FNTA (farnesyltransferase, CAAX box, alpha)

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Gene: FNTA (farnesyltransferase, CAAX box, alpha) Pan paniscus

Analyze

Symbol:

FNTA

Name:

farnesyltransferase, CAAX box, alpha

RGD ID:

11917182

Description:

ENCODES a protein that exhibits acetylcholine receptor regulator activity (ortholog); alpha-tubulin binding (ortholog); CAAX-protein geranylgeranyltransferase activity (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); negative regulation of nitric-oxide synthase biosynthetic process (ortholog); neurotransmitter receptor metabolic process (ortholog); ASSOCIATED WITH congenital muscular dystrophy-dystroglycanopathy type A12 (ortholog); Idiopathic Basal Ganglia Calcification 1 (ortholog); IMMUNODEFICIENCY 15 (ortholog); FOUND IN CAAX-protein geranylgeranyltransferase complex (ortholog); cytoplasm (ortholog); microtubule associated complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Dog

Squirrel

Pig

Green Monkey

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	8	39,744,142 - 39,774,039 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	39,743,768 - 39,774,031 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	8	42,303,987 - 42,333,743 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congenital muscular dystrophy-dystroglycanopathy type A12 (ISO)

Idiopathic Basal Ganglia Calcification 1 (ISO)

IMMUNODEFICIENCY 15 (ISO)

mucopolysaccharidosis type IIIC (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of apoptotic process (ISO)

negative regulation of nitric-oxide synthase biosynthetic process (ISO)

neurotransmitter receptor metabolic process (ISO)

positive regulation of cell cycle (ISO)

positive regulation of cell population proliferation (ISO)

positive regulation of deacetylase activity (ISO)

positive regulation of nitric-oxide synthase biosynthetic process (ISO)

positive regulation of tubulin deacetylation (ISO)

protein farnesylation (ISO)

protein geranylgeranylation (ISO)

response to cytokine (ISO)

response to inorganic substance (ISO)

response to organic cyclic compound (ISO)

Cellular Component

CAAX-protein geranylgeranyltransferase complex (ISO)

cytoplasm (ISO)

microtubule associated complex (ISO)

protein farnesyltransferase complex (ISO)

Molecular Function

acetylcholine receptor regulator activity (ISO)

alpha-tubulin binding (ISO)

CAAX-protein geranylgeranyltransferase activity (ISO)

microtubule binding (ISO)

peptide binding (ISO)

protein binding (ISO)

protein farnesyltransferase activity (ISO)

protein geranylgeranyltransferase activity (ISO)

Rab geranylgeranyltransferase activity (ISO)

receptor tyrosine kinase binding (ISO)

small molecule binding (ISO)

zinc ion binding (ISO)

References

Genomics

Comparative Map Data

FNTA
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	8	39,744,142 - 39,774,039 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	39,743,768 - 39,774,031 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	8	42,303,987 - 42,333,743 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

FNTA
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	8	43,034,194 - 43,085,788 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	8	43,056,323 - 43,085,785 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	8	42,911,466 - 42,940,928 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
GRCh37	8	42,911,442 - 42,940,931 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	43,030,599 - 43,060,088 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	8	43,030,640 - 43,060,080	NCBI
Celera	8	41,859,884 - 41,889,630 (+)	NCBI
Cytogenetic Map	8	p11.21	NCBI
HuRef	8	41,434,064 - 41,463,781 (+)	NCBI		HuRef
CHM1_1	8	42,958,364 - 42,987,853 (+)	NCBI		CHM1_1

Fnta
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	26,488,716 - 26,505,638 (-)	NCBI	GRCm39		mm39
GRCm38	8	25,998,688 - 26,015,610 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	25,998,722 - 26,015,650 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	27,109,194 - 27,126,073 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	8	27,464,267 - 27,481,146 (-)	NCBI			mm8
Celera	8	27,468,460 - 27,485,887 (-)	NCBI		Celera
Cytogenetic Map	8	A2	NCBI
cM Map	8	14.27	NCBI

