TNP2 (transition protein 2) - Rat Genome Database

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Gene: TNP2 (transition protein 2) Homo sapiens
Analyze
Symbol: TNP2
Name: transition protein 2
RGD ID: 736031
HGNC Page HGNC:11952
Description: Predicted to enable zinc ion binding activity. Predicted to be involved in several processes, including penetration of zona pellucida; positive regulation of protein processing; and sperm DNA condensation. Predicted to act upstream of or within binding activity of sperm to zona pellucida and flagellated sperm motility. Predicted to be located in male germ cell nucleus. Predicted to be part of nucleosome. Predicted to be active in nucleus.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC116783; MGC116785; nuclear transition protein 2; TP-2; TP2; transition protein 2 (during histone to protamine replacement)
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381611,267,857 - 11,269,325 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1611,267,748 - 11,269,533 (-)EnsemblGRCh38hg38GRCh38
GRCh371611,361,714 - 11,363,182 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361611,269,215 - 11,270,661 (-)NCBINCBI36Build 36hg18NCBI36
Build 341611,269,214 - 11,270,661NCBI
Celera1611,531,105 - 11,532,551 (-)NCBICelera
Cytogenetic Map16p13.13NCBI
HuRef1611,279,446 - 11,280,892 (-)NCBIHuRef
CHM1_11611,361,620 - 11,363,066 (-)NCBICHM1_1
T2T-CHM13v2.01611,304,079 - 11,305,547 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
chromosome  (IEA)
male germ cell nucleus  (ISO)
nucleolus  (IEA)
nucleosome  (IEA,ISS)
nucleus  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1385303   PMID:1395729   PMID:2250010   PMID:7711033   PMID:7983046   PMID:8428967   PMID:8961924   PMID:9809674   PMID:9837753   PMID:10659848   PMID:12477932   PMID:12775710  
PMID:16291974   PMID:16989827   PMID:17852044   PMID:18727729   PMID:18978792   PMID:19460752   PMID:19607827   PMID:19710011   PMID:20378615   PMID:20522125   PMID:20800603   PMID:21873635  
PMID:22190364   PMID:23327642   PMID:23568457   PMID:25416956   PMID:25536093   PMID:31515488   PMID:32296183   PMID:33440036   PMID:33961781   PMID:34235877  


Genomics

Comparative Map Data
TNP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381611,267,857 - 11,269,325 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1611,267,748 - 11,269,533 (-)EnsemblGRCh38hg38GRCh38
GRCh371611,361,714 - 11,363,182 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361611,269,215 - 11,270,661 (-)NCBINCBI36Build 36hg18NCBI36
Build 341611,269,214 - 11,270,661NCBI
Celera1611,531,105 - 11,532,551 (-)NCBICelera
Cytogenetic Map16p13.13NCBI
HuRef1611,279,446 - 11,280,892 (-)NCBIHuRef
CHM1_11611,361,620 - 11,363,066 (-)NCBICHM1_1
T2T-CHM13v2.01611,304,079 - 11,305,547 (-)NCBIT2T-CHM13v2.0
Tnp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391610,605,799 - 10,606,519 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1610,605,800 - 10,606,524 (-)EnsemblGRCm39 Ensembl
GRCm381610,787,935 - 10,788,655 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1610,787,936 - 10,788,660 (-)EnsemblGRCm38mm10GRCm38
MGSCv371610,788,028 - 10,788,748 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361610,701,513 - 10,702,233 (-)NCBIMGSCv36mm8
Celera1611,415,373 - 11,416,093 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map165.83NCBI
Tnp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8105,386,735 - 5,387,463 (+)NCBIGRCr8
mRatBN7.2104,879,812 - 4,880,540 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl104,879,812 - 4,880,538 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx109,576,387 - 9,577,115 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0109,097,503 - 9,098,231 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0104,735,784 - 4,736,512 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0104,953,898 - 4,954,626 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl104,953,879 - 4,954,624 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0103,780,384 - 3,781,112 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4104,816,612 - 4,817,340 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1104,816,611 - 4,817,338 (+)NCBI
Celera103,901,408 - 3,902,136 (+)NCBICelera
Cytogenetic Map10q11NCBI
Tnp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554427,311,826 - 7,314,046 (+)NCBIChiLan1.0ChiLan1.0
TNP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21811,817,009 - 11,819,356 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11615,587,457 - 15,589,800 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01610,209,801 - 10,211,466 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11611,431,694 - 11,433,158 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1611,431,822 - 11,433,087 (-)Ensemblpanpan1.1panPan2
TNP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1631,498,361 - 31,498,740 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl631,426,715 - 31,499,842 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha632,881,238 - 32,881,617 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0631,680,942 - 31,682,492 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1631,494,292 - 31,494,671 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0631,368,582 - 31,368,961 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0631,792,757 - 31,794,307 (+)NCBIUU_Cfam_GSD_1.0
TNP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl331,870,068 - 31,871,702 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1331,868,517 - 31,871,530 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2332,659,663 - 32,661,176 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap3p13-centNCBI
TNP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1510,744,762 - 10,746,244 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl510,744,915 - 10,746,159 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606819,417,005 - 19,418,243 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248248,453,667 - 8,454,987 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TNP2
16 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 16p13.3-13.13(chr16:23141-11296695)x3 copy number gain See cases [RCV000052367] Chr16:23141..11296695 [GRCh38]
Chr16:73141..11390552 [GRCh37]
Chr16:13141..11298053 [NCBI36]
Chr16:16p13.3-13.13		 pathogenic
GRCh38/hg38 16p13.3-11.2(chr16:4644892-29170820)x3 copy number gain See cases [RCV000133809] Chr16:4644892..29170820 [GRCh38]
Chr16:4694893..29182141 [GRCh37]
Chr16:4634894..29089642 [NCBI36]
Chr16:16p13.3-11.2		 pathogenic
GRCh38/hg38 16p13.3-13.13(chr16:46766-11525516)x3 copy number gain See cases [RCV000133780] Chr16:46766..11525516 [GRCh38]
Chr16:96766..11619372 [GRCh37]
Chr16:36766..11526873 [NCBI36]
Chr16:16p13.3-13.13		 pathogenic
GRCh38/hg38 16p13.13(chr16:10778551-11374173)x3 copy number gain See cases [RCV000137607] Chr16:10778551..11374173 [GRCh38]
Chr16:10872408..11468030 [GRCh37]
Chr16:10779909..11375531 [NCBI36]
Chr16:16p13.13		 likely benign
GRCh38/hg38 16p13.3-13.12(chr16:43732-13326806)x3 copy number gain See cases [RCV000139166] Chr16:43732..13326806 [GRCh38]
Chr16:93732..13420663 [GRCh37]
Chr16:33732..13328164 [NCBI36]
Chr16:16p13.3-13.12		 pathogenic
GRCh38/hg38 16p13.3-13.11(chr16:666662-15743104)x3 copy number gain See cases [RCV000143710] Chr16:666662..15743104 [GRCh38]
Chr16:716662..15836961 [GRCh37]
Chr16:656663..15744462 [NCBI36]
Chr16:16p13.3-13.11		 pathogenic
GRCh37/hg19 16p13.13(chr16:11173868-11681288)x3 copy number gain See cases [RCV000240209] Chr16:11173868..11681288 [GRCh37]
Chr16:16p13.13		 uncertain significance
GRCh37/hg19 16p13.3-11.2(chr16:102839-28327676)x3 copy number gain See cases [RCV000203445] Chr16:102839..28327676 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic
GRCh37/hg19 16p13.3-11.2(chr16:1279324-31926800)x3 copy number gain Breast ductal adenocarcinoma [RCV000207053] Chr16:1279324..31926800 [GRCh37]
Chr16:16p13.3-11.2		 uncertain significance
GRCh37/hg19 16p13.3-12.3(chr16:1274615-19073133)x3 copy number gain Breast ductal adenocarcinoma [RCV000207326] Chr16:1274615..19073133 [GRCh37]
Chr16:16p13.3-12.3		 uncertain significance
GRCh37/hg19 16p13.3-q24.3(chr16:69193-90274381)x3 copy number gain See cases [RCV000446684] Chr16:69193..90274381 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.2-13.13(chr16:9631472-12128275)x3 copy number gain See cases [RCV000511571] Chr16:9631472..12128275 [GRCh37]
Chr16:16p13.2-13.13		 uncertain significance
GRCh37/hg19 16p13.2-q24.3(chr16:9273328-89548493)x3 copy number gain See cases [RCV000511622] Chr16:9273328..89548493 [GRCh37]
Chr16:16p13.2-q24.3		 uncertain significance
maternal UPD(16p) complex Hemimegalencephaly [RCV000494707] Chr16:1280042..33710558 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062) copy number gain See cases [RCV000511296] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-12.3(chr16:85880-19806921)x3 copy number gain See cases [RCV000512194] Chr16:85880..19806921 [GRCh37]
Chr16:16p13.3-12.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062)x3 copy number gain See cases [RCV000512138] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-12.2(chr16:85880-22442007)x3 copy number gain See cases [RCV000511360] Chr16:85880..22442007 [GRCh37]
Chr16:16p13.3-12.2		 pathogenic
NM_005425.5(TNP2):c.379A>C (p.Lys127Gln) single nucleotide variant not specified [RCV004281806] Chr16:11268884 [GRCh38]
Chr16:11362741 [GRCh37]
Chr16:16p13.13		 uncertain significance
NM_005425.5(TNP2):c.302G>C (p.Arg101Pro) single nucleotide variant not specified [RCV004296397] Chr16:11268961 [GRCh38]
Chr16:11362818 [GRCh37]
Chr16:16p13.13		 uncertain significance
GRCh37/hg19 16p13.13(chr16:10529891-11889585)x3 copy number gain not provided [RCV000683759] Chr16:10529891..11889585 [GRCh37]
Chr16:16p13.13		 uncertain significance
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90163275)x3 copy number gain not provided [RCV000738917] Chr16:88165..90163275 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90274695)x3 copy number gain not provided [RCV000738918] Chr16:88165..90274695 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:61451-90294632)x3 copy number gain not provided [RCV000738915] Chr16:61451..90294632 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.13(chr16:11124777-11387164)x1 copy number loss not provided [RCV000846621] Chr16:11124777..11387164 [GRCh37]
Chr16:16p13.13		 uncertain significance
NM_005425.5(TNP2):c.302G>A (p.Arg101His) single nucleotide variant not specified [RCV004295393] Chr16:11268961 [GRCh38]
Chr16:11362818 [GRCh37]
Chr16:16p13.13		 uncertain significance
NC_000016.9:g.(?_8829597)_(11683693_?)dup duplication Landau-Kleffner syndrome [RCV003105356] Chr16:8829597..11683693 [GRCh37]
Chr16:16p13.2-13.13		 uncertain significance
NM_005425.5(TNP2):c.129C>A (p.Gly43=) single nucleotide variant not provided [RCV000957373] Chr16:11269134 [GRCh38]
Chr16:11362991 [GRCh37]
Chr16:16p13.13		 benign
GRCh37/hg19 16p13.3-11.2(chr16:4380767-30445350)x3 copy number gain not provided [RCV002472599] Chr16:4380767..30445350 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic
GRCh37/hg19 16p13.3-11.2(chr16:5805001-34230001) copy number gain Microcephaly [RCV001252948] Chr16:5805001..34230001 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic
GRCh37/hg19 16p13.3-11.2(chr16:2959279-30190593)x3 copy number gain See cases [RCV001263169] Chr16:2959279..30190593 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic|likely pathogenic
NC_000016.9:g.(?_8829597)_(11650586_?)dup duplication Charcot-Marie-Tooth disease type 1C [RCV003120793]|MHC class II deficiency [RCV002000309] Chr16:8829597..11650586 [GRCh37]
Chr16:16p13.2-13.13		 uncertain significance
GRCh37/hg19 16p13.2-13.13(chr16:10423631-12176517)x3 copy number gain not provided [RCV002474875] Chr16:10423631..12176517 [GRCh37]
Chr16:16p13.2-13.13		 uncertain significance
NM_005425.5(TNP2):c.287C>T (p.Thr96Ile) single nucleotide variant not specified [RCV004087454] Chr16:11268976 [GRCh38]
Chr16:11362833 [GRCh37]
Chr16:16p13.13		 uncertain significance
NM_005425.5(TNP2):c.341A>G (p.Lys114Arg) single nucleotide variant not specified [RCV004200008] Chr16:11268922 [GRCh38]
Chr16:11362779 [GRCh37]
Chr16:16p13.13		 uncertain significance
NM_005425.5(TNP2):c.379A>G (p.Lys127Glu) single nucleotide variant not specified [RCV004217357] Chr16:11268884 [GRCh38]
Chr16:11362741 [GRCh37]
Chr16:16p13.13		 uncertain significance
NM_005425.5(TNP2):c.22C>G (p.Leu8Val) single nucleotide variant not specified [RCV004114379] Chr16:11269241 [GRCh38]
Chr16:11363098 [GRCh37]
Chr16:16p13.13		 uncertain significance
NM_005425.5(TNP2):c.389C>T (p.Thr130Met) single nucleotide variant not specified [RCV004246683] Chr16:11268874 [GRCh38]
Chr16:11362731 [GRCh37]
Chr16:16p13.13		 uncertain significance
NM_005425.5(TNP2):c.413A>G (p.Asn138Ser) single nucleotide variant not specified [RCV004108050] Chr16:11268000 [GRCh38]
Chr16:11361857 [GRCh37]
Chr16:16p13.13		 uncertain significance
NM_005425.5(TNP2):c.133C>T (p.Arg45Trp) single nucleotide variant not specified [RCV004152307] Chr16:11269130 [GRCh38]
Chr16:11362987 [GRCh37]
Chr16:16p13.13		 uncertain significance
NM_005425.5(TNP2):c.209G>C (p.Ser70Thr) single nucleotide variant not specified [RCV004077999] Chr16:11269054 [GRCh38]
Chr16:11362911 [GRCh37]
Chr16:16p13.13		 uncertain significance
NM_005425.5(TNP2):c.326T>C (p.Leu109Ser) single nucleotide variant not specified [RCV004208111] Chr16:11268937 [GRCh38]
Chr16:11362794 [GRCh37]
Chr16:16p13.13		 uncertain significance
NM_005425.5(TNP2):c.315C>T (p.Asn105=) single nucleotide variant not provided [RCV003417647] Chr16:11268948 [GRCh38]
Chr16:11362805 [GRCh37]
Chr16:16p13.13		 likely benign
NM_005425.5(TNP2):c.4G>A (p.Asp2Asn) single nucleotide variant not specified [RCV004475423] Chr16:11269259 [GRCh38]
Chr16:11363116 [GRCh37]
Chr16:16p13.13		 uncertain significance
NM_005425.5(TNP2):c.70C>T (p.Arg24Cys) single nucleotide variant not specified [RCV004475424] Chr16:11269193 [GRCh38]
Chr16:11363050 [GRCh37]
Chr16:16p13.13		 uncertain significance
NC_000016.9:g.(?_10971188)_(11650586_?)del deletion MHC class II deficiency [RCV004581571] Chr16:10971188..11650586 [GRCh37]
Chr16:16p13.13		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:249
Count of miRNA genes:232
Interacting mature miRNAs:240
Transcripts:ENST00000312693, ENST00000560751
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH70860  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371611,361,741 - 11,361,867UniSTSGRCh37
Build 361611,269,242 - 11,269,368RGDNCBI36
Celera1611,531,132 - 11,531,258RGD
Cytogenetic Map16p13.13UniSTS
HuRef1611,279,473 - 11,279,599UniSTS
GeneMap99-GB4 RH Map1698.95UniSTS
UniSTS:482873  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371611,361,822 - 11,363,138UniSTSGRCh37
Celera1611,531,213 - 11,532,529UniSTS
HuRef1611,279,554 - 11,280,870UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
124 262 212 160 931 367 290 51 279 37 187 691 676 825 83 726 205 14

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_005425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB281701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC009121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF215715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI220577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX282422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC007348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L03378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U15422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X63758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X63759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z46940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000312693   ⟹   ENSP00000325738
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1611,267,857 - 11,269,325 (-)Ensembl
Ensembl Acc Id: ENST00000560751   ⟹   ENSP00000496261
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1611,267,748 - 11,269,533 (-)Ensembl
RefSeq Acc Id: NM_005425   ⟹   NP_005416
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381611,267,857 - 11,269,325 (-)NCBI
GRCh371611,361,714 - 11,363,160 (-)ENTREZGENE
Build 361611,269,215 - 11,270,661 (-)NCBI Archive
HuRef1611,279,446 - 11,280,892 (-)ENTREZGENE
CHM1_11611,361,620 - 11,363,066 (-)NCBI
T2T-CHM13v2.01611,304,079 - 11,305,547 (-)NCBI
Sequence:
RefSeq Acc Id: NP_005416   ⟸   NM_005425
- UniProtKB: Q9NZB0 (UniProtKB/Swiss-Prot),   Q05952 (UniProtKB/Swiss-Prot),   Q4VB56 (UniProtKB/TrEMBL),   A0A2R8Y7P0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000496261   ⟸   ENST00000560751
Ensembl Acc Id: ENSP00000325738   ⟸   ENST00000312693

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q05952-F1-model_v2 AlphaFold Q05952 1-138 view protein structure

Promoters
RGD ID:7231331
Promoter ID:EPDNEW_H21411
Type:single initiation site
Name:TNP2_1
Description:transition protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381611,269,325 - 11,269,385EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:11952 AgrOrtholog
COSMIC TNP2 COSMIC
Ensembl Genes ENSG00000178279 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000312693 ENTREZGENE
  ENST00000312693.4 UniProtKB/Swiss-Prot
  ENST00000560751.1 UniProtKB/TrEMBL
GTEx ENSG00000178279 GTEx
HGNC ID HGNC:11952 ENTREZGENE
Human Proteome Map TNP2 Human Proteome Map
InterPro TP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:7142 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 7142 ENTREZGENE
OMIM 190232 OMIM
PANTHER NUCLEAR TRANSITION PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR17488 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA36641 PharmGKB
PROSITE TP2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TP2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2R8Y7P0 ENTREZGENE, UniProtKB/TrEMBL
  Q05952 ENTREZGENE
  Q4VB54_HUMAN UniProtKB/TrEMBL
  Q4VB56 ENTREZGENE, UniProtKB/TrEMBL
  Q9NZB0 ENTREZGENE
  STP2_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary Q9NZB0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-26 TNP2  transition protein 2    transition protein 2 (during histone to protamine replacement)  Symbol and/or name change 5135510 APPROVED