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Gene: Degs1 (delta(4)-desaturase, sphingolipid 1) Rattus norvegicus
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Symbol: Degs1
Name: delta(4)-desaturase, sphingolipid 1
Description: Predicted to have retinol isomerase activity and sphingolipid delta-4 desaturase activity. Predicted to be involved in ceramide biosynthetic process; myelin maintenance; and positive regulation of apoptotic process. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy. Orthologous to human DEGS1 (delta 4-desaturase, sphingolipid 1); PARTICIPATES IN sphingolipid metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: degenerative spermatocyte homolog (Drosophila); degenerative spermatocyte homolog 1 (Drosophila); degenerative spermatocyte homolog 1, lipid desaturase; degenerative spermatocyte homolog 1, lipid desaturase (Drosophila); degenerative spermatocyte-like protein RDES; Degs; dihydroceramide desaturase-1; sphingolipid delta(4)-desaturase DES1
Orthologs:
Homo sapiens (human) : DEGS1 (delta 4-desaturase, sphingolipid 1)  HGNC  Alliance
Mus musculus (house mouse) : Degs1 (delta(4)-desaturase, sphingolipid 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Degs1 (delta 4-desaturase, sphingolipid 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DEGS1 (delta 4-desaturase, sphingolipid 1)
Canis lupus familiaris (dog) : DEGS1 (delta 4-desaturase, sphingolipid 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Degs1 (delta 4-desaturase, sphingolipid 1)
Sus scrofa (pig) : DEGS1 (delta 4-desaturase, sphingolipid 1)
Chlorocebus sabaeus (African green monkey) : DEGS1 (delta 4-desaturase, sphingolipid 1)
Heterocephalus glaber (naked mole-rat) : Degs1 (delta 4-desaturase, sphingolipid 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.013100,665,265 - 100,672,731 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13100,666,075 - 100,672,731 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013105,599,106 - 105,606,572 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41398,242,981 - 98,249,638 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11398,431,962 - 98,438,556 (-)NCBI
Celera1393,480,467 - 93,487,120 (-)NCBICelera
Cytogenetic Map13q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Degs1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 70917
Created: 2002-07-09
Species: Rattus norvegicus
Last Modified: 2020-06-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.