Cpsf7 (cleavage and polyadenylation specific factor 7) - Rat Genome Database

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Gene: Cpsf7 (cleavage and polyadenylation specific factor 7) Rattus norvegicus
Analyze
Symbol: Cpsf7
Name: cleavage and polyadenylation specific factor 7
RGD ID: 1305441
Description: Predicted to enable mRNA binding activity. Predicted to be involved in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway; mRNA alternative polyadenylation; and protein heterotetramerization. Predicted to be located in cytoplasm and nucleus. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Orthologous to human CPSF7 (cleavage and polyadenylation specific factor 7); PARTICIPATES IN 3'-end pre-mRNA processing pathway; RNA polymerase II transcription termination pathway; mRNA decay pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cleavage and polyadenylation specific factor 7, 59kDa; cleavage and polyadenylation specificity factor subunit 7; LOC365407; RGD1305441; similar to RIKEN cDNA 5730453I16
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81216,592,745 - 216,616,860 (+)NCBIGRCr8
mRatBN7.21207,167,690 - 207,191,938 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1207,167,859 - 207,191,905 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1215,546,294 - 215,570,323 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,601,738 - 222,625,783 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01215,296,741 - 215,320,782 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01226,572,399 - 226,596,185 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1226,573,105 - 226,596,131 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01233,518,603 - 233,542,664 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41213,009,572 - 213,032,612 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11213,168,001 - 213,191,028 (+)NCBI
Celera1204,662,017 - 204,685,057 (+)NCBICelera
Cytogenetic Map1q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cpsf7Ratintellectual disability  ISOCPSF7 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
Cpsf7RatJoubert syndrome 1  ISOCPSF7 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial aplasia of the vermisClinVarPMID:28492532
Cpsf7Ratleukocyte adhesion deficiency 3  ISOCPSF7 (Homo sapiens)8554872ClinVar Annotator: match by term: Leukocyte adhesion deficiency 3ClinVarPMID:28492532
Cpsf7Ratprostate cancer  ISOCPSF7 (Homo sapiens)8554872ClinVar Annotator: match by term: Malignant tumor of prostateClinVarPMID:23265383

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cpsf7Rat(1->4)-beta-D-glucan multiple interactionsISOCpsf7 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of CPSF7 mRNACTDPMID:36331819
Cpsf7Rat1,2-dimethylhydrazine decreases expressionISOCpsf7 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of CPSF7 mRNACTDPMID:22206623
Cpsf7Rat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of CPSF7 mRNACTDPMID:35192832
Cpsf7Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of CPSF7 mRNACTDPMID:33387578
Cpsf7Rataflatoxin B1 increases expressionISOCpsf7 (Mus musculus)6480464Aflatoxin B1 results in increased expression of CPSF7 mRNACTDPMID:19770486
Cpsf7Rataflatoxin B1 increases methylationISOCPSF7 (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of CPSF7 geneCTDPMID:27153756
Cpsf7Ratall-trans-retinoic acid decreases expressionISOCPSF7 (Homo sapiens)6480464Tretinoin results in decreased expression of CPSF7 mRNACTDPMID:33167477
Cpsf7Ratatrazine decreases expressionISOCpsf7 (Mus musculus)6480464Atrazine results in decreased expression of CPSF7 mRNACTDPMID:26518232
Cpsf7Ratatrazine increases expressionISOCPSF7 (Homo sapiens)6480464Atrazine results in increased expression of CPSF7 mRNACTDPMID:22378314
Cpsf7Ratbisphenol A increases expressionEXP 6480464bisphenol A results in increased expression of CPSF7 mRNACTDPMID:25181051
Cpsf7Ratbisphenol A decreases expressionISOCPSF7 (Homo sapiens)6480464bisphenol A results in decreased expression of CPSF7 proteinCTDPMID:34186270
Cpsf7Ratbisphenol A increases expressionISOCpsf7 (Mus musculus)6480464bisphenol A results in increased expression of CPSF7 mRNACTDPMID:33221593
Cpsf7Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of CPSF7 mRNACTDPMID:31129395 and PMID:35192832
Cpsf7Ratbisphenol A increases methylationEXP 6480464bisphenol A results in increased methylation of CPSF7 geneCTDPMID:28505145
Cpsf7Ratbisphenol F decreases expressionISOCpsf7 (Mus musculus)6480464bisphenol F results in decreased expression of CPSF7 mRNACTDPMID:38685157
Cpsf7RatBrodifacoum decreases expressionEXP 6480464bromfenacoum results in decreased expression of CPSF7 proteinCTDPMID:28903499
Cpsf7Ratcadmium atom multiple interactionsISOCPSF7 (Homo sapiens)6480464[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CPSF7 mRNACTDPMID:35301059
Cpsf7Ratcadmium dichloride decreases expressionISOCPSF7 (Homo sapiens)6480464Cadmium Chloride results in decreased expression of CPSF7 mRNACTDPMID:38568856
Cpsf7Ratcadmium dichloride multiple interactionsISOCPSF7 (Homo sapiens)6480464[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CPSF7 mRNACTDPMID:35301059
Cpsf7Ratcaffeine decreases phosphorylationISOCPSF7 (Homo sapiens)6480464Caffeine results in decreased phosphorylation of CPSF7 proteinCTDPMID:35688186

