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Gene: Nkx6-1 (NK6 homeobox 1) Rattus norvegicus

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Symbol:

Nkx6-1

Name:

NK6 homeobox 1

RGD ID:

69318

Description:

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including positive regulation of insulin secretion; type B pancreatic cell development; and type B pancreatic cell proliferation. Predicted to be active in nucleus. Orthologous to human NKX6-1 (NK6 homeobox 1); PARTICIPATES IN maturity-onset diabetes of the young pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

homeobox protein NK-6 homolog A; homeobox protein Nkx-6.1; NK homeobox (Drosophila), family 6, A; NK homeobox, family 6, A; NK6 transcription factor homolog A; NK6 transcription factor homolog A (Drosophila); NK6 transcription factor related locus 1; NK6 transcription factor related locus 1 (Drosophila); NK6 transcription factor related, locus 1; NK6 transcription factor related, locus 1 (Drosophila); Nkx6.1; Nkx61; Nkx6a

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NKX6-1 (NK6 homeobox 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Nkx6-1 (NK6 homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Nkx6-1 (NK6 homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NKX6-1 (NK6 homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NKX6-1 (NK6 homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Nkx6-1 (NK6 homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NKX6-1 (NK6 homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NKX6-1 (NK6 homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Nkx6-1 (NK6 homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	NKX6-2 (NK6 homeobox 2)	HGNC	OrthoDB
Alliance orthologs ³
Mus musculus (house mouse):	Nkx6-1 (NK6 homeobox 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	NKX6-1 (NK6 homeobox 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	nkx6.1 (NK6 homeobox 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cog-1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	nkx6-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	8,274,238 - 8,281,171 (+)	NCBI		GRCr8
mRatBN7.2	14	7,969,756 - 7,976,689 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	7,969,756 - 7,976,681 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	7,937,406 - 7,944,335 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	9,237,642 - 9,244,571 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	7,933,803 - 7,940,732 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	9,555,264 - 9,562,197 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	9,555,264 - 9,562,189 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	9,516,942 - 9,523,875 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	9,214,743 - 9,221,676 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	9,214,742 - 9,221,668 (+)	NCBI
Celera	14	8,087,941 - 8,094,874 (+)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

chromosome 4q21 deletion syndrome (ISO)

Experimental Diabetes Mellitus (ISO)

Spinal Cord Injuries (IMP)

type 2 diabetes mellitus (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

3,3',4,4',5-pentachlorobiphenyl (ISO)

4,4'-sulfonyldiphenol (ISO)

4-phenylbutyric acid (ISO)

6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide (EXP)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

ammonium chloride (EXP)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bisphenol A (ISO)

bisphenol F (ISO)

chlordecone (ISO)

choline (ISO)

cisplatin (ISO)

Cuprizon (EXP)

D-glucose (ISO)

dexamethasone (EXP)

folic acid (ISO)

FR900359 (ISO)

gentamycin (EXP)

glucose (ISO)

kojic acid (ISO)

L-methionine (ISO)

methylmercury chloride (EXP)

paracetamol (EXP)

phlorizin (ISO)

resveratrol (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

triptonide (ISO)

valproic acid (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell differentiation (IBA)

cellular response to cytokine stimulus (IEP)

cellular response to peptide hormone stimulus (IEP)

central nervous system neuron differentiation (ISO)

endocrine pancreas development (ISO)

negative regulation of oligodendrocyte differentiation (ISO)

negative regulation of transcription by RNA polymerase II (IDA)

neurogenesis (IMP)

neuron differentiation (ISO)

oligodendrocyte differentiation (ISO)

pancreatic A cell differentiation (ISO)

positive regulation of insulin secretion (IMP)

positive regulation of neuron differentiation (ISO)

positive regulation of oligodendrocyte differentiation (ISO)

regulation of axon extension (ISO)

regulation of neuron migration (ISO)

regulation of transcription by RNA polymerase II (IBA,ISO)

response to nicotine (IEP)

response to xenobiotic stimulus (IEP)

smoothened signaling pathway (ISO)

transcription by RNA polymerase II (IMP)

type B pancreatic cell development (IEP)

type B pancreatic cell differentiation (ISO)

type B pancreatic cell proliferation (IDA)

