Gene: Set (SET nuclear proto-oncogene) Rattus norvegicus
Analyze
Symbol:
Set
Name:
SET nuclear proto-oncogene
Description:
Predicted to have DNA binding activity. Predicted to be involved in negative regulation of neuron apoptotic process and negative regulation of transcription, DNA-templated. Predicted to localize to several cellular components, including the endoplasmic reticulum; lipid droplet; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Orthologous to human SET (SET nuclear proto-oncogene); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
Ab1-115; I-2PP2A; liver regeneration-related protein LRRGR00002; LOC307947; phosphatase 2A inhibitor I2PP2A; SET nuclear oncogene; SET translocation; TAF-I; template-activating factor I
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
SET (SET nuclear proto-oncogene) HGNC
EggNOG, Ensembl, HomoloGene, NCBI, OMA, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Set (SET nuclear oncogene) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Panther, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Set (SET nuclear proto-oncogene) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
SET (SET nuclear proto-oncogene) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
SET (SET nuclear proto-oncogene) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Set (SET nuclear proto-oncogene) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
SET (SET nuclear proto-oncogene) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
SETSIP (SET like protein) HGNC
Ensembl, OrthoDB, Panther
Alliance orthologs 3
Homo sapiens (human):
SET (SET nuclear proto-oncogene)
Alliance
DIOPT (HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Set (SET nuclear oncogene)
Alliance
DIOPT (OMA, OrthoFinder, PANTHER, TreeFam)
Mus musculus (house mouse):
Gm9531 (predicted gene 9531)
Alliance
DIOPT (Hieranoid, InParanoid, OMA, OrthoInspector, PhylomeDB)
Danio rerio (zebrafish):
setb (SET nuclear proto-oncogene b)
Alliance
DIOPT (Hieranoid, OMA, OrthoFinder, PANTHER, TreeFam)
Drosophila melanogaster (fruit fly):
Set
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):
VPS75
Alliance
DIOPT (Hieranoid, OrthoFinder, PhylomeDB)
Caenorhabditis elegans (roundworm):
spr-2
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 19 58,420,635 - 58,422,153 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 19 58,419,961 - 58,421,504 (+) Ensembl Rnor_5.0 19 69,119,722 - 69,121,240 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 19 55,797,060 - 55,798,578 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 19 55,801,940 - 55,803,459 (+) NCBI Celera 19 52,922,285 - 52,923,803 (+) NCBI Celera Cytogenetic Map 19 q12 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - CTD
Necrosis ISO RGD:1316679 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:24555657 Neoplasm Invasiveness ISO RGD:1316679 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:24555657
Imported Annotations - OMIM
Autosomal Dominant Mental Retardation 58 ISO RGD:1316679 7240710 OMIM
(+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of SET mRNA] CTD PMID:31150632 17alpha-ethynylestradiol increases expression ISO RGD:1316680 6480464 Ethinyl Estradiol results in increased expression of SET mRNA CTD PMID:17942748 17alpha-ethynylestradiol multiple interactions ISO RGD:1316680 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SET mRNA CTD PMID:17942748 17alpha-ethynylestradiol affects expression ISO RGD:1316680 6480464 Ethinyl Estradiol affects the expression of SET mRNA CTD PMID:17555576 17beta-estradiol multiple interactions ISO RGD:1316679 6480464 [Estradiol co-treated with Progesterone] results in decreased expression of SET mRNA CTD PMID:21453500 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1316680 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SET mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1316680 6480464 Tetrachlorodibenzodioxin affects the expression of SET mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of SET protein CTD PMID:16548065 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1316680 6480464 Tetrachlorodibenzodioxin results in increased expression of SET mRNA CTD PMID:17942748 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of SET mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of SET mRNA CTD PMID:21346803 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:1316679 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SET mRNA more ... CTD PMID:28628672 4,4'-sulfonyldiphenol multiple interactions ISO RGD:1316679 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SET mRNA CTD PMID:28628672 4-amino-2,6-dinitrotoluene affects expression EXP 6480464 4-amino-2, 6-dinitrotoluene affects the expression of SET mRNA CTD PMID:21346803 5-aza-2'-deoxycytidine increases expression ISO RGD:1316679 6480464 Decitabine results in increased expression of SET protein CTD PMID:19294695 5-aza-2'-deoxycytidine multiple interactions ISO RGD:1316679 6480464 [trichostatin A co-treated with Decitabine] results in increased expression of SET protein CTD PMID:19294695 5-fluorouracil decreases expression ISO RGD:1316680 6480464 Fluorouracil results in decreased expression of SET mRNA CTD PMID:19272435 aflatoxin B1 increases expression ISO RGD:1316680 6480464 Aflatoxin B1 results in increased