Setsip (SET like protein) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Setsip (SET like protein) Rattus norvegicus
Analyze
Symbol: Setsip
Name: SET like protein
RGD ID: 1307467
Description: Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in endothelial cell differentiation and positive regulation of transcription by RNA polymerase II. Predicted to be located in several cellular components, including lipid droplet; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 58. Orthologous to several human genes including SET (SET nuclear proto-oncogene); INTERACTS WITH acetamide; bisphenol A; thioacetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ab1-115; I-2PP2A; liver regeneration-related protein LRRGR00002; LOC307947; phosphatase 2A inhibitor I2PP2A; Set; SET nuclear oncogene; SET nuclear proto-oncogene; SET translocation; TAF-I; template-activating factor I
RGD Orthologs
Human
Bonobo
Dog
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81970,458,604 - 70,460,122 (+)NCBIGRCr8
mRatBN7.21953,561,262 - 53,562,780 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1953,561,190 - 53,563,819 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01958,420,635 - 58,422,153 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1958,419,961 - 58,421,504 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01969,119,722 - 69,121,240 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41955,797,060 - 55,798,578 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11955,801,940 - 55,803,459 (+)NCBI
Celera1952,922,285 - 52,923,803 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
SetsipRatautosomal dominant intellectual developmental disorder 58  ISOSETSIP (Homo sapiens)8554872ClinVar Annotator: match by term: INTELLECTUAL DEVELOPMENTAL DISORDER and AUTOSOMAL DOMINANT 58ClinVarPMID:25741868

1 to 14 of 14 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
SetsipRat17beta-estradiol increases expressionISOSETSIP (Homo sapiens)6480464Estradiol results in increased expression of SETSIP mRNACTDPMID:31614463
SetsipRatacetamide increases expressionEXP 6480464acetamide results in increased expression of SETSIP mRNACTDPMID:31881176
SetsipRatarsane multiple interactionsISOSETSIP (Homo sapiens)6480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of SETSIP mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SETSIP mRNACTDPMID:39836092
SetsipRatarsenic atom multiple interactionsISOSETSIP (Homo sapiens)6480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of SETSIP mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SETSIP mRNACTDPMID:39836092
SetsipRatbisphenol A multiple interactionsEXP 6480464[bisphenol A co-treated with tributyltin] results in decreased expression of SETSIP mRNACTDPMID:31129395
SetsipRatbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of SETSIP mRNACTDPMID:25181051
SetsipRatcadmium dichloride increases expressionISOSETSIP (Homo sapiens)6480464Cadmium Chloride results in increased expression of SETSIP mRNACTDPMID:26472689
SetsipRatmanganese atom multiple interactionsISOSETSIP (Homo sapiens)6480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of SETSIP mRNACTDPMID:39836092
SetsipRatmanganese(0) multiple interactionsISOSETSIP (Homo sapiens)6480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of SETSIP mRNACTDPMID:39836092
SetsipRatmanganese(II) chloride multiple interactionsISOSETSIP (Homo sapiens)6480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of SETSIP mRNACTDPMID:39836092
SetsipRatsodium arsenite multiple interactionsISOSETSIP (Homo sapiens)6480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of SETSIP mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SETSIP mRNACTDPMID:39836092
SetsipRatthioacetamide decreases expressionEXP 6480464Thioacetamide results in decreased expression of SETSIP mRNACTDPMID:23411599
SetsipRattributylstannane multiple interactionsEXP 6480464[bisphenol A co-treated with tributyltin] results in decreased expression of SETSIP mRNACTDPMID:31129395
SetsipRattrichloroethene increases methylationEXP 6480464Trichloroethylene results in increased methylation of SETSIP geneCTDPMID:27618143

1 to 14 of 14 rows

Biological Process

  

