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Gene: DEGS1 (delta 4-desaturase, sphingolipid 1) Chlorocebus sabaeus

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Symbol:

DEGS1

Name:

delta 4-desaturase, sphingolipid 1

RGD ID:

18711785

Description:

ENCODES a protein that exhibits isomerase activity (inferred); oxidoreductase activity (inferred); retinol isomerase activity (inferred); INVOLVED IN ceramide biosynthetic process (ortholog); positive regulation of apoptotic process (ortholog); ASSOCIATED WITH gastrointestinal stromal tumor (ortholog); genetic disease (ortholog); hypomyelinating leukodystrophy 18 (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

sphingolipid delta(4)-desaturase DES1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	5,589,530 - 5,603,261 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	5,589,383 - 5,603,227 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	5,771,384 - 5,781,608 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

hypomyelinating leukodystrophy 18 (ISO)

leukodystrophy (ISO)

parathyroid carcinoma (ISO)

Prostatic Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

ceramide biosynthetic process (IEA,ISO)

fatty acid biosynthetic process (IEA)

myelin maintenance (IEA)

positive regulation of apoptotic process (ISO)

sphingolipid biosynthetic process (IEA)

Cellular Component

endoplasmic reticulum (IEA)

endoplasmic reticulum membrane (IEA)

membrane (IEA)

mitochondrion (IEA)

Molecular Function

isomerase activity (IEA)

oxidoreductase activity (IEA)

protein binding (ISO)

retinol isomerase activity (IEA)

sphingolipid delta-4 desaturase activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

DEGS1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	5,589,530 - 5,603,261 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	5,589,383 - 5,603,227 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	5,771,384 - 5,781,608 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

DEGS1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	224,183,240 - 224,193,441 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	224,175,756 - 224,193,441 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	224,370,942 - 224,381,143 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	222,437,551 - 222,447,766 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	197,561,861 - 197,572,073 (+)	NCBI		Celera
Cytogenetic Map	1	q42.11	NCBI
HuRef	1	194,891,445 - 194,901,670 (+)	NCBI		HuRef
CHM1_1	1	225,643,571 - 225,653,792 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	223,372,483 - 223,382,685 (+)	NCBI		T2T-CHM13v2.0

Degs1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	182,103,529 - 182,110,366 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	182,103,337 - 182,110,369 (-)	Ensembl		GRCm39 Ensembl
GRCm38	1	182,275,964 - 182,282,854 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	182,275,772 - 182,282,804 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	184,205,901 - 184,212,890 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	184,112,445 - 184,119,434 (-)	NCBI		MGSCv36	mm8
Celera	1	189,318,025 - 189,324,947 (-)	NCBI		Celera
Cytogenetic Map	1	H5	NCBI
cM Map	1	84.93	NCBI

Degs1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	96,478,645 - 96,485,302 (-)	NCBI		GRCr8
mRatBN7.2	13	93,946,154 - 93,953,677 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	93,946,157 - 93,953,664 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	96,452,250 - 96,458,907 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	97,852,156 - 97,858,813 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	95,034,331 - 95,040,988 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	100,665,265 - 100,672,731 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	100,666,075 - 100,672,731 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	105,599,106 - 105,606,572 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	98,242,981 - 98,249,638 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	98,431,962 - 98,438,556 (-)	NCBI
Celera	13	93,480,467 - 93,487,120 (-)	NCBI		Celera
Cytogenetic Map	13	q26	NCBI

Degs1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955520	1,135,563 - 1,143,192 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955520	1,139,568 - 1,143,149 (-)	NCBI	ChiLan1.0	ChiLan1.0

DEGS1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	25,334,511 - 25,344,806 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	25,285,430 - 25,295,619 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	199,651,712 - 199,661,848 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	204,659,389 - 204,683,171 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	204,659,389 - 204,668,901 (+)	Ensembl	panpan1.1		panPan2

DEGS1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	40,147,293 - 40,152,190 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	40,147,505 - 40,153,085 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	39,629,447 - 39,639,491 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	39,982,286 - 39,992,310 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	39,980,406 - 39,992,266 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	39,822,856 - 39,832,860 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	39,830,750 - 39,840,481 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	40,099,271 - 40,109,303 (-)	NCBI		UU_Cfam_GSD_1.0

Degs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	53,593,665 - 53,597,297 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936526	1,149,984 - 1,153,632 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DEGS1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	12,557,767 - 12,568,978 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	12,529,021 - 12,568,447 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	14,976,597 - 15,053,245 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Degs1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624835	5,880,301 - 5,889,294 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624835	5,880,855 - 5,889,295 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in DEGS1
342 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007988341	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037985519	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000023	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000014280 ⟹ ENSCSAP00000012256

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	25	5,589,383 - 5,603,227 (-)	Ensembl

RefSeq Acc Id:

XM_007988341 ⟹ XP_007986532

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	25	5,589,530 - 5,603,261 (-)	NCBI
Vero_WHO_p1.0	NW_023666055	5,771,384 - 5,781,608 (-)	NCBI

