Idh1 (isocitrate dehydrogenase (NADP(+)) 1) - Rat Genome Database

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Gene: Idh1 (isocitrate dehydrogenase (NADP(+)) 1) Chinchilla lanigera
Analyze
Symbol: Idh1
Name: isocitrate dehydrogenase (NADP(+)) 1
RGD ID: 8814206
Description: ENCODES a protein that exhibits identical protein binding (ortholog); isocitrate dehydrogenase (NADP+) activity (ortholog); magnesium ion binding (ortholog); INVOLVED IN 2-oxoglutarate metabolic process (ortholog); female gonad development (ortholog); glutathione metabolic process (ortholog); ASSOCIATED WITH Acute Liver Failure (ortholog); acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: isocitrate dehydrogenase (NADP(+)) 1, cytosolic; isocitrate dehydrogenase 1 (NADP+), soluble; isocitrate dehydrogenase [NADP] cytoplasmic
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554576,851,517 - 6,872,367 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554576,851,542 - 6,869,452 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 15 of 15 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Idh1Chinchillaacute myeloid leukemia disease_progressionISOIDH1 (Homo sapiens)9068941DNA:mutation:cds:p.R132(human)RGDPMID:20368543 and REF_RGD_ID:11522718
Idh1Chinchillaacute myeloid leukemia disease_progressionISOIDH1 (Homo sapiens)9068941DNA:SNP::105C>T (rs11554137)(human)RGDPMID:25324972 and REF_RGD_ID:11522721
Idh1Chinchillaautoimmune disease  ISOIDH1 (Homo sapiens)9068941associated with intrahepatic cholangiocarcinoma more ...RGDPMID:31121195 and REF_RGD_ID:14974230
Idh1ChinchillaCholangiofibrosis severityISOIDH1 (Homo sapiens)9068941associated with intrahepatic cholangiocarcinoma more ...RGDPMID:31121195 and REF_RGD_ID:14974230
Idh1ChinchillaCOVID-19  ISOIDH1 (Homo sapiens)9068941mRNA:increased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226 and REF_RGD_ID:28912744
Idh1Chinchillaglioblastoma disease_progressionISOIDH1 (Homo sapiens)9068941DNA:mutation:cds:p.R132(human)RGDPMID:25495392 and REF_RGD_ID:11074562
Idh1Chinchillaglioblastoma onsetISOIDH1 (Homo sapiens)9068941DNA:mutation:cds:p.R132H(human)RGDPMID:19765000 and REF_RGD_ID:11522732
Idh1Chinchillahepatocellular clear cell carcinoma disease_progressionISOIDH1 (Homo sapiens)9068941DNA:polymorphism: :rs12478635(human)RGDPMID:25355558 and REF_RGD_ID:14974228
Idh1Chinchillahepatocellular clear cell carcinoma disease_progressionISOIDH1 (Homo sapiens)9068941DNA:misssense mutation:cds:p.Arg132Cys(human)RGDPMID:28403884 and REF_RGD_ID:14974227
Idh1Chinchillaintrahepatic cholangiocarcinoma no_associationISOIDH1 (Homo sapiens)9068941DNA:misssense mutations:cds:p.Arg132Cys and Arg132Leu (human)RGDPMID:26245674 and REF_RGD_ID:14974229
Idh1Chinchillalung adenocarcinoma disease_progressionISOIDH1 (Homo sapiens)9068941mRNA:increased expression:lung (human)RGDPMID:29537891 and REF_RGD_ID:149735539
Idh1Chinchillalung adenocarcinoma disease_progressionISOIDH1 (Homo sapiens)9068941protein:increased expression:blood plasma (human)RGDPMID:24046070 and REF_RGD_ID:149735540
Idh1Chinchillalung squamous cell carcinoma  ISOIDH1 (Homo sapiens)9068941protein:increased expression:blood plasma (human)RGDPMID:24046070 and REF_RGD_ID:149735540
Idh1Chinchillamyelodysplastic syndrome disease_progressionISOIDH1 (Homo sapiens)9068941DNA:mutation: :RGDPMID:24936872 and REF_RGD_ID:11522722
Idh1Chinchillaobesity  ISOIdh1 (Mus musculus)9068941 RGDPMID:14969338 and REF_RGD_ID:1626475
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Idh1Chinchillaacute myeloid leukemia  ISOIDH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Acute myeloid leukemiaClinVarPMID:25741868 more ...
Idh1Chinchillaadenoid cystic carcinoma  ISOIDH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Adenocystic carcinomaClinVarPMID:18772396 more ...
