Slc24a5 (solute carrier family 24 member 5)

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Gene: Slc24a5 (solute carrier family 24 member 5) Chinchilla lanigera

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Symbol:

Slc24a5

Name:

solute carrier family 24 member 5

RGD ID:

8719963

Description:

ENCODES a protein that exhibits calcium ion transmembrane transporter activity (ortholog); calcium, potassium:sodium antiporter activity (ortholog); INVOLVED IN calcium ion import (ortholog); melanin biosynthetic process (ortholog); monoatomic ion transmembrane transport (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH Bloom syndrome (ortholog); colorectal cancer (ortholog); genetic disease (ortholog); FOUND IN trans-Golgi network (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

sodium/potassium/calcium exchanger 5; solute carrier family 24 (sodium/potassium/calcium exchanger), member 5

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955409	5,747,624 - 5,768,122 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955409	5,747,624 - 5,768,122 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bloom syndrome (ISO)

colorectal cancer (ISO)

genetic disease (ISO)

Marfan syndrome (ISO)

ocular albinism 1 (ISO)

oculocutaneous albinism (ISO)

oculocutaneous albinism type VI (ISO)

Skin/Hair/Eye Pigmentation, Variation In, 4 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

calcium ion import (ISO)

melanin biosynthetic process (ISO)

monoatomic ion transmembrane transport (ISO)

negative regulation of melanin biosynthetic process (ISO)

Cellular Component

trans-Golgi network (ISO)

Molecular Function

calcium ion transmembrane transporter activity (ISO)

calcium, potassium:sodium antiporter activity (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

calcium transport pathway (ISO)

calcium/calcium-mediated signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Slc24a5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955409	5,747,624 - 5,768,122 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955409	5,747,624 - 5,768,122 (-)	NCBI	ChiLan1.0	ChiLan1.0

SLC24A5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	48,120,990 - 48,142,672 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	48,120,990 - 48,142,672 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	48,413,187 - 48,434,869 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	46,200,461 - 46,221,881 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	46,200,460 - 46,221,881	NCBI
Celera	15	25,305,700 - 25,327,109 (+)	NCBI		Celera
Cytogenetic Map	15	q21.1	NCBI
HuRef	15	25,246,372 - 25,267,781 (+)	NCBI		HuRef
CHM1_1	15	48,531,372 - 48,552,781 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	45,929,094 - 45,950,765 (+)	NCBI		T2T-CHM13v2.0

Slc24a5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	124,910,076 - 124,930,316 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	124,910,044 - 124,930,597 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	125,068,127 - 125,088,677 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	125,068,124 - 125,088,677 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	124,893,863 - 124,914,413 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	124,759,568 - 124,780,118 (+)	NCBI		MGSCv36	mm8
Celera	2	126,319,377 - 126,339,281 (+)	NCBI		Celera
Cytogenetic Map	2	F1	NCBI
cM Map	2	61.14	NCBI

Slc24a5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	132,772,804 - 132,792,342 (+)	NCBI		GRCr8
mRatBN7.2	3	112,319,349 - 112,338,889 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	112,319,308 - 112,339,231 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	116,180,534 - 116,199,802 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	124,776,063 - 124,795,331 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	122,436,426 - 122,455,694 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	117,335,212 - 117,354,480 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	117,335,212 - 117,354,480 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	123,859,070 - 123,878,338 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	112,368,177 - 112,387,444 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	112,228,292 - 112,292,568 (+)	NCBI
Celera	3	111,178,214 - 111,197,484 (+)	NCBI		Celera
Cytogenetic Map	3	q36	NCBI

SLC24A5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	37,375,304 - 37,382,935 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	41,556,643 - 41,564,274 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	27,069,937 - 27,091,619 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	45,394,090 - 45,415,550 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	45,394,090 - 45,415,823 (+)	Ensembl	panpan1.1		panPan2

