DEGS1 (delta 4-desaturase, sphingolipid 1) - Rat Genome Database
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Gene: DEGS1 (delta 4-desaturase, sphingolipid 1) Sus scrofa
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Symbol: DEGS1
Name: delta 4-desaturase, sphingolipid 1
RGD ID: 14123651
Description: ENCODES a protein that exhibits retinol isomerase activity (ortholog); sphingolipid delta-4 desaturase activity (ortholog); INVOLVED IN ceramide biosynthetic process (ortholog); positive regulation of apoptotic process (ortholog); ASSOCIATED WITH genetic disease (ortholog); Hypomyelinating Leukodystrophy 18 (ortholog); leukodystrophy (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); integral component of membrane (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: degenerative spermatocyte homolog 1, lipid desaturase; DES1; sphingolipid delta 4 desaturase; sphingolipid delta(4)-desaturase DES1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1012,557,766 - 12,569,008 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11012,529,021 - 12,568,447 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21014,976,597 - 15,053,245 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:15679890   PMID:17145712  


Genomics

Comparative Map Data
DEGS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1012,557,766 - 12,569,008 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11012,529,021 - 12,568,447 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21014,976,597 - 15,053,245 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DEGS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1224,175,756 - 224,193,441 (+)EnsemblGRCh38hg38GRCh38
GRCh381224,183,240 - 224,193,441 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371224,370,910 - 224,381,143 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh371224,370,942 - 224,381,143 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361222,437,551 - 222,447,766 (+)NCBINCBI36hg18NCBI36
Celera1197,561,861 - 197,572,073 (+)NCBI
Cytogenetic Map1q42.11NCBI
HuRef1194,891,445 - 194,901,670 (+)NCBIHuRef
CHM1_11225,643,571 - 225,653,792 (+)NCBICHM1_1
Degs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391182,103,529 - 182,110,366 (-)NCBIGRCm39mm39
GRCm381182,275,964 - 182,282,854 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1182,275,772 - 182,282,804 (-)EnsemblGRCm38mm10GRCm38
MGSCv371184,205,901 - 184,212,890 (-)NCBIGRCm37mm9NCBIm37
MGSCv361184,112,445 - 184,119,434 (-)NCBImm8
Celera1189,318,025 - 189,324,947 (-)NCBICelera
Cytogenetic Map1H5NCBI
Degs1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21393,946,154 - 93,953,677 (-)NCBI
Rnor_6.0 Ensembl13100,666,075 - 100,672,731 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.013100,665,265 - 100,672,731 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.013105,599,106 - 105,606,572 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41398,242,981 - 98,249,638 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11398,431,962 - 98,438,556 (-)NCBI
Celera1393,480,467 - 93,487,120 (-)NCBICelera
Cytogenetic Map13q26NCBI
Degs1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555201,135,563 - 1,143,192 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555201,139,568 - 1,143,149 (-)NCBIChiLan1.0ChiLan1.0
DEGS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11204,659,389 - 204,683,171 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1204,659,389 - 204,668,901 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01199,651,712 - 199,661,848 (+)NCBIMhudiblu_PPA_v0panPan3
DEGS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl740,147,505 - 40,153,085 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1740,147,293 - 40,152,190 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Degs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365261,149,984 - 1,153,632 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DEGS1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1255,589,530 - 5,603,261 (-)NCBI
ChlSab1.1 Ensembl255,589,383 - 5,603,227 (-)Ensembl
Degs1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248355,880,855 - 5,889,295 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 9 2 3 5 1 23 2 3 3
Low 1 2 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000025010   ⟹   ENSSSCP00000024516
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1012,557,766 - 12,569,008 (+)Ensembl
RefSeq Acc Id: NM_001244121   ⟹   NP_001231050
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11012,557,765 - 12,568,447 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005653768   ⟹   XP_005653825
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11012,529,021 - 12,568,447 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001231050 (Get FASTA)   NCBI Sequence Viewer  
  XP_005653825 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAV32451 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005653825   ⟸   XM_005653768
- Peptide Label: isoform X1
- UniProtKB: A0A286ZWK4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001231050   ⟸   NM_001244121
- UniProtKB: I3LKA2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000024516   ⟸   ENSSSCT00000025010
Protein Domains
Lipid_DES


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000024484 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070009117 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000024516 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070014667 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000025010 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070017687 UniProtKB/TrEMBL
InterPro DES1 UniProtKB/TrEMBL
  DES1/DES2 UniProtKB/TrEMBL
  FA_desaturase_dom UniProtKB/TrEMBL
  Sphingolipid_d4-desaturase_N UniProtKB/TrEMBL
KEGG Report ssc:100135677 UniProtKB/TrEMBL
NCBI Gene DEGS1 ENTREZGENE
PANTHER PTHR12879:SF2 UniProtKB/TrEMBL
Pfam FA_desaturase UniProtKB/TrEMBL
  Lipid_DES UniProtKB/TrEMBL
PIRSF Sphnglp_dlt4_des UniProtKB/TrEMBL
SMART Lipid_DES UniProtKB/TrEMBL
UniProt A0A286ZWK4 ENTREZGENE
  A0A4X1THG4_PIG UniProtKB/TrEMBL
  I3LKA2 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:95590 ENTREZGENE