Fnta (farnesyltransferase, CAAX box, subunit alpha)

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Gene: Fnta (farnesyltransferase, CAAX box, subunit alpha) Chinchilla lanigera

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Symbol:

Fnta

Name:

farnesyltransferase, CAAX box, subunit alpha

RGD ID:

8833897

Description:

ENCODES a protein that exhibits alpha-tubulin binding (ortholog); CAAX-protein geranylgeranyltransferase activity (ortholog); heterocyclic compound binding (ortholog); INVOLVED IN enzyme-linked receptor protein signaling pathway (ortholog); negative regulation of apoptotic process (ortholog); positive regulation of cell cycle (ortholog); ASSOCIATED WITH congenital muscular dystrophy-dystroglycanopathy type A12 (ortholog); Idiopathic Basal Ganglia Calcification 1 (ortholog); IMMUNODEFICIENCY 15 (ortholog); FOUND IN CAAX-protein geranylgeranyltransferase complex (ortholog); microtubule associated complex (ortholog); protein farnesyltransferase complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

farnesyltransferase, CAAX box, alpha

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955457	13,260,545 - 13,294,025 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955457	13,260,825 - 13,294,025 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congenital muscular dystrophy-dystroglycanopathy type A12 (ISO)

Idiopathic Basal Ganglia Calcification 1 (ISO)

IMMUNODEFICIENCY 15 (ISO)

immunodeficiency 15B (ISO)

mucopolysaccharidosis type IIIC (ISO)

torsion dystonia 6 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

enzyme-linked receptor protein signaling pathway (ISO)

negative regulation of apoptotic process (ISO)

positive regulation of cell cycle (ISO)

positive regulation of cell population proliferation (ISO)

positive regulation of deacetylase activity (ISO)

positive regulation of Rac protein signal transduction (ISO)

positive regulation of skeletal muscle acetylcholine-gated channel clustering (ISO)

positive regulation of tubulin deacetylation (ISO)

protein farnesylation (ISO)

protein geranylgeranylation (ISO)

Cellular Component

CAAX-protein geranylgeranyltransferase complex (ISO)

microtubule associated complex (ISO)

protein farnesyltransferase complex (ISO)

Molecular Function

alpha-tubulin binding (ISO)

CAAX-protein geranylgeranyltransferase activity (ISO)

heterocyclic compound binding (ISO)

microtubule binding (ISO)

molecular adaptor activity (ISO)

peptide binding (ISO)

protein binding (ISO)

protein farnesyltransferase activity (ISO)

protein geranylgeranyltransferase activity (ISO)

Rab geranylgeranyltransferase activity (ISO)

receptor tyrosine kinase binding (ISO)

small molecule binding (ISO)

zinc ion binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Fnta
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955457	13,260,545 - 13,294,025 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955457	13,260,825 - 13,294,025 (+)	NCBI	ChiLan1.0	ChiLan1.0

FNTA
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	43,056,323 - 43,085,785 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	43,034,194 - 43,085,788 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	42,911,466 - 42,940,928 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	43,030,599 - 43,060,088 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	43,030,640 - 43,060,080	NCBI
Celera	8	41,859,884 - 41,889,630 (+)	NCBI		Celera
Cytogenetic Map	8	p11.21	NCBI
HuRef	8	41,434,064 - 41,463,781 (+)	NCBI		HuRef
CHM1_1	8	42,958,364 - 42,987,853 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	43,325,268 - 43,354,718 (+)	NCBI		T2T-CHM13v2.0

Fnta
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	26,488,716 - 26,505,638 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	26,488,750 - 26,505,678 (-)	Ensembl		GRCm39 Ensembl
GRCm38	8	25,998,688 - 26,015,610 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	25,998,722 - 26,015,650 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	27,109,194 - 27,126,073 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	27,464,267 - 27,481,146 (-)	NCBI		MGSCv36	mm8
Celera	8	27,468,460 - 27,485,887 (-)	NCBI		Celera
Cytogenetic Map	8	A2	NCBI
cM Map	8	14.27	NCBI