Cellular Component
1 to 16 of 16 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
SetsipRatchromatin is_active_inIBAPANTHER:PTN000221934 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
SetsipRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
SetsipRatcytoplasm located_inISOSETSIP (Homo sapiens)1624291 PMID:22869753RGDPMID:22869753
SetsipRatcytoplasm located_inISSUniProtKB:Q011051600115GO_REF:0000024UniProtGO_REF:0000024
SetsipRatcytosol located_inIEAUniProtKB-SubCell:SL-00911600115GO_REF:0000044UniProtGO_REF:0000044
SetsipRatendoplasmic reticulum located_inIEAUniProtKB-SubCell:SL-00951600115GO_REF:0000044UniProtGO_REF:0000044
SetsipRatendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
SetsipRatendoplasmic reticulum located_inISSUniProtKB:Q011051600115GO_REF:0000024UniProtGO_REF:0000024
SetsipRatlipid droplet located_inISOSETSIP (Homo sapiens)1624291 RGDGO_REF:0000052
SetsipRatnucleoplasm located_inIEAUniProtKB-SubCell:SL-01901600115GO_REF:0000044UniProtGO_REF:0000044
SetsipRatnucleoplasm located_inISOSETSIP (Homo sapiens)1624291 RGDGO_REF:0000052
SetsipRatnucleus located_inISOSETSIP (Homo sapiens)1624291 PMID:22869753RGDPMID:22869753
SetsipRatnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
SetsipRatnucleus located_inIEAInterPro:IPR0021641600115GO_REF:0000002InterProGO_REF:0000002
SetsipRatnucleus is_active_inIBAFB:FBgn0015268 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
SetsipRatperinuclear region of cytoplasm located_inISSUniProtKB:Q011051600115GO_REF:0000024UniProtGO_REF:0000024
1 to 16 of 16 rows

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
SetsipRatchromatin binding enablesISOSETSIP (Homo sapiens)1624291 PMID:22869753RGDPMID:22869753
SetsipRatchromatin binding enablesIBAMGI:106654 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
SetsipRatDNA binding enablesIEAUniProtKB-KW:KW-02381600115GO_REF:0000043UniProtGO_REF:0000043
SetsipRathistone binding enablesIBAFB:FBgn0015268 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
SetsipRatprotein binding enablesIPIUniProtKB:Q9R0N38693368PMID:24882364ParkinsonsUK-UCL 


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Synaptotagmin 11 interacts with components of the RNA-induced silencing complex RISC in clonal pancreatic beta-cells. Milochau A, etal., FEBS Lett. 2014 Jun 27;588(14):2217-22. doi: 10.1016/j.febslet.2014.05.031. Epub 2014 May 29.
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:7508204   PMID:8889548   PMID:10715114   PMID:10716735   PMID:11078917   PMID:11555662   PMID:11909973   PMID:12477932   PMID:12524539   PMID:16162853   PMID:16396499   PMID:16791210  
PMID:17065150   PMID:18374643   PMID:19343227   PMID:20651003   PMID:23233674  



Setsip
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81970,458,604 - 70,460,122 (+)NCBIGRCr8
mRatBN7.21953,561,262 - 53,562,780 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1953,561,190 - 53,563,819 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01958,420,635 - 58,422,153 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1958,419,961 - 58,421,504 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01969,119,722 - 69,121,240 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41955,797,060 - 55,798,578 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11955,801,940 - 55,803,459 (+)NCBI
Celera1952,922,285 - 52,923,803 (+)NCBICelera
Cytogenetic Map19q12NCBI
SETSIP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38192,074,533 - 92,075,411 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl192,074,533 - 92,075,411 (-)EnsemblGRCh38hg38GRCh38
GRCh37192,540,090 - 92,540,968 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36192,311,800 - 92,313,616 (-)NCBINCBI36Build 36hg18NCBI36
Celera190,786,534 - 90,787,409 (-)NCBICelera
Cytogenetic Map1p22.1ENTREZGENE
HuRef190,660,347 - 90,661,222 (-)NCBIHuRef
CHM1_1192,654,917 - 92,655,792 (-)NCBICHM1_1
T2T-CHM13v2.0191,919,389 - 91,920,267 (-)NCBIT2T-CHM13v2.0
SET
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21110,654,526 - 10,675,049 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1910,656,876 - 10,677,399 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0999,806,876 - 99,819,825 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19128,473,334 - 128,486,295 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9128,473,806 - 128,484,563 (+)Ensemblpanpan1.1panPan2
SET
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1954,896,464 - 54,907,698 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha954,091,882 - 54,098,081 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0955,817,522 - 55,828,773 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl955,817,525 - 55,840,176 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1954,578,083 - 54,584,281 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0954,890,770 - 54,896,963 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0954,984,276 - 54,990,463 (-)NCBIUU_Cfam_GSD_1.0
SET
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1129,446,265 - 9,453,991 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660967,724 - 21,521 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Set
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247606,293,452 - 6,304,237 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Setsip
5 total Variants

