Agxt (alanine-glyoxylate aminotransferase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Agxt (alanine-glyoxylate aminotransferase) Mus musculus
Analyze
Symbol: Agxt
Name: alanine-glyoxylate aminotransferase
RGD ID: 736337
MGI Page MGI
Description: Enables alanine-glyoxylate transaminase activity. Acts upstream of or within Notch signaling pathway; glyoxylate metabolic process; and oxalic acid secretion. Predicted to be located in mitochondrial matrix and peroxisomal matrix. Predicted to be active in peroxisome. Is expressed in liver. Used to study primary hyperoxaluria type 1. Human ortholog(s) of this gene implicated in primary hyperoxaluria type 1. Orthologous to human AGXT (alanine--glyoxylate aminotransferase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AGT; Agt1; Agxt1; alanine--glyoxylate aminotransferase; alanine-glyoxylate aminotransferase 1; serine--pyruvate aminotransferase, mitochondrial; serine--pyruvate aminotransferase, peroxisomal; serine-pyruvate aminotransferase; SPT
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,062,962 - 93,073,143 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl193,062,962 - 93,073,143 (+)EnsemblGRCm39 Ensembl
GRCm38193,135,240 - 93,145,421 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,135,240 - 93,145,421 (+)EnsemblGRCm38mm10GRCm38
MGSCv37195,031,853 - 95,041,998 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36194,965,651 - 94,988,099 (+)NCBIMGSCv36mm8
Celera196,079,940 - 96,090,082 (+)NCBICelera
Cytogenetic Map1DNCBI
cM Map147.0NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AgxtMouseHyperoxaluria  ISOAGXT (Homo sapiens)1302510DNA:mutations:cds:RGD 
AgxtMouseHyperoxaluria  ISOAGXT (Homo sapiens)1300367DNA:mutation:cds:RGD 
AgxtMouseVitamin B Deficiency  ISOAgxt (Rattus norvegicus)1599455 RGD 
1 to 13 of 13 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AgxtMouseBethlem Myopathy 1A  ISOAGXT (Homo sapiens)8554872ClinVar Annotator: match by term: Bethlem myopathy 1AClinVarPMID:26004199 and PMID:28492532
AgxtMouseCardiac Arrhythmias  ISOAGXT (Homo sapiens)8554872ClinVar Annotator: match by term: Cardiac arrhythmiaClinVarPMID:19479957 more ...
AgxtMousechromosome 2q37 deletion syndrome  ISOAGXT (Homo sapiens)8554872ClinVar Annotator: match by term: Chromosome 2q37 deletion syndromeClinVarPMID:25741868
AgxtMouseD-2-hydroxyglutaric aciduria 1  ISOAGXT (Homo sapiens)8554872ClinVar Annotator: match by term: D-2-hydroxyglutaric aciduria 1ClinVarPMID:16081310 more ...
AgxtMousegenetic disease  ISOAGXT (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:19479957 more ...
AgxtMousehereditary spastic paraplegia 30  ISOAGXT (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary spastic paraplegia 30ClinVarPMID:16081310 more ...
AgxtMouseHyperoxaluria  ISOAGXT (Homo sapiens)8554872ClinVar Annotator: match by term: HyperoxaluriaClinVarPMID:10453743 more ...
AgxtMouseintellectual disability  ISOAGXT (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
AgxtMousenephrocalcinosis  ISOAGXT (Homo sapiens)8554872ClinVar Annotator: match by term: NephrocalcinosisClinVarPMID:10541294 more ...
AgxtMousenephrolithiasis  ISOAGXT (Homo sapiens)8554872ClinVar Annotator: match by term: NephrolithiasisClinVarPMID:10541294 more ...
AgxtMousenephrotic syndrome  ISOAGXT (Homo sapiens)8554872ClinVar Annotator: match by term: Nephrotic syndromeClinVarPMID:10453743 more ...
AgxtMouseprimary hyperoxaluria  ISOAGXT (Homo sapiens)8554872ClinVar Annotator: match by term: Primary hyperoxaluriaClinVarPMID:10400689 more ...
AgxtMouseprimary hyperoxaluria type 1  ISOAGXT (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10394939 more ...
1 to 13 of 13 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AgxtMouseprimary hyperoxaluria type 1  ISOAGXT (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AgxtMouseprimary hyperoxaluria type 1  IAGP 13592920OMIM:259900MouseDO 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AgxtMouseThrombocytopenia 7  ISOAGXT (Canis lupus familiaris)9068941Hyperoxaluria more ...OMIAPMID:1672096 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AgxtMouseprimary hyperoxaluria type 1  ISOAGXT (Homo sapiens)7240710 OMIM 

1 to 20 of 112 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AgxtMouse(1->4)-beta-D-glucan multiple interactionsEXP 6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of AGXT mRNACTDPMID:36331819
AgxtMouse1,2-dimethylhydrazine decreases expressionEXP 64804641 and 2-Dimethylhydrazine results in decreased expression of AGXT mRNACTDPMID:22206623
AgxtMouse1-naphthyl isothiocyanate decreases expressionISOAgxt (Rattus norvegicus)64804641-Naphthylisothiocyanate results in decreased expression of AGXT mRNACTDPMID:30723492
AgxtMouse17beta-estradiol decreases expressionISOAGXT (Homo sapiens)6480464Estradiol results in decreased expression of AGXT mRNACTDPMID:20106945
AgxtMouse17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of AGXT mRNACTDPMID:39298647
AgxtMouse17beta-estradiol increases expressionISOAgxt (Rattus norvegicus)6480464Estradiol results in increased expression of AGXT proteinCTDPMID:32145629
AgxtMouse2,2',4,4'-Tetrabromodiphenyl ether affects expressionEXP 64804642 more ...CTDPMID:30294300
AgxtMouse2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of AGXT mRNACTDPMID:19770486
AgxtMouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of AGXT mRNACTDPMID:27562557
AgxtMouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOAgxt (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in decreased expression of AGXT mRNACTDPMID:16054898 more ...
AgxtMouse2,3,7,8-tetrachlorodibenzodioxine increases expressionISOAGXT (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of AGXT mRNACTDPMID:20106945 and PMID:21632981
AgxtMouse2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionEXP 64804642 more ...CTDPMID:38648751
AgxtMouse3,7-dihydropurine-6-thione increases expressionISOAgxt (Rattus norvegicus)6480464Mercaptopurine results in increased expression of AGXT mRNACTDPMID:23358152
AgxtMouse3H-1,2-dithiole-3-thione increases expressionISOAgxt (Rattus norvegicus)64804641 and 2-dithiol-3-thione results in increased expression of AGXT mRNACTDPMID:19162173
AgxtMouse4,4'-sulfonyldiphenol decreases expressionEXP 6480464bisphenol S results in decreased expression of AGXT mRNACTDPMID:39298647
AgxtMouse4-hydroxyphenyl retinamide increases expressionISOAGXT (Homo sapiens)6480464Fenretinide results in increased expression of AGXT mRNACTDPMID:16671099
AgxtMouse7,12-dimethyltetraphene decreases expressionEXP 64804649 more ...CTDPMID:38307155
AgxtMouseacetamide decreases expressionISOAgxt (Rattus norvegicus)6480464acetamide results in decreased expression of AGXT mRNACTDPMID:31881176
AgxtMouseaflatoxin B1 affects expressionISOAGXT (Homo sapiens)6480464Aflatoxin B1 affects the expression of AGXT proteinCTDPMID:20106945
AgxtMouseaflatoxin B1 decreases methylationISOAGXT (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of AGXT exonCTDPMID:30157460