Fnta
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	72,767,864 - 72,786,193 (+)	NCBI		GRCr8
mRatBN7.2	16	66,065,131 - 66,083,460 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	66,065,132 - 66,083,460 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	71,343,827 - 71,362,199 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	74,750,156 - 74,768,528 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	69,990,195 - 70,008,625 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	70,834,957 - 70,854,724 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	70,834,957 - 70,854,724 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	70,499,605 - 70,519,062 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	70,440,340 - 70,458,433 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	70,440,604 - 70,458,698 (+)	NCBI
Celera	16	63,976,260 - 63,994,463 (+)	NCBI		Celera
RH 3.4 Map	16	622.7	RGD
Cytogenetic Map	16	q12.4	NCBI

FNTA
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	61,512,173 - 61,542,875 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	37,229,091 - 37,258,862 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	42,303,987 - 42,333,743 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	39,744,142 - 39,774,039 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	39,743,768 - 39,774,031 (+)	Ensembl	panpan1.1		panPan2

FNTA
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	22,739,070 - 22,767,942 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	22,739,079 - 22,767,914 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	23,244,269 - 23,273,147 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	24,491,021 - 24,519,909 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	24,491,022 - 24,652,650 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	22,859,185 - 22,888,061 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	23,424,042 - 23,452,916 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	23,475,354 - 23,504,242 (-)	NCBI		UU_Cfam_GSD_1.0

Fnta
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	45,764,313 - 45,791,302 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936570	362,655 - 389,649 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FNTA
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	11,928,358 - 11,951,684 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	11,928,327 - 11,953,139 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

FNTA
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	41,057,798 - 41,088,210 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	41,057,603 - 41,087,705 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666052	681,570 - 712,699 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005397076	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01047040	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01047752	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000019197 ⟹ ENSCLAP00000019012

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955457	13,260,545 - 13,294,025 (+)	Ensembl

RefSeq Acc Id:

XM_005397076 ⟹ XP_005397133

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955457	13,260,825 - 13,294,025 (+)	NCBI

Sequence:

