DCTN4 (dynactin subunit 4) - Rat Genome Database

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Gene: DCTN4 (dynactin subunit 4) Homo sapiens
Analyze
Symbol: DCTN4
Name: dynactin subunit 4
RGD ID: 736897
HGNC Page HGNC:15518
Description: Located in centrosome.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DYN4; dynactin 4; dynactin 4 (p62); dynactin p62 subunit; dynactin subunit p62; P62
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385150,708,440 - 150,759,017 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5150,706,840 - 150,759,095 (-)EnsemblGRCh38hg38GRCh38
GRCh375150,088,002 - 150,138,579 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365150,068,502 - 150,118,769 (-)NCBINCBI36Build 36hg18NCBI36
Build 345150,068,502 - 150,118,769NCBI
Celera5146,169,659 - 146,220,011 (-)NCBICelera
Cytogenetic Map5q33.1NCBI
HuRef5145,234,095 - 145,284,314 (-)NCBIHuRef
CHM1_15149,521,113 - 149,571,477 (-)NCBICHM1_1
T2T-CHM13v2.05151,244,948 - 151,295,528 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
DCTN4Humanfamilial adenomatous polyposis 1  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Familial adenomatous polyposis 1ClinVarPMID:17963004 more ...
DCTN4HumanHereditary Neoplastic Syndromes  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary cancer-predisposing syndromeClinVarPMID:17963004 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
DCTN4Humancystic fibrosis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:22772370
DCTN4HumanPseudomonas Infections  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:22772370

1 to 20 of 60 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
DCTN4Human1,2-dimethylhydrazine multiple interactionsISODctn4 (Mus musculus)6480464Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of DCTN4 mRNA]CTDPMID:22206623
DCTN4Human1,2-dimethylhydrazine decreases expressionISODctn4 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of DCTN4 mRNACTDPMID:22206623
DCTN4Human17alpha-ethynylestradiol multiple interactionsISODctn4 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DCTN4 mRNACTDPMID:17942748
DCTN4Human17beta-estradiol decreases expressionISODctn4 (Mus musculus)6480464Estradiol results in decreased expression of DCTN4 mRNACTDPMID:39298647
DCTN4Human2,3',4,4',5-Pentachlorobiphenyl increases expressionISODctn4 (Mus musculus)64804642 more ...CTDPMID:31388691
DCTN4Human2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISODctn4 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DCTN4 mRNA and DCTN4 promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]CTDPMID:17942748 and PMID:23997114
DCTN4Human2,3,7,8-tetrachlorodibenzodioxine affects expressionISODctn4 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of DCTN4 mRNACTDPMID:21570461
DCTN4Human2,4-dinitrotoluene affects expressionISODctn4 (Rattus norvegicus)64804642 and 4-dinitrotoluene affects the expression of DCTN4 mRNACTDPMID:21346803
DCTN4Human3,4-methylenedioxymethamphetamine increases expressionISODctn4 (Rattus norvegicus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of DCTN4 mRNACTDPMID:30071829
DCTN4Human4-hydroxyphenyl retinamide decreases expressionISODctn4 (Mus musculus)6480464Fenretinide results in decreased expression of DCTN4 mRNACTDPMID:28973697
DCTN4Human6-propyl-2-thiouracil decreases expressionISODctn4 (Rattus norvegicus)6480464Propylthiouracil results in decreased expression of DCTN4 mRNACTDPMID:30047161
DCTN4Humanaflatoxin B1 decreases methylationEXP 6480464Aflatoxin B1 results in decreased methylation of DCTN4 intronCTDPMID:30157460
DCTN4Humanammonium chloride affects expressionISODctn4 (Rattus norvegicus)6480464Ammonium Chloride affects the expression of DCTN4 mRNACTDPMID:16483693
DCTN4Humanaristolochic acid A increases expressionEXP 6480464aristolochic acid I results in increased expression of DCTN4 proteinCTDPMID:33212167
DCTN4Humanbenzo[a]pyrene affects methylationEXP 6480464Benzo(a)pyrene affects the methylation of DCTN4 intronCTDPMID:30157460
DCTN4Humanbenzo[e]pyrene decreases methylationEXP 6480464benzo(e)pyrene results in decreased methylation of DCTN4 intronCTDPMID:30157460
DCTN4Humanbisphenol A decreases expressionISODctn4 (Rattus norvegicus)6480464bisphenol A results in decreased expression of DCTN4 mRNACTDPMID:25181051
DCTN4Humanbisphenol A increases expressionEXP 6480464bisphenol A results in increased expression of DCTN4 mRNA and bisphenol A results in increased expression of DCTN4 proteinCTDPMID:33670352 and PMID:34186270
DCTN4Humanbisphenol A increases expressionISODctn4 (Rattus norvegicus)6480464bisphenol A results in increased expression of DCTN4 mRNACTDPMID:34947998
DCTN4Humanbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of DCTN4 proteinCTDPMID:33376534

