Apol7al1 (apolipoprotein L7a like 1) - Rat Genome Database

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Gene: Apol7al1 (apolipoprotein L7a like 1) Rattus norvegicus
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Symbol: Apol7al1 (Ensembl: LOC108351606)
Name: apolipoprotein L7a like 1 (Ensembl:uncharacterized LOC108351606)
RGD ID: 11460844
Description: Predicted to enable lipid binding activity. Predicted to be involved in lipid transport and lipoprotein metabolic process. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human APOL1 (apolipoprotein L1); APOL2 (apolipoprotein L2); and APOL3 (apolipoprotein L3); INTERACTS WITH 1,2-dimethylhydrazine (ortholog); 17beta-estradiol (ortholog); 2,2',4,4',5,5'-hexachlorobiphenyl (ortholog).
Type: ncrna (Ensembl: protein-coding)
RefSeq Status: VALIDATED
Previously known as: AABR07058464.1; Apol7a; apolipoprotein L 7a; apolipoprotein L 7a like 1; apolipoprotein L3-like; LOC108351606; uncharacterized LOC108351606
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
NCBI Annotation Information: Genome Annotation Status: not in current annotation release
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27109,118,559 - 109,149,798 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7109,131,064 - 109,147,649 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.07118,459,981 - 118,468,104 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7118,473,070 - 118,474,609 (-)NCBIRnor6.0rn6Rnor6.0
Celera7105,466,000 - 105,474,128 (-)NCBICelera
Cytogenetic Map7q34NCBI


1 to 20 of 36 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Apol7al1Rat1,2-dimethylhydrazine affects expressionISOApol7a (Mus musculus)64804641 and 2-Dimethylhydrazine affects the expression of APOL7A mRNACTDPMID:22206623
Apol7al1Rat17beta-estradiol increases expressionISOApol7a (Mus musculus)6480464Estradiol results in increased expression of APOL7A mRNACTDPMID:30077407
Apol7al1Rat17beta-estradiol affects expressionISOApol7a (Mus musculus)6480464Estradiol affects the expression of APOL7A mRNACTDPMID:39298647
Apol7al1Rat17beta-estradiol multiple interactionsISOApol7a (Mus musculus)6480464[Polyphenols co-treated with Estradiol] results in increased expression of APOL7A mRNACTDPMID:30077407
Apol7al1Rat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISOApol7a (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with 2 more ...CTDPMID:28433925
Apol7al1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOApol7a (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of APOL7A mRNACTDPMID:28922406
Apol7al1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOApol7a (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with 2 more ...CTDPMID:28433925
Apol7al1Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOApol7a (Mus musculus)64804642 more ...CTDPMID:38648751
Apol7al1Rat3,3',4,4'-tetrachlorobiphenyl multiple interactionsISOApol7a (Mus musculus)64804643 more ...CTDPMID:19467301
Apol7al1Rataflatoxin B1 decreases expressionISOApol7a (Mus musculus)6480464Aflatoxin B1 results in decreased expression of APOL7A mRNACTDPMID:19770486
Apol7al1Ratbenzo[a]pyrene increases expressionISOApol7a (Mus musculus)6480464Benzo(a)pyrene results in increased expression of APOL7A mRNACTDPMID:23735875
Apol7al1Ratbis(2-ethylhexyl) phthalate multiple interactionsISOApol7a (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with 2 more ...CTDPMID:28433925
Apol7al1Ratbisphenol A increases expressionISOApol7a (Mus musculus)6480464bisphenol A results in increased expression of APOL7A mRNACTDPMID:32156529
Apol7al1Ratbisphenol A multiple interactionsISOApol7a (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with 2 more ...CTDPMID:28433925
Apol7al1Ratcarbon nanotube decreases expressionISOApol7a (Mus musculus)6480464Nanotubes more ...CTDPMID:25620056
Apol7al1Ratcarbon nanotube affects expressionISOApol7a (Mus musculus)6480464Nanotubes and Carbon affects the expression of APOL7A mRNACTDPMID:25554681
Apol7al1Ratclofibrate decreases expressionISOApol7a (Mus musculus)6480464Clofibrate results in decreased expression of APOL7A mRNACTDPMID:23811191
Apol7al1Ratdibenzofurans increases expressionISOApol7a (Mus musculus)6480464Dibenzofurans results in increased expression of APOL7A mRNACTDPMID:34254344
Apol7al1Ratdimethylarsinic acid multiple interactionsISOApol7a (Mus musculus)6480464[sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in decreased expression of APOL7A mRNACTDPMID:34876320
Apol7al1Ratepoxiconazole decreases expressionISOApol7a (Mus musculus)6480464epoxiconazole results in decreased expression of APOL7A mRNACTDPMID:35436446

1 to 20 of 36 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Apol7al1Ratlipid transport involved_inIEAInterPro:IPR0084051600115GO_REF:0000002InterProGO_REF:0000002
Apol7al1Ratlipoprotein metabolic process involved_inIEAInterPro:IPR0084051600115GO_REF:0000002InterProGO_REF:0000002

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Apol7al1Ratextracellular region located_inIEAInterPro:IPR0084051600115GO_REF:0000002InterProGO_REF:0000002

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Apol7al1Ratlipid binding enablesIBAPANTHER:PTN001422588 and UniProtKB:O147911600115GO_REF:0000033GO_CentralGO_REF:0000033
Apol7al1Ratlipid binding enablesIEAInterPro:IPR0084051600115GO_REF:0000002InterProGO_REF:0000002


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.


Apol7al1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27109,118,559 - 109,149,798 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7109,131,064 - 109,147,649 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.07118,459,981 - 118,468,104 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7118,473,070 - 118,474,609 (-)NCBIRnor6.0rn6Rnor6.0
Celera7105,466,000 - 105,474,128 (-)NCBICelera
Cytogenetic Map7q34NCBI
Apol7a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391577,272,417 - 77,283,310 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1577,272,419 - 77,283,310 (-)EnsemblGRCm39 Ensembl
GRCm381577,388,217 - 77,399,110 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1577,388,219 - 77,399,110 (-)EnsemblGRCm38mm10GRCm38
MGSCv371577,218,647 - 77,229,540 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361577,215,477 - 77,226,367 (-)NCBIMGSCv36mm8
Celera1578,877,195 - 78,888,086 (-)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1536.4NCBI

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Variants in Apol7al1
53 total Variants

1 to 10 of 34 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat

1 to 10 of 34 rows






Ensembl Acc Id: ENSRNOT00000089076   ⟹   ENSRNOP00000070447
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7109,131,645 - 109,136,503 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094291   ⟹   ENSRNOP00000084943
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7109,131,065 - 109,138,745 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104767   ⟹   ENSRNOP00000087259
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7109,131,064 - 109,147,649 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118110   ⟹   ENSRNOP00000079251
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7109,131,645 - 109,138,745 (-)Ensembl
RefSeq Acc Id: XM_039080553   ⟹   XP_038936481
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27109,129,956 - 109,147,626 (-)NCBI
RefSeq Acc Id: XR_005487524
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27109,118,560 - 109,147,626 (-)NCBI
RefSeq Acc Id: XR_005487525
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27109,118,560 - 109,147,626 (-)NCBI
RefSeq Acc Id: XR_005487526
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27109,118,559 - 109,149,791 (-)NCBI
RefSeq Acc Id: XR_005487527
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27109,118,560 - 109,149,798 (-)NCBI
Ensembl Protein ENSRNOP00000070447.2
  ENSRNOP00000079251.1
RefSeq Acc Id: XP_038936481   ⟸   XM_039080553
Ensembl Acc Id: ENSRNOP00000079251   ⟸   ENSRNOT00000118110
Ensembl Acc Id: ENSRNOP00000070447   ⟸   ENSRNOT00000089076
Ensembl Acc Id: ENSRNOP00000087259   ⟸   ENSRNOT00000104767
Ensembl Acc Id: ENSRNOP00000084943   ⟸   ENSRNOT00000094291

Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JXY3-F1-model_v2 AlphaFold A0A0G2JXY3 1-322 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 14 of 14 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-32882 BioCyc
Ensembl Genes ENSRNOG00000052981 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000089076.2 UniProtKB/TrEMBL
  ENSRNOT00000118110.1 UniProtKB/TrEMBL
InterPro ApoL UniProtKB/TrEMBL
NCBI Gene LOC108351606 ENTREZGENE
PANTHER APOLIPOPROTEIN L UniProtKB/TrEMBL
  APOLIPOPROTEIN L2 UniProtKB/TrEMBL
Pfam ApoL UniProtKB/TrEMBL
PhenoGen Apol7al1 PhenoGen
RatGTEx ENSRNOG00000052981 RatGTEx
RNAcentral URS0000CCFAD3 RNACentral
UniProt A0A0G2JXY3_RAT UniProtKB/TrEMBL
  A0A8I6G518_RAT UniProtKB/TrEMBL
1 to 14 of 14 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-10-22 Apol7al1  apolipoprotein L7a like 1  Apol7al1  apolipoprotein L 7a like 1  Name changed 629549 APPROVED
2024-04-18 Apol7al1  apolipoprotein L 7a like 1  Apol7al1  apolipoprotein L 7a like 1  Type changed (type changed from [protein-coding] to [ncrna]) 629549 APPROVED
2024-04-18 Apol7al1  apolipoprotein L 7a like 1  oApol7a  old apolipoprotein L 7a  Name and Symbol changed 629549 APPROVED
2024-03-29 oApol7a  old apolipoprotein L 7a  Apol7a  apolipoprotein L 7a  Name and Symbol changed 629549 APPROVED
2023-08-03 Apol7a  apolipoprotein L 7a  LOC108351606  uncharacterized LOC108351606  Name and Symbol changed 629549 APPROVED
2022-06-02 LOC108351606  uncharacterized LOC108351606  AABR07058464.1    Data merged from RGD:15007564 737654 PROVISIONAL
2019-11-08 AABR07058464.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2016-08-02 LOC108351606  uncharacterized LOC108351606      Symbol and Name status set to provisional 70820 PROVISIONAL