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Biological Process
1 to 16 of 16 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cpsf7Ratbiological_process  ND 159840701/2015: no relevant rat dataRGD 
Cpsf7Ratco-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway involved_inISOCPSF7 (Homo sapiens)1624291 PMID:29276085RGDPMID:29276085
Cpsf7Ratco-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway involved_inIEAUniProtKB:Q8N684 and ensembl:ENSP000003972031600115GO_REF:0000107EnsemblGO_REF:0000107
Cpsf7Ratco-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway involved_inISSUniProtKB:Q8N6841600115GO_REF:0000024UniProtGO_REF:0000024
Cpsf7RatmRNA 3'-end processing involved_inISOCPSF7 (Homo sapiens)1624291 PMID:20695905RGDPMID:20695905
Cpsf7RatmRNA 3'-end processing involved_inIEAUniProtKB:Q8N684 and ensembl:ENSP000003972031600115GO_REF:0000107EnsemblGO_REF:0000107
Cpsf7RatmRNA alternative polyadenylation involved_inISSUniProtKB:Q8N6841600115GO_REF:0000024UniProtGO_REF:0000024
Cpsf7RatmRNA alternative polyadenylation involved_inIBAPANTHER:PTN002755060 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cpsf7RatmRNA alternative polyadenylation involved_inISOCPSF7 (Homo sapiens)1624291 PMID:20695905 and PMID:29276085RGDPMID:20695905 and PMID:29276085
Cpsf7RatmRNA alternative polyadenylation involved_inIEAUniProtKB:Q8N684 and ensembl:ENSP000003972031600115GO_REF:0000107EnsemblGO_REF:0000107
Cpsf7RatmRNA processing involved_inIEAUniProtKB-KW:KW-05071600115GO_REF:0000043UniProtGO_REF:0000043
Cpsf7Ratprotein heterotetramerization involved_inISOCPSF7 (Homo sapiens)1624291 PMID:23187700RGDPMID:23187700
Cpsf7Ratprotein heterotetramerization involved_inIEAUniProtKB:Q8N684 and ensembl:ENSP000003972031600115GO_REF:0000107EnsemblGO_REF:0000107
Cpsf7Ratprotein heterotetramerization involved_inISSUniProtKB:Q8N6841600115GO_REF:0000024UniProtGO_REF:0000024
Cpsf7Ratprotein tetramerization involved_inISOCPSF7 (Homo sapiens)1624291 PMID:20695905RGDPMID:20695905
Cpsf7Ratprotein tetramerization involved_inIEAUniProtKB:Q8N684 and ensembl:ENSP000003972031600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
1 to 17 of 17 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cpsf7Ratcytoplasm located_inIEAUniProtKB:Q8N684 and ensembl:ENSP000003972031600115GO_REF:0000107EnsemblGO_REF:0000107
Cpsf7Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Cpsf7Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Cpsf7Ratcytoplasm located_inISSUniProtKB:Q8N6841600115GO_REF:0000024UniProtGO_REF:0000024
Cpsf7Ratcytoplasm located_inISOCPSF7 (Homo sapiens)1624291 PMID:19864460RGDPMID:19864460
Cpsf7RatmRNA cleavage and polyadenylation specificity factor complex part_ofISOCPSF7 (Homo sapiens)1624291 PMID:23187700RGDPMID:23187700
Cpsf7RatmRNA cleavage and polyadenylation specificity factor complex part_ofIBAPANTHER:PTN002755060 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cpsf7RatmRNA cleavage and polyadenylation specificity factor complex part_ofIEAUniProtKB:Q8N684 and ensembl:ENSP000003972031600115GO_REF:0000107EnsemblGO_REF:0000107
Cpsf7RatmRNA cleavage factor complex part_ofISOCPSF7 (Homo sapiens)1624291 PMID:20695905 and PMID:29276085RGDPMID:20695905 and PMID:29276085
Cpsf7RatmRNA cleavage factor complex part_ofIEAUniProtKB:Q8N684 and ensembl:ENSP000003972031600115GO_REF:0000107EnsemblGO_REF:0000107
Cpsf7RatmRNA cleavage factor complex part_ofISSUniProtKB:Q8N6841600115GO_REF:0000024UniProtGO_REF:0000024
Cpsf7Ratnucleus located_inISOCPSF7 (Homo sapiens)1624291 PMID:19864460 and PMID:20695905RGDPMID:19864460 and PMID:20695905
Cpsf7Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Cpsf7Ratnucleus located_inIEAARBA:ARBA000263301600115GO_REF:0000117UniProtGO_REF:0000117
Cpsf7Ratnucleus located_inIEAUniProtKB:Q8N684 and ensembl:ENSP000003972031600115GO_REF:0000107EnsemblGO_REF:0000107
Cpsf7Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Cpsf7Ratnucleus located_inISSUniProtKB:Q8N6841600115GO_REF:0000024UniProtGO_REF:0000024
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Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cpsf7RatmRNA binding enablesIBAFB:FBgn0035872 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cpsf7Ratnucleic acid binding enablesIEAInterPro:IPR0359791600115GO_REF:0000002InterProGO_REF:0000002
Cpsf7Ratprotein binding enablesISOCPSF7 (Homo sapiens) and UniProtKB:Q8N684-31624291UniProtKB:O43639 more ...RGDPMID:25910212 more ...
Cpsf7Ratprotein binding enablesISOCPSF7 (Homo sapiens)1624291UniProtKB:O43639 more ...RGDPMID:16189514 more ...
Cpsf7RatRNA binding enablesIEAUniRule:UR0004146191600115GO_REF:0000104UniProtGO_REF:0000104
Cpsf7RatRNA binding enablesIEAUniProtKB-KW:KW-06941600115GO_REF:0000043UniProtGO_REF:0000043
Cpsf7RatRNA binding enablesIEAInterPro:IPR0005041600115GO_REF:0000002InterProGO_REF:0000002