Cellular Component

nucleus (IBA,ISO)

Molecular Function

chromatin binding (IDA)

DNA-binding transcription factor activity (IDA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

DNA-binding transcription repressor activity, RNA polymerase II-specific (IDA)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,IDA)

sequence-specific DNA binding (IDA)

Molecular Pathway Annotations Click to see Annotation Detail View

maturity-onset diabetes of the young pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Role of the mitogen-activated protein kinases in cytokine-mediated inhibition of insulin gene expression.	Chin-Chance CV, etal., J Investig Med. 2006 Apr;54(3):132-42.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Expression of pancreatic endocrine markers by prolactin-treated rat bone marrow mesenchymal stem cells.	Gonzalez P, etal., Transplant Proc. 2010 Mar;42(2):566-9.
5.	Cloning and DNA-binding properties of the rat pancreatic beta-cell-specific factor Nkx6.1.	Jorgensen MC, etal., FEBS Lett 1999 Nov 19;461(3):287-94.
6.	Effects of diazoxide on gene expression in rat pancreatic islets are largely linked to elevated glucose and potentially serve to enhance beta-cell sensitivity.	Ma Z, etal., Diabetes. 2007 Apr;56(4):1095-106. Epub 2007 Jan 17.
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	Peroxisome proliferator-activated receptor-gamma regulates expression of PDX-1 and NKX6.1 in INS-1 cells.	Moibi JA, etal., Diabetes. 2007 Jan;56(1):88-95.
9.	Rat endocrine pancreatic development in relation to two homeobox gene products (Pdx-1 and Nkx 6.1).	Oster A, etal., J Histochem Cytochem. 1998 Jun;46(6):707-15.
10.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
11.	GOA pipeline	RGD automated data pipeline
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1.	Schisler JC, etal., Mol Cell Biol. 2008 May;28(10):3465-76. Epub 2008 Mar 17.
14.	The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells.	Schisler JC, etal., Proc Natl Acad Sci U S A. 2005 May 17;102(20):7297-302. Epub 2005 May 9.
15.	Prenatal nicotine exposure alters early pancreatic islet and adipose tissue development with consequences on the control of body weight and glucose metabolism later in life.	Somm E, etal., Endocrinology. 2008 Dec;149(12):6289-99. Epub 2008 Aug 7.
16.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
17.	Nkx6.1 regulates islet beta-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors.	Tessem JS, etal., Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5242-7. doi: 10.1073/pnas.1320953111. Epub 2014 Mar 24.

Additional References at PubMed

PMID:10830170	PMID:11567614	PMID:14573534	PMID:15605246	PMID:15629701	PMID:15629702	PMID:15944193	PMID:16306355	PMID:17928203	PMID:18076286	PMID:18590716	PMID:19056867
PMID:19592574	PMID:20081190	PMID:24365150	PMID:25285789	PMID:26030060	PMID:27164028	PMID:29142323	PMID:36639413

Genomics

Comparative Map Data

Nkx6-1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	8,274,238 - 8,281,171 (+)	NCBI		GRCr8
mRatBN7.2	14	7,969,756 - 7,976,689 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	7,969,756 - 7,976,681 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	7,937,406 - 7,944,335 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	9,237,642 - 9,244,571 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	7,933,803 - 7,940,732 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	9,555,264 - 9,562,197 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	9,555,264 - 9,562,189 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	9,516,942 - 9,523,875 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	9,214,743 - 9,221,676 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	9,214,742 - 9,221,668 (+)	NCBI
Celera	14	8,087,941 - 8,094,874 (+)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