Idh1ChinchillaBrain Neoplasms  ISOIDH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Brain NeoplasmsClinVarPMID:18772396 more ...
Idh1ChinchillaBrain Neoplasms  ISOIDH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Brain neoplasmClinVarPMID:18772396 more ...
Idh1ChinchillaBreast Neoplasms  ISOIDH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Breast NeoplasmsClinVarPMID:18772396 more ...
Idh1ChinchillaBreast Neoplasms  ISOIDH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Breast NeoplasmsClinVarPMID:18772396 more ...
Idh1Chinchilladiffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype  ISOIDH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Diffuse pediatric-type high-grade glioma and H3-wildtype and IDH-wildtypeClinVarPMID:25741868
Idh1Chinchillaglioblastoma  ISOIDH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Glioblastoma and somaticClinVarPMID:18772396 more ...
Idh1Chinchillahigh grade glioma  ISOIDH1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:18772396 more ...
Idh1Chinchillahigh grade glioma  ISOIDH1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:18772396 more ...
Idh1Chinchillahigh grade glioma  ISOIDH1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:18772396 more ...
Idh1Chinchillalung adenocarcinoma  ISOIDH1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:18772396 more ...
Idh1Chinchillalung adenocarcinoma  ISOIDH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Adenocarcinoma of lungClinVarPMID:18772396 more ...
Idh1Chinchillalung adenocarcinoma  ISOIDH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Adenocarcinoma of lungClinVarPMID:18772396 more ...
Idh1Chinchillalymphoma  ISOIDH1 (Homo sapiens)8554872ClinVar Annotator: match by term: LymphomaClinVar 
Idh1ChinchillaMaffucci syndrome  ISOIDH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Maffucci syndromeClinVarPMID:25741868 more ...
Idh1ChinchillaNeurodevelopmental Disorders  ISOIDH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
Idh1ChinchillaOllier disease  ISOIDH1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:18772396 more ...
Idh1Chinchillaosteochondrodysplasia  ISOIDH1 (Homo sapiens)8554872ClinVar Annotator: match by term: DyschondroplasiaClinVarPMID:18772396 more ...
Idh1Chinchillaparoxysmal extreme pain disorder  ISOIDH1 (Homo sapiens)8554872ClinVar Annotator: match by term: Paroxysmal extreme pain disorderClinVarPMID:25741868 and PMID:34298581
1 to 20 of 23 rows
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Idh1ChinchillaAcute Liver Failure  ISOIDH1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:35172013
Idh1Chinchillaacute lymphoblastic leukemia  ISOIDH1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:22674224
Idh1Chinchillaacute promyelocytic leukemia  ISOIDH1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:26285909
Idh1Chinchillacholangiocarcinoma  ISOIDH1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:24185509
Idh1Chinchillachondroma  ISOIDH1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:22057234 and PMID:25895133
Idh1Chinchillahemangioma  ISOIDH1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:22057234
Idh1Chinchillahepatocellular carcinoma  ISOIDH1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:21472284
Idh1ChinchillaNeoplasm Recurrence, Local  ISOIDH1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:26285909
Idh1Chinchillaoligodendroglioma  ISOIDH1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:20160062
Idh1ChinchillaProstatic Neoplasms  ISOIDH1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:29610475
1 to 10 of 10 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Idh1Chinchillahigh grade glioma susceptibilityISOIDH1 (Homo sapiens)7240710 OMIM 


