DCTN4 (dynactin subunit 4) - Rat Genome Database

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Gene: DCTN4 (dynactin subunit 4) Canis lupus familiaris
Analyze
Symbol: DCTN4
Name: dynactin subunit 4
RGD ID: 12432068
Description: PARTICIPATES IN mitochondria transport pathway; ASSOCIATED WITH cystic fibrosis (ortholog); familial adenomatous polyposis 1 (ortholog); Hereditary Neoplastic Syndromes (ortholog); FOUND IN cytoplasmic dynein complex (ortholog); focal adhesion (ortholog); kinetochore (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1458,423,591 - 58,453,055 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl458,423,635 - 58,450,874 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha458,188,803 - 58,218,047 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0458,903,399 - 58,932,644 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl458,903,411 - 58,932,644 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1458,691,730 - 58,720,975 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0458,806,123 - 58,835,620 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0459,337,230 - 59,366,747 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
DCTN4Dogfamilial adenomatous polyposis 1  ISODCTN4 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial adenomatous polyposis 1ClinVarPMID:17963004 more ...
DCTN4DogHereditary Neoplastic Syndromes  ISODCTN4 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary cancer-predisposing syndromeClinVarPMID:17963004 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
DCTN4Dogcystic fibrosis  ISODCTN4 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:22772370
DCTN4DogPseudomonas Infections  ISODCTN4 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:22772370


Cellular Component
1 to 13 of 13 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
DCTN4Dogcell cortex located_inIEAUniProtKB-SubCell:SL-0138150520179 UniProtGO_REF:0000044
DCTN4Dogcentrosome located_inIEAUniProtKB:Q9UJW0 and ensembl:ENSP00000416968150520179 EnsemblGO_REF:0000107
DCTN4Dogcentrosome located_inIEAUniProtKB-SubCell:SL-0048150520179 UniProtGO_REF:0000044
DCTN4Dogcytoplasm located_inIEAUniProtKB-KW:KW-0963150520179 UniProtGO_REF:0000043
DCTN4Dogcytoplasmic dynein complex part_ofISODctn4 (Rattus norvegicus)9068941PMID:10525537MGIPMID:10525537 and REF_RGD_ID:632517
DCTN4Dogcytoskeleton located_inIEAUniProtKB-KW:KW-0206150520179 UniProtGO_REF:0000043
DCTN4Dogdynactin complex part_ofIEAInterPro:IPR008603150520179 InterProGO_REF:0000002
DCTN4Dogdynactin complex part_ofIBAPANTHER:PTN000989859 and WB:WBGene00016124150520179 GO_CentralGO_REF:0000033
DCTN4Dogfocal adhesion located_inISODctn4 (Rattus norvegicus)9068941 RGDPMID:10607597 and REF_RGD_ID:70710
DCTN4Dogkinetochore  ISODctn4 (Rattus norvegicus)9068941 RGDPMID:10607597 and REF_RGD_ID:70710
DCTN4Dogsarcomere located_inIEAUniProtKB-SubCell:SL-0313150520179 UniProtGO_REF:0000044
DCTN4Dogspindle pole  ISODctn4 (Rattus norvegicus)9068941 RGDPMID:10607597 and REF_RGD_ID:70710
DCTN4Dogstress fiber located_inIEAUniProtKB-SubCell:SL-0501150520179 UniProtGO_REF:0000044
1 to 13 of 13 rows

Molecular Function

  

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
DCTN4Dogmitochondria transport pathway  ISODCTN4 (Homo sapiens)9068941 RGDPMID:15473859 and REF_RGD_ID:10402155
PMID:22301074   PMID:30032202  



DCTN4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1458,423,591 - 58,453,055 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl458,423,635 - 58,450,874 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha458,188,803 - 58,218,047 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0458,903,399 - 58,932,644 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl458,903,411 - 58,932,644 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1458,691,730 - 58,720,975 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0458,806,123 - 58,835,620 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0459,337,230 - 59,366,747 (+)NCBIUU_Cfam_GSD_1.0
DCTN4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385150,708,440 - 150,759,017 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5150,706,840 - 150,759,095 (-)EnsemblGRCh38hg38GRCh38
GRCh375150,088,002 - 150,138,579 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365150,068,502 - 150,118,769 (-)NCBINCBI36Build 36hg18NCBI36
Build 345150,068,502 - 150,118,769NCBI
Celera5146,169,659 - 146,220,011 (-)NCBICelera
Cytogenetic Map5q33.1NCBI
HuRef5145,234,095 - 145,284,314 (-)NCBIHuRef
CHM1_15149,521,113 - 149,571,477 (-)NCBICHM1_1
T2T-CHM13v2.05151,244,948 - 151,295,528 (-)NCBIT2T-CHM13v2.0
Dctn4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391860,659,226 - 60,691,838 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1860,659,257 - 60,691,838 (+)EnsemblGRCm39 Ensembl
GRCm381860,526,154 - 60,558,766 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1860,526,185 - 60,558,766 (+)EnsemblGRCm38mm10GRCm38
MGSCv371860,685,875 - 60,718,416 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361860,651,590 - 60,684,131 (+)NCBIMGSCv36mm8
Celera1861,811,724 - 61,843,194 (+)NCBICelera
Cytogenetic Map18D3NCBI
cM Map1834.36NCBI
Dctn4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81856,251,187 - 56,279,844 (+)NCBIGRCr8
mRatBN7.21853,982,355 - 54,009,409 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1853,982,358 - 54,009,399 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1856,070,601 - 56,095,730 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01856,785,203 - 56,810,332 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01854,606,356 - 54,630,946 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01855,797,188 - 55,824,195 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1855,797,198 - 55,822,036 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01855,030,617 - 55,057,675 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41856,478,185 - 56,502,775 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11856,550,362 - 56,576,103 (+)NCBI
Celera1852,136,101 - 52,160,691 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
Dctn4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554153,850,086 - 3,886,953 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554153,850,475 - 3,886,953 (+)NCBIChiLan1.0ChiLan1.0
DCTN4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24145,938,960 - 145,992,459 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15144,078,506 - 144,128,568 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05146,134,587 - 146,184,639 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15152,138,052 - 152,187,140 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5152,138,052 - 152,187,140 (-)Ensemblpanpan1.1panPan2
Dctn4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213142,678,462 - 142,711,176 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365044,252,431 - 4,285,151 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365044,252,442 - 4,285,151 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DCTN4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2151,681,003 - 151,783,746 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12151,681,001 - 151,713,923 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DCTN4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12353,321,724 - 53,364,507 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603424,355,939 - 24,401,037 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dctn4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247749,951,228 - 9,986,164 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247749,951,520 - 9,986,194 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in DCTN4
327 total Variants



adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10



Ensembl Acc Id: ENSCAFT00000028722   ⟹   ENSCAFP00000026716
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl458,423,635 - 58,450,874 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000035516   ⟹   ENSCAFP00000030784
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl458,423,635 - 58,450,874 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845011249   ⟹   ENSCAFP00845008774
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl458,903,411 - 58,932,642 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845011279   ⟹   ENSCAFP00845008798
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl458,903,428 - 58,932,644 (+)Ensembl
RefSeq Acc Id: XM_038473926   ⟹   XP_038329854
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1458,691,730 - 58,720,975 (+)NCBI
RefSeq Acc Id: XM_038473927   ⟹   XP_038329855
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1458,691,730 - 58,720,975 (+)NCBI
RefSeq Acc Id: XM_038535017   ⟹   XP_038390945
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0459,337,230 - 59,366,747 (+)NCBI
RefSeq Acc Id: XM_038535018   ⟹   XP_038390946
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0459,337,230 - 59,366,747 (+)NCBI
RefSeq Acc Id: XM_038599322   ⟹   XP_038455250
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0458,806,123 - 58,835,620 (+)NCBI
RefSeq Acc Id: XM_038599323   ⟹   XP_038455251
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0458,806,123 - 58,835,620 (+)NCBI
RefSeq Acc Id: XM_038663626   ⟹   XP_038519554
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0458,903,399 - 58,932,644 (+)NCBI
RefSeq Acc Id: XM_038663627   ⟹   XP_038519555
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0458,903,399 - 58,932,644 (+)NCBI
RefSeq Acc Id: XM_848442   ⟹   XP_853535
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1458,423,591 - 58,453,055 (+)NCBI
Dog10K_Boxer_Tasha458,188,803 - 58,218,047 (+)NCBI
Sequence:
RefSeq Acc Id: XM_862430   ⟹   XP_867523
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1458,423,592 - 58,453,055 (+)NCBI
Dog10K_Boxer_Tasha458,188,803 - 58,218,047 (+)NCBI
Sequence:
1 to 5 of 14 rows
1 to 5 of 14 rows
RefSeq Acc Id: XP_853535   ⟸   XM_848442
- Peptide Label: isoform X1
- UniProtKB: A0A8C0S0Y8 (UniProtKB/TrEMBL),   A0A8I3N2P7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_867523   ⟸   XM_862430
- Peptide Label: isoform X2
- UniProtKB: A0A8C0LE05 (UniProtKB/TrEMBL),   A0A8C0M733 (UniProtKB/TrEMBL),   A0A8I3MS09 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000030784   ⟸   ENSCAFT00000035516
Ensembl Acc Id: ENSCAFP00000026716   ⟸   ENSCAFT00000028722
RefSeq Acc Id: XP_038329854   ⟸   XM_038473926
- Peptide Label: isoform X1

RGD ID:13683021
Promoter ID:EPDNEW_C1089
Type:multiple initiation site
Name:DCTN4_1
Description:dynactin subunit 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1458,423,622 - 58,423,682EPDNEW


1 to 26 of 26 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCAFG00000018072 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030003102 UniProtKB/TrEMBL
  ENSCAFG00040008365 UniProtKB/TrEMBL
  ENSCAFG00845006343 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000028722.6 UniProtKB/TrEMBL
  ENSCAFT00000035516.4 UniProtKB/TrEMBL
  ENSCAFT00030005872.1 UniProtKB/TrEMBL
  ENSCAFT00030005878.1 UniProtKB/TrEMBL
  ENSCAFT00040015923.1 UniProtKB/TrEMBL
  ENSCAFT00040015928.1 UniProtKB/TrEMBL
  ENSCAFT00845011249 ENTREZGENE
  ENSCAFT00845011249.1 UniProtKB/TrEMBL
  ENSCAFT00845011279 ENTREZGENE
  ENSCAFT00845011279.1 UniProtKB/TrEMBL
InterPro DCTN4 UniProtKB/TrEMBL
KEGG Report cfa:479326 UniProtKB/TrEMBL
NCBI Gene DCTN4 ENTREZGENE
PANTHER DYNACTIN SUBUNIT 4 UniProtKB/TrEMBL
  PTHR13034 UniProtKB/TrEMBL
Pfam Dynactin_p62 UniProtKB/TrEMBL
UniProt A0A8C0LE05 ENTREZGENE
  A0A8C0M733 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0S0Y8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MS09 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N2P7 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:39819 ENTREZGENE
1 to 26 of 26 rows