SLC24A5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	14,372,019 - 14,400,262 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	14,371,778 - 14,400,152 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	14,293,747 - 14,321,766 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	14,505,907 - 14,533,924 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	14,505,892 - 14,537,914 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	14,428,709 - 14,456,722 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	14,544,152 - 14,572,176 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	14,655,945 - 14,684,011 (+)	NCBI		UU_Cfam_GSD_1.0

Slc24a5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	92,621,921 - 92,644,271 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	10,470,046 - 10,493,104 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	10,470,078 - 10,492,334 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC24A5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	123,635,043 - 123,656,736 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	123,635,077 - 123,657,205 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	137,663,480 - 137,685,118 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC24A5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	35,143,004 - 35,164,134 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	35,143,097 - 35,163,718 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	105,948,002 - 105,968,929 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc24a5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624731	11,552,969 - 11,574,044 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624731	11,552,865 - 11,573,987 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005376708	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01009322	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01009323	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDI01093137	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000013954 ⟹ ENSCLAP00000013798

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955409	5,747,624 - 5,768,122 (-)	Ensembl

RefSeq Acc Id:

XM_005376708 ⟹ XP_005376765

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955409	5,747,624 - 5,768,122 (-)	NCBI

Sequence:

show sequence

GGAAAGGGAGGCTGCCTGGGCCTGCCCTGAGGATCGAGCCCGAGGGGACAGATGTAGAGAATGC
TCGTAGGCTCCCCTCCCTGGTTCCTCCGACCTCCCTGGGCTTGGGATTCCTGATTAGGGAAGCT
TGGCTGGCTCCAGTCACCCTCTCCCCTGTGCTGGCCTTGCTGAGATGGGCCCCAGGCAGGCCCT
AGGCGGCAGGAAAGAGACTCCTCACATGACTCGGCGGAATCCTCCTGCTCCCCCTTCCCACGCT
GCATGCTCCAGACGGCGCAGCAGAAATGCAGAGGAATCGGGGCCTAGCATGGGCTAGAAGGGTC
CTGCTGCTCAGCATCGTCGGGACCATGGGACCCCTGCCCTCCCCGGGAGCCTCCCTGCCTCAGC
GTCTCCCAAGGGCCACAGGAAATAGCACCCAGTGTGTTCTGTCTCCTTCATCCGAGTTTCCCGA
AGGGTTTTTCACGCAACAGGAGCGTGCAGACGGGGGCGTCGTTATCTACTTCCTCATCATCCTT
TACATGTTCCTGGCCGTGTCGATTGTCTGTGACGAGTACTTTTTGCCCTCCCTGGAAATCATCA
GTGAATCCCTTGGATTATCTCAGGATGTTGCAGGTGCAACTTTCATGGCAGCGGGTAGCTCAGC
TCCTGAATTAGTTACTGCTTTTCTAGGTGTATTTATCACAAAAGGAGACATCGGCATTAGCACC
ATTCTCGGATCTGCAATTTACAATCTCCTTGGCATCTGCGCAGCCTGTGGCTTGCTCTCTAACA
TGGCCTCACCACTGTCCTGCTGGCCTCTATTCAGAGACTGCACAGCATACACCGTGAGTGCAGC
AGCGGTTTTTGCTGTAATATTTGACAACCAAGTTTACTGGTATGAAGGGAGTTTACTACTTTTG
ATATATGGACTCTACGTTCTGGTGCTGTGTTTTGACGTTAAAATTCAGCAATGCGTTGTAAGGA
AGTGCAGTCCCTGCTGCACCTGTCTTGTCCAAGCTATGGAGGAGAGAAGCGAGCAGGTACCGAT
GGAATGGGAAGATGAGGGTCAGCCGTTCATTCGCCGGCAGTCAAGAACCGACAGTGGGATATTT
CACGAGGACTCTGGCTACTCCCAGCTCTCCCTAAGTTTACATGGTCTCAGTCAAGCGTCTGAAG
ACCCACCAAGTGTTTTCCATGTGCCTGAAGCAGACTTTAGAAGAATTTTTTGGGTATTATCCCT
TCCTATCATTACATTACTTTTTCTAACAACACCAGATTGTCGAAGAATGTTTTGGAAAAAATAC
TACATAATAACCTTTTTCATGTCTGCACTATGGATATCTGCATTTACATATGTCCTGGTTTGGA
TGGTCACTATAACTGGCGAAACGCTGCAGATCCCGGACACAGTGATGGGCCTCACTCTGTTAGC
AGCAGGAACCAGCATTCCAGACACCGTCGCAAGCGTGCTGGTGGCCAGAAAAGGGAAAGGCGAC
ATGGCTATGTCTAACATCGTAGGATCCAACGTGTTTGATATGCTATGCTTAGGCGTTCCCTGGC
TCATTCAAACTGCATTCATAAACACATCAGCTCCTGTAGGAGTGAACAGCAGAGGACTCACTTA
CATCACTGTCGCCCTCAACTTTTCAATTCTTTTTCTCTTCCTAGCAGTTCACTTTAATGGCTGG
AAACTGGACAGAAAGTTGGGAGCAGGCTGCCTGTTACTGTACGTGGGGCTCGCTACACTATCAG
TTCTATATGAACTTGGAATTATTGGCAATAATAAAATAAAGGGTTGTGGAGGCTGATTTTATTA
ACAGTGCTATGTGAAAAATGTGAATGGGAGAACATGGAAAAATCCCTTTCTTCATTTAAATCAA
ATAAAAAACATCCTGAACTTTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005376765	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000013798
	ENSCLAP00000013798.1