RGD Manual Annotations


  

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cpsf7RatmRNA decay pathway  IEA 6907045 KEGGrno:03015

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#
Reference Title
Reference Citation
1. Pre-mRNA 3'-end processing complex assembly and function. Chan S, etal., Wiley Interdiscip Rev RNA. 2011 May-Jun;2(3):321-35. doi: 10.1002/wrna.54. Epub 2010 Oct 18.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Means to an end: mechanisms of alternative polyadenylation of messenger RNA precursors. Gruber AR, etal., Wiley Interdiscip Rev RNA. 2014 Mar-Apr;5(2):183-96. doi: 10.1002/wrna.1206. Epub 2013 Nov 14.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
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PMID:15489334   PMID:19864460   PMID:19946888   PMID:20695905   PMID:22658674   PMID:22681889   PMID:23187700   PMID:29276085   PMID:31505169  



Cpsf7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81216,592,745 - 216,616,860 (+)NCBIGRCr8
mRatBN7.21207,167,690 - 207,191,938 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1207,167,859 - 207,191,905 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1215,546,294 - 215,570,323 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,601,738 - 222,625,783 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01215,296,741 - 215,320,782 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01226,572,399 - 226,596,185 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1226,573,105 - 226,596,131 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01233,518,603 - 233,542,664 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41213,009,572 - 213,032,612 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11213,168,001 - 213,191,028 (+)NCBI
Celera1204,662,017 - 204,685,057 (+)NCBICelera
Cytogenetic Map1q43NCBI
CPSF7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,402,729 - 61,429,975 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,402,641 - 61,430,031 (-)EnsemblGRCh38hg38GRCh38
GRCh371161,170,201 - 61,197,447 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361160,926,777 - 60,953,849 (-)NCBINCBI36Build 36hg18NCBI36
Celera1158,505,642 - 58,532,986 (-)NCBICelera
Cytogenetic Map11q12.2NCBI
HuRef1157,498,010 - 57,525,354 (-)NCBIHuRef
CHM1_11161,053,123 - 61,080,467 (-)NCBICHM1_1
T2T-CHM13v2.01161,391,627 - 61,418,874 (-)NCBIT2T-CHM13v2.0
Cpsf7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391910,502,594 - 10,525,099 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1910,502,630 - 10,525,017 (+)EnsemblGRCm39 Ensembl
GRCm381910,525,223 - 10,547,735 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1910,525,266 - 10,547,653 (+)EnsemblGRCm38mm10GRCm38
MGSCv371910,599,734 - 10,622,225 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361910,592,311 - 10,614,698 (+)NCBIMGSCv36mm8
Celera1911,221,128 - 11,243,624 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map196.6NCBI
Cpsf7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555116,139,118 - 6,161,130 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555116,139,118 - 6,161,130 (+)NCBIChiLan1.0ChiLan1.0
CPSF7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2962,570,633 - 62,597,988 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11163,614,202 - 63,641,631 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01156,702,510 - 56,729,316 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11160,065,832 - 60,092,720 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1160,065,832 - 60,092,720 (-)Ensemblpanpan1.1panPan2
CPSF7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11854,986,709 - 55,012,499 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1854,986,810 - 55,009,382 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1853,559,662 - 53,585,514 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01856,034,104 - 56,060,195 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1856,034,171 - 56,058,185 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11855,092,629 - 55,118,450 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01854,714,618 - 54,740,435 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01855,594,658 - 55,620,764 (+)NCBIUU_Cfam_GSD_1.0
Cpsf7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494711,515,249 - 11,537,317 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365811,629,041 - 1,651,328 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365811,629,078 - 1,651,147 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CPSF7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl210,087,632 - 10,115,076 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1210,087,581 - 10,112,929 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.229,635,042 - 9,659,648 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CPSF7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1112,417,452 - 12,445,984 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl112,417,490 - 12,446,527 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038109,794,801 - 109,823,341 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cpsf7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624926802,033 - 822,372 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Cpsf7
85 total Variants

