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Gene: APOL2 (apolipoprotein L2) Homo sapiens

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Symbol:

APOL2

Name:

apolipoprotein L2

RGD ID:

1320008

HGNC Page

HGNC:619

Description:

Predicted to enable lipid binding activity. Predicted to be involved in several processes, including acute-phase response; cholesterol metabolic process; and maternal process involved in female pregnancy. Located in membrane. Implicated in schizophrenia.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

APOL-II; APOL3; apolipoprotein L, 2; apolipoprotein L-II

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	36,226,209 - 36,239,954 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	36,226,209 - 36,239,954 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	36,622,255 - 36,636,000 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	34,952,201 - 34,965,946 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	34,946,754 - 34,960,500	NCBI
Celera	22	20,424,825 - 20,438,568 (-)	NCBI		Celera
Cytogenetic Map	22	q12.3	NCBI
HuRef	22	19,590,366 - 19,604,109 (-)	NCBI		HuRef
CHM1_1	22	36,581,376 - 36,595,119 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	22	36,686,335 - 36,700,070 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
APOL2	Human	adenylosuccinase lyase deficiency		IAGP	(Homo sapiens)	8554872	ClinVar Annotator: match by term: Adenylosuccinate lyase deficiency	ClinVar	PMID:28492532

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
APOL2	Human	cannabis abuse		EXP		11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:17205118
APOL2	Human	Cocaine-Related Disorders		EXP		11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:17205118
APOL2	Human	phencyclidine abuse		EXP		11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:17205118
APOL2	Human	schizophrenia		EXP		11554173	CTD Direct Evidence: marker/mechanism	CTD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
APOL2	Human	schizophrenia		IAGP		7240710		OMIM

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
APOL2	Human	(-)-epigallocatechin 3-gallate	multiple interactions	EXP		6480464	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of APOL2 mRNA	CTD	PMID:22079256
APOL2	Human	17beta-estradiol	decreases expression	ISO	Apol2 (Rattus norvegicus)	6480464	Estradiol results in decreased expression of APOL3 mRNA	CTD	PMID:32145629
APOL2	Human	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	ISO	Apol2 (Rattus norvegicus)	6480464	Tetrachlorodibenzodioxin results in decreased expression of APOL3 mRNA	CTD	PMID:33387578
APOL2	Human	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	Apol2 (Rattus norvegicus)	6480464	Tetrachlorodibenzodioxin affects the expression of APOL3 mRNA	CTD	PMID:34747641
APOL2	Human	2,4-dinitrotoluene	affects expression	ISO	Apol2 (Rattus norvegicus)	6480464	2 and 4-dinitrotoluene affects the expression of APOL3 mRNA	CTD	PMID:21346803
APOL2	Human	2,6-dimethoxyphenol	multiple interactions	EXP		6480464	[Sodium Chloride co-treated with pyrogallol 1 more ...	CTD	PMID:38598786
APOL2	Human	6-propyl-2-thiouracil	decreases expression	ISO	Apol2 (Rattus norvegicus)	6480464	Propylthiouracil results in decreased expression of APOL3 mRNA	CTD	PMID:24780913
APOL2	Human	actinomycin D	multiple interactions	EXP		6480464	[Dactinomycin co-treated with nutlin 3] results in increased expression of APOL2 mRNA and [Dactinomycin co-treated with nutlin 3] results in increased expression of APOL2 protein	CTD	PMID:38460933
APOL2	Human	aflatoxin B1	increases methylation	EXP		6480464	Aflatoxin B1 results in increased methylation of APOL2 3' UTR	CTD	PMID:30157460
APOL2	Human	all-trans-retinoic acid	increases expression	EXP		6480464	Tretinoin results in increased expression of APOL2 mRNA	CTD	PMID:33167477
APOL2	Human	amitrole	decreases expression	ISO	Apol2 (Rattus norvegicus)	6480464	Amitrole results in decreased expression of APOL3 mRNA	CTD	PMID:38685447
APOL2	Human	antirheumatic drug	decreases expression	EXP		6480464	Antirheumatic Agents results in decreased expression of APOL2 mRNA	CTD	PMID:24449571
APOL2	Human	aristolochic acid A	increases expression	EXP		6480464	aristolochic acid I results in increased expression of APOL2 mRNA	CTD	PMID:33212167
APOL2	Human	arsane	multiple interactions	EXP		6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of APOL2 mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of APOL2 mRNA	CTD	PMID:39836092
APOL2	Human	arsenic atom	multiple interactions	EXP		6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of APOL2 mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of APOL2 mRNA	CTD	PMID:39836092
APOL2	Human	arsenite(3-)	multiple interactions	EXP		6480464	arsenite promotes the reaction [G3BP1 protein binds to APOL2 mRNA]	CTD	PMID:32406909
APOL2	Human	bisphenol A	affects expression	ISO	Apol2 (Rattus norvegicus)	6480464	bisphenol A affects the expression of APOL3 mRNA	CTD	PMID:25181051 and PMID:30903817
APOL2	Human	bisphenol A	increases expression	EXP		6480464	bisphenol A results in increased expression of APOL2 protein	CTD	PMID:34186270
APOL2	Human	bisphenol A	multiple interactions	ISO	Apol2 (Rattus norvegicus)	6480464	[bisphenol A co-treated with tributyltin] results in decreased expression of APOL2 mRNA	CTD	PMID:31129395
APOL2	Human	bisphenol A	decreases expression	ISO	Apol2 (Rattus norvegicus)	6480464	bisphenol A results in decreased expression of APOL3 mRNA	CTD	PMID:30816183 more ...
APOL2	Human	bisphenol AF	increases expression	EXP		6480464	bisphenol AF results in increased expression of APOL2 protein	CTD	PMID:34186270
APOL2	Human	Bisphenol B	increases expression	EXP		6480464	bisphenol B results in increased expression of APOL2 protein	CTD	PMID:34186270
APOL2	Human	cisplatin	increases expression	EXP		6480464	Cisplatin results in increased expression of APOL2 mRNA	CTD	PMID:27392435
APOL2	Human	cisplatin	multiple interactions	EXP		6480464	[Cisplatin co-treated with jinfukang] results in increased expression of APOL2 mRNA	CTD	PMID:27392435
APOL2	Human	clofibric acid	multiple interactions	ISO	Apol2 (Rattus norvegicus)	6480464	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of APOL3 mRNA	CTD	PMID:17602206
APOL2	Human	cobalt dichloride	increases expression	EXP		6480464	cobaltous chloride results in increased expression of APOL2 mRNA	CTD	PMID:19320972
APOL2	Human	cocaine	increases expression	EXP		6480464	Cocaine results in increased expression of APOL2 mRNA	CTD	PMID:17205118
APOL2	Human	endosulfan	decreases expression	ISO	Apol2 (Rattus norvegicus)	6480464	Endosulfan results in decreased expression of APOL3 mRNA	CTD	PMID:29391264
APOL2	Human	ethylparaben	decreases expression	EXP		6480464	ethyl-p-hydroxybenzoate results in decreased expression of APOL2 mRNA	CTD	PMID:37690743
APOL2	Human	furfural	multiple interactions	EXP		6480464	[Sodium Chloride co-treated with Furaldehyde] results in decreased expression of and affects the localization of APOL2 protein and [Sodium Chloride co-treated with Furaldehyde] results in decreased expression of APOL2 protein	CTD	PMID:38598786
APOL2	Human	gentamycin	decreases expression	ISO	Apol2 (Rattus norvegicus)	6480464	Gentamicins results in decreased expression of APOL3 mRNA	CTD	PMID:33387578
APOL2	Human	ivermectin	decreases expression	EXP		6480464	Ivermectin results in decreased expression of APOL2 protein	CTD	PMID:32959892
APOL2	Human	leflunomide	decreases expression	EXP		6480464	leflunomide results in decreased expression of APOL2 mRNA	CTD	PMID:28988120
APOL2	Human	manganese atom	increases expression	EXP		6480464	Manganese results in increased expression of APOL2 mRNA	CTD	PMID:17175027
APOL2	Human	manganese atom	multiple interactions	EXP		6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of APOL2 mRNA	CTD	PMID:39836092
APOL2	Human	manganese(0)	increases expression	EXP		6480464	Manganese results in increased expression of APOL2 mRNA	CTD	PMID:17175027
APOL2	Human	manganese(0)	multiple interactions	EXP		6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of APOL2 mRNA	CTD	PMID:39836092
APOL2	Human	manganese(II) chloride	increases expression	EXP		6480464	manganese chloride results in increased expression of APOL2 mRNA	CTD	PMID:17175027
APOL2	Human	manganese(II) chloride	multiple interactions	EXP		6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of APOL2 mRNA	CTD	PMID:39836092
APOL2	Human	Monobutylphthalate	increases expression	ISO	Apol2 (Rattus norvegicus)	6480464	monobutyl phthalate results in increased expression of APOL3 mRNA	CTD	PMID:29162477
APOL2	Human	N-methyl-4-phenylpyridinium	decreases expression	ISO	Apol2 (Rattus norvegicus)	6480464	1-Methyl-4-phenylpyridinium results in decreased expression of APOL3 mRNA	CTD	PMID:28801915
APOL2	Human	N-nitrosodiethylamine	multiple interactions	ISO	Apol2 (Rattus norvegicus)	6480464	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of APOL3 mRNA	CTD	PMID:17602206
APOL2	Human	nefazodone	decreases expression	ISO	Apol2 (Rattus norvegicus)	6480464	nefazodone results in decreased expression of APOL3 mRNA	CTD	PMID:24136188
APOL2	Human	nickel atom	increases expression	EXP		6480464	Nickel results in increased expression of APOL2 mRNA	CTD	PMID:24768652 and PMID:25583101
APOL2	Human	nickel dichloride	increases expression	EXP		6480464	nickel chloride results in increased expression of APOL2 mRNA	CTD	PMID:21455298
APOL2	Human	nimesulide	decreases expression	ISO	Apol2 (Rattus norvegicus)	6480464	nimesulide results in decreased expression of APOL3 mRNA	CTD	PMID:24136188
APOL2	Human	nitrofen	decreases expression	ISO	Apol2 (Rattus norvegicus)	6480464	nitrofen results in decreased expression of APOL3 mRNA	CTD	PMID:26720608
APOL2	Human	Nutlin-3	multiple interactions	EXP		6480464	[Dactinomycin co-treated with nutlin 3] results in increased expression of APOL2 mRNA and [Dactinomycin co-treated with nutlin 3] results in increased expression of APOL2 protein	CTD	PMID:38460933
APOL2	Human	oxybenzone	increases expression	ISO	Apol2 (Rattus norvegicus)	6480464	oxybenzone results in increased expression of APOL2 mRNA	CTD	PMID:30316929
APOL2	Human	paracetamol	decreases expression	EXP		6480464	Acetaminophen results in decreased expression of APOL2 mRNA	CTD	PMID:21420995
APOL2	Human	paracetamol	decreases expression	ISO	Apol2 (Rattus norvegicus)	6480464	Acetaminophen results in decreased expression of APOL3 mRNA	CTD	PMID:33387578
APOL2	Human	perfluorooctanoic acid	decreases expression	EXP		6480464	perfluorooctanoic acid results in decreased expression of APOL2 protein	CTD	PMID:26879310
APOL2	Human	phencyclidine	increases expression	EXP		6480464	Phencyclidine results in increased expression of APOL2 mRNA	CTD	PMID:17205118
APOL2	Human	pirinixic acid	decreases expression	ISO	Apol2 (Rattus norvegicus)	6480464	pirinixic acid results in decreased expression of APOL3 mRNA	CTD	PMID:19162173
APOL2	Human	potassium chromate	multiple interactions	EXP		6480464	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of APOL2 mRNA	CTD	PMID:22079256
APOL2	Human	potassium chromate	decreases expression	EXP		6480464	potassium chromate(VI) results in decreased expression of APOL2 mRNA	CTD	PMID:22079256
APOL2	Human	resveratrol	multiple interactions	EXP		6480464	[Plant Extracts co-treated with Resveratrol] results in increased expression of APOL2 mRNA	CTD	PMID:23557933
APOL2	Human	sodium arsenite	increases expression	EXP		6480464	sodium arsenite results in increased expression of APOL2 mRNA	CTD	PMID:38568856
APOL2	Human	sodium arsenite	multiple interactions	EXP		6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of APOL2 mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of APOL2 mRNA	CTD	PMID:39836092
APOL2	Human	sodium chloride	multiple interactions	EXP		6480464	[Sodium Chloride co-treated with Furaldehyde] results in decreased expression of and affects the localization of APOL2 protein more ...	CTD	PMID:38598786
APOL2	Human	tetrachloromethane	decreases expression	ISO	Apol2 (Rattus norvegicus)	6480464	Carbon Tetrachloride results in decreased expression of APOL3 mRNA	CTD	PMID:31150632
APOL2	Human	thioacetamide	decreases expression	ISO	Apol2 (Rattus norvegicus)	6480464	Thioacetamide results in decreased expression of APOL3 mRNA	CTD	PMID:23411599
APOL2	Human	thioacetamide	increases expression	ISO	Apol2 (Rattus norvegicus)	6480464	Thioacetamide results in increased expression of APOL2 mRNA	CTD	PMID:34492290
APOL2	Human	tributylstannane	multiple interactions	ISO	Apol2 (Rattus norvegicus)	6480464	[bisphenol A co-treated with tributyltin] results in decreased expression of APOL2 mRNA	CTD	PMID:31129395
APOL2	Human	tributylstannane	decreases expression	ISO	Apol2 (Rattus norvegicus)	6480464	tributyltin results in decreased expression of APOL2 mRNA	CTD	PMID:31129395
APOL2	Human	trichloroethene	increases expression	ISO	Apol2 (Rattus norvegicus)	6480464	Trichloroethylene results in increased expression of APOL2 mRNA	CTD	PMID:33387578
APOL2	Human	trichostatin A	decreases expression	EXP		6480464	trichostatin A results in decreased expression of APOL2 mRNA	CTD	PMID:28542535
APOL2	Human	triphenyl phosphate	affects expression	EXP		6480464	triphenyl phosphate affects the expression of APOL2 mRNA	CTD	PMID:37042841
APOL2	Human	urethane	decreases expression	EXP		6480464	Urethane results in decreased expression of APOL2 mRNA	CTD	PMID:28818685