RefSeq Acc Id:

XP_005376765 ⟸ XM_005376708

- UniProtKB:

A0A8C2VD47 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MQRNRGLAWARRVLLLSIVGTMGPLPSPGASLPQRLPRATGNSTQCVLSPSSEFPEGFFTQQER
ADGGVVIYFLIILYMFLAVSIVCDEYFLPSLEIISESLGLSQDVAGATFMAAGSSAPELVTAFL
GVFITKGDIGISTILGSAIYNLLGICAACGLLSNMASPLSCWPLFRDCTAYTVSAAAVFAVIFD
NQVYWYEGSLLLLIYGLYVLVLCFDVKIQQCVVRKCSPCCTCLVQAMEERSEQVPMEWEDEGQP
FIRRQSRTDSGIFHEDSGYSQLSLSLHGLSQASEDPPSVFHVPEADFRRIFWVLSLPIITLLFL
TTPDCRRMFWKKYYIITFFMSALWISAFTYVLVWMVTITGETLQIPDTVMGLTLLAAGTSIPDT
VASVLVARKGKGDMAMSNIVGSNVFDMLCLGVPWLIQTAFINTSAPVGVNSRGLTYITVALNFS
ILFLFLAVHFNGWKLDRKLGAGCLLLYVGLATLSVLYELGIIGNNKIKGCGG

hide sequence

Ensembl Acc Id:

ENSCLAP00000013798 ⟸ ENSCLAT00000013954

Protein Domains

Sodium/calcium exchanger membrane region

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000009536	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000013954	ENTREZGENE
	ENSCLAT00000013954.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1420.30	UniProtKB/TrEMBL
InterPro	K/Na/Ca-exchanger	UniProtKB/TrEMBL
	NaCa_Exmemb	UniProtKB/TrEMBL
	NCX_ion-bd_dom_sf	UniProtKB/TrEMBL
NCBI Gene	Slc24a5	ENTREZGENE
PANTHER	PTHR10846	UniProtKB/TrEMBL
	PTHR10846:SF61	UniProtKB/TrEMBL
Pfam	Na_Ca_ex	UniProtKB/TrEMBL
UniProt	A0A8C2VD47	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Slc24a5	solute carrier family 24 member 5		solute carrier family 24 (sodium/potassium/calcium exchanger), member 5	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations