RGD Reference Report - A peptide derived from activity-dependent neuroprotective protein (ADNP) ameliorates injury response in closed head injury in mice. - Rat Genome Database

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A peptide derived from activity-dependent neuroprotective protein (ADNP) ameliorates injury response in closed head injury in mice.

Authors: Beni-Adani, L  Gozes, I  Cohen, Y  Assaf, Y  Steingart, RA  Brenneman, DE  Eizenberg, O  Trembolver, V  Shohami, E 
Citation: Beni-Adani L, etal., J Pharmacol Exp Ther. 2001 Jan;296(1):57-63.
RGD ID: 2312784
Pubmed: PMID:11123362   (View Abstract at PubMed)

Brain injury induces disruption of the blood-brain barrier, edema, and release of autodestructive factors that produce delayed neuronal damage. NAPSVIPQ (NAP), a femtomolar-acting peptide, is shown to be neuroprotective in a mouse model of closed head injury. NAP injection after injury reduced mortality and facilitated neurobehavioral recovery (P < 0.005). Edema was reduced by 70% in the NAP-treated mice (P < 0.01). Furthermore, in vivo magnetic resonance imaging demonstrated significant brain-tissue recovery in the NAP-treated animals. NAP treatment decreased tumor necrosis factor-alpha levels in the injured brain and was shown to protect pheochromocytoma (PC12 cells) against tumor necrosis factor-alpha-induced toxicity. Thus, NAP provides significant amelioration from the complex array of injuries elicited by head trauma.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Craniocerebral Trauma  ISOAdnp (Mus musculus)2312784; 2312784 RGD 
Craniocerebral Trauma  IDA 2312784 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Adnp  (activity-dependent neuroprotector homeobox)

Genes (Mus musculus)
Adnp  (activity-dependent neuroprotective protein)

Genes (Homo sapiens)
ADNP  (activity dependent neuroprotector homeobox)


Additional Information