1 to 20 of 112 rows

Biological Process
1 to 20 of 27 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AgxtMouseglycine biosynthetic process, by transamination of glyoxylate  ISOAgxt (Rattus norvegicus)9068941 RGDPMID:12383475 and REF_RGD_ID:1599457
AgxtMouseglycine biosynthetic process, by transamination of glyoxylate involved_inISOUniProtKB:P215492290270 GO_CentralGO_REF:0000119
AgxtMouseglycine biosynthetic process, by transamination of glyoxylate involved_inIEAUniProtKB:P09139 more ...2290270 EnsemblGO_REF:0000107
AgxtMouseglycine biosynthetic process, by transamination of glyoxylate involved_inISOAgxt (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
AgxtMouseglycine biosynthetic process, by transamination of glyoxylate involved_inIBAPANTHER:PTN000475663 more ...2290270 GO_CentralGO_REF:0000033
AgxtMouseglyoxylate catabolic process involved_inIEAUniProtKB:P21549 and ensembl:ENSP000003026202290270 EnsemblGO_REF:0000107
AgxtMouseglyoxylate catabolic process involved_inISOUniProtKB:P215492290270 GO_CentralGO_REF:0000119
AgxtMouseglyoxylate metabolic process involved_inISOUniProtKB:P215492290270 GO_CentralGO_REF:0000119
AgxtMouseglyoxylate metabolic process involved_inISSUniProtKB:P215492290270 UniProtGO_REF:0000024
AgxtMouseglyoxylate metabolic process acts_upstream_of_or_withinIMPMGI:35262192290270 PMID:17110443MGIPMID:17110443
AgxtMouseL-alanine catabolic process involved_inIEAUniProtKB:P21549 and ensembl:ENSP000003026202290270 EnsemblGO_REF:0000107
AgxtMouseL-alanine catabolic process involved_inISOUniProtKB:P215492290270 GO_CentralGO_REF:0000119
AgxtMouseL-cysteine catabolic process involved_inISOUniProtKB:P215492290270 GO_CentralGO_REF:0000119
AgxtMouseL-cysteine catabolic process involved_inIEAUniProtKB:P21549 and ensembl:ENSP000003026202290270 EnsemblGO_REF:0000107
AgxtMouseL-serine metabolic process involved_inIEAUniProtKB:P21549 and ensembl:ENSP000003026202290270 EnsemblGO_REF:0000107
AgxtMouseL-serine metabolic process involved_inISOUniProtKB:P215492290270 GO_CentralGO_REF:0000119
AgxtMouseNotch signaling pathway acts_upstream_of_or_withinIDA 2290270 PMID:25446530MGIPMID:25446530
AgxtMouseoxalic acid secretion acts_upstream_of_or_withinIMPMGI:35262192290270 PMID:17110443MGIPMID:17110443
AgxtMousepyruvate biosynthetic process involved_inISOAgxt (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
AgxtMousepyruvate biosynthetic process involved_inIEAUniProtKB:P09139 and ensembl:ENSRNOP000000303402290270 EnsemblGO_REF:0000107
1 to 20 of 27 rows

Cellular Component
1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AgxtMouseintracellular membrane-bounded organelle located_inISOUniProtKB:P215492290270 GO_CentralGO_REF:0000119
AgxtMousemitochondrial matrix located_inIEAUniProtKB-SubCell:SL-01702290270 UniProtGO_REF:0000044
AgxtMousemitochondrial matrix located_inISOAgxt (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
AgxtMousemitochondrion located_inTAS 2290270 PMID:7813517HGNC-UCLPMID:7813517
AgxtMouseperoxisomal matrix located_inISOUniProtKB:P215492290270 GO_CentralGO_REF:0000119
AgxtMouseperoxisomal matrix located_inIEAUniProtKB:P21549 and ensembl:ENSP000003026202290270 EnsemblGO_REF:0000107
AgxtMouseperoxisome located_inISOAgxt (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
AgxtMouseperoxisome located_inISSUniProtKB:P215492290270 UniProtGO_REF:0000024
AgxtMouseperoxisome located_inTAS 2290270 PMID:7813517HGNC-UCLPMID:7813517
AgxtMouseperoxisome located_inISOUniProtKB:P215492290270 GO_CentralGO_REF:0000119
AgxtMouseperoxisome is_active_inIBAPANTHER:PTN000475663 more ...2290270 GO_CentralGO_REF:0000033
AgxtMouseperoxisome  ISOAgxt (Rattus norvegicus)9068941 RGDPMID:10739960 more ...
1 to 12 of 12 rows

