Adnp (activity dependent neuroprotector homeobox) - Rat Genome Database

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Gene: Adnp (activity dependent neuroprotector homeobox) Chinchilla lanigera
Analyze
Symbol: Adnp
Name: activity dependent neuroprotector homeobox
RGD ID: 9012098
Description: ENCODES a protein that exhibits beta-catenin binding (ortholog); beta-tubulin binding (ortholog); chromatin binding (ortholog); INVOLVED IN activation of protein kinase activity (ortholog); cGMP-mediated signaling (ortholog); estrous cycle (ortholog); ASSOCIATED WITH Agenesis of Corpus Callosum (ortholog); Alzheimer's disease (ortholog); autism spectrum disorder (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: activity-dependent neuroprotector homeobox
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554457,492,257 - 7,531,862 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554457,498,223 - 7,530,828 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 16 of 16 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AdnpChinchillaAgenesis of Corpus Callosum  ISOADNP (Homo sapiens)8554872ClinVar Annotator: match by term: Corpus callosum and agenesis ofClinVarPMID:24531329 more ...
AdnpChinchillaautism spectrum disorder  ISOADNP (Homo sapiens)8554872ClinVar Annotator: match by term: Autism spectrum disorderClinVarPMID:30504930
AdnpChinchillaautistic disorder  ISOADNP (Homo sapiens)8554872ClinVar Annotator: match by term: Autism and severeClinVarPMID:25741868
AdnpChinchillacongenital disorder of glycosylation Ie  ISOADNP (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital disorder of glycosylation type 1EClinVarPMID:10642597 more ...
AdnpChinchillaDevelopmental Disabilities  ISOADNP (Homo sapiens)8554872ClinVar Annotator: match by term: Global developmental delayClinVarPMID:24531329 more ...
AdnpChinchillaDevelopmental Disease  ISOADNP (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental disorderClinVarPMID:25741868
AdnpChinchillaepilepsy  ISOADNP (Homo sapiens)8554872ClinVar Annotator: match by term: SeizureClinVarPMID:24531329 more ...
AdnpChinchillagenetic disease  ISOADNP (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:18414213 more ...
AdnpChinchillaHelsmoortel-Van Der Aa syndrome  ISOADNP (Homo sapiens)8554872ClinVar more ...ClinVarPMID:18414213 more ...
AdnpChinchillahypothyroidism  ISOADNP (Homo sapiens)8554872ClinVar Annotator: match by term: HypothyroidismClinVarPMID:24531329 more ...
AdnpChinchillaintellectual disability  ISOADNP (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVarPMID:18414213 more ...
AdnpChinchillaisolated growth hormone deficiency  ISOADNP (Homo sapiens)8554872ClinVar Annotator: match by term: Growth hormone deficiencyClinVarPMID:24531329 more ...
AdnpChinchillamicrocephaly  ISOADNP (Homo sapiens)8554872ClinVar Annotator: match by term: MicrocephalyClinVarPMID:25741868
AdnpChinchillaMowat-Wilson syndrome  ISOADNP (Homo sapiens)8554872ClinVar Annotator: match by term: Hirschsprung disease mental retardation syndromeClinVarPMID:25741868
AdnpChinchillaNeurodevelopmental Disorders  ISOADNP (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:18414213 more ...
AdnpChinchillastereotypic movement disorder  ISOADNP (Homo sapiens)8554872ClinVar Annotator: match by term: Stereotypic movement disorderClinVarPMID:24531329 more ...
1 to 16 of 16 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AdnpChinchillaHelsmoortel-Van Der Aa syndrome  ISOADNP (Homo sapiens)7240710 OMIM 


