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Gene: DEAF1 (DEAF1 transcription factor) Homo sapiens
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Symbol: DEAF1
Name: DEAF1 transcription factor
Description: Exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; and regulation of mammary gland epithelial cell proliferation. Localizes to the cytoplasm; fibrillar center; and nucleoplasm. Implicated in autosomal dominant non-syndromic intellectual disability 24.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: deaf-1 related transcriptional regulator (nudr); DEAF1, transcription factor; deformed epidermal autoregulatory factor 1 homolog; MRD24; nuclear DEAF-1-related transcriptional regulator; NUDR; SPN; suppressin; zinc finger MYND domain-containing protein 5; ZMYND5
Orthologs:
Mus musculus (house mouse) : Deaf1 (DEAF1, transcription factor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Deaf1 (DEAF1 transcription factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Deaf1 (DEAF1 transcription factor)
Pan paniscus (bonobo/pygmy chimpanzee) : DEAF1 (DEAF1 transcription factor)
Canis lupus familiaris (dog) : DEAF1 (DEAF1 transcription factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Deaf1 (DEAF1 transcription factor)
Sus scrofa (pig) : DEAF1 (DEAF1 transcription factor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl11644,233 - 706,715 (-)Ensembl
GRCh3811644,220 - 707,083 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711644,225 - 695,740 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611634,225 - 685,740 (-)NCBINCBI36hg18NCBI36
Build 3411634,224 - 685,740NCBI
Cytogenetic Map11p15.5NCBI
HuRef11460,942 - 512,153 (-)NCBIHuRef
CHM1_111643,446 - 694,676 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on DEAF1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731970
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.