expression of SET mRNA CTD PMID:19770486 antirheumatic drug increases expression ISO RGD:1316679 6480464 Antirheumatic Agents results in increased expression of SET mRNA CTD PMID:24449571 Aroclor 1254 decreases expression ISO RGD:1316680 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of SET mRNA CTD PMID:23650126 arsane increases expression ISO RGD:1316679 6480464 Arsenic results in increased expression of SET protein CTD PMID:19818359 arsenic atom increases expression ISO RGD:1316679 6480464 Arsenic results in increased expression of SET protein CTD PMID:19818359 arsenous acid increases expression ISO RGD:1316679 6480464 Arsenic Trioxide results in increased expression of SET mRNA CTD PMID:20458559 benzene affects expression ISO RGD:1316679 6480464 Benzene affects the expression of SET mRNA CTD PMID:16188086 benzo[a]pyrene diol epoxide I increases expression ISO RGD:1316679 6480464 7 more ... CTD PMID:19150397 bis(2-ethylhexyl) phthalate increases expression ISO RGD:1316679 6480464 Diethylhexyl Phthalate results in increased expression of SET protein CTD PMID:31163220 bisphenol A decreases expression ISO RGD:1316680 6480464 bisphenol A results in decreased expression of SET mRNA, bisphenol A results in decreased expression of SET protein CTD PMID:22938446 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with tributyltin] results in increased expression of SET protein CTD PMID:31129395 bisphenol A affects expression ISO RGD:1316679 6480464 bisphenol A affects the expression of SET mRNA CTD PMID:30903817 bisphenol A multiple interactions ISO RGD:1316679 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SET mRNA CTD PMID:28628672 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of SET mRNA CTD PMID:25181051 bisphenol F multiple interactions ISO RGD:1316679 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SET mRNA CTD PMID:28628672 cadmium dichloride increases expression ISO RGD:1316679 6480464 Cadmium Chloride results in increased expression of SET mRNA CTD PMID:26472689 calcitriol decreases expression ISO RGD:1316679 6480464 Calcitriol results in decreased expression of SET mRNA CTD PMID:12798352 carbon nanotube increases expression ISO RGD:1316680 6480464 Nanotubes, Carbon analog results in increased expression of SET mRNA, Nanotubes, Carbon results in increased expression of SET mRNA CTD PMID:25554681 chloropicrin affects expression ISO RGD:1316679 6480464 chloropicrin affects the expression of SET mRNA CTD PMID:26352163 chromium(6+) affects expression ISO RGD:1316680 6480464 chromium hexavalent ion affects the expression of SET mRNA CTD PMID:28472532 cisplatin increases expression ISO RGD:1316679 6480464 Cisplatin results in increased expression of SET protein CTD PMID:21924258 cisplatin increases response to substance ISO RGD:1316679 6480464 SET mutant form results in increased susceptibility to Cisplatin CTD PMID:24555657 clofibric acid affects expression EXP 6480464 Clofibric Acid affects the expression of SET mRNA CTD PMID:17602206 cobalt dichloride decreases expression ISO RGD:1316679 6480464 cobaltous chloride results in decreased expression of SET mRNA CTD PMID:19320972 copper atom increases expression ISO RGD:1316680 6480464 Copper results in increased expression of SET mRNA CTD PMID:16629173 copper(0) increases expression ISO RGD:1316680 6480464 Copper results in increased expression of SET mRNA CTD PMID:16629173 cyclosporin A increases expression ISO RGD:1316680 6480464 Cyclosporine results in increased expression of SET mRNA CTD PMID:19770486 cyclosporin A decreases expression ISO RGD:1316679 6480464 Cyclosporine results in decreased expression of SET mRNA CTD PMID:25562108 dexamethasone multiple interactions ISO RGD:1316679 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SET mRNA more ... CTD PMID:28628672 diarsenic trioxide increases expression ISO RGD:1316679 6480464 Arsenic Trioxide results in increased expression of SET mRNA CTD PMID:20458559 dibutyl phthalate decreases expression ISO RGD:1316680 6480464 Dibutyl Phthalate results in decreased expression of SET mRNA CTD PMID:17361019 , PMID:21266533 doxorubicin affects expression ISO RGD:1316679 6480464 Doxorubicin affects the expression of SET protein CTD PMID:29385562 elemental selenium multiple interactions ISO RGD:1316679 6480464 [Selenium co-treated with Vitamin E] results in decreased expression of SET mRNA CTD PMID:19244175 enzyme inhibitor multiple interactions ISO RGD:1316679 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SET protein CTD PMID:23301498 ethanol decreases expression EXP 6480464 Ethanol results in decreased expression of SET protein CTD PMID:24646710 finasteride increases expression EXP 6480464 Finasteride results in increased expression of SET mRNA CTD PMID:24136188 flutamide increases expression EXP 6480464 Flutamide results in increased expression of SET mRNA CTD PMID:24136188 hydrogen sulfide increases expression ISO RGD:1316680 6480464 Hydrogen Sulfide results in increased expression of SET protein CTD PMID:29932956 indometacin multiple interactions ISO RGD:1316679 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SET mRNA more ... CTD PMID:28628672 isoprenaline decreases expression ISO RGD:1316680 6480464 Isoproterenol results in decreased expression of SET mRNA CTD PMID:20003209 lead(0) decreases expression ISO RGD:1316679 6480464 Lead results in decreased expression of SET mRNA CTD PMID:19921347 lead(2+) decreases expression ISO RGD:1316679 6480464 Lead results in decreased expression of SET mRNA CTD PMID:19921347 methoxychlor increases methylation EXP 6480464 Methoxychlor results in increased methylation of SET gene CTD PMID:23303685 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal decreases expression ISO RGD:1316679 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SET protein CTD PMID:21692457 nefazodone increases expression EXP 6480464 nefazodone results in increased expression of SET mRNA CTD PMID:24136188 nimesulide increases expression EXP 6480464 nimesulide results in increased expression of SET mRNA CTD PMID:24136188 ochratoxin A increases expression EXP 6480464 ochratoxin A results in increased expression of SET mRNA CTD PMID:18417182 paraoxon increases expression ISO RGD:1316679 6480464 Paraoxon results in increased expression of SET mRNA CTD PMID:24413757 paraquat affects expression EXP 6480464 Paraquat affects the expression of SET mRNA CTD PMID:15206577 paraquat decreases expression EXP 6480464 Paraquat results in decreased expression of SET mRNA CTD PMID:18198484 pentachlorophenol increases expression ISO RGD:1316680 6480464 Pentachlorophenol results in increased expression of SET mRNA CTD PMID:23892564 perfluorooctanoic acid decreases expression ISO RGD:1316679 6480464 perfluorooctanoic acid results in decreased expression of SET protein CTD PMID:26879310 progesterone multiple interactions ISO RGD:1316679 6480464 [Estradiol co-treated with Progesterone] results in decreased expression of SET mRNA CTD PMID:21453500 rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of SET mRNA CTD PMID:19013527 selenium atom multiple interactions ISO RGD:1316679 6480464 [Selenium co-treated with Vitamin E] results in decreased expression of SET mRNA CTD PMID:19244175 silicon dioxide affects expression ISO RGD:1316679 6480464 Silicon Dioxide analog affects the expression of SET mRNA CTD PMID:25895662 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of SET protein CTD PMID:29459688 sulindac decreases expression EXP 6480464 Sulindac results in decreased expression of SET mRNA CTD PMID:24136188 T-2 Toxin affects expression EXP 6480464 T-2 Toxin affects the expression of SET protein CTD PMID:26141394 tamoxifen affects expression ISO RGD:1316680 6480464 Tamoxifen affects the expression of SET mRNA CTD PMID:17555576 tetrachloromethane affects expression ISO RGD:1316680 6480464 Carbon Tetrachloride affects the expression of SET mRNA CTD PMID:17484886 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of SET mRNA] CTD PMID:31150632 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of SET mRNA CTD PMID:31150632 thapsigargin decreases expression ISO RGD:1316679 6480464 Thapsigargin results in decreased expression of SET mRNA, Thapsigargin results in decreased expression of SET protein CTD PMID:21692457 titanium dioxide decreases phosphorylation ISO RGD:1316679 6480464 titanium dioxide results in decreased phosphorylation of SET protein CTD PMID:21439344 tributylstannane multiple interactions EXP 6480464 [bisphenol A co-treated with tributyltin] results in increased expression of SET protein CTD PMID:31129395 trichloroethene increases expression ISO RGD:1316680 6480464 Trichloroethylene results in increased expression of SET mRNA CTD PMID:19448997 trichloroethene increases expression ISO RGD:1316679 6480464 Trichloroethylene results in increased expression of SET mRNA, Trichloroethylene results in increased expression of SET protein CTD PMID:22245669 trichloroethene affects response to substance ISO RGD:1316679 6480464 SET protein affects the susceptibility to Trichloroethylene CTD PMID:22245669 trichloroethene multiple interactions ISO RGD:1316679 6480464 SET protein affects the reaction [Trichloroethylene results in increased activity of CASP3 protein] CTD PMID:22245669 trichostatin A multiple interactions ISO RGD:1316679 6480464 [trichostatin A co-treated with decitabine] results in increased expression of SET protein CTD PMID:19294695 trichostatin A increases expression ISO RGD:1316679 6480464 trichostatin A results in increased expression of SET protein CTD PMID:19294695 trimellitic anhydride increases expression ISO RGD:1316680 6480464 trimellitic anhydride results in increased expression of SET mRNA CTD PMID:19042947 valproic acid decreases expression ISO RGD:1316679 6480464 Valproic Acid results in decreased expression of SET mRNA CTD PMID:23179753 valproic acid affects expression ISO RGD:1316679 6480464 Valproic Acid affects the expression of SET mRNA CTD PMID:25979313 vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of SET mRNA CTD PMID:19015723 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of SET mRNA CTD PMID:22615374 , PMID:23034163 vitamin E multiple interactions ISO RGD:1316679 6480464 [Selenium co-treated with Vitamin E] results in decreased expression of SET mRNA CTD PMID:19244175 vitamin E decreases expression ISO RGD:1316679 6480464 Vitamin E results in decreased expression of SET mRNA CTD PMID:19244175 vorinostat decreases expression ISO RGD:1316679 6480464 vorinostat results in decreased expression of SET protein CTD PMID:20543569
Gene-Chemical Interaction Annotations
