TNP2 (transition protein 2) - Rat Genome Database

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Gene: TNP2 (transition protein 2) Chlorocebus sabaeus
Analyze
Symbol: TNP2
Name: transition protein 2
RGD ID: 18535592
Description: ENCODES a protein that exhibits zinc ion binding (ortholog); INVOLVED IN acrosome reaction (ortholog); binding of sperm to zona pellucida (ortholog); flagellated sperm motility (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth disease type 1C (ortholog); Landau-Kleffner syndrome (ortholog); MHC class II deficiency (ortholog); FOUND IN male germ cell nucleus (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: nuclear transition protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1510,744,762 - 10,746,244 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl510,744,915 - 10,746,159 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606819,417,005 - 19,418,243 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TNP2Green MonkeyCharcot-Marie-Tooth disease type 1C  ISORGD:7360318554872ClinVar Annotator: match by term: Charcot-Marie-Tooth disease type 1CClinVarPMID:28492532
TNP2Green MonkeyLandau-Kleffner syndrome  ISORGD:7360318554872ClinVar Annotator: match by term: Landau-Kleffner syndromeClinVarPMID:28492532
TNP2Green MonkeyMHC class II deficiency  ISORGD:7360318554872ClinVar Annotator: match by term: MHC class II deficiencyClinVarPMID:26271388|PMID:27484032|PMID:28492532|PMID:8402893|PMID:9099848


Biological Process
1 to 14 of 14 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TNP2Green Monkeyacrosome reaction involved_inIEAPANTHER:PTN001820371150520179 TreeGrafterGO_REF:0000118
TNP2Green Monkeyacrosome reaction acts_upstream_of_or_withinISOMGI:21807799068941 PMID:11385107MGIPMID:11385107
TNP2Green Monkeybinding of sperm to zona pellucida acts_upstream_of_or_withinISOMGI:1888530|MGI:87884|MGI:969459068941 PMID:15685642MGIPMID:15685642
TNP2Green Monkeycell differentiation involved_inIEAUniProtKB-KW:KW-0221150520179 UniProtGO_REF:0000043
TNP2Green Monkeyflagellated sperm motility acts_upstream_of_or_withinISOMGI:1888530|MGI:87884|MGI:969459068941 PMID:15685642MGIPMID:15685642
TNP2Green Monkeyflagellated sperm motility acts_upstream_of_or_withinISOMGI:969459068941 PMID:15051954MGIPMID:15051954
TNP2Green Monkeypenetration of zona pellucida acts_upstream_of_or_withinISOMGI:21807799068941 PMID:11385107MGIPMID:11385107
TNP2Green Monkeypenetration of zona pellucida involved_inIEAPANTHER:PTN001820371150520179 TreeGrafterGO_REF:0000118
TNP2Green Monkeypositive regulation of protein processing involved_inISORGD:114389068941 PMID:28366643UniProtPMID:28366643
TNP2Green Monkeysperm DNA condensation involved_inISORGD:114389068941 PMID:15083521, PMID:15163613, PMID:15189834, PMID:28366643UniProtPMID:15083521|PMID:15163613|PMID:15189834|PMID:28366643
TNP2Green Monkeyspermatogenesis involved_inIEAPANTHER:PTN001820371150520179 TreeGrafterGO_REF:0000118
TNP2Green Monkeyspermatogenesis acts_upstream_of_or_withinISOMGI:21807799068941 PMID:11385107MGIPMID:11385107
TNP2Green Monkeyspermatogenesis involved_inIEAInterPro:IPR000678150520179 InterProGO_REF:0000002
TNP2Green Monkeyspermatogenesis involved_inIEAUniProtKB-KW:KW-0744150520179 UniProtGO_REF:0000043
1 to 14 of 14 rows

Cellular Component
1 to 9 of 9 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TNP2Green Monkeychromosome located_inIEAUniProtKB-KW:KW-0158150520179 UniProtGO_REF:0000043
TNP2Green Monkeychromosome located_inIEAUniProtKB-SubCell:SL-0468150520179 UniProtGO_REF:0000044
TNP2Green Monkeymale germ cell nucleus located_inISORGD:114389068941 PMID:14680821MGIPMID:14680821
TNP2Green Monkeynucleolus located_inIEAUniProtKB-SubCell:SL-0188150520179 UniProtGO_REF:0000044
TNP2Green Monkeynucleosome part_ofIEAInterPro:IPR000678150520179 InterProGO_REF:0000002
TNP2Green Monkeynucleosome part_ofIEAUniProtKB-KW:KW-0544150520179 UniProtGO_REF:0000043
TNP2Green Monkeynucleus located_inIEAUniProtKB-KW:KW-0539150520179 UniProtGO_REF:0000043
TNP2Green Monkeynucleus is_active_inISORGD:38859068941PMID:17682055UniProtPMID:17682055|REF_RGD_ID:152025521
TNP2Green Monkeynucleus located_inIEAInterPro:IPR000678150520179 InterProGO_REF:0000002
1 to 9 of 9 rows

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
TNP2Green MonkeyDNA binding enablesIEAInterPro:IPR000678150520179 InterProGO_REF:0000002
TNP2Green MonkeyDNA binding enablesIEAUniProtKB-KW:KW-0238150520179 UniProtGO_REF:0000043
TNP2Green Monkeymetal ion binding enablesIEAUniProtKB-KW:KW-0479150520179 UniProtGO_REF:0000043
TNP2Green Monkeyprotein binding enablesISOUniProtKB:P60328|UniProtKB:P60410|UniProtKB:P60411|UniProtKB:Q07627|UniProtKB:Q92624|UniProtKB:Q99750|UniProtKB:Q9BYR99068941 PMID:32296183IntActPMID:32296183
TNP2Green Monkeyprotein binding enablesISOUniProtKB:P60370|UniProtKB:P60409|UniProtKB:P60410|UniProtKB:P60411|UniProtKB:Q7Z3S9|UniProtKB:Q997509068941 PMID:25416956IntActPMID:25416956
TNP2Green Monkeyprotein binding enablesISOUniProtKB:Q997509068941 PMID:31515488IntActPMID:31515488
TNP2Green Monkeyzinc ion binding  ISORGD:38859068941 RGDPMID:8954887|REF_RGD_ID:634495
TNP2Green Monkeyzinc ion binding enablesIEAPANTHER:PTN001820371150520179 TreeGrafterGO_REF:0000118

PMID:22301074   PMID:30032202  



TNP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1510,744,762 - 10,746,244 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl510,744,915 - 10,746,159 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606819,417,005 - 19,418,243 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
TNP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381611,267,857 - 11,269,325 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1611,267,748 - 11,269,533 (-)EnsemblGRCh38hg38GRCh38
GRCh371611,361,714 - 11,363,182 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361611,269,215 - 11,270,661 (-)NCBINCBI36Build 36hg18NCBI36
Build 341611,269,214 - 11,270,661NCBI
Celera1611,531,105 - 11,532,551 (-)NCBICelera
Cytogenetic Map16p13.13NCBI
HuRef1611,279,446 - 11,280,892 (-)NCBIHuRef
CHM1_11611,361,620 - 11,363,066 (-)NCBICHM1_1
T2T-CHM13v2.01611,304,079 - 11,305,547 (-)NCBIT2T-CHM13v2.0
Tnp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391610,605,799 - 10,606,519 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1610,605,800 - 10,606,524 (-)EnsemblGRCm39 Ensembl
GRCm381610,787,935 - 10,788,655 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1610,787,936 - 10,788,660 (-)EnsemblGRCm38mm10GRCm38
MGSCv371610,788,028 - 10,788,748 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361610,701,513 - 10,702,233 (-)NCBIMGSCv36mm8
Celera1611,415,373 - 11,416,093 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map165.83NCBI
Tnp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8105,386,735 - 5,387,463 (+)NCBIGRCr8
mRatBN7.2104,879,812 - 4,880,540 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl104,879,812 - 4,880,538 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx109,576,387 - 9,577,115 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0109,097,503 - 9,098,231 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0104,735,784 - 4,736,512 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0104,953,898 - 4,954,626 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl104,953,879 - 4,954,624 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0103,780,384 - 3,781,112 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4104,816,612 - 4,817,340 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1104,816,611 - 4,817,338 (+)NCBI
Celera103,901,408 - 3,902,136 (+)NCBICelera
Cytogenetic Map10q11NCBI
Tnp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554427,311,826 - 7,314,046 (+)NCBIChiLan1.0ChiLan1.0
TNP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21811,817,009 - 11,819,356 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11615,587,457 - 15,589,800 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01610,209,801 - 10,211,466 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11611,431,694 - 11,433,158 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1611,431,822 - 11,433,087 (-)Ensemblpanpan1.1panPan2
TNP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1631,498,361 - 31,498,740 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl631,426,715 - 31,499,842 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha632,881,238 - 32,881,617 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0631,680,942 - 31,682,492 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1631,494,292 - 31,494,671 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0631,368,582 - 31,368,961 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0631,792,757 - 31,794,307 (+)NCBIUU_Cfam_GSD_1.0
TNP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl331,870,068 - 31,871,702 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1331,868,517 - 31,871,530 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2332,659,663 - 32,661,176 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap3p13-centNCBI
Tnp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248248,453,667 - 8,454,987 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in TNP2
27 total Variants



ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
36 6 18 18 18 36 6



Ensembl Acc Id: ENSCSAT00000006442   ⟹   ENSCSAP00000004646
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl510,744,915 - 10,746,159 (-)Ensembl
RefSeq Acc Id: XM_037989854   ⟹   XP_037845782
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366606819,417,005 - 19,418,243 (+)NCBI
Protein RefSeqs XP_072871805 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000004646.1
Ensembl Acc Id: ENSCSAP00000004646   ⟸   ENSCSAT00000006442
RefSeq Acc Id: XP_037845782   ⟸   XM_037989854



1 to 11 of 11 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCSAG00000008391 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000006442.1 UniProtKB/TrEMBL
InterPro TP2 UniProtKB/TrEMBL
KEGG Report csab:103228304 UniProtKB/TrEMBL
NCBI Gene TNP2 ENTREZGENE
PANTHER NUCLEAR TRANSITION PROTEIN 2 UniProtKB/TrEMBL
  PTHR17488 UniProtKB/TrEMBL
Pfam TP2 UniProtKB/TrEMBL
PROSITE TP2_1 UniProtKB/TrEMBL
  TP2_2 UniProtKB/TrEMBL
UniProt A0A0D9R7Q7_CHLSB UniProtKB/TrEMBL
1 to 11 of 11 rows