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Gene: Idh1 (isocitrate dehydrogenase 1 (NADP+), soluble) Mus musculus
Symbol: Idh1
Name: isocitrate dehydrogenase 1 (NADP+), soluble
RGD ID: 10758
Description: Exhibits isocitrate dehydrogenase (NADP+) activity. Involved in glutathione metabolic process; regulation of phospholipid metabolic process; and response to oxidative stress. Localizes to cytosol and mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autoimmune disease; hematologic cancer (multiple); hepatocellular clear cell carcinoma; and malignant glioma (multiple). Orthologous to human IDH1 (isocitrate dehydrogenase (NADP(+)) 1); PARTICIPATES IN citric acid cycle pathway; glutathione metabolic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI314845; AI788952; cytosolic NADP-isocitrate dehydrogenase; E030024J03Rik; ID; Id-; Id-1; IDH; Idh-; Idh-1; IDP; Idpc; isocitrate dehydrogenase [NADP] cytoplasmic; MGC115782; NADP(+)-specific ICDH; oxalosuccinate decarboxylase
Homo sapiens (human) : IDH1 (isocitrate dehydrogenase (NADP(+)) 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Idh1 (isocitrate dehydrogenase (NADP(+)) 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Idh1 (isocitrate dehydrogenase (NADP(+)) 1)
Pan paniscus (bonobo/pygmy chimpanzee) : IDH1 (isocitrate dehydrogenase (NADP(+)) 1)
Canis lupus familiaris (dog) : IDH1 (isocitrate dehydrogenase (NADP(+)) 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Idh1 (isocitrate dehydrogenase (NADP(+)) 1)
Sus scrofa (pig) : IDH1 (isocitrate dehydrogenase (NADP(+)) 1)
Chlorocebus sabaeus (African green monkey) : IDH1 (isocitrate dehydrogenase (NADP(+)) 1)
Heterocephalus glaber (naked mole-rat) : Idh1 (isocitrate dehydrogenase (NADP(+)) 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39165,197,775 - 65,225,638 (-)NCBI
GRCm38165,158,616 - 65,186,479 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl165,158,616 - 65,186,500 (-)EnsemblGRCm38mm10GRCm38
MGSCv37165,205,190 - 65,233,053 (-)NCBIGRCm37mm9NCBIm37
MGSCv36165,092,904 - 65,113,390 (-)NCBImm8
Celera165,649,214 - 65,677,085 (-)NCBICelera
Cytogenetic Map1C2NCBI
cM Map132.91NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Idh1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10758
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.