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
APOL2	Human	acute-phase response	involved_in	NAS		150520179	PMID:11374903	UniProt	PMID:11374903
APOL2	Human	cholesterol metabolic process	involved_in	NAS		150520179	PMID:11374903	UniProt	PMID:11374903
APOL2	Human	lipid metabolic process	involved_in	NAS		150520179	PMID:11374903 and PMID:11944986	UniProt	PMID:11374903 and PMID:11944986
APOL2	Human	lipid transport	involved_in	IEA	InterPro:IPR008405	150520179		InterPro	GO_REF:0000002
APOL2	Human	lipid transport	involved_in	IEA	UniProtKB-KW:KW-0445	150520179		UniProt	GO_REF:0000043
APOL2	Human	lipid transport	involved_in	NAS		150520179	PMID:11374903	UniProt	PMID:11374903
APOL2	Human	lipoprotein metabolic process	involved_in	IEA	InterPro:IPR008405	150520179		InterPro	GO_REF:0000002
APOL2	Human	maternal process involved in female pregnancy	involved_in	NAS		150520179	PMID:11374903	UniProt	PMID:11374903

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
APOL2	Human	cytoplasm	located_in	IEA	UniProtKB-SubCell:SL-0086	150520179		UniProt	GO_REF:0000044
APOL2	Human	cytoplasm	located_in	IEA	UniProtKB-KW:KW-0963	150520179		UniProt	GO_REF:0000043
APOL2	Human	endoplasmic reticulum membrane	located_in	NAS		150520179	PMID:11374903	UniProt	PMID:11374903
APOL2	Human	extracellular region	located_in	IEA	InterPro:IPR008405	150520179		InterPro	GO_REF:0000002
APOL2	Human	membrane	located_in	HDA		150520179	PMID:19946888	UniProt	PMID:19946888
APOL2	Human	membrane	located_in	IEA	UniProtKB-KW:KW-0472	150520179		UniProt	GO_REF:0000043

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
APOL2	Human	high-density lipoprotein particle binding	enables	NAS		150520179	PMID:11374903	UniProt	PMID:11374903
APOL2	Human	lipid binding	enables	IEA	InterPro:IPR008405	150520179		InterPro	GO_REF:0000002
APOL2	Human	lipid binding	enables	IBA	PANTHER:PTN001422588 and UniProtKB:O14791	150520179		GO_Central	GO_REF:0000033
APOL2	Human	lipid binding	enables	NAS		150520179	PMID:11374903	UniProt	PMID:11374903
APOL2	Human	protein binding	enables	IPI	UniProtKB:O00258 more ...	150520179	PMID:32296183	IntAct	PMID:32296183
APOL2	Human	signaling receptor binding	enables	NAS		150520179	PMID:11374903	UniProt	PMID:11374903

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
APOL2	Human	Autosomal dominant inheritance		IAGP		8699517		HPO	MIM:181500
APOL2	Human	Delusion		IAGP		8699517		HPO	MIM:181500
APOL2	Human	EEG abnormality		IAGP		8699517		HPO	MIM:181500
APOL2	Human	Hallucinations		IAGP		8699517		HPO	MIM:181500
APOL2	Human	Negativism		IAGP		8699517		HPO	MIM:181500
APOL2	Human	Schizophrenia		IAGP		8699517		HPO	MIM:181500
APOL2	Human	Social and occupational deterioration		IAGP		8699517		HPO	MIM:181500

#	Reference Title	Reference Citation
1.	GOAs Human GO annotations	GOA_HUMAN data from the GO Consortium
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