Fnta
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	16	66,065,131 - 66,083,460 (+)	NCBI
Rnor_6.0 Ensembl	16	70,834,957 - 70,854,724 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	16	70,834,957 - 70,854,724 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	16	70,499,605 - 70,519,062 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	70,440,340 - 70,458,433 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	16	70,440,604 - 70,458,698 (+)	NCBI
Celera	16	63,976,260 - 63,994,463 (+)	NCBI		Celera
RH 3.4 Map	16	622.7	RGD
Cytogenetic Map	16	q12.4	NCBI

Fnta
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955457	13,260,545 - 13,294,025 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955457	13,260,825 - 13,294,025 (+)	NCBI	ChiLan1.0	ChiLan1.0

FNTA
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	16	22,739,079 - 22,767,914 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	16	22,739,070 - 22,767,942 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Fnta
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936570	362,655 - 389,649 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FNTA
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	11,928,357 - 11,978,915 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	11,928,327 - 11,953,139 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

FNTA
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	41,057,798 - 41,088,210 (+)	NCBI
ChlSab1.1 Ensembl	8	41,057,603 - 41,087,705 (+)	Ensembl

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008976895	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034966033	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034966034	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	SSBP01000218	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSPPAT00000060249 ⟹ ENSPPAP00000037349

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	8	39,743,768 - 39,773,533 (+)	Ensembl

RefSeq Acc Id:

ENSPPAT00000060257 ⟹ ENSPPAP00000037357

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	8	39,744,142 - 39,774,031 (+)	Ensembl

RefSeq Acc Id:

ENSPPAT00000060260 ⟹ ENSPPAP00000037360

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	8	39,744,644 - 39,773,533 (+)	Ensembl

RefSeq Acc Id:

XM_008976895 ⟹ XP_008975143

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1	8	39,744,142 - 39,774,039 (+)	NCBI
Mhudiblu_PPA_v0	8	42,303,987 - 42,333,743 (+)	NCBI

Sequence:

show sequence

GACCTCCCTGGCTCACATGATCCTCCCGCCGCGGCCTCCGAGCGGCTGGGATCAGGCGTGAATC
ACCGCGCCCGGGCTTTATATTTCGTTTTGAAAATGCTGAGATGGACGCAAAGGGCTGAGTGCTC
AGTGTCCCCCAGTCACCCTCAGTTGCAGCTTCCGTCCAAAGAAGGAATCGCCCTCTCCCTGCTG
GGGCCACTAACAGCACTAACACGGTCCGAATGGCATCGGCAAAGCTCGGGAACGGCGACAGATG
GGAAGACGCGTGGGAGCCTGGGGGATCTCGGGAGAGCCGCGCAACCTCGCGGCGGACGCAGCCA
GCACCCGCAGCCAGCACCCGCACACTCCCACCCATACCCCGGCAGCCCGCCAAGACTCTCTGGC
CCGCACCTCTATGGGACAGAGCAGAATGGGCTGATATAGATCCAGTGCCGCAGAATGATGGCCC
CAATCCCGTGGTCCAGATCATTTATAGTGACAAATTTAGAGATGTTTATGATTACTTCCGAGCT
GTCCTGCAGCGTGATGAAAGAAGTGAACGAGCTTTTAAGCTAACCCGGGATGCTATTGAGTTAA
ATGCAGCCAATTATACAGTGTGGCATTTCCGGAGAGTTCTTTTGAAGTCACTTCAGAAGGATCT
ACATGAGGAAATGAACTACATCACTGCAATAATTGAGGAGCAGCCCAAAAACTATCAAGTTTGG
CATCATAGGCGAGTATTAGTGGAATGGCTAAGAGATCCATCTCAGGAGCTTGAATTTATTGCTG
ATATTCTTAATCAGGATGCAAAGAATTATCATGCCTGGCAGCATCGACAATGGGTTATTCAGGA
ATTTAAACTTTGGGATAATGAGCTGCAGTATGTGGACCAACTTCTGAAAGAGGATGTGAGAAAT
AACTCTGTCTGGAACCAAAGATACTTCGTTATTTCTAACACCACTGGCTACAATGATCGTGCTG
TATTGGAGAGAGAAGTCCAATACACTCTGGAAATGATTAAACTAGTACCACATAATGAAAGTGC
ATGGAACTATTTGAAAGGGATTTTGCAGGATCGTGGTCTTTCCAAATATCCTAATCTGTTAAAT
CAATTACTTGATTTACAACCAAGTCATAGTTCCCCCTACCTAATTGCCTTTCTTGTGGATATCT
ATGAAGACATGCTAGAAAATCAGTGTGACAATAAGGAAGACATTCTTAATAAAGCATTAGAGTT
ATGTGAAATCCTAGCTAAAGAAAAGGACACTATAAGAAAGGAATATTGGAGATACATTGGAAGA
TCCCTTCAAAGCAAACACAGCACAGAAAATGACTCAGCAACAAATGTACAGCAATAACACCATC
CAGAAGAACTTGATGGAATGCTTTTATTTTTTATTAAGGGACCCTGCAGGAGTTTCACACGAGA
GTGGTCCTTCCCTTTGCCTGTGGTGTAAAAGTGCATCACACAGGTATTGCTTTTTAACAAGAAC
TGATGCTCCTTGGGTGCTGCTGCTACTCAGACTAGCTCTAAGTAATGTGATTCTTCTAAAGCAA
AGTCATTGGATGGGAGGAGGAAGAAAAAGTCCCATAAAGGAACTTTTGTAGTCTTATCAACATA
TAATCTAATCCCTTAGCATCAGCTCCTCCCTCAGTGGTACATGCGTCAAGATTTGTAGCAGTAA
TAATTGCAGGTCACTTGTATGTAATGGATGTGAGGTAGCCGAAGTTTGGTTCAGTAAGCAGGGA
ATACAGTCGTTCCATCAGAGCTGGTCTGCACACTCACATTATCTTGCTATCACTGTAACCAACT
AATGCCAAAAGAACGGTTTTGTAATAAAATTATAGCTGTATCTAAAAACAA