NKX6-1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	84,491,985 - 84,499,292 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	84,491,985 - 84,499,292 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	85,413,138 - 85,420,445 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	85,633,460 - 85,638,411 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	85,771,614 - 85,776,566	NCBI
Celera	4	82,704,620 - 82,709,571 (-)	NCBI		Celera
Cytogenetic Map	4	q21.23	NCBI
HuRef	4	81,156,194 - 81,161,143 (-)	NCBI		HuRef
CHM1_1	4	85,391,105 - 85,396,056 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	87,821,981 - 87,829,288 (-)	NCBI		T2T-CHM13v2.0

Nkx6-1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	101,807,050 - 101,812,577 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	101,806,005 - 101,812,862 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	101,659,184 - 101,664,711 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	101,658,139 - 101,664,996 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	102,088,203 - 102,093,730 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	101,899,486 - 101,905,013 (-)	NCBI		MGSCv36	mm8
Celera	5	98,983,622 - 98,988,403 (-)	NCBI		Celera
Cytogenetic Map	5	E4- E5	NCBI
cM Map	5	48.84	NCBI

Nkx6-1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955474	5,211,281 - 5,214,785 (+)	NCBI	ChiLan1.0	ChiLan1.0

NKX6-1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	45,550,491 - 45,556,815 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	45,739,898 - 45,746,216 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	39,683,420 - 39,689,651 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	45,534,145 - 45,538,784 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

NKX6-1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	32	8,256,513 - 8,263,238 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	32	8,256,254 - 8,262,004 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	32	33,622,505 - 33,627,982 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	32	8,275,814 - 8,281,289 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	32	8,275,544 - 8,281,289 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	32	8,357,520 - 8,362,989 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	32	8,219,935 - 8,225,407 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	32	31,736,036 - 31,741,514 (+)	NCBI		UU_Cfam_GSD_1.0

Nkx6-1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	4,155,070 - 4,162,340 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936738	317,907 - 324,235 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936738	318,020 - 322,869 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NKX6-1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	134,138,097 - 134,144,254 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	134,137,064 - 134,143,524 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	143,799,026 - 143,801,555 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NKX6-1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	32,846,436 - 32,851,526 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	32,846,528 - 32,851,447 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	11,472,384 - 11,478,823 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nkx6-1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624900	1,618,563 - 1,623,793 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624900	1,618,019 - 1,623,975 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	119
Count of miRNA genes:	102
Interacting mature miRNAs:	109
Transcripts:	ENSRNOT00000002928
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300114	Srn2	Serum renin concentration QTL 2	3.27		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	14	3957878	21572472	Rat
70195	Mcs8	Mammary carcinoma susceptibility QTL 8	4.28		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	14	3957878	24886169	Rat
2293089	Iddm31	Insulin dependent diabetes mellitus QTL 31	4.7		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	14	3957878	18558812	Rat
7411573	Bw139	Body weight QTL 139	4.7	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	14	1	40068101	Rat
9589814	Gluco67	Glucose level QTL 67	4.54	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	1	40068101	Rat
724541	Niddm53	Non-insulin dependent diabetes mellitus QTL 53		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	3957878	9393298	Rat
1331740	Bw26	Body weight QTL 26	3.028		body mass (VT:0001259)	body weight (CMO:0000012)	14	3957878	31121464	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	41415516	Rat
71115	Niddm15	Non-insulin dependent diabetes mellitus QTL 15	4.8		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	1	11334906	Rat
71117	Niddm17	Non-insulin dependent diabetes mellitus QTL 17	2.35		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	1	17877928	Rat
70204	Niddm20	Non-insulin dependent diabetes mellitus QTL 20	5.1	0.000008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	1	31893212	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
3	9	96	20	26	9	5	9	4	77	20	86	45	49	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031737	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF004431	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474022	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000002928 ⟹ ENSRNOP00000002928

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	7,969,756 - 7,976,681 (+)	Ensembl
Rnor_6.0 Ensembl	14	9,555,264 - 9,562,189 (+)	Ensembl

RefSeq Acc Id:

NM_031737 ⟹ NP_113925

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	8,274,238 - 8,281,171 (+)	NCBI
mRatBN7.2	14	7,969,756 - 7,976,689 (+)	NCBI
Rnor_6.0	14	9,555,264 - 9,562,197 (+)	NCBI
Rnor_5.0	14	9,516,942 - 9,523,875 (+)	NCBI
RGSC_v3.4	14	9,214,743 - 9,221,676 (+)	RGD
Celera	14	8,087,941 - 8,094,874 (+)	RGD

Sequence:

show sequence

CCGGCTTGCACAAGCGGACGGACGATCGGAACCGGCCCGTCAGACTTTTCCCACTTAGGTTTAT
TTTCTCTTTCTTCCTTTTTCGGTCCCGCTACTCCGGCGCCGCGTGGCCCGGAGGGAAGCAGGCG
CGTGGGCGGCAAGTGCCCAGCCGCCGGAGCGGTGCCGCCACTGCCCTTTCTGGCGCAGTAACGC
CGGTCCCACGGCGGTACGGGCGCGATCTCCGCGAGAGCCGTTTGCGCTCCATCCCCTGGGCGAG
CGGCGAGTGCGACTCAGCTGCGCGGCCGCCGGGAGCGCGGAGTACCGAAGCGAGAACAGAGGCG
CGCACCGGGCGGAACCGGGCCCGCTTTGAAGCTCCCCTAGGCGGGCGAGCCGGCCCCACCTCTT
ACATCAAAGCGATCGCTCCGCGCCTCCCAACCTTGTTGAAACTCTCTGGGCCAGCCCGGGTACG
TCTTCCTGATTTCCCGCGGGGGTGGAGAGATGAGAAGCCGAGCTCTCTGAGTCGGGAGCGAGGG
ACCAGCGCCCGGGATCGAATCCCGGACTCCCGGAGTCGAGAAAGCGCCAAGCGGNCCCGCGCCC
CTGCCGCCCTCGCCCGCCGCCGCCTCCCGCGGGGCATTTGGACATTTTCTGCTGCGCAGCTCGC
ACCCCAGCTCTCGGAGCCCGCCGCAGAGTCACACTTCGCTTGCGCGCGAGCGCTTCCCCAGCGC
CTCCGGCTCTCCTGCGCCTCGGGCTCTCCTGAGCCCCGGCGGGCCACCGGCCTGCTTGGCTGCG
GGTTCGGGTCTGGCTGTGGGATGTTAGCTGTGGGGGCGATGGAGGGCCCCCGGCAGAGCGCGTT
CCTGCTCAGCAGCCCGCCCTTGGCCGCCCTGCACAGCATGGCCGAGATGAAGACCCCGCTCTAC
CCTGCCGCCTATCCCCCGCTGCCCACCGGGCCCCCCTCCTCCTCGTCCTCGTCCTCCTCGTCCT
CGTCGCCCTCCCCACCTTTGGGCGCACACAACCCGGGCGGTTTGAAGCCCCCGGCCGCGGGGGG
CCTCTCGTCCCTGGGCAGCCCCCCGCAGCAGCTTTCGGCGGCCACTCCGCACGGCATCAACGAC
ATCCTGAGCCGGCCCTCCATGCCGGTGGCCTCGGGGGCCGCCCTGCCCTCCGCCTCGCCCTCGG
GGTCTTCTTCCTCCTCCTCCTCGTCCGCCTCCGCCACCTCGGCCTCTGCGGCCGCCGCTGCTGC
TGCCGCTGCCGCCGCCGCTGCCGCCTCATCGCCCGCCGGGCTGTTGGCCGGCCTGCCCCGCTTC
AGCAGCCTGAGCCCTCCGCCACCGCCGCCCGGGCTCTACTTTAGCCCCAGCGCCGCGGCCGTGG
CCGCCGTGGGCCGGTACCCCAAGCCCCTGGCCGAGCTGCCCGGTCGGACGCCCATCTTCTGGCC
TGGGGTGATGCAGAGCCCGCCTTGGAGGGACGCGCGCCTTGCCTGTACCCCCCATCAAGGATCC
ATTTTGTTGGACAAAGATGGGAAGAGAAAACACACCAGACCCACATTCTCCGGCCAGCAGATCT
TCGCCCTGGAGAAGACTTTCGAACAAACGAAGTACTTGGCAGGACCAGAGAGAGCACGCTTGGC