Biological Process
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Cellular Component

  


#
Reference Title
Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
PMID:22301074   PMID:30032202  



Idh1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554576,851,517 - 6,872,367 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554576,851,542 - 6,869,452 (+)NCBIChiLan1.0ChiLan1.0
IDH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382208,236,227 - 208,255,071 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2208,236,229 - 208,266,074 (-)EnsemblGRCh38hg38GRCh38
GRCh372209,100,951 - 209,119,795 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362208,809,198 - 208,828,051 (-)NCBINCBI36Build 36hg18NCBI36
Build 342208,926,459 - 208,945,312NCBI
Celera2202,868,863 - 202,887,731 (-)NCBICelera
Cytogenetic Map2q34NCBI
HuRef2200,949,019 - 200,967,890 (-)NCBIHuRef
CHM1_12209,106,806 - 209,125,662 (-)NCBICHM1_1
T2T-CHM13v2.02208,716,002 - 208,734,866 (-)NCBIT2T-CHM13v2.0
Idh1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39165,197,775 - 65,225,638 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl165,197,775 - 65,225,659 (-)EnsemblGRCm39 Ensembl
GRCm38165,158,616 - 65,186,479 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl165,158,616 - 65,186,500 (-)EnsemblGRCm38mm10GRCm38
MGSCv37165,205,190 - 65,233,053 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36165,092,904 - 65,113,390 (-)NCBIMGSCv36mm8
Celera165,649,214 - 65,677,085 (-)NCBICelera
Cytogenetic Map1C2- C3NCBI
cM Map132.91NCBI
Idh1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8974,027,887 - 74,057,442 (-)NCBIGRCr8
mRatBN7.2966,534,146 - 66,563,703 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl966,534,146 - 66,563,708 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx975,040,843 - 75,062,176 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0980,176,139 - 80,197,291 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0978,586,353 - 78,607,819 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0971,882,108 - 71,911,645 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl971,882,105 - 71,900,044 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0970,660,443 - 70,689,968 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4963,769,401 - 63,790,622 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1963,916,382 - 63,937,604 (-)NCBI
Celera963,929,810 - 63,951,008 (-)NCBICelera
Cytogenetic Map9q32NCBI
IDH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213110,846,026 - 110,865,064 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B110,861,000 - 110,891,100 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B95,475,320 - 95,494,286 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B213,599,036 - 213,628,840 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B213,599,036 - 213,617,175 (-)Ensemblpanpan1.1panPan2
IDH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13716,512,027 - 16,531,269 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3716,512,770 - 16,531,219 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3717,394,694 - 17,413,933 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03716,447,690 - 16,466,938 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3716,447,695 - 16,466,985 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13716,391,770 - 16,406,979 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03716,365,144 - 16,384,346 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03716,374,393 - 16,393,573 (-)NCBIUU_Cfam_GSD_1.0
Idh1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303164,878,089 - 164,892,414 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936950334,934 - 348,363 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936950334,894 - 349,221 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IDH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15111,341,153 - 111,362,296 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115111,341,153 - 111,362,330 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215122,861,672 - 122,883,887 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IDH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11094,021,002 - 94,039,997 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1094,020,818 - 94,039,975 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040105,331,403 - 105,350,750 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Idh1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247657,806,560 - 7,825,520 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.






Ensembl Acc Id: ENSCLAT00000019430   ⟹   ENSCLAP00000019244
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554576,851,517 - 6,872,367 (+)Ensembl
RefSeq Acc Id: XM_005396966   ⟹   XP_005397023
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554576,851,542 - 6,869,452 (+)NCBI
Sequence:
Protein RefSeqs XP_005397023 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000019244
  ENSCLAP00000019244.1
RefSeq Acc Id: XP_005397023   ⟸   XM_005396966
- UniProtKB: A0A8C2VYA0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000019244   ⟸   ENSCLAT00000019430


1 to 16 of 16 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCLAG00000013186 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000019430 ENTREZGENE
  ENSCLAT00000019430.1 UniProtKB/TrEMBL
Gene3D-CATH Isopropylmalate Dehydrogenase UniProtKB/TrEMBL
InterPro IsoCit/isopropylmalate_DH_CS UniProtKB/TrEMBL
  Isocitrate_DH_NADP UniProtKB/TrEMBL
  IsoPropMal-DH-like_dom UniProtKB/TrEMBL
NCBI Gene Idh1 ENTREZGENE
PANTHER ISOCITRATE DEHYDROGENASE [NADP] CYTOPLASMIC UniProtKB/TrEMBL
  PTHR11822 UniProtKB/TrEMBL
Pfam Iso_dh UniProtKB/TrEMBL
PIRSF IDH_NADP UniProtKB/TrEMBL
PROSITE IDH_IMDH UniProtKB/TrEMBL
SMART Iso_dh UniProtKB/TrEMBL
Superfamily-SCOP Isocitrate/Isopropylmalate dehydrogenase-like UniProtKB/TrEMBL
UniProt A0A8C2VYA0 ENTREZGENE, UniProtKB/TrEMBL
1 to 16 of 16 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-07-16 Idh1  isocitrate dehydrogenase (NADP(+)) 1  Idh1  isocitrate dehydrogenase (NADP(+)) 1, cytosolic  Symbol and/or name change 5135510 APPROVED
2016-08-03 Idh1  isocitrate dehydrogenase (NADP(+)) 1, cytosolic    isocitrate dehydrogenase 1 (NADP+), soluble  Symbol and/or name change 5135510 APPROVED