Fnta (farnesyltransferase, CAAX box, subunit alpha) - Rat Genome Database

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Gene: Fnta (farnesyltransferase, CAAX box, subunit alpha) Chinchilla lanigera
Analyze
Symbol: Fnta
Name: farnesyltransferase, CAAX box, subunit alpha
RGD ID: 8833897
Description: ENCODES a protein that exhibits acetyltransferase activator activity (ortholog); alpha-tubulin binding (ortholog); CAAX-protein geranylgeranyltransferase activity (ortholog); INVOLVED IN enzyme-linked receptor protein signaling pathway (ortholog); negative regulation of apoptotic process (ortholog); positive regulation of cell cycle (ortholog); ASSOCIATED WITH congenital muscular dystrophy-dystroglycanopathy type A12 (ortholog); Idiopathic Basal Ganglia Calcification 1 (ortholog); IMMUNODEFICIENCY 15 (ortholog); FOUND IN CAAX-protein geranylgeranyltransferase complex (ortholog); microtubule associated complex (ortholog); protein farnesyltransferase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: farnesyltransferase, CAAX box, alpha
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545713,260,545 - 13,294,025 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545713,260,825 - 13,294,025 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FntaChinchillacongenital muscular dystrophy-dystroglycanopathy type A12  ISOFNTA (Homo sapiens)8554872ClinVar Annotator: match by term: Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a and 12ClinVarPMID:28492532
FntaChinchillaIdiopathic Basal Ganglia Calcification 1  ISOFNTA (Homo sapiens)8554872ClinVar Annotator: match by term: Idiopathic basal ganglia calcification 1ClinVarPMID:27726124
FntaChinchillaIMMUNODEFICIENCY 15  ISOFNTA (Homo sapiens)8554872ClinVar Annotator: match by term: Immunodeficiency 15ClinVarPMID:28492532
FntaChinchillaimmunodeficiency 15B  ISOFNTA (Homo sapiens)8554872ClinVar Annotator: match by term: IMMUNODEFICIENCY 15BClinVarPMID:28492532
FntaChinchillamucopolysaccharidosis type IIIC  ISOFNTA (Homo sapiens)8554872ClinVar Annotator: match by term: Mucopolysaccharidosis and MPS-III-CClinVarPMID:28492532
FntaChinchillatorsion dystonia 6  ISOFNTA (Homo sapiens)8554872ClinVar Annotator: match by term: Torsion dystonia 6ClinVarPMID:28492532


Biological Process
1 to 14 of 14 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FntaChinchillaenzyme-linked receptor protein signaling pathway involved_inISOMGI:1035819068941 PMID:8653787MGIPMID:8653787
FntaChinchillaenzyme-linked receptor protein signaling pathway involved_inISOFnta (Mus musculus)9068941 PMID:18848351 and PMID:18957220MGIPMID:18848351 and PMID:18957220
FntaChinchillaenzyme-linked receptor protein signaling pathway involved_inISOFnta (Mus musculus)9068941 PMID:14622576MGIPMID:14622576
FntaChinchillanegative regulation of apoptotic process  ISOFnta (Rattus norvegicus)9068941 RGDPMID:11313965 and REF_RGD_ID:2302977
FntaChinchillapositive regulation of cell cycle  ISOFnta (Rattus norvegicus)9068941 RGDPMID:10544242 and REF_RGD_ID:2302976
FntaChinchillapositive regulation of cell population proliferation  ISOFnta (Rattus norvegicus)9068941 RGDPMID:10544242 and REF_RGD_ID:2302976
FntaChinchillapositive regulation of Rac protein signal transduction involved_inISOFnta (Mus musculus)9068941 PMID:14622576MGIPMID:14622576
FntaChinchillapositive regulation of skeletal muscle acetylcholine-gated channel clustering involved_inISOMGI:1035819068941 PMID:8653787MGIPMID:8653787
FntaChinchillapositive regulation of skeletal muscle acetylcholine-gated channel clustering involved_inISOFnta (Mus musculus)9068941 PMID:14622576MGIPMID:14622576
FntaChinchillapositive regulation of skeletal muscle acetylcholine-gated channel clustering involved_inISOFnta (Mus musculus)9068941 PMID:18848351 and PMID:18957220MGIPMID:18848351 and PMID:18957220
FntaChinchillaprotein farnesylation involved_inISOFNTA (Homo sapiens)9068941 PMID:16893176UniProtPMID:16893176
FntaChinchillaprotein geranylgeranylation involved_inISOFNTA (Homo sapiens)9068941 PMID:16893176UniProtPMID:16893176
FntaChinchillaRac protein signal transduction acts_upstream_of_or_withinISOMGI:1046839068941 PMID:14622576MGIPMID:14622576
FntaChinchillaregulation of microtubule-based movement involved_inISOFNTA (Homo sapiens)9068941 PMID:19228685BHF-UCLPMID:19228685
1 to 14 of 14 rows

Cellular Component

  

Molecular Function
1 to 20 of 41 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FntaChinchillaacetyltransferase activator activity enablesISOFNTA (Homo sapiens)9068941 PMID:19228685BHF-UCLPMID:19228685
FntaChinchillaalpha-tubulin binding enablesISOFNTA (Homo sapiens)9068941 PMID:19228685BHF-UCLPMID:19228685
FntaChinchillaCAAX-protein geranylgeranyltransferase activity contributes_toISOFnta (Rattus norvegicus)9068941 RGDPMID:8089111 and REF_RGD_ID:2302973
FntaChinchillaenzyme binding enablesISOUniProtKB:Q9UBN79068941 PMID:19228685BHF-UCLPMID:19228685
FntaChinchillaheterocyclic compound binding contributes_toISOFnta (Rattus norvegicus)9068941anticancer clinical candidate L-778 and 123RGDPMID:15248757 and REF_RGD_ID:2302978
FntaChinchillamicrotubule binding enablesISOFNTA (Homo sapiens)9068941 PMID:19228685BHF-UCLPMID:19228685
FntaChinchillamolecular adaptor activity enablesISOFNTA (Homo sapiens)9068941 PMID:11687658DisProtPMID:11687658
FntaChinchillapeptide binding contributes_toISOFnta (Rattus norvegicus)9068941 RGDPMID:9705207 and REF_RGD_ID:2302975
FntaChinchillaprotein binding enablesISOUniProtKB:Q022939068941PMID:12657282IntActPMID:12657282 and REF_RGD_ID:8554767
FntaChinchillaprotein binding enablesISOUniProtKB:P493569068941 PMID:11687658 more ...IntActPMID:11687658 more ...
FntaChinchillaprotein binding enablesISOUniProtKB:O00189 more ...9068941 PMID:32296183IntActPMID:32296183
FntaChinchillaprotein binding enablesISOUniProtKB:Q022939068941PMID:12667062IntActPMID:12667062 and REF_RGD_ID:8554159
FntaChinchillaprotein binding enablesISOUniProtKB:P01116-29068941PMID:10673434IntActPMID:10673434 and REF_RGD_ID:11041072
FntaChinchillaprotein binding enablesISOUniProtKB:Q022939068941PMID:9065406IntActPMID:9065406 and REF_RGD_ID:13432295
FntaChinchillaprotein binding enablesISOUniProtKB:P536109068941PMID:15248757IntActPMID:15248757 and REF_RGD_ID:2302978
FntaChinchillaprotein binding enablesISOUniProtKB:Q636049068941PMID:18957540IntActPMID:18957540 and REF_RGD_ID:2302981
FntaChinchillaprotein binding enablesISOUniProtKB:P536109068941PMID:14609943IntActPMID:14609943 and REF_RGD_ID:8554040
FntaChinchillaprotein binding enablesISOUniProtKB:P49356 and UniProtKB:P536099068941 PMID:24981860 and PMID:33961781IntActPMID:24981860 and PMID:33961781
FntaChinchillaprotein binding enablesISOUniProtKB:Q022939068941PMID:12699757IntActPMID:12699757 and REF_RGD_ID:8554635
FntaChinchillaprotein binding enablesISOUniProtKB:P01116-29068941PMID:15451670IntActPMID:15451670 and REF_RGD_ID:8553417
1 to 20 of 41 rows


#
Reference Title
Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
PMID:30032202  



Fnta
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545713,260,545 - 13,294,025 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545713,260,825 - 13,294,025 (+)NCBIChiLan1.0ChiLan1.0
FNTA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38843,056,323 - 43,085,785 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl843,034,194 - 43,085,788 (+)EnsemblGRCh38hg38GRCh38
GRCh37842,911,466 - 42,940,928 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36843,030,599 - 43,060,088 (+)NCBINCBI36Build 36hg18NCBI36
Build 34843,030,640 - 43,060,080NCBI
Celera841,859,884 - 41,889,630 (+)NCBICelera
Cytogenetic Map8p11.21NCBI
HuRef841,434,064 - 41,463,781 (+)NCBIHuRef
CHM1_1842,958,364 - 42,987,853 (+)NCBICHM1_1
T2T-CHM13v2.0843,325,268 - 43,354,718 (+)NCBIT2T-CHM13v2.0
Fnta
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39826,488,716 - 26,505,638 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl826,488,750 - 26,505,678 (-)EnsemblGRCm39 Ensembl
GRCm38825,998,688 - 26,015,610 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl825,998,722 - 26,015,650 (-)EnsemblGRCm38mm10GRCm38
MGSCv37827,109,194 - 27,126,073 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36827,464,267 - 27,481,146 (-)NCBIMGSCv36mm8
Celera827,468,460 - 27,485,887 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map814.27NCBI
Fnta
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81672,767,864 - 72,786,193 (+)NCBIGRCr8
mRatBN7.21666,065,131 - 66,083,460 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1666,065,132 - 66,083,460 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1671,343,827 - 71,362,199 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01674,750,156 - 74,768,528 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01669,990,195 - 70,008,625 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01670,834,957 - 70,854,724 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1670,834,957 - 70,854,724 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01670,499,605 - 70,519,062 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41670,440,340 - 70,458,433 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11670,440,604 - 70,458,698 (+)NCBI
Celera1663,976,260 - 63,994,463 (+)NCBICelera
RH 3.4 Map16622.7RGD
Cytogenetic Map16q12.4NCBI
FNTA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2761,512,173 - 61,542,875 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1837,229,091 - 37,258,862 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0842,303,987 - 42,333,743 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1839,744,142 - 39,774,039 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl839,743,768 - 39,774,031 (+)Ensemblpanpan1.1panPan2
FNTA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11622,739,070 - 22,767,942 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1622,739,079 - 22,767,914 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1623,244,269 - 23,273,147 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01624,491,021 - 24,519,909 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1624,491,022 - 24,652,650 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11622,859,185 - 22,888,061 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01623,424,042 - 23,452,916 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01623,475,354 - 23,504,242 (-)NCBIUU_Cfam_GSD_1.0
Fnta
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494345,764,313 - 45,791,302 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936570362,655 - 389,649 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FNTA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1711,928,358 - 11,951,684 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11711,928,327 - 11,953,139 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FNTA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1841,057,798 - 41,088,210 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl841,057,603 - 41,087,705 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666052681,570 - 712,699 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

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RefSeq Transcripts XM_005397076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AGCD01047040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GBDF01047752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCLAT00000019197   ⟹   ENSCLAP00000019012
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545713,260,545 - 13,294,025 (+)Ensembl
RefSeq Acc Id: XM_005397076   ⟹   XP_005397133
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545713,260,825 - 13,294,025 (+)NCBI
Sequence:
Protein RefSeqs XP_005397133 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000019012
  ENSCLAP00000019012.1
RefSeq Acc Id: XP_005397133   ⟸   XM_005397076
- UniProtKB: A0A8C2VQG3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000019012   ⟸   ENSCLAT00000019197



1 to 12 of 12 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCLAG00000013021 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000019197 ENTREZGENE
  ENSCLAT00000019197.1 UniProtKB/TrEMBL
Gene3D-CATH Protein prenylyltransferase UniProtKB/TrEMBL
InterPro Prenyl_trans_a UniProtKB/TrEMBL
NCBI Gene Fnta ENTREZGENE
PANTHER PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT UniProtKB/TrEMBL
  PROTEIN FARNESYLTRANSFERASE/GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA UniProtKB/TrEMBL
Pfam PPTA UniProtKB/TrEMBL
PROSITE PFTA UniProtKB/TrEMBL
Superfamily-SCOP Protein prenylyltransferase UniProtKB/TrEMBL
UniProt A0A8C2VQG3 ENTREZGENE, UniProtKB/TrEMBL
1 to 12 of 12 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-03-19 Fnta  farnesyltransferase, CAAX box, subunit alpha  Fnta  farnesyltransferase, CAAX box, alpha  Symbol and/or name change 5135510 APPROVED