RGD Reference Report - Rat endocrine pancreatic development in relation to two homeobox gene products (Pdx-1 and Nkx 6.1). - Rat Genome Database

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Rat endocrine pancreatic development in relation to two homeobox gene products (Pdx-1 and Nkx 6.1).

Authors: Oster, A  Jensen, J  Serup, P  Galante, P  Madsen, OD  Larsson, LI 
Citation: Oster A, etal., J Histochem Cytochem. 1998 Jun;46(6):707-15.
RGD ID: 2326025
Pubmed: PMID:9603781   (View Abstract at PubMed)

We studied the distribution of the homeodomain proteins Pdx-1 and Nkx 6.1 in the developing rat pancreas. During early development, nuclear staining for both Pdx-1 and Nkx 6.1 occurred in most epithelial cells of the pancreatic anlage. Subsequently, Nkx 6.1 became more beta-cell-restricted, and Pdx-1 also occurred in other islet cell types and in the duodenal epithelium. During early pancreatic development, cells co-storing insulin and glucagon were regularly detected. The vast majority of these did not possess nuclear staining for either Pdx-1 or Nkx 6.1. Subsequently, cells storing insulin only appeared. Such cells displayed strongly Pdx-1- and Nkx 6.1-positive nuclei. Therefore, Nkx 6.1, like Pdx-1, may be an important factor in pancreatic development and in mature insulin cell function.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Nkx6-1Rattype B pancreatic cell development  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Nkx6-1  (NK6 homeobox 1)


Additional Information