CTATTCTCTGGGGATGACGGAGAGTCAGGTCAAGGTCTGGTTCCAGAATCGGCGGACCAAGTGG
AGAAAGAAGCACGCAGCCGAGATGGCCACCGCCAAGAAGAAGCAGGACTCGGAGACTGAGCGGC
TCAAGGGGACTTCGGAGAACGAGGAGGACGACGACGATTACAACAAGCCCCTGGACCCGAACTC
TGACGACGAGAAAATCACTCAGCTGCTGAAAAAGCACAAATCCAGCGGAGGCAGCCTCCTGCTG
CACGCGTCGGAGGCCGAGGGCTCGTCCTGAGCGCGGCCCGCACCGCGGGGATCCCGACCGCGCC
CCACAGCCGGTCCCGCGGTCCCCCCCCGCACCCCGGCTGCTCGCCCGGCTTTACTATTTTCTAA
GATGTACATATCTATTTTTTTAACCTAGAAATTTTGGCGGGGAGGGTGGGGGTCGTCGGTAGGA
CGGCGCGGTGATGGCGAGGAAAGGAGCCCGCCAAGTGCACTGCTCAAAAAACCCCGCAGCCGAA
CCCGCATCCCCGCGGCTTCCCAGGACCCTTCCCACCCGCGACGTCAGGCGTCCCCGGTCCAGGC
TCGGTCCTTTGCTTTGCGTTCCCTGAGCACCGGGCCGTGTTTCCGAAAGGTCGTCGGCCACCGC
CTGGTGGGAATCTCAGAGCCACCGAGGGCAGCTGCCACCAAGGGAGAAAGGGACGCTACCCCTC
CCCCCAACTGCTCTGCCGACCAAGTAACCTGTTGACGGCTCTCTATGTAAATAAATCGTGAGTC
ACACTGACTAGAAGTTACTTTATTGTGAATATTTAAAATGTAAAAGGCTTTTTGGAATTTGGTA
TAAAGAGATGAACTGTACTCTCGTTGATTTAAGGTATTCACACCACTTGGCCGCCTTTCATATT
AACTTGAAAAGCTTAGAAAAACGACGTCATCGCCCTACTCAGACGCCTCCCGACTCACTCCTCT
TTCGGCTCTGCTTCTTTCCTAACCGCTTTTCTCCTTCACCAATTCCTGCAGGGCCCCAGGCAGC
CCCAGGCCCCCACCCCGGTCCAGCTCCAAGACTTGCAGTCTGAGATCCCGGGACCCACGAGCTT
CTCACACCAGCCTTTGGGTTCCCTTCCGAATTTGCACAGTCGTTTGTTGCTATTTATTAGTGAT
TAAAAAAAGATATCGGGGAGGAAAGGACTACAGTACCTTGTATTTAATTTAACTCCTTTCTGAT
AAAAATGCGTGTTAAAAGTAGATGGTGGGAATTGTTACAAGCGCTCTGGTCAGAACATAAACGT
TCCATTTAATTGCTGTAATTGAATTCGAAGTGTTTTGTATCATAAGAATACTATAGACTATGTA
AATTGTTTTCTTTTAAGCTAATAACGGTGATATATCAGCCTCTTTAACACTTATTAATTTATAT
GAGGAATTCGGTTTGTAAAGAAAAGGCAGCCCCTTTGCGAGAACCATGAAATGTAATGCACTTT
CTGTTTCAAAGGATAAATCGAATTAAAAACAGCAACAAAAAATAGTTTGAAGACGTCTGTTGCC
TTAAGGGAACATGTACAGGTTACCTGGCCTCATCAGAGATCTCAAATAAAGTCAAGAGCACATT
TAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_113925	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB61665	(Get FASTA)	NCBI Sequence Viewer
	EDL99539	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000002928.2
	ENSRNOP00055034882
	ENSRNOP00060013387
	ENSRNOP00065014805
GenBank Protein	O35762	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_113925 ⟸ NM_031737

- UniProtKB:

O35762 (UniProtKB/Swiss-Prot), A6K5W9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLAVGAMEGPRQSAFLLSSPPLAALHSMAEMKTPLYPAAYPPLPTGPPSSSSSSSSSSSPSPPL
GAHNPGGLKPPAAGGLSSLGSPPQQLSAATPHGINDILSRPSMPVASGAALPSASPSGSSSSSS
SSASATSASAAAAAAAAAAAAAASSPAGLLAGLPRFSSLSPPPPPPGLYFSPSAAAVAAVGRYP
KPLAELPGRTPIFWPGVMQSPPWRDARLACTPHQGSILLDKDGKRKHTRPTFSGQQIFALEKTF
EQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMATAKKKQDSETERLKGTSEN
EEDDDDYNKPLDPNSDDEKITQLLKKHKSSGGSLLLHASEAEGSS

hide sequence

Ensembl Acc Id:

ENSRNOP00000002928 ⟸ ENSRNOT00000002928

Protein Domains

Homeobox

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O35762-F1-model_v2	AlphaFold	O35762	1-365	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699186

Promoter ID:

EPDNEW_R9711

Type:

single initiation site

Name:

Nkx6-1_1

Description:

NK6 homeobox 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	14	9,555,220 - 9,555,280	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:69318	AgrOrtholog
BioCyc Gene	G2FUF-16435	BioCyc
Ensembl Genes	ENSRNOG00000002149	Ensembl, UniProtKB/Swiss-Prot
	ENSRNOG00055024791	UniProtKB/Swiss-Prot
	ENSRNOG00060010212	UniProtKB/Swiss-Prot
	ENSRNOG00065011922	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000002928.4	UniProtKB/Swiss-Prot
	ENSRNOT00055042722	UniProtKB/Swiss-Prot
	ENSRNOT00060017235	UniProtKB/Swiss-Prot
	ENSRNOT00065019362	UniProtKB/Swiss-Prot
Gene3D-CATH	Homeodomain-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Homeobox-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Homeobox_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Homeobox_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Homeobox_metazoa	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Homeobox_NK-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HTH_motif	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:65193	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	65193	ENTREZGENE
PANTHER	HOMEOBOX PROTEIN NKX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HOMEOBOX PROTEIN NKX-6.1	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
Pfam	Homeodomain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Nkx6-1	PhenoGen
PRINTS	HOMEOBOX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HTHREPRESSR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	HOMEOBOX_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HOMEOBOX_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000002149	RatGTEx
	ENSRNOG00055024791	RatGTEx
	ENSRNOG00060010212	RatGTEx
	ENSRNOG00065011922	RatGTEx
SMART	HOX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Homeodomain-like	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR	TC221725
UniProt	A6K5W9	ENTREZGENE, UniProtKB/TrEMBL
	NKX61_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-09-26	Nkx6-1	NK6 homeobox 1	Nkx6-1	NK6 transcription factor related, locus 1 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Nkx6-1	NK6 transcription factor related, locus 1 (Drosophila)	Nkx6a	NK homeobox (Drosophila), family 6, A	Symbol and Name updated	1299863	APPROVED
2002-06-10	Nkx6a	NK homeobox (Drosophila), family 6, A			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_process	induces expression of the endogenous insulin gene in a subset of the alpha-cell-like MSL-G-AN cells	68818

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)