Predicted Target Of
Summary Value
Count of predictions:905
Count of miRNA genes:331
Interacting mature miRNAs:426
Transcripts:ENSRNOT00000028074
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat

1 to 10 of 88 rows
RH142902  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21207,183,794 - 207,183,909 (+)MAPPERmRatBN7.2
Rnor_6.01226,588,339 - 226,588,453NCBIRnor6.0
Rnor_5.01233,534,594 - 233,534,708UniSTSRnor5.0
RGSC_v3.47139,916,134 - 139,916,248UniSTSRGSC3.4
RGSC_v3.41213,024,806 - 213,024,920UniSTSRGSC3.4
Celera1204,677,251 - 204,677,365UniSTS
RH 3.4 Map11510.2UniSTS
Cytogenetic Map1q43UniSTS
Cytogenetic Map7q35UniSTS
RH139325  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21207,183,793 - 207,183,924 (+)MAPPERmRatBN7.2
Rnor_6.01226,588,338 - 226,588,468NCBIRnor6.0
Rnor_5.01233,534,593 - 233,534,723UniSTSRnor5.0
RGSC_v3.47139,916,133 - 139,916,263UniSTSRGSC3.4
RGSC_v3.41213,024,805 - 213,024,935UniSTSRGSC3.4
Celera1204,677,250 - 204,677,380UniSTS
Cytogenetic Map1q43UniSTS
Cytogenetic Map7q35UniSTS
RH140202  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21207,191,213 - 207,191,395 (+)MAPPERmRatBN7.2
Rnor_6.01226,595,758 - 226,595,939NCBIRnor6.0
Rnor_5.01233,542,013 - 233,542,194UniSTSRnor5.0
RGSC_v3.41213,032,225 - 213,032,406UniSTSRGSC3.4
Celera1204,684,670 - 204,684,851UniSTS
RH 3.4 Map11510.5UniSTS
Cytogenetic Map1q43UniSTS
AW521848  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21207,167,685 - 207,167,836 (+)MAPPERmRatBN7.2
Rnor_6.01226,572,291 - 226,572,441NCBIRnor6.0
Rnor_5.01233,518,487 - 233,518,637UniSTSRnor5.0
RGSC_v3.41213,008,699 - 213,008,849UniSTSRGSC3.4
Celera1204,661,144 - 204,661,294UniSTS
RH 3.4 Map11510.3UniSTS
Cytogenetic Map1q43UniSTS
UniSTS:478984  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21207,189,926 - 207,190,468 (+)MAPPERmRatBN7.2
Rnor_6.01226,594,471 - 226,595,012NCBIRnor6.0
Rnor_5.01233,540,726 - 233,541,267UniSTSRnor5.0
RGSC_v3.41213,030,938 - 213,031,479UniSTSRGSC3.4
Celera1204,683,383 - 204,683,924UniSTS
Cytogenetic Map1q43UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 23 of 23 rows
RefSeq Transcripts NM_001014245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001399757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC095662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC083864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 23 of 23 rows