Biological Process
1 to 20 of 21 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AdnpChinchillaactivation of protein kinase activity  ISOAdnp (Rattus norvegicus)9068941Fyn kinaseRGDPMID:19047645 and REF_RGD_ID:2312772
AdnpChinchillacGMP-mediated signaling  ISOAdnp (Rattus norvegicus)9068941 RGDPMID:11438390 and REF_RGD_ID:1358228
AdnpChinchillaestrous cycle  ISOAdnp (Rattus norvegicus)9068941 RGDPMID:16023261 and REF_RGD_ID:2312777
AdnpChinchillaintracellular nitric oxide homeostasis  ISOAdnp (Rattus norvegicus)9068941 RGDPMID:16938277 and REF_RGD_ID:2312775
AdnpChinchillanegative regulation of gene expression  ISOAdnp (Rattus norvegicus)9068941p53RGDPMID:15314252 and REF_RGD_ID:2312780
AdnpChinchillanegative regulation of neuron apoptotic process  ISOAdnp (Rattus norvegicus)9068941 RGDPMID:16938277 and REF_RGD_ID:2312775
AdnpChinchillanegative regulation of neuron apoptotic process acts_upstream_of_or_withinISOAdnp (Mus musculus)9068941 PMID:10037502MGIPMID:10037502
AdnpChinchillanegative regulation of protein binding  ISOAdnp (Rattus norvegicus)9068941beta-amyloid aggregationRGDPMID:14706557 and REF_RGD_ID:2312790
AdnpChinchillanegative regulation of synaptic transmission  ISOAdnp (Rattus norvegicus)9068941 RGDPMID:15963648 and REF_RGD_ID:2312778
AdnpChinchillaneuron apoptotic process acts_upstream_ofISOAdnp (Mus musculus)9068941 PMID:10037502MGIPMID:10037502
AdnpChinchillaneuron differentiation involved_inISOAdnp (Mus musculus)9068941 PMID:32533114UniProtPMID:32533114
AdnpChinchillapositive regulation of axon extension  ISOAdnp (Rattus norvegicus)9068941 RGDPMID:19047645 and REF_RGD_ID:2312772
AdnpChinchillapositive regulation of canonical Wnt signaling pathway involved_inISOAdnp (Mus musculus)9068941 PMID:32533114UniProtPMID:32533114
AdnpChinchillapositive regulation of neuron projection development  ISOAdnp (Rattus norvegicus)9068941 RGDPMID:15800376 and REF_RGD_ID:2312779
AdnpChinchillapositive regulation of peptidyl-tyrosine phosphorylation  ISOAdnp (Rattus norvegicus)9068941 RGDPMID:19047645 and REF_RGD_ID:2312772
AdnpChinchillapositive regulation of synapse assembly  ISOAdnp (Rattus norvegicus)9068941 RGDPMID:15800376 and REF_RGD_ID:2312779
AdnpChinchillaregulation of gene expression involved_inISOAdnp (Mus musculus)9068941 PMID:32533114UniProtPMID:32533114
AdnpChinchillaregulation of protein ADP-ribosylation  ISOAdnp (Rattus norvegicus)9068941upregulationRGDPMID:16093393 and REF_RGD_ID:1601081
AdnpChinchillaregulation of transcription by RNA polymerase II involved_inISOAdnp (Mus musculus)9068941 PMID:17222401ARUK-UCLPMID:17222401
AdnpChinchillaresponse to carbohydrate  ISOAdnp (Rattus norvegicus)9068941NOS inhibitor L-NAME and kainic acidRGDPMID:19130308 and REF_RGD_ID:2312770
1 to 20 of 21 rows

Cellular Component

  

Molecular Function
1 to 14 of 14 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AdnpChinchillabeta-catenin binding enablesISOUniProtKB:Q022489068941 PMID:32533114UniProtPMID:32533114
AdnpChinchillabeta-tubulin binding  ISOTubb3 (Rattus norvegicus)9068941 RGDPMID:16893427 and REF_RGD_ID:2312776
AdnpChinchillachromatin binding enablesISOAdnp (Mus musculus)9068941 PMID:17222401MGIPMID:17222401
AdnpChinchillacopper ion binding  ISOAdnp (Rattus norvegicus)9068941 RGDPMID:14706557 and REF_RGD_ID:2312790
AdnpChinchillaDNA-binding transcription factor activity, RNA polymerase II-specific enablesISOAdnp (Mus musculus)9068941 PMID:17222401ARUK-UCLPMID:17222401
AdnpChinchillapeptide binding  ISOAdnp (Rattus norvegicus)9068941beta-amyloidRGDPMID:14706557 and REF_RGD_ID:2312790
AdnpChinchillaprotein binding enablesISOUniProtKB:Q131859068941 PMID:33961781 and PMID:36950384IntActPMID:33961781 and PMID:36950384
AdnpChinchillaprotein binding enablesISOPR:Q616869068941 PMID:17222401MGIPMID:17222401
AdnpChinchillaprotein binding enablesISOUniProtKB:P45973 more ...9068941 PMID:21888893 and PMID:27705803IntActPMID:21888893 and PMID:27705803
AdnpChinchillaprotein binding enablesISOUniProtKB:P83916 and UniProtKB:Q131859068941 PMID:24981860IntActPMID:24981860
AdnpChinchillaprotein binding enablesISOUniProtKB:P459739068941 PMID:20562864IntActPMID:20562864
AdnpChinchillaprotein binding enablesISOUniProtKB:Q13185 and UniProtKB:Q148399068941 PMID:29795351ARUK-UCLPMID:29795351
AdnpChinchillaprotein binding enablesISOUniProtKB:P839169068941 PMID:35271311IntActPMID:35271311
AdnpChinchillaRNA polymerase II transcription regulatory region sequence-specific DNA binding enablesISOAdnp (Mus musculus)9068941 PMID:17222401ARUK-UCLPMID:17222401
1 to 14 of 14 rows