Molecular Function
1 to 20 of 25 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AgxtMousealanine-glyoxylate transaminase activity  ISOAgxt (Rattus norvegicus)9068941 RGDPMID:12383475 and REF_RGD_ID:1599457
AgxtMousealanine-glyoxylate transaminase activity enablesIMP 2290270 PMID:17110443MGIPMID:17110443
AgxtMousealanine-glyoxylate transaminase activity enablesISOAgxt (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
AgxtMousealanine-glyoxylate transaminase activity enablesISOUniProtKB:P215492290270 GO_CentralGO_REF:0000119
AgxtMousealanine-glyoxylate transaminase activity enablesIBAPANTHER:PTN000475663 more ...2290270 GO_CentralGO_REF:0000033
AgxtMousealanine-glyoxylate transaminase activity enablesISSUniProtKB:P215492290270 UniProtGO_REF:0000024
AgxtMouseamino acid binding enablesISOAgxt (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
AgxtMouseamino acid binding enablesIEAUniProtKB:P09139 more ...2290270 EnsemblGO_REF:0000107
AgxtMouseamino acid binding enablesISOUniProtKB:P215492290270 GO_CentralGO_REF:0000119
AgxtMouseamino acid binding  ISOAgxt (Rattus norvegicus)9068941 RGDPMID:12383475 and REF_RGD_ID:1599457
AgxtMouseidentical protein binding enablesISOUniProtKB:P215492290270 GO_CentralGO_REF:0000119
AgxtMouseL-serine-pyruvate transaminase activity enablesIEARHEA:228522290270 RHEAGO_REF:0000116
AgxtMouseL-serine-pyruvate transaminase activity enablesIEAEC:2.6.1.512290270 UniProtGO_REF:0000003
AgxtMouseL-serine-pyruvate transaminase activity enablesISOAgxt (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
AgxtMouseL-serine-pyruvate transaminase activity enablesISOUniProtKB:P215492290270 GO_CentralGO_REF:0000119
AgxtMouseL-serine-pyruvate transaminase activity enablesIBAPANTHER:PTN000475663 more ...2290270 GO_CentralGO_REF:0000033
AgxtMouseL-serine-pyruvate transaminase activity  ISOAgxt (Rattus norvegicus)9068941 RGDPMID:3894025 and REF_RGD_ID:1598894
AgxtMouseprotein binding enablesISOUniProtKB:P50542-19068941 PMID:22529745IntActPMID:22529745
AgxtMouseprotein binding enablesISOUniProtKB:P505429068941 PMID:15911627HGNC-UCLPMID:15911627
AgxtMouseprotein binding enablesISOUniProtKB:A1KXE4-2 more ...9068941 PMID:32296183IntActPMID:32296183
1 to 20 of 25 rows

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AgxtMousealanine, aspartate and glutamate metabolic pathway  IEA 6907045 KEGGmmu:00250
AgxtMouseglycine, serine and threonine metabolic pathway  IEA 6907045 KEGGmmu:00260
1 to 10 of 10 rows
1 to 10 of 10 rows

1 to 12 of 12 rows
#
Reference Title
Reference Citation
1. Enzymological and mutational analysis of a complex primary hyperoxaluria type 1 phenotype involving alanine:glyoxylate aminotransferase peroxisome-to-mitochondrion mistargeting and intraperoxisomal aggregation. Danpure CJ, etal., Am J Hum Genet 1993 Aug;53(2):417-32.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Hepatic alanine-glyoxylate aminotransferase activity and oxalate metabolism in vitamin B6 deficient rats. Nishijima S, etal., J Urol. 2003 Feb;169(2):683-6.
5. Primary hyperoxaluria type I due to a point mutation of T to C in the coding region of the serine:pyruvate aminotransferase gene. Nishiyama K, etal., Biochem Biophys Res Commun 1991 May 15;176(3):1093-9.
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
1 to 12 of 12 rows
PMID:7813517   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11225057   PMID:12477932   PMID:14651853   PMID:14681479   PMID:16141072   PMID:16141073   PMID:17110443  
PMID:18614015   PMID:20977670   PMID:21163900   PMID:21873635   PMID:22189945   PMID:25446530   PMID:26655602   PMID:27239044   PMID:30676254   PMID:31055082   PMID:31821850   PMID:33268508  
PMID:34320345   PMID:34433051   PMID:35402636   PMID:38182795  



Agxt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,062,962 - 93,073,143 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl193,062,962 - 93,073,143 (+)EnsemblGRCm39 Ensembl
GRCm38193,135,240 - 93,145,421 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,135,240 - 93,145,421 (+)EnsemblGRCm38mm10GRCm38
MGSCv37195,031,853 - 95,041,998 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36194,965,651 - 94,988,099 (+)NCBIMGSCv36mm8
Celera196,079,940 - 96,090,082 (+)NCBICelera
Cytogenetic Map1DNCBI
cM Map147.0NCBI
AGXT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382240,868,824 - 240,880,500 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2240,868,824 - 240,880,502 (+)EnsemblGRCh38hg38GRCh38
GRCh372241,808,241 - 241,819,917 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362241,456,835 - 241,467,210 (+)NCBINCBI36Build 36hg18NCBI36
Build 342241,528,151 - 241,538,527NCBI
Celera2235,480,100 - 235,491,174 (+)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2233,568,172 - 233,579,109 (+)NCBIHuRef
CHM1_12241,814,212 - 241,824,586 (+)NCBICHM1_1
T2T-CHM13v2.02241,367,223 - 241,379,660 (+)NCBIT2T-CHM13v2.0
Agxt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89101,122,793 - 101,132,746 (+)NCBIGRCr8
mRatBN7.2993,675,384 - 93,685,337 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl993,675,384 - 93,685,336 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9102,110,940 - 102,120,893 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09107,246,884 - 107,256,803 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09105,603,034 - 105,612,953 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09100,281,339 - 100,291,292 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9100,281,339 - 100,291,291 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0999,939,444 - 99,949,397 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4992,412,128 - 92,422,075 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1992,616,896 - 92,626,844 (+)NCBI
Celera991,210,785 - 91,220,737 (+)NCBICelera
Cytogenetic Map9q36NCBI
Agxt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955542710,005 - 717,741 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955542710,506 - 720,564 (-)NCBIChiLan1.0ChiLan1.0
AGXT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213143,555,885 - 143,567,244 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B143,570,805 - 143,582,039 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B128,125,289 - 128,137,091 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B246,928,784 - 246,939,837 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B246,928,784 - 246,939,837 (+)Ensemblpanpan1.1panPan2
AGXT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12550,968,291 - 50,976,089 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2551,181,404 - 51,189,176 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02551,163,250 - 51,171,015 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2551,163,418 - 51,170,784 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12551,004,270 - 51,012,034 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02550,750,660 - 50,758,423 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02551,026,487 - 51,034,252 (+)NCBIUU_Cfam_GSD_1.0
Agxt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303192,351,908 - 192,362,526 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936745857,102 - 867,477 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936745856,915 - 867,477 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGXT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15139,720,612 - 139,730,736 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115139,720,648 - 139,730,737 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215157,616,991 - 157,627,404 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AGXT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110126,933,711 - 126,943,980 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10126,933,835 - 126,944,354 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604072,444,112 - 72,454,149 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Agxt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248475,067,201 - 5,077,525 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248475,066,356 - 5,073,538 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Agxt
520 total Variants

Predicted Target Of
Summary Value
Count of predictions:141
Count of miRNA genes:127
Interacting mature miRNAs:138
Transcripts:ENSMUST00000027491
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 38 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
15039333Nmrs1_mNAFLD-associated magnetic resonance shift 1 (mouse)189786512123786512Mouse
1357847Jckm2_mjuvenile cystic kidney modifier 2 (mouse)Not determined174991977133290937Mouse
4141627Bwq7_mbody weight, QTL 7 (mouse)Not determined192940909124497796Mouse
4142394Mssq1_mmandible size and shape QTL 1 (mouse)Not determined73615692107615830Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
1558928Mord2_mmodifier of retinal degeneration 2 (mouse)Not determined177123115110536075Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
14697706Stsl3a_mSalmonella typhimurium susceptibility locus 3a (mouse)17747663795827725Mouse

1 to 10 of 38 rows
Agxt  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38193,139,000 - 93,139,231UniSTSGRCm38
MGSCv37195,035,577 - 95,035,808UniSTSGRCm37
Celera196,083,666 - 96,083,897UniSTS
Cytogenetic Map1DUniSTS
cM Map159.0UniSTS
D17849  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38193,145,083 - 93,145,258UniSTSGRCm38
MGSCv37195,041,660 - 95,041,835UniSTSGRCm37
Celera196,089,744 - 96,089,919UniSTS
Cytogenetic Map1DUniSTS
cM Map159.0UniSTS
Whitehead_YAC1 UniSTS
Agxt  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1DUniSTS