PMID:7566098	PMID:10591208	PMID:11290834	PMID:11374903	PMID:11944986	PMID:12477932	PMID:14702039	PMID:15107424	PMID:15489334	PMID:15949655	PMID:18632255	PMID:19946888
PMID:20602615	PMID:20665705	PMID:21873635	PMID:24623722	PMID:24901046	PMID:26186194	PMID:26496610	PMID:26638075	PMID:26760575	PMID:27432908	PMID:28514442	PMID:28712289
PMID:29117863	PMID:30021884	PMID:30442662	PMID:31466081	PMID:31536960	PMID:32296183	PMID:32393512	PMID:32687490	PMID:32788342	PMID:32877691	PMID:33729478	PMID:33961781
PMID:34079125	PMID:34316015	PMID:34948065	PMID:35696571	PMID:36517590	PMID:36724073	PMID:36949045	PMID:37120454	PMID:37314216	PMID:37433992	PMID:38177924	PMID:38569033
PMID:39147351	PMID:39468006

APOL2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	36,226,209 - 36,239,954 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	36,226,209 - 36,239,954 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	36,622,255 - 36,636,000 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	34,952,201 - 34,965,946 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	34,946,754 - 34,960,500	NCBI
Celera	22	20,424,825 - 20,438,568 (-)	NCBI		Celera
Cytogenetic Map	22	q12.3	NCBI
HuRef	22	19,590,366 - 19,604,109 (-)	NCBI		HuRef
CHM1_1	22	36,581,376 - 36,595,119 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	22	36,686,335 - 36,700,070 (-)	NCBI		T2T-CHM13v2.0

Apol8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	77,629,309 - 77,641,306 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	77,631,998 - 77,641,203 (-)	Ensembl		GRCm39 Ensembl
GRCm38	15	77,745,109 - 77,757,062 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	77,747,798 - 77,757,003 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	77,579,043 - 77,585,659 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	77,575,052 - 77,582,522 (-)	NCBI		MGSCv36	mm8
Celera	15	79,215,063 - 79,221,679 (-)	NCBI		Celera
Cytogenetic Map	15	E1	NCBI
cM Map	15	36.79	NCBI

Apol2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	111,211,944 - 111,219,209 (-)	NCBI		GRCr8
mRatBN7.2	7	109,331,367 - 109,338,632 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	109,331,392 - 109,338,558 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	7	118,727,658 - 118,735,453 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	118,979,608 - 118,983,984 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	7	118,728,617 - 118,732,738 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	118,725,207 - 118,732,485 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	115,668,899 - 115,673,029 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	115,703,128 - 115,711,697 (-)	NCBI
Celera	7	105,672,006 - 105,679,878 (-)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

LOC100982122
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	46,111,536 - 46,125,016 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	48,803,106 - 48,816,584 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	17,172,486 - 17,186,260 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	35,011,137 - 35,024,913 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	35,011,137 - 35,024,913 (-)	Ensembl	panpan1.1		panPan2

LOC100156062
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	5	11,543,551 - 11,567,675 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	9,313,095 - 9,331,836 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

APOL2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	18,945,972 - 18,956,039 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666045	106,942,769 - 106,954,000 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants in APOL2
53 total Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 22q12.3-13.1(chr22:35333993-38900177)x1	copy number loss	See cases [RCV000051364]	Chr22:35333993..38900177 [GRCh38] Chr22:35729986..39296182 [GRCh37] Chr22:34059986..37626128 [NCBI36] Chr22:22q12.3-13.1	pathogenic
GRCh38/hg38 22q12.3-13.1(chr22:36068124-38002382)x3	copy number gain	See cases [RCV000051683]	Chr22:36068124..38002382 [GRCh38] Chr22:36464172..38398389 [GRCh37] Chr22:34794118..36728335 [NCBI36] Chr22:22q12.3-13.1	pathogenic
GRCh38/hg38 22q12.3-13.33(chr22:33768441-50739977)x3	copy number gain	See cases [RCV000051682]	Chr22:33768441..50739977 [GRCh38] Chr22:34164428..51178405 [GRCh37] Chr22:32494428..49525271 [NCBI36] Chr22:22q12.3-13.33	pathogenic
GRCh38/hg38 22q12.3(chr22:35753347-36593973)x3	copy number gain	See cases [RCV000052854]	Chr22:35753347..36593973 [GRCh38] Chr22:36149394..36990020 [GRCh37] Chr22:34479340..35319966 [NCBI36] Chr22:22q12.3	uncertain significance
GRCh38/hg38 22q11.1-13.33(chr22:16916608-50739836)x3	copy number gain	See cases [RCV000133646]	Chr22:16916608..50739836 [GRCh38] Chr22:17397498..51178264 [GRCh37] Chr22:15777498..49525130 [NCBI36] Chr22:22q11.1-13.33	pathogenic
GRCh38/hg38 22q11.1-13.33(chr22:16916743-50739785)x3	copy number gain	See cases [RCV000134730]	Chr22:16916743..50739785 [GRCh38] Chr22:17397633..51178213 [GRCh37] Chr22:15777633..49525079 [NCBI36] Chr22:22q11.1-13.33	pathogenic
GRCh38/hg38 22q11.23-12.3(chr22:23279231-36247369)x3	copy number gain	See cases [RCV000138172]	Chr22:23279231..36247369 [GRCh38] Chr22:23621418..36643415 [GRCh37] Chr22:21951418..34973361 [NCBI36] Chr22:22q11.23-12.3	pathogenic
GRCh38/hg38 22q11.21-12.3(chr22:20907226-37187347)x3	copy number gain	See cases [RCV000137926]	Chr22:20907226..37187347 [GRCh38] Chr22:21261514..37583387 [GRCh37] Chr22:19591514..35913333 [NCBI36] Chr22:22q11.21-12.3	pathogenic
GRCh38/hg38 22q12.3(chr22:36218250-36311777)x3	copy number gain	See cases [RCV000141655]	Chr22:36218250..36311777 [GRCh38] Chr22:36614296..36707822 [GRCh37] Chr22:34944242..35037768 [NCBI36] Chr22:22q12.3	uncertain significance
GRCh37/hg19 22q12.3-13.1(chr22:35680095-38098981)x1	copy number loss	See cases [RCV000207444]	Chr22:35680095..38098981 [GRCh37] Chr22:22q12.3-13.1	pathogenic
GRCh37/hg19 22q12.3(chr22:36623928-36677639)x3	copy number gain	See cases [RCV000239870]	Chr22:36623928..36677639 [GRCh37] Chr22:22q12.3	uncertain significance
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51237518)x3	copy number gain	See cases [RCV000240091]	Chr22:16054691..51237518 [GRCh37] Chr22:22q11.1-13.33	pathogenic
GRCh37/hg19 22q12.3-13.33(chr22:35728929-51220961)x3	copy number gain	See cases [RCV000240469]	Chr22:35728929..51220961 [GRCh37] Chr22:22q12.3-13.33	pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51220902)x3	copy number gain	See cases [RCV000446956]	Chr22:16054691..51220902 [GRCh37] Chr22:22q11.1-13.33	pathogenic
GRCh37/hg19 22q12.3(chr22:36614412-36716248)x3	copy number gain	See cases [RCV000448104]	Chr22:36614412..36716248 [GRCh37] Chr22:22q12.3	uncertain significance
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51237463)x3	copy number gain	See cases [RCV000448847]	Chr22:16054691..51237463 [GRCh37] Chr22:22q11.1-13.33	pathogenic
GRCh37/hg19 22q12.3(chr22:36623928-36677580)x3	copy number gain	See cases [RCV000447827]	Chr22:36623928..36677580 [GRCh37] Chr22:22q12.3	uncertain significance
GRCh37/hg19 22q11.1-13.33(chr22:16888900-51197838)	copy number gain	See cases [RCV000510873]	Chr22:16888900..51197838 [GRCh37] Chr22:22q11.1-13.33	pathogenic
NM_030882.4(APOL2):c.842G>T (p.Gly281Val)	single nucleotide variant	not specified [RCV004332783]	Chr22:36227576 [GRCh38] Chr22:36623622 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.835A>C (p.Thr279Pro)	single nucleotide variant	not specified [RCV004312039]	Chr22:36227583 [GRCh38] Chr22:36623629 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.517A>G (p.Asn173Asp)	single nucleotide variant	not specified [RCV004308763]	Chr22:36227901 [GRCh38] Chr22:36623947 [GRCh37] Chr22:22q12.3	uncertain significance
GRCh37/hg19 22q11.1-13.33(chr22:16888900-51197838)x3	copy number gain	See cases [RCV000512333]	Chr22:16888900..51197838 [GRCh37] Chr22:22q11.1-13.33	pathogenic
GRCh37/hg19 22q12.3-13.1(chr22:35674826-39466442)x3	copy number gain	See cases [RCV000512385]	Chr22:35674826..39466442 [GRCh37] Chr22:22q12.3-13.1	likely pathogenic
GRCh37/hg19 22q12.3(chr22:36614412-36716248)x3	copy number gain	not provided [RCV000684454]	Chr22:36614412..36716248 [GRCh37] Chr22:22q12.3	uncertain significance
GRCh37/hg19 22q11.1-13.33(chr22:16888899-51197838)x3	copy number gain	not provided [RCV000846344]	Chr22:16888899..51197838 [GRCh37] Chr22:22q11.1-13.33	pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054667-51243435)x3	copy number gain	not provided [RCV000741689]	Chr22:16054667..51243435 [GRCh37] Chr22:22q11.1-13.33	pathogenic
GRCh37/hg19 22q12.3(chr22:36611863-36714089)x3	copy number gain	not provided [RCV000741937]	Chr22:36611863..36714089 [GRCh37] Chr22:22q12.3	benign
GRCh37/hg19 22q12.3(chr22:36614056-36710183)x3	copy number gain	not provided [RCV000741938]	Chr22:36614056..36710183 [GRCh37] Chr22:22q12.3	benign
GRCh37/hg19 22q12.3(chr22:36616135-36712903)x3	copy number gain	not provided [RCV000741939]	Chr22:36616135..36712903 [GRCh37] Chr22:22q12.3	benign
GRCh37/hg19 22q12.3(chr22:36616135-36713869)x3	copy number gain	not provided [RCV000741940]	Chr22:36616135..36713869 [GRCh37] Chr22:22q12.3	benign
GRCh37/hg19 22q11.1-13.33(chr22:16114244-51195728)x3	copy number gain	not provided [RCV000741691]	Chr22:16114244..51195728 [GRCh37] Chr22:22q11.1-13.33	pathogenic
GRCh37/hg19 22q12.3(chr22:36616135-36714652)x3	copy number gain	not provided [RCV000741941]	Chr22:36616135..36714652 [GRCh37] Chr22:22q12.3	benign
GRCh37/hg19 22q11.1-13.33(chr22:16114244-51211392)x3	copy number gain	not provided [RCV000741692]	Chr22:16114244..51211392 [GRCh37] Chr22:22q11.1-13.33	pathogenic
NM_030882.4(APOL2):c.233G>A (p.Arg78Lys)	single nucleotide variant	not provided [RCV000963050]	Chr22:36228185 [GRCh38] Chr22:36624231 [GRCh37] Chr22:22q12.3	benign
GRCh37/hg19 22q12.2-13.33(chr22:30654764-51197838)x3	copy number gain	not provided [RCV001007181]	Chr22:30654764..51197838 [GRCh37] Chr22:22q12.2-13.33	pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16197005-51224252)x3	copy number gain	See cases [RCV001263056]	Chr22:16197005..51224252 [GRCh37] Chr22:22q11.1-13.33	pathogenic
GRCh37/hg19 22q12.3(chr22:36296883-36631953)x3	copy number gain	not provided [RCV001832996]	Chr22:36296883..36631953 [GRCh37] Chr22:22q12.3	uncertain significance
GRCh37/hg19 22q12.3(chr22:36614412-36716248)	copy number gain	not specified [RCV002052754]	Chr22:36614412..36716248 [GRCh37] Chr22:22q12.3	uncertain significance
NC_000022.10:g.(?_35776672)_(42486826_?)dup	duplication	Adenylosuccinate lyase deficiency [RCV003119093]	Chr22:35776672..42486826 [GRCh37] Chr22:22q12.3-13.2	uncertain significance
NM_030882.4(APOL2):c.136A>G (p.Arg46Gly)	single nucleotide variant	not specified [RCV004204938]	Chr22:36231341 [GRCh38] Chr22:36627387 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.536C>T (p.Ala179Val)	single nucleotide variant	not specified [RCV004100444]	Chr22:36227882 [GRCh38] Chr22:36623928 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.59T>G (p.Val20Gly)	single nucleotide variant	not specified [RCV004087392]	Chr22:36231418 [GRCh38] Chr22:36627464 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.391A>T (p.Thr131Ser)	single nucleotide variant	not specified [RCV004194934]	Chr22:36228027 [GRCh38] Chr22:36624073 [GRCh37] Chr22:22q12.3	likely benign
NM_030882.4(APOL2):c.673C>T (p.Arg225Cys)	single nucleotide variant	not specified [RCV004197807]	Chr22:36227745 [GRCh38] Chr22:36623791 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.206A>T (p.Asn69Ile)	single nucleotide variant	not specified [RCV004141887]	Chr22:36228212 [GRCh38] Chr22:36624258 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.836C>T (p.Thr279Ile)	single nucleotide variant	not specified [RCV004187570]	Chr22:36227582 [GRCh38] Chr22:36623628 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.607A>T (p.Thr203Ser)	single nucleotide variant	not specified [RCV004082780]	Chr22:36227811 [GRCh38] Chr22:36623857 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.538C>G (p.Gln180Glu)	single nucleotide variant	not specified [RCV004167875]	Chr22:36227880 [GRCh38] Chr22:36623926 [GRCh37] Chr22:22q12.3	likely benign
NM_030882.4(APOL2):c.341C>T (p.Thr114Ile)	single nucleotide variant	not specified [RCV004214931]	Chr22:36228077 [GRCh38] Chr22:36624123 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.622A>C (p.Thr208Pro)	single nucleotide variant	not specified [RCV004077025]	Chr22:36227796 [GRCh38] Chr22:36623842 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.650C>T (p.Thr217Ile)	single nucleotide variant	not specified [RCV004111585]	Chr22:36227768 [GRCh38] Chr22:36623814 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.67G>A (p.Glu23Lys)	single nucleotide variant	not specified [RCV004079470]	Chr22:36231410 [GRCh38] Chr22:36627456 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.760G>A (p.Gly254Ser)	single nucleotide variant	not specified [RCV004194743]	Chr22:36227658 [GRCh38] Chr22:36623704 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.259C>T (p.Arg87Trp)	single nucleotide variant	not specified [RCV004188734]	Chr22:36228159 [GRCh38] Chr22:36624205 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.298C>T (p.Arg100Cys)	single nucleotide variant	not specified [RCV004260996]	Chr22:36228120 [GRCh38] Chr22:36624166 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.281A>G (p.Asp94Gly)	single nucleotide variant	not specified [RCV004253191]	Chr22:36228137 [GRCh38] Chr22:36624183 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.269G>C (p.Arg90Thr)	single nucleotide variant	not specified [RCV004250235]	Chr22:36228149 [GRCh38] Chr22:36624195 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.158G>A (p.Arg53His)	single nucleotide variant	not specified [RCV004328267]	Chr22:36228260 [GRCh38] Chr22:36624306 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.490A>T (p.Ile164Phe)	single nucleotide variant	not specified [RCV004302097]	Chr22:36227928 [GRCh38] Chr22:36623974 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.298C>G (p.Arg100Gly)	single nucleotide variant	not specified [RCV004343550]	Chr22:36228120 [GRCh38] Chr22:36624166 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.712G>A (p.Ala238Thr)	single nucleotide variant	not specified [RCV004354328]	Chr22:36227706 [GRCh38] Chr22:36623752 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.256C>T (p.Pro86Ser)	single nucleotide variant	not specified [RCV004350388]	Chr22:36228162 [GRCh38] Chr22:36624208 [GRCh37] Chr22:22q12.3	uncertain significance
GRCh37/hg19 22q12.3(chr22:36340692-36640557)x3	copy number gain	not provided [RCV003485245]	Chr22:36340692..36640557 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.222C>G (p.Asp74Glu)	single nucleotide variant	not specified [RCV004417854]	Chr22:36228196 [GRCh38] Chr22:36624242 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.988A>C (p.Met330Leu)	single nucleotide variant	not specified [RCV004419929]	Chr22:36227430 [GRCh38] Chr22:36623476 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.157C>T (p.Arg53Cys)	single nucleotide variant	not specified [RCV004417853]	Chr22:36228261 [GRCh38] Chr22:36624307 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.467G>A (p.Gly156Glu)	single nucleotide variant	not specified [RCV004417856]	Chr22:36227951 [GRCh38] Chr22:36623997 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.623C>T (p.Thr208Ile)	single nucleotide variant	not specified [RCV004419927]	Chr22:36227795 [GRCh38] Chr22:36623841 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.455G>T (p.Gly152Val)	single nucleotide variant	not specified [RCV004417855]	Chr22:36227963 [GRCh38] Chr22:36624009 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.746T>C (p.Ile249Thr)	single nucleotide variant	not specified [RCV004664573]	Chr22:36227672 [GRCh38] Chr22:36623718 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.94G>A (p.Asp32Asn)	single nucleotide variant	not specified [RCV004653822]	Chr22:36231383 [GRCh38] Chr22:36627429 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.299G>A (p.Arg100His)	single nucleotide variant	not specified [RCV004653811]	Chr22:36228119 [GRCh38] Chr22:36624165 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.209G>A (p.Arg70His)	single nucleotide variant	not specified [RCV004844282]	Chr22:36228209 [GRCh38] Chr22:36624255 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.138G>C (p.Arg46Ser)	single nucleotide variant	not specified [RCV004844317]	Chr22:36228280 [GRCh38] Chr22:36624326 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.54C>A (p.Asp18Glu)	single nucleotide variant	not specified [RCV004844333]	Chr22:36231423 [GRCh38] Chr22:36627469 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.719C>A (p.Ala240Asp)	single nucleotide variant	not specified [RCV004844362]	Chr22:36227699 [GRCh38] Chr22:36623745 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.776G>A (p.Arg259Lys)	single nucleotide variant	not specified [RCV004844367]	Chr22:36227642 [GRCh38] Chr22:36623688 [GRCh37] Chr22:22q12.3	likely benign
NM_030882.4(APOL2):c.379T>A (p.Ser127Thr)	single nucleotide variant	not specified [RCV004844373]	Chr22:36228039 [GRCh38] Chr22:36624085 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.617T>C (p.Val206Ala)	single nucleotide variant	not specified [RCV004844381]	Chr22:36227801 [GRCh38] Chr22:36623847 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.155T>C (p.Leu52Pro)	single nucleotide variant	not specified [RCV004844382]	Chr22:36228263 [GRCh38] Chr22:36624309 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.941C>T (p.Ala314Val)	single nucleotide variant	not specified [RCV004850420]	Chr22:36227477 [GRCh38] Chr22:36623523 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.791C>T (p.Pro264Leu)	single nucleotide variant	not specified [RCV004850421]	Chr22:36227627 [GRCh38] Chr22:36623673 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.794C>T (p.Ala265Val)	single nucleotide variant	not specified [RCV004850422]	Chr22:36227624 [GRCh38] Chr22:36623670 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.970C>G (p.Leu324Val)	single nucleotide variant	not specified [RCV004850424]	Chr22:36227448 [GRCh38] Chr22:36623494 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.743G>A (p.Arg248Gln)	single nucleotide variant	not specified [RCV004844326]	Chr22:36227675 [GRCh38] Chr22:36623721 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.674G>A (p.Arg225His)	single nucleotide variant	not specified [RCV004844309]	Chr22:36227744 [GRCh38] Chr22:36623790 [GRCh37] Chr22:22q12.3	uncertain significance
NM_030882.4(APOL2):c.202A>G (p.Lys68Glu)	single nucleotide variant	not specified [RCV004844292]	Chr22:36228216 [GRCh38] Chr22:36624262 [GRCh37] Chr22:22q12.3	uncertain significance

Predicted Target Of

	Summary Value
Count of predictions:	3763
Count of miRNA genes:	932
Interacting mature miRNAs:	1152
Transcripts:	ENST00000249066, ENST00000358502, ENST00000451256, ENST00000454728, ENST00000473549, ENST00000476579, ENST00000484830, ENST00000489186, ENST00000529194
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1581529	BP71_H	Blood pressure QTL 71 (human)	2	0.001	Blood pressure	pulse pressure	22	11094966	37094966	Human
597431727	GWAS1527801_H	protein measurement QTL GWAS1527801 (human)		5e-29	protein measurement		22	36226776	36226777	Human
597301918	GWAS1397992_H	level of apolipoprotein L2 in blood serum QTL GWAS1397992 (human)		8e-58	level of apolipoprotein L2 in blood serum		22	36226782	36226783	Human
2289428	BW313_H	Body weight QTL 313 (human)	2.09	0.0015	Body weight	BMI	22	11344284	37344284	Human
406980538	GWAS629514_H	aging, epigenetic status QTL GWAS629514 (human)		5e-08	aging, epigenetic status		22	36237790	36237791	Human
406979694	GWAS628670_H	aging, epigenetic status QTL GWAS628670 (human)		0.0000004	aging, epigenetic status		22	36235645	36235646	Human

D22S1173

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	22	36,636,625 - 36,636,886	UniSTS	GRCh37
Build 36	22	34,966,571 - 34,966,832	RGD	NCBI36
Celera	22	20,439,193 - 20,439,454	RGD
Cytogenetic Map	22	q12	UniSTS
HuRef	22	19,604,734 - 19,604,999	UniSTS
Marshfield Genetic Map	22	37.82	RGD
Marshfield Genetic Map	22	37.82	UniSTS
Genethon Genetic Map	22	32.6	UniSTS
deCODE Assembly Map	22	42.01	UniSTS
Stanford-G3 RH Map	22	1009.0	UniSTS
GeneMap99-G3 RH Map	22	1009.0	UniSTS

RH80142

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	22	36,663,369 - 36,663,546	UniSTS	GRCh37
GRCh37	22	36,622,280 - 36,622,457	UniSTS	GRCh37
Build 36	22	34,952,226 - 34,952,403	RGD	NCBI36
Celera	22	20,465,937 - 20,466,114	UniSTS
Celera	22	20,424,850 - 20,425,027	RGD
Cytogenetic Map	22	q13.1	UniSTS
Cytogenetic Map	22	q12	UniSTS
HuRef	22	19,590,391 - 19,590,568	UniSTS
HuRef	22	19,631,446 - 19,631,623	UniSTS
GeneMap99-GB4 RH Map	22	117.88	UniSTS

D22S592

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	22	36,663,624 - 36,663,823	UniSTS	GRCh37
GRCh37	22	36,622,003 - 36,622,202	UniSTS	GRCh37
Build 36	22	34,951,949 - 34,952,148	RGD	NCBI36
Celera	22	20,424,573 - 20,424,772	RGD
Celera	22	20,466,192 - 20,466,391	UniSTS
Cytogenetic Map	22	q13.1	UniSTS
Cytogenetic Map	22	q12	UniSTS
HuRef	22	19,631,701 - 19,631,900	UniSTS
HuRef	22	19,590,114 - 19,590,313	UniSTS

APOL2_299.2

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	22	36,622,173 - 36,623,032	UniSTS	GRCh37
GRCh37	22	36,662,482 - 36,663,653	UniSTS	GRCh37
Build 36	22	34,952,119 - 34,952,978	RGD	NCBI36
Celera	22	20,465,050 - 20,466,221	UniSTS
Celera	22	20,424,743 - 20,425,602	RGD
HuRef	22	19,590,284 - 19,591,144	UniSTS
HuRef	22	19,630,597 - 19,631,730	UniSTS

APOL3_301

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	22	36,622,255 - 36,623,028	UniSTS	GRCh37
GRCh37	22	36,536,377 - 36,537,145	UniSTS	GRCh37
Build 36	22	34,866,323 - 34,867,091	RGD	NCBI36
Celera	22	20,424,825 - 20,425,598	UniSTS
Celera	22	20,338,949 - 20,339,717	RGD
HuRef	22	19,590,366 - 19,591,140	UniSTS
HuRef	22	19,504,525 - 19,505,293	UniSTS

AL021679

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	22	36,627,881 - 36,628,012	UniSTS	GRCh37
Build 36	22	34,957,827 - 34,957,958	RGD	NCBI36
Celera	22	20,430,446 - 20,430,577	RGD
Cytogenetic Map	22	q12	UniSTS
HuRef	22	19,595,988 - 19,596,119	UniSTS

D22S541

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	22	36,649,842 - 36,649,962	UniSTS	GRCh37
GRCh37	22	36,634,756 - 36,634,876	UniSTS	GRCh37
Build 36	22	34,964,702 - 34,964,822	RGD	NCBI36
Celera	22	20,437,324 - 20,437,444	RGD
Celera	22	20,452,410 - 20,452,530	UniSTS
Cytogenetic Map	22	q13.1	UniSTS
Cytogenetic Map	22	q12	UniSTS
HuRef	22	19,617,956 - 19,618,076	UniSTS
HuRef	22	19,602,865 - 19,602,985	UniSTS

D22S924

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	22	36,631,766 - 36,631,962	UniSTS	GRCh37
Build 36	22	34,961,712 - 34,961,908	RGD	NCBI36
Celera	22	20,434,332 - 20,434,530	RGD
Cytogenetic Map	22	q12	UniSTS
HuRef	22	19,599,873 - 19,600,071	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	entire extraembryonic component	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	pharyngeal arch	renal system	reproductive system	respiratory system	sensory system	visual system
1204	2439	2788	2252	4974	1726	2351	6	624	1950	465	2270	7306	6472	53	3734	1	852	1744	1617	175	1


RefSeq Transcripts	NG_023229	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_030882	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_145637	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_011530074	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_011530075	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_011530076	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_011530077	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_011530078	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017028724	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_047441284	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_047441285	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054325432	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054325433	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054325434	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB208990	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF305225	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF305429	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF324223	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF324224	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AH010392	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK056938	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK303978	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL031426	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC004395	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471095	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068256	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HY306110	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KF457434	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	Z82215	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	Z95114	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENST00000249066 ⟹ ENSP00000249066

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	22	36,226,210 - 36,239,954 (-)	Ensembl

Ensembl Acc Id:

ENST00000358502 ⟹ ENSP00000351292

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	22	36,226,209 - 36,239,527 (-)	Ensembl

Ensembl Acc Id:

ENST00000451256 ⟹ ENSP00000403153

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	22	36,227,342 - 36,239,527 (-)	Ensembl

Ensembl Acc Id:

ENST00000454728 ⟹ ENSP00000400486

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	22	36,228,195 - 36,239,561 (-)	Ensembl

Ensembl Acc Id:

ENST00000473549

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	22	36,236,933 - 36,239,673 (-)	Ensembl

Ensembl Acc Id:

ENST00000476579

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	22	36,236,885 - 36,239,239 (-)	Ensembl

Ensembl Acc Id:

ENST00000484830

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	22	36,236,964 - 36,239,570 (-)	Ensembl

Ensembl Acc Id:

ENST00000489186

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	22	36,236,927 - 36,239,582 (-)	Ensembl

Ensembl Acc Id:

ENST00000529194 ⟹ ENSP00000431231

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	22	36,228,032 - 36,239,227 (-)	Ensembl

RefSeq Acc Id:

NM_030882 ⟹ NP_112092

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	22	36,226,209 - 36,239,527 (-)	NCBI
GRCh37	22	36,622,255 - 36,636,000 (-)	RGD
Build 36	22	34,952,201 - 34,965,635 (-)	NCBI Archive
Celera	22	20,424,825 - 20,438,568 (-)	RGD
HuRef	22	19,590,366 - 19,604,109 (-)	RGD
CHM1_1	22	36,581,376 - 36,594,808 (-)	NCBI
T2T-CHM13v2.0	22	36,686,335 - 36,699,643 (-)	NCBI

Sequence:

show sequence

ATTACACAGATGCACAGCTGGACGTGGGATCCACACAGCTCAGAACAGTTGGATCTTGCTCAGTCTCTGTCAGAGGAAGATCCCTTGGACAAGAGGACCCTGCCTTGGTGTGAGAGTGAGGGAAGAGG
AAGCTGGAACGAGGGTTAAGGAAAACCTTCCAGTCTGGACAGTGACTGGAGAGCTCCAAGGAAAGCCCCTCGGTAACCCAGCCGCTGGCACCATGAACCCAGAGAGCAGTATCTTTATTGAGGATTAC
CTTAAGTATTTCCAGGACCAAGTGAGCAGAGAGAATCTGCTACAACTGCTGACTGATGATGAAGCCTGGAATGGATTCGTGGCTGCTGCTGAACTGCCCAGGGATGAGGCAGATGAGCTCCGTAAAGC
TCTGAACAAGCTTGCAAGTCACATGGTCATGAAGGACAAAAACCGCCACGATAAAGACCAGCAGCACAGGCAGTGGTTTTTGAAAGAGTTTCCTCGGTTGAAAAGGGAGCTTGAGGATCACATAAGGA
AGCTCCGTGCCCTTGCAGAGGAGGTTGAGCAGGTCCACAGAGGCACCACCATTGCCAATGTGGTGTCCAACTCTGTTGGCACTACCTCTGGCATCCTGACCCTCCTCGGCCTGGGTCTGGCACCCTTC
ACAGAAGGAATCAGTTTTGTGCTCTTGGACACTGGCATGGGTCTGGGAGCAGCAGCTGCTGTGGCTGGGATTACCTGCAGTGTGGTAGAACTAGTAAACAAATTGCGGGCACGAGCCCAAGCCCGCAA
CTTGGACCAAAGCGGCACCAATGTAGCAAAGGTGATGAAGGAGTTTGTGGGTGGGAACACACCCAATGTTCTTACCTTAGTTGACAATTGGTACCAAGTCACACAAGGGATTGGGAGGAACATCCGTG
CCATCAGACGAGCCAGAGCCAACCCTCAGTTAGGAGCGTATGCCCCACCCCCGCATGTCATTGGGCGAATCTCAGCTGAAGGCGGTGAACAGGTTGAGAGGGTTGTTGAAGGCCCCGCCCAGGCAATG
AGCAGAGGAACCATGATCGTGGGTGCAGCCACTGGAGGCATCTTGCTTCTGCTGGATGTGGTCAGCCTTGCATATGAGTCAAAGCACTTGCTTGAGGGGGCAAAGTCAGAGTCAGCTGAGGAGCTGAA
GAAGCGGGCTCAGGAGCTGGAGGGGAAGCTCAACTTTCTCACCAAGATCCATGAGATGCTGCAGCCAGGCCAAGACCAATGACCCCAGAGCAGTGCAGCCACCAGGGCAGAAATGCCGGGCACAGGCC
AGGACAAAATGCAGACTTTTTTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTATCGCCCAGGATGGAGTGCAGTGGCTCAATCTCGGCTCACTGCAAACTCCGCCTCCCGGGTTCACACC
ATTCTCCGGCCTCAGTCTCCCGAGTAGCTGGGACTACAGGCACCTGCCACCACGCCCGGCTAATTTTTTTGTATTTTCACTGGAGACGGGGTTTCACTGTGTTAGCCACGATGGTCTCCATCTCCTGA
CCTCGTGATCTGCCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCTGGCCAAAATGCAGACATTTTATTAGGGGGATAAGGAGGGCAAGGTAAAGCTTATGGAACTGAGT
GTTAGTGACTTTGGCATTTGTGTAGCTGAGCACAGCAAGGGAGGGGTTAATGCAGATGGCAAGTGCACCAAGGAGAAGGCAGGAACACTGGAGCCTGCAATAAGGGAGGAGAGAGGACTGGAGAGTGT
GGGGAATGGGAAGAAGTAGTTTACTTTGGACTAAAGAATATATTGGGCGAAGAATAGAGGGGGAGCTTGCAGGAACCAGCAATGAGAAGGCCAGGAAAAGAAAGAGCTGAAAATGGAGAAAACCAGAG
TTAGAACTGTTGGATACAGGAGAAGAAACAGCAGCTCCACTACCGACCCCCCCCCAGGTTTGATGTCCTTCCAAGAATAAAGTCTTTCCCTGGTGATGGTCTCTCGCTCTGTCTTTCCAGCATCCACT
CTCCCTTGTCCTTCTGGGGGTGTATCACAGTCAGCCAGTGGCTTCTTCATGATGGTGGTTGGGGTGGTTGTCATGTGACGGGTCCCCTCCAGGTTACTAAAGGGTGCATGTCCCCTGCTTGAACCCTG
AGAGGCAGGTGGTAGGCCATGGCCACAATCCCCAGCTGAGGAGCAGGTGTCCCTGAGAACCCAAACTTCCCAGAGAGTATCTGAGAACCAACCAATGAAAACAGTCCCATCGCTCTTAGCCGGTAAGT
AAACAGTCAGAAGATTAGCATGAAAGCAGTTTAGCATTGGGAGGAAGCACAGATCTCTAGAGCTGTCCTGTCGCTGCCCAGGATTGACCTGTGTGTAAGTCCCAATAAACTCACCTACTCACCAA

hide sequence

RefSeq Acc Id:

NM_145637 ⟹ NP_663612

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	22	36,226,209 - 36,239,954 (-)	NCBI
GRCh37	22	36,622,255 - 36,636,000 (-)	RGD
Build 36	22	34,952,201 - 34,965,946 (-)	NCBI Archive
Celera	22	20,424,825 - 20,438,568 (-)	RGD
HuRef	22	19,590,366 - 19,604,109 (-)	RGD
CHM1_1	22	36,581,376 - 36,595,119 (-)	NCBI
T2T-CHM13v2.0	22	36,686,335 - 36,700,070 (-)	NCBI

Sequence:

show sequence

ATCAGACAGTAAAACAGGGGCAGAGCCTGGAATTGCACTGAGGCTTGAGTCTGACTTCTCTCCCCCACCTGCTGTGCCCTTAAACTGCAGAGATCGGGGCGGGGGTTGGGGGGCAAGCGGCTCAGATG
GGTTCAAAAAACTCCCCAGGCTCAACTCTGGTTCTGACTGCCTGAGACATGGGCAGCTGACACAGCAGACCTTGAATCCTGAGGATGTGAGGCAGGGTATATCTGGGAGGCCGGAGGACGTGTCTGGT
TATTACACAGATGCACAGCTGGACGTGGGATCCACACAGCTCAGAACAGTTGGATCTTGCTCAGTCTCTGTCAGAGGAAGATCCCTTGGACAAGAGGACCCTGCCTTGGTGTGAGAGTGAGGGAAGAG
GAAGCTGGAACGAGGGTTAAGGAAAACCTTCCAGTCTGGACAGTGACTGGAGAGCTCCAAGGAAAGCCCCTCGGTAACCCAGCCGCTGGCACCATGAACCCAGAGAGCAGTATCTTTATTGAGGATTA
CCTTAAGTATTTCCAGGACCAAGTGAGCAGAGAGAATCTGCTACAACTGCTGACTGATGATGAAGCCTGGAATGGATTCGTGGCTGCTGCTGAACTGCCCAGGGATGAGGCAGATGAGCTCCGTAAAG
CTCTGAACAAGCTTGCAAGTCACATGGTCATGAAGGACAAAAACCGCCACGATAAAGACCAGCAGCACAGGCAGTGGTTTTTGAAAGAGTTTCCTCGGTTGAAAAGGGAGCTTGAGGATCACATAAGG
AAGCTCCGTGCCCTTGCAGAGGAGGTTGAGCAGGTCCACAGAGGCACCACCATTGCCAATGTGGTGTCCAACTCTGTTGGCACTACCTCTGGCATCCTGACCCTCCTCGGCCTGGGTCTGGCACCCTT
CACAGAAGGAATCAGTTTTGTGCTCTTGGACACTGGCATGGGTCTGGGAGCAGCAGCTGCTGTGGCTGGGATTACCTGCAGTGTGGTAGAACTAGTAAACAAATTGCGGGCACGAGCCCAAGCCCGCA
ACTTGGACCAAAGCGGCACCAATGTAGCAAAGGTGATGAAGGAGTTTGTGGGTGGGAACACACCCAATGTTCTTACCTTAGTTGACAATTGGTACCAAGTCACACAAGGGATTGGGAGGAACATCCGT
GCCATCAGACGAGCCAGAGCCAACCCTCAGTTAGGAGCGTATGCCCCACCCCCGCATGTCATTGGGCGAATCTCAGCTGAAGGCGGTGAACAGGTTGAGAGGGTTGTTGAAGGCCCCGCCCAGGCAAT
GAGCAGAGGAACCATGATCGTGGGTGCAGCCACTGGAGGCATCTTGCTTCTGCTGGATGTGGTCAGCCTTGCATATGAGTCAAAGCACTTGCTTGAGGGGGCAAAGTCAGAGTCAGCTGAGGAGCTGA
AGAAGCGGGCTCAGGAGCTGGAGGGGAAGCTCAACTTTCTCACCAAGATCCATGAGATGCTGCAGCCAGGCCAAGACCAATGACCCCAGAGCAGTGCAGCCACCAGGGCAGAAATGCCGGGCACAGGC
CAGGACAAAATGCAGACTTTTTTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTATCGCCCAGGATGGAGTGCAGTGGCTCAATCTCGGCTCACTGCAAACTCCGCCTCCCGGGTTCACAC
CATTCTCCGGCCTCAGTCTCCCGAGTAGCTGGGACTACAGGCACCTGCCACCACGCCCGGCTAATTTTTTTGTATTTTCACTGGAGACGGGGTTTCACTGTGTTAGCCACGATGGTCTCCATCTCCTG
ACCTCGTGATCTGCCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCTGGCCAAAATGCAGACATTTTATTAGGGGGATAAGGAGGGCAAGGTAAAGCTTATGGAACTGAG
TGTTAGTGACTTTGGCATTTGTGTAGCTGAGCACAGCAAGGGAGGGGTTAATGCAGATGGCAAGTGCACCAAGGAGAAGGCAGGAACACTGGAGCCTGCAATAAGGGAGGAGAGAGGACTGGAGAGTG
TGGGGAATGGGAAGAAGTAGTTTACTTTGGACTAAAGAATATATTGGGCGAAGAATAGAGGGGGAGCTTGCAGGAACCAGCAATGAGAAGGCCAGGAAAAGAAAGAGCTGAAAATGGAGAAAACCAGA
GTTAGAACTGTTGGATACAGGAGAAGAAACAGCAGCTCCACTACCGACCCCCCCCCAGGTTTGATGTCCTTCCAAGAATAAAGTCTTTCCCTGGTGATGGTCTCTCGCTCTGTCTTTCCAGCATCCAC
TCTCCCTTGTCCTTCTGGGGGTGTATCACAGTCAGCCAGTGGCTTCTTCATGATGGTGGTTGGGGTGGTTGTCATGTGACGGGTCCCCTCCAGGTTACTAAAGGGTGCATGTCCCCTGCTTGAACCCT
GAGAGGCAGGTGGTAGGCCATGGCCACAATCCCCAGCTGAGGAGCAGGTGTCCCTGAGAACCCAAACTTCCCAGAGAGTATCTGAGAACCAACCAATGAAAACAGTCCCATCGCTCTTAGCCGGTAAG
TAAACAGTCAGAAGATTAGCATGAAAGCAGTTTAGCATTGGGAGGAAGCACAGATCTCTAGAGCTGTCCTGTCGCTGCCCAGGATTGACCTGTGTGTAAGTCCCAATAAACTCACCTACTCACCAA

hide sequence

RefSeq Acc Id:

XM_011530077 ⟹ XP_011528379

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	22	36,226,209 - 36,239,527 (-)	NCBI

Sequence:

show sequence

GGGGAAAACAGCTTAGATGGGTTCACAAAGCTCCCCGGGCTCAGCTCTGGTTCTGACACCCTCAGACACGGCCAGCTGACCCCAGAAGAAAGGACAAGAGGACCCTGCCTTGGTGTGAGAGTGAGGGA
AGAGGAAGCTGGAACGAGGGTTAAGGAAAACCTTCCAGTCTGGACAGTGACTGGAGAGCTCCAAGGAAAGCCCCTCGGTAACCCAGCCGCTGGCACCATGAACCCAGAGAGCAGTATCTTTATTGAGG
ATTACCTTAAGTATTTCCAGGACCAAGTGAGCAGAGAGAATCTGCTACAACTGCTGACTGATGATGAAGCCTGGAATGGATTCGTGGCTGCTGCTGAACTGCCCAGGGATGAGGCAGATGAGCTCCGT
AAAGCTCTGAACAAGCTTGCAAGTCACATGGTCATGAAGGACAAAAACCGCCACGATAAAGACCAGCAGCACAGGCAGTGGTTTTTGAAAGAGTTTCCTCGGTTGAAAAGGGAGCTTGAGGATCACAT
AAGGAAGCTCCGTGCCCTTGCAGAGGAGGTTGAGCAGGTCCACAGAGGCACCACCATTGCCAATGTGGTGTCCAACTCTGTTGGCACTACCTCTGGCATCCTGACCCTCCTCGGCCTGGGTCTGGCAC
CCTTCACAGAAGGAATCAGTTTTGTGCTCTTGGACACTGGCATGGGTCTGGGAGCAGCAGCTGCTGTGGCTGGGATTACCTGCAGTGTGGTAGAACTAGTAAACAAATTGCGGGCACGAGCCCAAGCC
CGCAACTTGGACCAAAGCGGCACCAATGTAGCAAAGGTGATGAAGGAGTTTGTGGGTGGGAACACACCCAATGTTCTTACCTTAGTTGACAATTGGTACCAAGTCACACAAGGGATTGGGAGGAACAT
CCGTGCCATCAGACGAGCCAGAGCCAACCCTCAGTTAGGAGCGTATGCCCCACCCCCGCATGTCATTGGGCGAATCTCAGCTGAAGGCGGTGAACAGGTTGAGAGGGTTGTTGAAGGCCCCGCCCAGG
CAATGAGCAGAGGAACCATGATCGTGGGTGCAGCCACTGGAGGCATCTTGCTTCTGCTGGATGTGGTCAGCCTTGCATATGAGTCAAAGCACTTGCTTGAGGGGGCAAAGTCAGAGTCAGCTGAGGAG
CTGAAGAAGCGGGCTCAGGAGCTGGAGGGGAAGCTCAACTTTCTCACCAAGATCCATGAGATGCTGCAGCCAGGCCAAGACCAATGACCCCAGAGCAGTGCAGCCACCAGGGCAGAAATGCCGGGCAC
AGGCCAGGACAAAATGCAGACTTTTTTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTATCGCCCAGGATGGAGTGCAGTGGCTCAATCTCGGCTCACTGCAAACTCCGCCTCCCGGGTTC
ACACCATTCTCCGGCCTCAGTCTCCCGAGTAGCTGGGACTACAGGCACCTGCCACCACGCCCGGCTAATTTTTTTGTATTTTCACTGGAGACGGGGTTTCACTGTGTTAGCCACGATGGTCTCCATCT
CCTGACCTCGTGATCTGCCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCTGGCCAAAATGCAGACATTTTATTAGGGGGATAAGGAGGGCAAGGTAAAGCTTATGGAAC
TGAGTGTTAGTGACTTTGGCATTTGTGTAGCTGAGCACAGCAAGGGAGGGGTTAATGCAGATGGCAAGTGCACCAAGGAGAAGGCAGGAACACTGGAGCCTGCAATAAGGGAGGAGAGAGGACTGGAG
AGTGTGGGGAATGGGAAGAAGTAGTTTACTTTGGACTAAAGAATATATTGGGCGAAGAATAGAGGGGGAGCTTGCAGGAACCAGCAATGAGAAGGCCAGGAAAAGAAAGAGCTGAAAATGGAGAAAAC
CAGAGTTAGAACTGTTGGATACAGGAGAAGAAACAGCAGCTCCACTACCGACCCCCCCCCAGGTTTGATGTCCTTCCAAGAATAAAGTCTTTCCCTGGTGATGGTCTCTCGCTCTGTCTTTCCAGCAT
CCACTCTCCCTTGTCCTTCTGGGGGTGTATCACAGTCAGCCAGTGGCTTCTTCATGATGGTGGTTGGGGTGGTTGTCATGTGACGGGTCCCCTCCAGGTTACTAAAGGGTGCATGTCCCCTGCTTGAA
CCCTGAGAGGCAGGTGGTAGGCCATGGCCACAATCCCCAGCTGAGGAGCAGGTGTCCCTGAGAACCCAAACTTCCCAGAGAGTATCTGAGAACCAACCAATGAAAACAGTCCCATCGCTCTTAGCCGG
TAAGTAAACAGTCAGAAGATTAGCATGAAAGCAGTTTAGCATTGGGAGGAAGCACAGATCTCTAGAGCTGTCCTGTCGCTGCCCAGGATTGACCTGTGTGTAAGTCCCAATAAACTCACCTACTCACC
AA

hide sequence

RefSeq Acc Id:

XM_047441284 ⟹ XP_047297240

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	22	36,226,209 - 36,236,848 (-)	NCBI

RefSeq Acc Id:

XM_047441285 ⟹ XP_047297241

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	22	36,226,209 - 36,239,954 (-)	NCBI

RefSeq Acc Id:

XM_054325432 ⟹ XP_054181407

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
T2T-CHM13v2.0	22	36,686,335 - 36,696,964 (-)	NCBI

RefSeq Acc Id:

XM_054325433 ⟹ XP_054181408

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
T2T-CHM13v2.0	22	36,686,335 - 36,700,070 (-)	NCBI

RefSeq Acc Id:

XM_054325434 ⟹ XP_054181409

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
T2T-CHM13v2.0	22	36,686,335 - 36,699,550 (-)	NCBI


Protein RefSeqs	NP_112092	(Get FASTA)	NCBI Sequence Viewer
	NP_663612	(Get FASTA)	NCBI Sequence Viewer
	XP_011528379	(Get FASTA)	NCBI Sequence Viewer
	XP_047297240	(Get FASTA)	NCBI Sequence Viewer
	XP_047297241	(Get FASTA)	NCBI Sequence Viewer
	XP_054181407	(Get FASTA)	NCBI Sequence Viewer
	XP_054181408	(Get FASTA)	NCBI Sequence Viewer
	XP_054181409	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH04395	(Get FASTA)	NCBI Sequence Viewer
	AAK11592	(Get FASTA)	NCBI Sequence Viewer
	AAK11593	(Get FASTA)	NCBI Sequence Viewer
	AAK20211	(Get FASTA)	NCBI Sequence Viewer
	AAL09359	(Get FASTA)	NCBI Sequence Viewer
	BAB71315	(Get FASTA)	NCBI Sequence Viewer
	BAD92227	(Get FASTA)	NCBI Sequence Viewer
	BAG64897	(Get FASTA)	NCBI Sequence Viewer
	EAW60087	(Get FASTA)	NCBI Sequence Viewer
	EAW60088	(Get FASTA)	NCBI Sequence Viewer
	EAW60089	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000249066
	ENSP00000249066.6
	ENSP00000351292
	ENSP00000351292.5
GenBank Protein	Q9BQE5	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_663612 ⟸ NM_145637
- UniProtKB:	Q9UGT1 (UniProtKB/Swiss-Prot), Q9BT28 (UniProtKB/Swiss-Prot), Q969T6 (UniProtKB/Swiss-Prot), Q5TH96 (UniProtKB/Swiss-Prot), Q59GW9 (UniProtKB/Swiss-Prot), O95915 (UniProtKB/Swiss-Prot), B0QYK7 (UniProtKB/Swiss-Prot), Q9UH10 (UniProtKB/Swiss-Prot), Q9BQE5 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MNPESSIFIEDYLKYFQDQVSRENLLQLLTDDEAWNGFVAAAELPRDEADELRKALNKLASHMVMKDKNRHDKDQQHRQWFLKEFPRLKRELEDHIRKLRALAEEVEQVHRGTTIANVVSNSVGTTSG ILTLLGLGLAPFTEGISFVLLDTGMGLGAAAAVAGITCSVVELVNKLRARAQARNLDQSGTNVAKVMKEFVGGNTPNVLTLVDNWYQVTQGIGRNIRAIRRARANPQLGAYAPPPHVIGRISAEGGEQ VERVVEGPAQAMSRGTMIVGAATGGILLLLDVVSLAYESKHLLEGAKSESAEELKKRAQELEGKLNFLTKIHEMLQPGQDQ hide sequence

RefSeq Acc Id:	NP_112092 ⟸ NM_030882
- UniProtKB:	Q9UGT1 (UniProtKB/Swiss-Prot), Q9BT28 (UniProtKB/Swiss-Prot), Q969T6 (UniProtKB/Swiss-Prot), Q5TH96 (UniProtKB/Swiss-Prot), Q59GW9 (UniProtKB/Swiss-Prot), O95915 (UniProtKB/Swiss-Prot), B0QYK7 (UniProtKB/Swiss-Prot), Q9UH10 (UniProtKB/Swiss-Prot), Q9BQE5 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MNPESSIFIEDYLKYFQDQVSRENLLQLLTDDEAWNGFVAAAELPRDEADELRKALNKLASHMVMKDKNRHDKDQQHRQWFLKEFPRLKRELEDHIRKLRALAEEVEQVHRGTTIANVVSNSVGTTSG ILTLLGLGLAPFTEGISFVLLDTGMGLGAAAAVAGITCSVVELVNKLRARAQARNLDQSGTNVAKVMKEFVGGNTPNVLTLVDNWYQVTQGIGRNIRAIRRARANPQLGAYAPPPHVIGRISAEGGEQ VERVVEGPAQAMSRGTMIVGAATGGILLLLDVVSLAYESKHLLEGAKSESAEELKKRAQELEGKLNFLTKIHEMLQPGQDQ hide sequence

RefSeq Acc Id:	XP_011528379 ⟸ XM_011530077
- Peptide Label:	isoform X1
- UniProtKB:	Q9UGT1 (UniProtKB/Swiss-Prot), Q9BT28 (UniProtKB/Swiss-Prot), Q969T6 (UniProtKB/Swiss-Prot), Q5TH96 (UniProtKB/Swiss-Prot), Q59GW9 (UniProtKB/Swiss-Prot), O95915 (UniProtKB/Swiss-Prot), B0QYK7 (UniProtKB/Swiss-Prot), Q9UH10 (UniProtKB/Swiss-Prot), Q9BQE5 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MNPESSIFIEDYLKYFQDQVSRENLLQLLTDDEAWNGFVAAAELPRDEADELRKALNKLASHMVMKDKNRHDKDQQHRQWFLKEFPRLKRELEDHIRKLRALAEEVEQVHRGTTIANVVSNSVGTTSG ILTLLGLGLAPFTEGISFVLLDTGMGLGAAAAVAGITCSVVELVNKLRARAQARNLDQSGTNVAKVMKEFVGGNTPNVLTLVDNWYQVTQGIGRNIRAIRRARANPQLGAYAPPPHVIGRISAEGGEQ VERVVEGPAQAMSRGTMIVGAATGGILLLLDVVSLAYESKHLLEGAKSESAEELKKRAQELEGKLNFLTKIHEMLQPGQDQ hide sequence

Ensembl Acc Id:

ENSP00000403153 ⟸ ENST00000451256

Ensembl Acc Id:

ENSP00000400486 ⟸ ENST00000454728

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9BQE5-F1-model_v2	AlphaFold	Q9BQE5	1-337	view protein structure

RGD ID:

6800472

Promoter ID:

HG_KWN:42591

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, CD4+TCell_12Hour, CD4+TCell_2Hour, HeLa_S3, K562, Lymphoblastoid, NB4

Transcripts:

NM_030882, NM_145637, OTTHUMT00000319281, OTTHUMT00000319282, OTTHUMT00000319283, OTTHUMT00000319284, OTTHUMT00000319285, UC003APB.1

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	22	34,964,076 - 34,965,797 (-)	MPROMDB

RGD ID:

13603890

Promoter ID:

EPDNEW_H28128

Type:

initiation region

Name:

APOL2_1

Description:

apolipoprotein L2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H28129

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	22	36,239,527 - 36,239,587	EPDNEW

RGD ID:

13603888

Promoter ID:

EPDNEW_H28129

Type:

initiation region

Name:

APOL2_2

Description:

apolipoprotein L2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H28128

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	22	36,239,978 - 36,240,038	EPDNEW

Database	Acc Id	Source(s)
COSMIC	APOL2	COSMIC
Ensembl Genes	ENSG00000128335	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000249066	ENTREZGENE
	ENST00000249066.10	UniProtKB/Swiss-Prot
	ENST00000358502	ENTREZGENE
	ENST00000358502.10	UniProtKB/Swiss-Prot
GTEx	ENSG00000128335	GTEx
HGNC ID	HGNC:619	ENTREZGENE
Human Proteome Map	APOL2	Human Proteome Map
InterPro	ApoL	UniProtKB/Swiss-Prot
KEGG Report	hsa:23780	UniProtKB/Swiss-Prot
NCBI Gene	23780	ENTREZGENE
OMIM	607252	OMIM
PANTHER	APOLIPOPROTEIN L2	UniProtKB/Swiss-Prot
	PTHR14096	UniProtKB/Swiss-Prot
Pfam	ApoL	UniProtKB/Swiss-Prot
PharmGKB	PA24905	PharmGKB
UniProt	APOL2_HUMAN	UniProtKB/Swiss-Prot
	B0QYK7	ENTREZGENE
	B0QYK8_HUMAN	UniProtKB/TrEMBL
	E9PM95_HUMAN	UniProtKB/TrEMBL
	J3KQL8_HUMAN	UniProtKB/TrEMBL
	O95915	ENTREZGENE
	Q59GW9	ENTREZGENE
	Q5TH96	ENTREZGENE
	Q969T6	ENTREZGENE
	Q9BQE5	ENTREZGENE
	Q9BT28	ENTREZGENE
	Q9UGT1	ENTREZGENE
	Q9UH10	ENTREZGENE
UniProt Secondary	B0QYK7	UniProtKB/Swiss-Prot
	O95915	UniProtKB/Swiss-Prot
	Q59GW9	UniProtKB/Swiss-Prot
	Q5TH96	UniProtKB/Swiss-Prot
	Q969T6	UniProtKB/Swiss-Prot
	Q9BT28	UniProtKB/Swiss-Prot
	Q9UGT1	UniProtKB/Swiss-Prot
	Q9UH10	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-12-22	APOL2	apolipoprotein L2	APOL2	apolipoprotein L, 2	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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