#
Reference Title
Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
PMID:22301074   PMID:30032202  



Adnp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554457,492,257 - 7,531,862 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554457,498,223 - 7,530,828 (+)NCBIChiLan1.0ChiLan1.0
ADNP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382050,888,918 - 50,931,437 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2050,888,916 - 50,931,437 (-)EnsemblGRCh38hg38GRCh38
GRCh372049,505,455 - 49,547,974 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362048,940,290 - 48,980,934 (-)NCBINCBI36Build 36hg18NCBI36
Build 342048,940,289 - 48,980,934NCBI
Celera2046,211,143 - 46,251,787 (-)NCBICelera
Cytogenetic Map20q13.13NCBI
HuRef2046,255,283 - 46,295,816 (-)NCBIHuRef
CHM1_12049,412,276 - 49,452,793 (-)NCBICHM1_1
T2T-CHM13v2.02052,659,514 - 52,702,036 (-)NCBIT2T-CHM13v2.0
Adnp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392168,022,885 - 168,049,032 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2168,022,906 - 168,049,032 (-)EnsemblGRCm39 Ensembl
GRCm382168,180,965 - 168,207,112 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2168,180,986 - 168,207,112 (-)EnsemblGRCm38mm10GRCm38
MGSCv372168,006,465 - 168,032,562 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362168,006,465 - 168,032,562 (-)NCBIMGSCv36mm8
Celera2174,124,697 - 174,151,114 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map288.41NCBI
Adnp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83177,310,258 - 177,340,379 (-)NCBIGRCr8
mRatBN7.23156,886,921 - 156,921,500 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3156,891,381 - 156,917,312 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3160,686,196 - 160,712,108 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03169,185,277 - 169,211,206 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03166,926,977 - 166,952,906 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03164,937,188 - 164,964,819 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3164,937,198 - 164,964,702 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03171,077,543 - 171,087,330 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43159,345,280 - 159,355,067 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13159,253,471 - 159,255,943 (-)NCBI
Celera3155,464,855 - 155,474,635 (-)NCBICelera
Cytogenetic Map3q42NCBI
ADNP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22156,639,252 - 56,680,364 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12056,632,380 - 56,673,982 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02047,233,696 - 47,276,075 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12048,361,036 - 48,400,399 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2048,361,043 - 48,400,387 (-)Ensemblpanpan1.1panPan2
ADNP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12437,211,776 - 37,245,938 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2437,213,942 - 37,243,702 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2436,453,839 - 36,487,910 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02437,921,440 - 37,955,536 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2437,922,782 - 37,953,382 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12437,156,924 - 37,191,002 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02437,290,872 - 37,324,932 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02437,835,833 - 37,869,965 (-)NCBIUU_Cfam_GSD_1.0
Adnp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640188,401,492 - 188,429,717 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365143,855,672 - 3,885,718 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365143,855,113 - 3,883,036 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADNP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1752,317,913 - 52,332,079 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11752,316,388 - 52,350,732 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21758,757,490 - 58,790,779 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADNP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1213,037,446 - 13,080,287 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl213,039,866 - 13,081,161 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605061,470,166 - 61,513,443 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adnp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247904,832,494 - 4,854,845 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247904,822,467 - 4,854,852 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.






Ensembl Acc Id: ENSCLAT00000018524   ⟹   ENSCLAP00000018344
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554457,492,257 - 7,531,862 (+)Ensembl
RefSeq Acc Id: XM_005392308   ⟹   XP_005392365
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554457,498,223 - 7,530,828 (+)NCBI
Sequence:
Protein RefSeqs XP_005392365 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000018344
  ENSCLAP00000018344.1
RefSeq Acc Id: XP_005392365   ⟸   XM_005392308
- UniProtKB: A0A8C2VW19 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000018344   ⟸   ENSCLAT00000018524
C2H2-type   Homeobox



1 to 22 of 22 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCLAG00000012575 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000018524 ENTREZGENE
  ENSCLAT00000018524.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
InterPro ADNP/ADNP2 UniProtKB/TrEMBL
  ADNP_Znf UniProtKB/TrEMBL
  Homeobox-like_sf UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
NCBI Gene Adnp ENTREZGENE
PANTHER ACTIVITY-DEPENDENT NEUROPROTECTOR HOMEOBOX PROTEIN UniProtKB/TrEMBL
  PTHR15740 UniProtKB/TrEMBL
Pfam ADNP_N UniProtKB/TrEMBL
  Homeodomain UniProtKB/TrEMBL
PROSITE HOMEOBOX_2 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART HOX UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
UniProt A0A8C2VW19 ENTREZGENE, UniProtKB/TrEMBL
1 to 22 of 22 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Adnp  activity dependent neuroprotector homeobox    activity-dependent neuroprotector homeobox  Symbol and/or name change 5135510 APPROVED