Ensembl Acc Id: ENSMUST00000027491   ⟹   ENSMUSP00000027491
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl193,062,962 - 93,073,143 (+)Ensembl
GRCm38.p6 Ensembl193,135,240 - 93,145,421 (+)Ensembl
Ensembl Acc Id: ENSMUST00000190603
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl193,067,601 - 93,073,139 (+)Ensembl
GRCm38.p6 Ensembl193,139,879 - 93,145,417 (+)Ensembl
Ensembl Acc Id: ENSMUST00000191039
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl193,063,290 - 93,065,724 (+)Ensembl
GRCm38.p6 Ensembl193,135,568 - 93,138,002 (+)Ensembl
RefSeq Acc Id: NM_001276710   ⟹   NP_001263639
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39193,062,962 - 93,073,143 (+)NCBI
GRCm38193,135,240 - 93,145,421 (+)NCBI
Celera196,079,904 - 96,090,082 (+)NCBI
Sequence:
RefSeq Acc Id: NM_016702   ⟹   NP_057911
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39193,062,962 - 93,073,143 (+)NCBI
GRCm38193,135,240 - 93,145,421 (+)NCBI
MGSCv37195,031,853 - 95,041,998 (+)RGD
Celera196,079,904 - 96,090,082 (+)NCBI
cM Map1 ENTREZGENE
Sequence:
1 to 10 of 10 rows
Protein RefSeqs NP_001263639 (Get FASTA)   NCBI Sequence Viewer  
  NP_057911 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB82001 (Get FASTA)   NCBI Sequence Viewer  
  AAH25799 (Get FASTA)   NCBI Sequence Viewer  
  BAE28872 (Get FASTA)   NCBI Sequence Viewer  
  EDL39971 (Get FASTA)   NCBI Sequence Viewer  
  EDL39972 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000027491
  ENSMUSP00000027491.6
GenBank Protein O35423 (Get FASTA)   NCBI Sequence Viewer  
1 to 10 of 10 rows
RefSeq Acc Id: NP_057911   ⟸   NM_016702
- Peptide Label: isoform 1 precursor
- UniProtKB: Q8R128 (UniProtKB/Swiss-Prot),   O35423 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001263639   ⟸   NM_001276710
- Peptide Label: isoform 2
- UniProtKB: Q3UEN9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000027491   ⟸   ENSMUST00000027491
Aminotransferase class V

Name Modeler Protein Id AA Range Protein Structure
AF-O35423-F1-model_v2 AlphaFold O35423 1-414 view protein structure

RGD ID:6874526
Promoter ID:EPDNEW_M714
Type:multiple initiation site
Name:Agxt_1
Description:Mus musculus alanine-glyoxylate aminotransferase , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38193,135,318 - 93,135,378EPDNEW
RGD ID:6817276
Promoter ID:MM_KWN:1679
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:ENSMUST00000027491
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36195,031,636 - 95,032,136 (+)MPROMDB


1 to 26 of 26 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000026272 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000027491 ENTREZGENE
  ENSMUST00000027491.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.640.10 UniProtKB/Swiss-Prot
  3.90.1150.10 UniProtKB/Swiss-Prot
InterPro Aminotrans_V_dom UniProtKB/Swiss-Prot
  Aminotrans_V_PyrdxlP_BS UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase_dom1 UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase_major UniProtKB/Swiss-Prot
  SP_NH2Trfase/AEP_transaminase UniProtKB/Swiss-Prot
KEGG Report mmu:11611 UniProtKB/Swiss-Prot
MGD MGI:1329033 ENTREZGENE
NCBI Gene 11611 ENTREZGENE
PANTHER ALANINE--GLYOXYLATE AMINOTRANSFERASE UniProtKB/Swiss-Prot
  AMINOTRANSFERASE CLASS V UniProtKB/Swiss-Prot
Pfam Aminotran_5 UniProtKB/Swiss-Prot
PhenoGen Agxt PhenoGen
PIRSF SPT UniProtKB/Swiss-Prot
PROSITE AA_TRANSFER_CLASS_5 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53383 UniProtKB/Swiss-Prot
UniProt O35423 ENTREZGENE
  Q3UEN9 ENTREZGENE, UniProtKB/TrEMBL
  Q8R128 ENTREZGENE
  SPYA_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q8R128 UniProtKB/Swiss-Prot
1 to 26 of 26 rows