1 to 20 of 60 rows

Cellular Component
1 to 20 of 21 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
DCTN4Humancell cortex located_inIEAUniProtKB-SubCell:SL-0138150520179 UniProtGO_REF:0000044
DCTN4Humancentrosome located_inIEAUniProtKB-SubCell:SL-0048150520179 UniProtGO_REF:0000044
DCTN4Humancentrosome located_inTAS 150520179 PMID:10671518PINCPMID:10671518
DCTN4Humancentrosome located_inIDA 150520179 PMID:21399614UniProtPMID:21399614
DCTN4Humancytoplasm located_inIEAUniProtKB-KW:KW-0963150520179 UniProtGO_REF:0000043
DCTN4Humancytoplasm located_inTAS 150520179 PMID:10671518PINCPMID:10671518
DCTN4Humancytoplasmic dynein complex part_ofIEAUniProtKB:Q9QUR2 and ensembl:ENSRNOP00000026394150520179 EnsemblGO_REF:0000107
DCTN4Humancytoskeleton located_inIEAUniProtKB-KW:KW-0206150520179 UniProtGO_REF:0000043
DCTN4Humancytoskeleton located_inIEAUniProtKB-SubCell:SL-0090150520179 UniProtGO_REF:0000044
DCTN4Humancytosol located_inTAS 150520179 ReactomeReactome:R-HSA-2213248 more ...
DCTN4Humandynactin complex part_ofIEAInterPro:IPR008603150520179 InterProGO_REF:0000002
DCTN4Humandynactin complex part_ofIBAPANTHER:PTN000989859 and WB:WBGene00016124150520179 GO_CentralGO_REF:0000033
DCTN4Humanfocal adhesion located_inIEAUniProtKB:Q9QUR2 and ensembl:ENSRNOP00000026394150520179 EnsemblGO_REF:0000107
DCTN4Humankinetochore  ISODctn4 (Rattus norvegicus)9068941 RGDPMID:10607597 and REF_RGD_ID:70710
DCTN4Humankinetochore located_inIEAUniProtKB:Q9QUR2 and ensembl:ENSRNOP00000026394150520179 EnsemblGO_REF:0000107
DCTN4Humannucleus located_inTAS 150520179 PMID:10671518PINCPMID:10671518
DCTN4Humansarcomere located_inIEAUniProtKB-SubCell:SL-0313150520179 UniProtGO_REF:0000044
DCTN4Humanspindle pole  ISODctn4 (Rattus norvegicus)9068941 RGDPMID:10607597 and REF_RGD_ID:70710
DCTN4Humanspindle pole located_inIEAUniProtKB:Q9QUR2 and ensembl:ENSRNOP00000026394150520179 EnsemblGO_REF:0000107
DCTN4Humanstress fiber located_inIEAUniProtKB-SubCell:SL-0501150520179 UniProtGO_REF:0000044
1 to 20 of 21 rows

Molecular Function

  

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
DCTN4Humanmitochondria transport pathway  TAS 10402155 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
DCTN4HumanHuntington's disease pathway   IEA 6907045 KEGGhsa:05016
DCTN4Humanvasopressin signaling pathway via receptor type 2   IEA 6907045 KEGGhsa:04962
1 to 20 of 35 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
DCTN4HumanAbnormality of the liver  IAGP 8699517 HPOORPHA:586
DCTN4HumanAbsent vas deferens  IAGP 8699517 HPOORPHA:586
DCTN4HumanAirway obstruction  IAGP 8699517 HPOORPHA:586
DCTN4HumanAnxiety  IAGP 8699517 HPOORPHA:586
DCTN4HumanAsthma  IAGP 8699517 HPOORPHA:586
DCTN4HumanBronchiectasis  IAGP 8699517 HPOORPHA:586
DCTN4HumanCirrhosis  IAGP 8699517 HPOORPHA:586
DCTN4HumanDecreased body mass index  IAGP 8699517 HPOORPHA:586
DCTN4HumanDepression  IAGP 8699517 HPOORPHA:586
DCTN4HumanElevated circulating hepatic transaminase concentration  IAGP 8699517 HPOORPHA:586
DCTN4HumanElevated sweat chloride  IAGP 8699517 HPOORPHA:586
DCTN4HumanExocrine pancreatic insufficiency  IAGP 8699517 HPOORPHA:586
DCTN4HumanFailure to thrive  IAGP 8699517 HPOORPHA:586
DCTN4HumanGastroesophageal reflux  IAGP 8699517 HPOORPHA:586
DCTN4HumanHearing impairment  IAGP 8699517 HPOORPHA:586
DCTN4HumanHemoptysis  IAGP 8699517 HPOORPHA:586
DCTN4HumanMalabsorption  IAGP 8699517 HPOORPHA:586
DCTN4HumanMale infertility  IAGP 8699517 HPOORPHA:586
DCTN4HumanMeconium ileus  IAGP 8699517 HPOORPHA:586
DCTN4HumanNasal polyposis  IAGP 8699517 HPOORPHA:586
1 to 20 of 35 rows

#
Reference Title
Reference Citation
1. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
4. Dynactin. Schroer TA, Annu Rev Cell Dev Biol. 2004;20:759-79.
PMID:10074429   PMID:10671518   PMID:10843801   PMID:12477932   PMID:14702039   PMID:15489334   PMID:16554302   PMID:19109891   PMID:19490893   PMID:20360068   PMID:21399614   PMID:21516116  
PMID:21873635   PMID:22772370   PMID:22863883   PMID:22939629   PMID:25416956   PMID:25763772   PMID:25921289   PMID:26186194   PMID:26344197   PMID:26485645   PMID:26496610   PMID:26638075  
PMID:26871637   PMID:26972000   PMID:27173435   PMID:27432908   PMID:28514442   PMID:28718761   PMID:29053956   PMID:29117863   PMID:29467282   PMID:29509190   PMID:29511261   PMID:29568061  
PMID:29911972   PMID:29955894   PMID:30033366   PMID:30554943   PMID:30572598   PMID:30737378   PMID:30890647   PMID:31091453   PMID:31741433   PMID:31980649   PMID:32296183   PMID:32457219  
PMID:32513696   PMID:32572027   PMID:32707033   PMID:32814053   PMID:33417871   PMID:33462405   PMID:33644029   PMID:33660365   PMID:33896271   PMID:33961781   PMID:34079125   PMID:34373451  
PMID:34432599   PMID:34591612   PMID:34597346   PMID:34709727   PMID:35256949   PMID:35271311   PMID:35384245   PMID:35446349   PMID:35509820   PMID:35831314   PMID:35850772   PMID:35944360  
PMID:36215168   PMID:36736316   PMID:37314216   PMID:37317656   PMID:37827155  



DCTN4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385150,708,440 - 150,759,017 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5150,706,840 - 150,759,095 (-)EnsemblGRCh38hg38GRCh38
GRCh375150,088,002 - 150,138,579 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365150,068,502 - 150,118,769 (-)NCBINCBI36Build 36hg18NCBI36
Build 345150,068,502 - 150,118,769NCBI
Celera5146,169,659 - 146,220,011 (-)NCBICelera
Cytogenetic Map5q33.1NCBI
HuRef5145,234,095 - 145,284,314 (-)NCBIHuRef
CHM1_15149,521,113 - 149,571,477 (-)NCBICHM1_1
T2T-CHM13v2.05151,244,948 - 151,295,528 (-)NCBIT2T-CHM13v2.0
Dctn4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391860,659,226 - 60,691,838 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1860,659,257 - 60,691,838 (+)EnsemblGRCm39 Ensembl
GRCm381860,526,154 - 60,558,766 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1860,526,185 - 60,558,766 (+)EnsemblGRCm38mm10GRCm38
MGSCv371860,685,875 - 60,718,416 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361860,651,590 - 60,684,131 (+)NCBIMGSCv36mm8
Celera1861,811,724 - 61,843,194 (+)NCBICelera
Cytogenetic Map18D3NCBI
cM Map1834.36NCBI
Dctn4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81856,251,187 - 56,279,844 (+)NCBIGRCr8
mRatBN7.21853,982,355 - 54,009,409 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1853,982,358 - 54,009,399 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1856,070,601 - 56,095,730 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01856,785,203 - 56,810,332 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01854,606,356 - 54,630,946 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01855,797,188 - 55,824,195 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1855,797,198 - 55,822,036 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01855,030,617 - 55,057,675 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41856,478,185 - 56,502,775 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11856,550,362 - 56,576,103 (+)NCBI
Celera1852,136,101 - 52,160,691 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
Dctn4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554153,850,086 - 3,886,953 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554153,850,475 - 3,886,953 (+)NCBIChiLan1.0ChiLan1.0
DCTN4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24145,938,960 - 145,992,459 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15144,078,506 - 144,128,568 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05146,134,587 - 146,184,639 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15152,138,052 - 152,187,140 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5152,138,052 - 152,187,140 (-)Ensemblpanpan1.1panPan2
DCTN4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1458,423,591 - 58,453,055 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl458,423,635 - 58,450,874 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha458,188,803 - 58,218,047 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0458,903,399 - 58,932,644 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl458,903,411 - 58,932,644 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1458,691,730 - 58,720,975 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0458,806,123 - 58,835,620 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0459,337,230 - 59,366,747 (+)NCBIUU_Cfam_GSD_1.0
Dctn4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213142,678,462 - 142,711,176 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365044,252,431 - 4,285,151 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365044,252,442 - 4,285,151 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DCTN4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2151,681,003 - 151,783,746 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12151,681,001 - 151,713,923 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DCTN4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12353,321,724 - 53,364,507 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603424,355,939 - 24,401,037 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dctn4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247749,951,228 - 9,986,164 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247749,951,520 - 9,986,194 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in DCTN4
35 total Variants

1 to 10 of 48 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
GRCh38/hg38 5q23.3-33.2(chr5:130860928-155321811)x3 copy number gain See cases [RCV000051193] Chr5:130860928..155321811 [GRCh38]
Chr5:130196621..154701371 [GRCh37]
Chr5:130224520..154681564 [NCBI36]
Chr5:5q23.3-33.2
pathogenic
GRCh38/hg38 5q32-35.3(chr5:149714592-181272151)x3 copy number gain See cases [RCV000051863] Chr5:149714592..181272151 [GRCh38]
Chr5:149094155..180699152 [GRCh37]
Chr5:149074348..180631758 [NCBI36]
Chr5:5q32-35.3
pathogenic
GRCh38/hg38 5q21.3-33.2(chr5:106619588-156124387)x1 copy number loss See cases [RCV000053524] Chr5:106619588..156124387 [GRCh38]
Chr5:105955289..155551397 [GRCh37]
Chr5:105983188..155483975 [NCBI36]
Chr5:5q21.3-33.2
pathogenic
GRCh38/hg38 5q23.3-33.2(chr5:129847794-153353546)x3 copy number gain See cases [RCV000138808] Chr5:129847794..153353546 [GRCh38]
Chr5:129183487..152733106 [GRCh37]
Chr5:129211386..152713299 [NCBI36]
Chr5:5q23.3-33.2
pathogenic
GRCh37/hg19 5q15-35.3(chr5:94844077-178830410)x3 copy number gain not provided [RCV000487658] Chr5:94844077..178830410 [GRCh37]
Chr5:5q15-35.3
likely benign
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910)x3 copy number gain See cases [RCV000449349] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q21.3-35.3(chr5:106716357-180687338)x3 copy number gain See cases [RCV000448245] Chr5:106716357..180687338 [GRCh37]
Chr5:5q21.3-35.3
pathogenic
NC_000005.9:g.(?_86400000)_(154000000_?)del deletion Familial adenomatous polyposis 1 [RCV004561496]|Hereditary cancer-predisposing syndrome [RCV000554476] Chr5:86400000..154000000 [GRCh37]
Chr5:5q14.3-33.2
pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2
pathogenic
1 to 10 of 48 rows

Predicted Target Of
Summary Value
Count of predictions:3078
Count of miRNA genes:1033
Interacting mature miRNAs:1239
Transcripts:ENST00000424236, ENST00000446090, ENST00000447998, ENST00000517421, ENST00000518015, ENST00000518909, ENST00000519313, ENST00000519552, ENST00000520195, ENST00000521093, ENST00000521448, ENST00000521533, ENST00000521728, ENST00000522625
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
597068554GWAS1164628_Hlung adenocarcinoma QTL GWAS1164628 (human)8e-08lung adenocarcinoma5150730677150730678Human
597072649GWAS1168723_Hcholangiocarcinoma QTL GWAS1168723 (human)0.000001cholangiocarcinoma5150732056150732057Human

A002Q42  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375150,088,362 - 150,088,540UniSTSGRCh37
Build 365150,068,555 - 150,068,733RGDNCBI36
Celera5146,169,712 - 146,169,890RGD
Cytogenetic Map5q31-q32UniSTS
HuRef5145,234,148 - 145,234,326UniSTS
GeneMap99-GB4 RH Map5583.96UniSTS
NCBI RH Map5891.6UniSTS
RH71171  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375150,088,415 - 150,088,595UniSTSGRCh37
Build 365150,068,608 - 150,068,788RGDNCBI36
Celera5146,169,765 - 146,169,945RGD
Cytogenetic Map5q31-q32UniSTS
HuRef5145,234,201 - 145,234,381UniSTS
GeneMap99-GB4 RH Map5577.03UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1204 2433 2788 2245 4962 1725 2348 5 622 1949 464 2269 7287 6458 52 3726 850 1739 1614 172


1 to 30 of 32 rows
RefSeq Transcripts NM_001135643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001135644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_016221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005268457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011537644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011537645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011537646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011537647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047417261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047417262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047417263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054352717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054352718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054352719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC008450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC008453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF156165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF195120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK000299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK125973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK299517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK307757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL162085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC321382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU178637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 32 rows

Ensembl Acc Id: ENST00000424236   ⟹   ENSP00000411251
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5150,708,748 - 150,758,520 (-)Ensembl
Ensembl Acc Id: ENST00000446090   ⟹   ENSP00000414906
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5150,706,840 - 150,759,035 (-)Ensembl
Ensembl Acc Id: ENST00000447998   ⟹   ENSP00000416968
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5150,708,440 - 150,759,017 (-)Ensembl
Ensembl Acc Id: ENST00000517421   ⟹   ENSP00000431042
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5150,736,309 - 150,759,095 (-)Ensembl
Ensembl Acc Id: ENST00000518015   ⟹   ENSP00000430993
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5150,731,454 - 150,758,698 (-)Ensembl
Ensembl Acc Id: ENST00000518909
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5150,718,276 - 150,731,310 (-)Ensembl
Ensembl Acc Id: ENST00000519313
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5150,731,375 - 150,758,690 (-)Ensembl
Ensembl Acc Id: ENST00000519552
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5150,731,111 - 150,733,909 (-)Ensembl
Ensembl Acc Id: ENST00000520195
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5150,733,396 - 150,734,475 (-)Ensembl
Ensembl Acc Id: ENST00000521093
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5150,733,394 - 150,758,636 (-)Ensembl
Ensembl Acc Id: ENST00000521448   ⟹   ENSP00000429489
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5150,733,384 - 150,759,020 (-)Ensembl
Ensembl Acc Id: ENST00000521533   ⟹   ENSP00000430183
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5150,733,391 - 150,758,504 (-)Ensembl
Ensembl Acc Id: ENST00000521728   ⟹   ENSP00000428987
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5150,731,064 - 150,743,159 (-)Ensembl
Ensembl Acc Id: ENST00000522625
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5150,730,635 - 150,731,794 (-)Ensembl
Ensembl Acc Id: ENST00000627368   ⟹   ENSP00000487323
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5150,710,858 - 150,759,035 (-)Ensembl
RefSeq Acc Id: NM_001135643   ⟹   NP_001129115
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385150,708,440 - 150,759,017 (-)NCBI
GRCh375150,088,309 - 150,138,657 (-)RGD
Celera5146,169,659 - 146,220,011 (-)RGD
HuRef5145,234,095 - 145,284,314 (-)ENTREZGENE
CHM1_15149,521,113 - 149,571,477 (-)NCBI
T2T-CHM13v2.05151,244,948 - 151,295,528 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001135644   ⟹   NP_001129116
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385150,708,440 - 150,758,507 (-)NCBI
GRCh375150,088,309 - 150,138,657 (-)RGD
Celera5146,169,659 - 146,220,011 (-)RGD
HuRef5145,234,095 - 145,284,314 (-)ENTREZGENE
CHM1_15149,521,113 - 149,570,902 (-)NCBI
T2T-CHM13v2.05151,244,948 - 151,295,018 (-)NCBI
Sequence:
RefSeq Acc Id: NM_016221   ⟹   NP_057305
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385150,708,440 - 150,759,017 (-)NCBI
GRCh375150,088,309 - 150,138,657 (-)RGD
Build 365150,068,502 - 150,118,769 (-)NCBI Archive
Celera5146,169,659 - 146,220,011 (-)RGD
HuRef5145,234,095 - 145,284,314 (-)ENTREZGENE
CHM1_15149,521,113 - 149,571,477 (-)NCBI
T2T-CHM13v2.05151,244,948 - 151,295,528 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011537644   ⟹   XP_011535946
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385150,708,440 - 150,758,698 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011537645   ⟹   XP_011535947
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385150,708,440 - 150,758,698 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047417261   ⟹   XP_047273217
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385150,708,440 - 150,758,698 (-)NCBI
RefSeq Acc Id: XM_047417262   ⟹   XP_047273218
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385150,708,440 - 150,755,554 (-)NCBI
RefSeq Acc Id: XM_047417263   ⟹   XP_047273219
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385150,708,440 - 150,753,561 (-)NCBI
RefSeq Acc Id: XM_054352717   ⟹   XP_054208692
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.05151,244,948 - 151,294,454 (-)NCBI
RefSeq Acc Id: XM_054352718   ⟹   XP_054208693
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.05151,244,948 - 151,292,064 (-)NCBI
RefSeq Acc Id: XM_054352719   ⟹   XP_054208694
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.05151,244,948 - 151,290,071 (-)NCBI
1 to 30 of 32 rows
Protein RefSeqs NP_001129115 (Get FASTA)   NCBI Sequence Viewer  
  NP_001129116 (Get FASTA)   NCBI Sequence Viewer  
  NP_057305 (Get FASTA)   NCBI Sequence Viewer  
  XP_011535946 (Get FASTA)   NCBI Sequence Viewer  
  XP_011535947 (Get FASTA)   NCBI Sequence Viewer  
  XP_047273217 (Get FASTA)   NCBI Sequence Viewer  
  XP_047273218 (Get FASTA)   NCBI Sequence Viewer  
  XP_047273219 (Get FASTA)   NCBI Sequence Viewer  
  XP_054208692 (Get FASTA)   NCBI Sequence Viewer  
  XP_054208693 (Get FASTA)   NCBI Sequence Viewer  
  XP_054208694 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF03896 (Get FASTA)   NCBI Sequence Viewer  
  AAH26323 (Get FASTA)   NCBI Sequence Viewer  
  ALQ34095 (Get FASTA)   NCBI Sequence Viewer  
  ALQ34096 (Get FASTA)   NCBI Sequence Viewer  
  ALQ34097 (Get FASTA)   NCBI Sequence Viewer  
  BAA91066 (Get FASTA)   NCBI Sequence Viewer  
  BAG54272 (Get FASTA)   NCBI Sequence Viewer  
  BAG59365 (Get FASTA)   NCBI Sequence Viewer  
  BAG61469 (Get FASTA)   NCBI Sequence Viewer  
  CAB82417 (Get FASTA)   NCBI Sequence Viewer  
  EAW61706 (Get FASTA)   NCBI Sequence Viewer  
  EAW61707 (Get FASTA)   NCBI Sequence Viewer  
  EAW61708 (Get FASTA)   NCBI Sequence Viewer  
  EAW61709 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000411251
  ENSP00000411251.1
  ENSP00000414906
  ENSP00000414906.2
  ENSP00000416968
1 to 30 of 32 rows
1 to 5 of 20 rows
1 to 5 of 20 rows
RefSeq Acc Id: NP_057305   ⟸   NM_016221
- Peptide Label: isoform b
- UniProtKB: E5RGT5 (UniProtKB/Swiss-Prot),   D3DQH0 (UniProtKB/Swiss-Prot),   B3KWW0 (UniProtKB/Swiss-Prot),   Q8TAN8 (UniProtKB/Swiss-Prot),   Q9UJW0 (UniProtKB/Swiss-Prot),   A0A0S2Z5D4 (UniProtKB/TrEMBL),   A0A0S2Z5B8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001129115   ⟸   NM_001135643
- Peptide Label: isoform a
- UniProtKB: A0A0S2Z5B8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001129116   ⟸   NM_001135644
- Peptide Label: isoform c
- UniProtKB: A0A0S2Z5B8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011535946   ⟸   XM_011537644
- Peptide Label: isoform X1
- UniProtKB: A0A0S2Z5B8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011535947   ⟸   XM_011537645
- Peptide Label: isoform X1
- UniProtKB: A0A0S2Z5B8 (UniProtKB/TrEMBL)
- Sequence:

Name Modeler Protein Id AA Range Protein Structure
AF-Q9UJW0-F1-model_v2 AlphaFold Q9UJW0 1-460 view protein structure

RGD ID:6802994
Promoter ID:HG_KWN:51543
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000252372,   UC003LSU.1,   UC010JHI.1,   UC010JHJ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 365150,118,261 - 150,118,832 (-)MPROMDB
RGD ID:6871282
Promoter ID:EPDNEW_H8806
Type:initiation region
Name:DCTN4_1
Description:dynactin subunit 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H8807  EPDNEW_H8810  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh385150,759,006 - 150,759,066EPDNEW


1 to 37 of 37 rows
Database
Acc Id
Source(s)
COSMIC DCTN4 COSMIC
Ensembl Genes ENSG00000132912 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000424236 ENTREZGENE
  ENST00000424236.5 UniProtKB/Swiss-Prot
  ENST00000446090 ENTREZGENE
  ENST00000446090.7 UniProtKB/Swiss-Prot
  ENST00000447998 ENTREZGENE
  ENST00000447998.7 UniProtKB/Swiss-Prot
GTEx ENSG00000132912 GTEx
HGNC ID HGNC:15518 ENTREZGENE
Human Proteome Map DCTN4 Human Proteome Map
InterPro DCTN4 UniProtKB/Swiss-Prot
KEGG Report hsa:51164 UniProtKB/Swiss-Prot
NCBI Gene 51164 ENTREZGENE
OMIM 614758 OMIM
PANTHER DYNACTIN SUBUNIT 4 UniProtKB/Swiss-Prot
  PTHR13034 UniProtKB/Swiss-Prot
Pfam Dynactin_p62 UniProtKB/Swiss-Prot
PharmGKB PA27183 PharmGKB
UniProt A0A0S2Z5B8 ENTREZGENE, UniProtKB/TrEMBL
  A0A0S2Z5D4 ENTREZGENE, UniProtKB/TrEMBL
  A0A0S2Z5D5_HUMAN UniProtKB/TrEMBL
  B3KWW0 ENTREZGENE
  D3DQH0 ENTREZGENE
  DCTN4_HUMAN UniProtKB/Swiss-Prot
  E5RGG1_HUMAN UniProtKB/TrEMBL
  E5RGT5 ENTREZGENE
  E5RI97_HUMAN UniProtKB/TrEMBL
  E5RK21_HUMAN UniProtKB/TrEMBL
  H9KVE0_HUMAN UniProtKB/TrEMBL
  Q8TAN8 ENTREZGENE
  Q9NSJ5_HUMAN UniProtKB/TrEMBL
  Q9UJW0 ENTREZGENE
UniProt Secondary B3KWW0 UniProtKB/Swiss-Prot
  D3DQH0 UniProtKB/Swiss-Prot
  E5RGT5 UniProtKB/Swiss-Prot
  Q8TAN8 UniProtKB/Swiss-Prot
1 to 37 of 37 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-01 DCTN4  dynactin subunit 4    dynactin 4 (p62)  Symbol and/or name change 5135510 APPROVED