Ensembl Acc Id: ENSRNOT00000028074   ⟹   ENSRNOP00000028074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1207,167,859 - 207,191,905 (+)Ensembl
Rnor_6.0 Ensembl1226,573,105 - 226,596,131 (+)Ensembl
RefSeq Acc Id: NM_001014245   ⟹   NP_001014267
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,592,790 - 216,616,860 (+)NCBI
mRatBN7.21207,167,866 - 207,191,938 (+)NCBI
Rnor_6.01226,573,105 - 226,596,145 (+)NCBI
Rnor_5.01233,518,603 - 233,542,664 (+)NCBI
RGSC_v3.41213,009,572 - 213,032,612 (+)RGD
Celera1204,662,017 - 204,685,057 (+)RGD
Sequence:
RefSeq Acc Id: NM_001399757   ⟹   NP_001386686
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,592,790 - 216,616,860 (+)NCBI
mRatBN7.21207,167,866 - 207,191,938 (+)NCBI
RefSeq Acc Id: XM_039085585   ⟹   XP_038941513
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,592,988 - 216,616,856 (+)NCBI
mRatBN7.21207,167,979 - 207,191,865 (+)NCBI
RefSeq Acc Id: XM_039085601   ⟹   XP_038941529
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,593,459 - 216,608,543 (+)NCBI
mRatBN7.21207,167,975 - 207,183,620 (+)NCBI
RefSeq Acc Id: XM_039085607   ⟹   XP_038941535
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,599,449 - 216,616,856 (+)NCBI
mRatBN7.21207,174,523 - 207,191,865 (+)NCBI
RefSeq Acc Id: XM_063269902   ⟹   XP_063125972
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,599,450 - 216,616,856 (+)NCBI
RefSeq Acc Id: XM_063269906   ⟹   XP_063125976
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,599,451 - 216,616,856 (+)NCBI
RefSeq Acc Id: XM_063269909   ⟹   XP_063125979
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,599,451 - 216,616,856 (+)NCBI
RefSeq Acc Id: XR_010055261
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,592,760 - 216,616,856 (+)NCBI
RefSeq Acc Id: XR_010055262
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,592,988 - 216,616,856 (+)NCBI
RefSeq Acc Id: XR_010055263
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,593,459 - 216,616,856 (+)NCBI
RefSeq Acc Id: XR_010055264
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,592,745 - 216,616,856 (+)NCBI
RefSeq Acc Id: XR_010055265
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,592,760 - 216,616,856 (+)NCBI
RefSeq Acc Id: XR_010055266
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,592,760 - 216,616,856 (+)NCBI
RefSeq Acc Id: XR_010055267
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,592,760 - 216,616,856 (+)NCBI
RefSeq Acc Id: NP_001014267   ⟸   NM_001014245
- Peptide Label: isoform 2
- UniProtKB: Q5XI29 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028074   ⟸   ENSRNOT00000028074
RefSeq Acc Id: XP_038941529   ⟸   XM_039085601
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038941513   ⟸   XM_039085585
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QG69 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941535   ⟸   XM_039085607
- Peptide Label: isoform X3
RRM

Name Modeler Protein Id AA Range Protein Structure
AF-Q5XI29-F1-model_v2 AlphaFold Q5XI29 1-462 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 23 of 23 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-56427 BioCyc
Ensembl Genes ENSRNOG00000020668 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000028074 ENTREZGENE
  ENSRNOT00000166988 ENTREZGENE
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7127736 IMAGE-MGC_LOAD
InterPro CPSF6/7 UniProtKB/Swiss-Prot
  CPSF7_RRM UniProtKB/Swiss-Prot
  Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot
  RBD_domain_sf UniProtKB/Swiss-Prot
  RRM_dom UniProtKB/Swiss-Prot
KEGG Report rno:365407 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95116 IMAGE-MGC_LOAD
NCBI Gene 365407 ENTREZGENE
PANTHER PTHR23204 UniProtKB/Swiss-Prot
Pfam RRM_1 UniProtKB/Swiss-Prot
PhenoGen Cpsf7 PhenoGen
PROSITE RRM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020668 RatGTEx
SMART RRM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot
UniProt A0A8L2QG69 ENTREZGENE, UniProtKB/TrEMBL
  CPSF7_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 23 of 23 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-04-27 Cpsf7  cleavage and polyadenylation specific factor 7  Cpsf7  cleavage and polyadenylation specific factor 7, 59kDa  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-06-12 Cpsf7  cleavage and polyadenylation specific factor 7, 59kDa  RGD1305441  similar to RIKEN cDNA 5730453I16  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1305441  similar to RIKEN cDNA 5730453I16  RGD1305441_predicted  similar to RIKEN cDNA 5730453I16 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1305441_predicted  similar to RIKEN cDNA 5730453I16 (predicted)  LOC365407_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC365407_predicted  similar to RIKEN cDNA 5730453I16 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL