UniProtKB/TrEMBL
  PHD_4 UniProtKB/TrEMBL
  zf-CXXC UniProtKB/TrEMBL
PhenoGen Kdm2a PhenoGen
PROSITE JMJC UniProtKB/TrEMBL
  ZF_CXXC UniProtKB/TrEMBL
  ZF_PHD_1 UniProtKB/TrEMBL
  ZF_PHD_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019145 RatGTEx
SMART JmjC UniProtKB/TrEMBL
  LRR_CC UniProtKB/TrEMBL
  PHD UniProtKB/TrEMBL
Superfamily-SCOP Clavaminate synthase-like UniProtKB/TrEMBL
1 to 40 of 46 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Kdm2a  lysine demethylase 2A  Kdm2a  lysine (K)-specific demethylase 2A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-20 Kdm2a  lysine (K)-specific demethylase 2A  Fbxl11  F-box and leucine-rich repeat protein 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Fbxl11  F-box and leucine-rich repeat protein 11   Fbxl11_predicted  F-box and leucine-rich repeat protein 11 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Fbxl11_predicted  F-box and leucine-rich repeat protein 11 (predicted)      Symbol and Name status set to approved 70820 APPROVED