Predicted Target Of
Summary Value
Count of predictions:224
Count of miRNA genes:152
Interacting mature miRNAs:161
Transcripts:ENSRNOT00000051397
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 9 of 9 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat

1 to 9 of 9 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
15 11 55 144 125 120 77 31 77 12 276 121 112 55 79 43



Ensembl Acc Id: ENSRNOT00000051397   ⟹   ENSRNOP00000039454
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1958,419,961 - 58,421,504 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102684   ⟹   ENSRNOP00000078925
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1953,561,190 - 53,563,819 (+)Ensembl
RefSeq Acc Id: NM_001012504   ⟹   NP_001012522
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81970,458,604 - 70,460,122 (+)NCBI
mRatBN7.21953,561,262 - 53,562,780 (+)NCBI
Rnor_6.01958,420,635 - 58,422,153 (+)NCBI
Rnor_5.01969,119,722 - 69,121,240 (+)NCBI
RGSC_v3.41955,797,060 - 55,798,578 (+)RGD
Celera1952,922,285 - 52,923,803 (+)RGD
Sequence:
Protein RefSeqs NP_001012522 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC60681 (Get FASTA)   NCBI Sequence Viewer  
  AAP92538 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000077721.1
  ENSRNOP00000078925
  ENSRNOP00000078925.1
GenBank Protein Q63945 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001012522   ⟸   NM_001012504
- UniProtKB: A0A8I6G2K3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000039454   ⟸   ENSRNOT00000051397
Ensembl Acc Id: ENSRNOP00000078925   ⟸   ENSRNOT00000102684

Name Modeler Protein Id AA Range Protein Structure
AF-Q63945-F1-model_v2 AlphaFold Q63945 1-289 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 25 of 25 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-5209 BioCyc
Ensembl Genes ENSRNOG00000025892 UniProtKB/Swiss-Prot
  ENSRNOG00000034241 Ensembl
  ENSRNOG00000062793 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000102290.1 UniProtKB/Swiss-Prot
  ENSRNOT00000102684 ENTREZGENE
  ENSRNOT00000102684.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.1500 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleosome assembly protein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9089104 IMAGE-MGC_LOAD
InterPro NAP-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAP_family UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:307947 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:187306 IMAGE-MGC_LOAD
NCBI Gene 307947 ENTREZGENE
PANTHER PTHR11875 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam NAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Setsip PhenoGen
RatGTEx ENSRNOG00000025892 RatGTEx
  ENSRNOG00000034241 RatGTEx
  ENSRNOG00000062793 RatGTEx
Superfamily-SCOP SSF143113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6G2K3 ENTREZGENE, UniProtKB/TrEMBL
  Q63945 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q7TPA3 UniProtKB/Swiss-Prot
1 to 25 of 25 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-03-17 Setsip  SET like protein  Set  SET nuclear proto-oncogene  Name and Symbol changed 629549 APPROVED
2014-07-10 Set  SET nuclear proto-oncogene  Set  SET nuclear oncogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-14 Set  SET nuclear oncogene  Set  SET translocation   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Set  SET translocation   Set_predicted  SET translocation (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Set_predicted  SET translocation (predicted)      Symbol and Name status set to approved 70820 APPROVED