show sequence

TCGGGCGCCGCGGGCCAGGGGGCGCGGGCGAGGCCGCGGGGGCGTGGCCTCCGCGCTGCCTGCG
CTGCGGACTAGGCGAGATGGCGGCCACCGAGGGGGTCGGGGAGCCTGCGCAGGGCGGCGAGCCC
GGTCAGCCGGAGCAGCCTCCGCCACAGCCTCACCCCCCACCGCCCCAGCAGCCACAGGAGGACG
AGATGGCAGCTGAGGCCGGGGAAGCCGTGCCGTCCCCTATGGACGACGGGTTCCTGAGCCTGGA
CTCGCCCACCTACGTCCTGTACAGGGACAGAGCAGAATGGGCTGATATAGATCCAGTGCCACAG
AATGATGGTCCAAACCCAGTGGTGCAGATCATCTATAGTGAAAAATTCCGAGATGTTTATGATT
ATTTCCGAGCTGTTCTGCAGCGTGATGAAAGAAGTGAGCGAGCCTTGCAGCTCACTCGGGATGC
CATTGAGTTAAATGCAGCCAATTACACAGTGTGGCATTTCCGGAGAGTTCTCTTACGGTCCCTT
CAAAAGGATCTTCATGAAGAAATGAACTACATCACTACGATAATTGAGGAACAGCCCAAAAACT
ATCAAGTTTGGCACCATAGGCGTGTATTAGTGGAATGGCTGAAGGACCCATCCCAGGAGCTTGA
GTTTATTGCTGATATTCTTAATCAGGATGCAAAGAATTACCATGCCTGGCAGCACCGACAGTGG
GTCATTCAGGAATTTAGACTTTGGGATAATGAATTGCAGTATGTAGACCAACTTCTCAAAGAGG
ATGTGAGAAATAACTCTGCGTGGAACCAAAGATACTTCGTCATTTCTAACACTACTGGCTACAA
TGGTCATGCTGTATTAGAGAGAGAAGTCCAGTACACTCTGGAAATGATAAAACTTGTACCACAT
AATGAAAGTGCATGGAATTACTTGAAAGGGATTTTGCAGGATCGTGGTCTTTCCAAATACCCCA
ACTTACTAAGTCAATTACTTGATTTACAACCAAGTCATAGTTCTCCCTACCTAATTGCCTTTCT
TGTGGATGTCTATGAAGACATGCTAGAAAACCAGTGTGACAACAAGGAAGACATTCTTAATAAA
GCATTAGAGTTATGTGAGATCCTAGCTAAAGAAAAGGACACCATAAGAAAGGAATATTGGAGAT
ATATTGGAAGATCTCTTCAAAGCAAACACAGAGAAAGTGACCTACCAACAAATGCACAGCAATA
ACGCCATCTGGAAGAACTTGATGGAATGCTTTTATTTTTTCAAGGGACTCTGAACAGGAGTTTA
AAGCTAAAGTGAGCATTCCCTTACCTGTGGTGTAAAAGATGAATCACACAGGTGTTGCTTTTTA
ACAAGAACTAAGTGTGATGTTCCTTGGGTGCTGCTGCTATTCAGACTCGCTCTGAGAAATTCGA
TTCTTCTAAAGCGAAGTAATAGGAGGGAGGGGGAATTAAAAAGTCCCATAAAGGAACCACTACT
TTTGTAGTCTTACCAACATTTAATCTACTCGCTTTGCATCTGTAATGAGTGCAGGGTCCTTGGC
TGTAGTAGAGTTGGGGTAACTGAAGTTGGCCTCAGTAAGTTGGGAGACTGGTTGTCCCGTGCCA
CACTCACAGTATGTAGCTATCACTGTAACCAACTAATGCCAAAAGAATGGTTTTGTAATAAAAT
CACAGGTATATCTAAAAGCAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005397133	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000019012
	ENSCLAP00000019012.1

RefSeq Acc Id:

XP_005397133 ⟸ XM_005397076

- UniProtKB:

A0A8C2VQG3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAATEGVGEPAQGGEPGQPEQPPPQPHPPPPQQPQEDEMAAEAGEAVPSPMDDGFLSLDSPTYV
LYRDRAEWADIDPVPQNDGPNPVVQIIYSEKFRDVYDYFRAVLQRDERSERALQLTRDAIELNA
ANYTVWHFRRVLLRSLQKDLHEEMNYITTIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADI
LNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSAWNQRYFVISNTTGYNGHAVL
EREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSKYPNLLSQLLDLQPSHSSPYLIAFLVDVYE
DMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHRESDLPTNAQQ

hide sequence

Ensembl Acc Id:

ENSCLAP00000019012 ⟸ ENSCLAT00000019197

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000013021	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000019197	ENTREZGENE
	ENSCLAT00000019197.1	UniProtKB/TrEMBL
Gene3D-CATH	Protein prenylyltransferase	UniProtKB/TrEMBL
InterPro	Prenyl_trans_a	UniProtKB/TrEMBL
NCBI Gene	Fnta	ENTREZGENE
PANTHER	PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT	UniProtKB/TrEMBL
	PROTEIN FARNESYLTRANSFERASE/GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA	UniProtKB/TrEMBL
Pfam	PPTA	UniProtKB/TrEMBL
PROSITE	PFTA	UniProtKB/TrEMBL
Superfamily-SCOP	Protein prenylyltransferase	UniProtKB/TrEMBL
UniProt	A0A8C2VQG3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2024-03-19	Fnta	farnesyltransferase, CAAX box, subunit alpha	Fnta	farnesyltransferase, CAAX box, alpha	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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