Sequence:

show sequence

CTCCTCCGCGCTCCGCCGCAGTCGGCCGACACCACACGAGTCGGGAAGCCGCCGCAGCCACCTC
TGAGGAGCCGGCCAGGAGCGAGAGCCGACAGCGAGCCTGCGAGCCACCTCCGCCGCCATGGGGA
GCCGCGTGTCGCGGGAAGACTTCGAGTGGGTCTACACCGACCAGCCCCACGCCGACCGGCGCCG
GGAGATCCTGGCAAAGTATCCAGAGATAAAGTCCTTGATGAAACCTGATCCCAATTTGATATGG
ATTATAATTATGATGTTTCTCACCCAGTTGGCTGCATTTTACATAGTAAAAGACTTGGACTGGA
AATGGGTCATATTTGGGGCCTATGCGTTTGGCAGTTGCATTAACCACTCAATGACTCTGGCTAT
TCATGAGATTTCCCACAATGCTGCCTTTGGCAACTGCAAAGCAATGTGGAATCGCTGGTTTGGA
ATGTTCGCTAATCTTCCTATTGGGATTCCATATTCAATTTCCTTTAAGAGATATCACATGGATC
ATCACCGGTACCTTGGAGCTGATGGCGTCGATGTAGATATTCCCACCGATTTTGAGGGCTGGTT
CTTCTGTACCGCTTTCAGAAAGTTTATATGGGTTATTCTTCAGCCTCTCTTCTATGCCTTTCGA
CCTCTGTTCATCAACCCCAAACCAATTACTTATTTGGAAGTTATCAATATCGTGGCCCAGGTCA
CATTTGACATTTTAATTTATTACTTTTTGGGAATTAAATCCTTAGTCTACATGTTGGCAGCATC
TTTACTTGGCCTGGGTTTGCACCCGATTTCTGGACATTTTATAGCTGAGCATTACATGTTCTTA
AAGGGTCACGAAACTTACTCATATTATGGGCCTCTGAATTTATTTACCTTCAATGTAGGTTATC
ATAATGAACATCATGACTTCCCCAACATTCCTGGAAAAAGCCTTCCACTGGTGAGGAAAATAGC
AGCTGAATACTATGACAACCTCCCCCACTACAATTCCTGGATAAAAGTACTGTATGATTTTGTG
ATGGATGATACAATAAGTCCCTACTCAAGAATGAAGAGGCACCAAAAAGGAGAGATGGTGCTGG
AGTAGATATCATTAGTGCCAAAGGGATTCCTCTCCAAAACTTTAGATGATAAAGTGGAAGTTTT
GCATTATTAAACTTGAGACCAGGGATACTTAGAAGCTCCCCTGGCACAATTTCAGAGTAAGAGG
TCAGTGATATCAAGAAGTAAATCTGGCTTTTCTACAGTCAGCCTGACTCTGTACTGCTCGGCTT
CACTCACAGAAAACTTGTGACTTGTGTATTATCGTCATTGAGGATGTTTCACTCATGTCTGTCA
TTTTATAAGCATATCATTTTAAAAGCTTTTAAAAAGGTATTTTGCCAGGCATGGTGGCTCATGC
CTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACCTGAGGTCAGGAGTTCGAGACC
AGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATGCAAAAATTAGCCGGGCATGGCAG
CACATGCCTGTAATCCCAGCTACATGGGAGGCTGAGGTGGGAGAATTGCTTGAACCCAGGAGGC
GAAGGCAGAGGCTGCAGTGAGCCAAGATTGTGCCACTGCACTCCAGCCTGGGCAACAGAGCAAG
ACCCCATCTCAAAAATAAATATATAAAATAAAAAGCTATTTCTAGTTTATTTCACTATAAAGTT
TTGCTTTATTAAAAAGCTAATAAACAGCTATTAATCACAGTGTGTTAGTATTTGTTACATTTTT
GTATTTCACTATCTTTATTACATTTTTGTATTTCACTATCTTTATAATATGGTAACCAGGGTAC
TGGGGGAACTTTAAAATTTCATCTCAAAAATAATTTTTAAAAAGCCTGAGATATGATATAGCAT
AAAAGATTGGATGAAAATATATTTCACCATAAGCTGAATTGCTTGTTTAAAAATTTTAGCTATC
ATATATGGGACTCGAATTAGACACTGTTGAATCCTGTACAGCCTTACTCATAAATAAAGTACTT
ACTGAATTTCCACCGTTCAA

hide sequence

RefSeq Acc Id:

XM_037985519 ⟹ XP_037841447

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666055	5,771,394 - 5,781,566 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_007986532	(Get FASTA)	NCBI Sequence Viewer
	XP_037841447	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000012256
	ENSCSAP00000012256.1

RefSeq Acc Id:	XP_007986532 ⟸ XM_007988341
- Peptide Label:	isoform X1
- UniProtKB:	A0A0D9RUG7 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000012256 ⟸ ENSCSAT00000014280

RefSeq Acc Id:	XP_037841447 ⟸ XM_037985519
- Peptide Label:	isoform X2

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000016186	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000014280.1	UniProtKB/TrEMBL
InterPro	DES1/DES2	UniProtKB/TrEMBL
	FA_desaturase_dom	UniProtKB/TrEMBL
	Sphingolipid_d4-desaturase_N	UniProtKB/TrEMBL
KEGG Report	csab:103230017	UniProtKB/TrEMBL
NCBI Gene	DEGS1	ENTREZGENE
PANTHER	PTHR12879:SF2	UniProtKB/TrEMBL
	SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2	UniProtKB/TrEMBL
Pfam	FA_desaturase	UniProtKB/TrEMBL
	Lipid_DES	UniProtKB/TrEMBL
PIRSF	Sphnglp_dlt4_des	UniProtKB/TrEMBL
SMART	Lipid_DES	UniProtKB/TrEMBL
UniProt	A0A0D9RUG7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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