hide sequence

RefSeq Acc Id:

XM_034966033 ⟹ XP_034821924

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
Mhudiblu_PPA_v0	8	42,304,253 - 42,333,743 (+)	NCBI

RefSeq Acc Id:

XM_034966034 ⟹ XP_034821925

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
Mhudiblu_PPA_v0	8	42,304,252 - 42,333,743 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_008975143	(Get FASTA)	NCBI Sequence Viewer
	XP_034821924	(Get FASTA)	NCBI Sequence Viewer
	XP_034821925	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_008975143 ⟸ XM_008976895

- Peptide Label:

isoform X2

- Sequence:

show sequence

MASAKLGNGDRWEDAWEPGGSRESRATSRRTQPAPAASTRTLPPIPRQPAKTLWPAPLWDRAEW
ADIDPVPQNDGPNPVVQIIYSDKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHF
RRVLLKSLQKDLHEEMNYITAIIEEQPKNYQVWHHRRVLVEWLRDPSQELEFIADILNQDAKNY
HAWQHRQWVIQEFKLWDNELQYVDQLLKEDVRNNSVWNQRYFVISNTTGYNDRAVLEREVQYTL
EMIKLVPHNESAWNYLKGILQDRGLSKYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCD
NKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSTENDSATNVQQ

hide sequence

RefSeq Acc Id:	XP_034821925 ⟸ XM_034966034
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_034821924 ⟸ XM_034966033
- Peptide Label:	isoform X1

RefSeq Acc Id:

ENSPPAP00000037349 ⟸ ENSPPAT00000060249

RefSeq Acc Id:

ENSPPAP00000037357 ⟸ ENSPPAT00000060257

RefSeq Acc Id:

ENSPPAP00000037360 ⟸ ENSPPAT00000060260

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000041427	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSPPAP00000037349	ENTREZGENE, UniProtKB/TrEMBL
	ENSPPAP00000037357	UniProtKB/TrEMBL
	ENSPPAP00000037360	UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000060249	UniProtKB/TrEMBL
	ENSPPAT00000060257	UniProtKB/TrEMBL
	ENSPPAT00000060260	UniProtKB/TrEMBL
InterPro	Prenyl_trans_a	UniProtKB/TrEMBL
NCBI Gene	FNTA	ENTREZGENE
Pfam	PPTA	UniProtKB/TrEMBL
PROSITE	PFTA	UniProtKB/TrEMBL
UniProt	A0A2R9C614_PANPA	UniProtKB/TrEMBL
	A0A2R9C6C9_PANPA	UniProtKB/TrEMBL
	A0A2R9CGN2_PANPA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar