Fah (fumarylacetoacetate hydrolase) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Fah (fumarylacetoacetate hydrolase) Mus musculus
Analyze
Symbol: Fah
Name: fumarylacetoacetate hydrolase
RGD ID: 62225
MGI Page MGI
Description: Enables fumarylacetoacetase activity. Acts upstream of or within arginine catabolic process. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and skeleton. Used to study tyrosinemia type I. Human ortholog(s) of this gene implicated in tyrosinemia type I. Orthologous to human FAH (fumarylacetoacetate hydrolase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: beta-diketonase; FAA; fumarylacetoacetase; sw; swst
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39784,234,367 - 84,255,150 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl784,234,367 - 84,255,930 (-)EnsemblGRCm39 Ensembl
GRCm38784,585,159 - 84,605,942 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl784,585,159 - 84,606,722 (-)EnsemblGRCm38mm10GRCm38
MGSCv37791,733,669 - 91,754,452 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36784,461,355 - 84,481,937 (-)NCBIMGSCv36mm8
Celera781,987,620 - 82,008,470 (-)NCBICelera
Cytogenetic Map7D3NCBI
cM Map748.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (ISO)
2-methoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
amphetamine  (EXP)
arotinoid acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
benzoates  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromobenzene  (ISO)
Butylbenzyl phthalate  (EXP)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
CGP 52608  (ISO)
CHIR 99021  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (ISO)
cortisol  (ISO)
coumestrol  (ISO)
Cuprizon  (ISO)
cyclosporin A  (EXP,ISO)
cyproconazole  (EXP)
DDE  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl maleate  (ISO)
diethyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dorsomorphin  (ISO)
endosulfan  (ISO)
epoxiconazole  (EXP)
ethylisopropylamiloride  (ISO)
fenofibrate  (ISO)
fenthion  (EXP)
flutamide  (ISO)
folic acid  (EXP)
fumonisin B1  (EXP)
furan  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead diacetate  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methidathion  (EXP)
methimazole  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-nitrosodimethylamine  (ISO)
nicotine  (ISO)
nitrofen  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (EXP,ISO)
propiconazole  (EXP)
pyrogallol  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sulfadimethoxine  (ISO)
tauroursodeoxycholic acid  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetrahydropalmatine  (ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
triadimefon  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vorinostat  (ISO)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal amino acid level  (IAGP)
abnormal blood vessel morphology  (IEA)
abnormal circulating amino acid level  (IAGP)
abnormal circulating aspartate transaminase level  (IAGP)
abnormal hepatocyte mitochondrial morphology  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal hepatocyte physiology  (IAGP)
abnormal kidney morphology  (IEA)
abnormal liver lobule morphology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal liver physiology  (IAGP)
abnormal liver regeneration  (IAGP)
abnormal placenta morphology  (IEA)
abnormal placenta vasculature  (IEA)
abnormal retina blood vessel morphology  (IEA)
abnormal retina vasculature morphology  (IEA)
abnormal skin morphology  (IEA)
abnormal sleep pattern  (IEA)
abnormal spleen morphology  (IEA)
abnormal testis morphology  (IEA)
abnormal urine homeostasis  (IAGP)
abnormal vitreous body morphology  (IEA)
aminoaciduria  (IAGP)
cataract  (IEA)
decreased hepatocyte apoptosis  (IAGP)
decreased hepatocyte proliferation  (IAGP)
dilated proximal convoluted tubule  (IAGP)
dilated renal tubule  (IAGP)
edema  (IEA)
embryonic growth retardation  (IEA)
enlarged kidney  (IAGP)
enlarged spleen  (IEA)
enlarged testis  (IEA)
hypoglycemia  (IAGP)
impaired liver regeneration  (IAGP)
increased alpha-fetoprotein level  (IAGP)
increased circulating aspartate transaminase level  (IAGP)
increased circulating bilirubin level  (IAGP)
increased circulating creatinine level  (IAGP)
increased circulating tyrosine level  (IAGP)
increased hepatocellular carcinoma incidence  (IAGP)
increased hepatocyte apoptosis  (IAGP)
increased hepatocyte proliferation  (IAGP)
increased hepatoma incidence  (IAGP)
increased liver adenoma incidence  (IAGP)
increased liver tumor incidence  (IAGP)
increased pancreatic alpha cell number  (IAGP)
increased renal carcinoma incidence  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
increased susceptibility to injury  (IAGP)
increased susceptibility to xenobiotic induced morbidity/mortality  (IAGP)
jaundice  (IAGP)
kidney cyst  (IAGP)
kidney degeneration  (IAGP)
kidney inflammation  (IAGP)
liver failure  (IAGP)
liver inflammation  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
pale kidney  (IAGP)
pale liver  (IAGP)
pancreas hyperplasia  (IAGP)
persistence of hyaloid vascular system  (IEA)
postnatal lethality, complete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
small kidney  (IEA)
small liver  (IEA)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Point mutations in the murine fumarylacetoacetate hydrolase gene: Animal models for the human genetic disorder hereditary tyrosinemia type 1. Aponte JL, etal., Proc Natl Acad Sci U S A 2001 Jan 16;98(2):641-5.
2. Silent Tyrosinemia Type I Without Elevated Tyrosine or Succinylacetone Associated with Liver Cirrhosis and Hepatocellular Carcinoma. Blackburn PR, etal., Hum Mutat. 2016 Oct;37(10):1097-105. doi: 10.1002/humu.23047. Epub 2016 Aug 8.
3. Dendrimer-Based Lipid Nanoparticles Deliver Therapeutic FAH mRNA to Normalize Liver Function and Extend Survival in a Mouse Model of Hepatorenal Tyrosinemia Type I. Cheng Q, etal., Adv Mater. 2018 Dec;30(52):e1805308. doi: 10.1002/adma.201805308. Epub 2018 Oct 25.
4. Complete rescue of lethal albino c14CoS mice by null mutation of 4-hydroxyphenylpyruvate dioxygenase and induction of apoptosis of hepatocytes in these mice by in vivo retrieval of the tyrosine catabolic pathway. Endo F, etal., J Biol Chem 1997 Sep 26;272(39):24426-32.
5. Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type I. Grompe M, etal., Nat Genet 1995 Aug;10(4):453-60.
6. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. MGD IEA MGD IEA
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. Mouse MP Annotation Import Pipeline RGD automated import pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Cas9-nickase-mediated genome editing corrects hereditary tyrosinemia in rats. Shao Y, etal., J Biol Chem. 2018 May 4;293(18):6883-6892. doi: 10.1074/jbc.RA117.000347. Epub 2018 Mar 5.
16. Identification of hypertension-related genes through an integrated genomic-transcriptomic approach. Yagil C, etal., Circ Res. 2005 Apr 1;96(6):617-25. Epub 2005 Feb 24.
17. Efficient liver repopulation of transplanted hepatocyte prevents cirrhosis in a rat model of hereditary tyrosinemia type I. Zhang L, etal., Sci Rep. 2016 Aug 11;6:31460. doi: 10.1038/srep31460.
Additional References at PubMed
PMID:1297646   PMID:1520318   PMID:1524868   PMID:1644288   PMID:1741389   PMID:2344618   PMID:2697636   PMID:7670492   PMID:7767008   PMID:8253377   PMID:8253378   PMID:8589717  
PMID:8889548   PMID:9095403   PMID:9101289   PMID:9168903   PMID:9722945   PMID:10224267   PMID:10349636   PMID:10508789   PMID:10518553   PMID:10665936   PMID:10922068   PMID:11042159  
PMID:11062533   PMID:11076861   PMID:11154690   PMID:11159194   PMID:11172053   PMID:11217851   PMID:11247670   PMID:11489931   PMID:11825062   PMID:12466851   PMID:12477932   PMID:12899938  
PMID:14610273   PMID:14681479   PMID:14767996   PMID:15327392   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16180137   PMID:16317004   PMID:16573641   PMID:16581029  
PMID:16602821   PMID:16899383   PMID:17064256   PMID:17664939   PMID:18023223   PMID:18435462   PMID:18598944   PMID:18617288   PMID:18837044   PMID:19229314   PMID:19234449   PMID:20059953  
PMID:20162619   PMID:20546455   PMID:20861837   PMID:21267068   PMID:21374658   PMID:21632826   PMID:21873635   PMID:21917493   PMID:22209984   PMID:22496890   PMID:22863619   PMID:22996664  
PMID:23354049   PMID:23444141   PMID:23526443   PMID:23582328   PMID:24223822   PMID:24681508   PMID:25191899   PMID:25312494   PMID:26276631   PMID:26360553   PMID:27158907   PMID:27478039  
PMID:27535619   PMID:27572891   PMID:28006671   PMID:28961327   PMID:28993411   PMID:29091290   PMID:29348399   PMID:29527263   PMID:29719266   PMID:29760381   PMID:29787760   PMID:30500539  
PMID:30928253   PMID:30975706   PMID:30976745   PMID:31097476   PMID:31609965   PMID:31611405   PMID:31740768   PMID:31866222   PMID:31887661   PMID:31915293   PMID:32244944   PMID:32332735  
PMID:33484913   PMID:33510149   PMID:33670179   PMID:34557483   PMID:34725353   PMID:35090595   PMID:35145162   PMID:35259493   PMID:35361222   PMID:35418601   PMID:36450762   PMID:36720957  
PMID:37025950   PMID:37043562   PMID:38355793   PMID:38490194   PMID:38750036  


Genomics

Comparative Map Data
Fah
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39784,234,367 - 84,255,150 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl784,234,367 - 84,255,930 (-)EnsemblGRCm39 Ensembl
GRCm38784,585,159 - 84,605,942 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl784,585,159 - 84,606,722 (-)EnsemblGRCm38mm10GRCm38
MGSCv37791,733,669 - 91,754,452 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36784,461,355 - 84,481,937 (-)NCBIMGSCv36mm8
Celera781,987,620 - 82,008,470 (-)NCBICelera
Cytogenetic Map7D3NCBI
cM Map748.36NCBI
FAH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381580,152,789 - 80,186,949 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1580,152,490 - 80,186,946 (+)EnsemblGRCh38hg38GRCh38
GRCh371580,445,131 - 80,479,291 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361578,232,396 - 78,265,737 (+)NCBINCBI36Build 36hg18NCBI36
Build 341578,232,395 - 78,265,737NCBI
Celera1557,382,789 - 57,416,130 (+)NCBICelera
Cytogenetic Map15q25.1NCBI
HuRef1557,208,400 - 57,236,922 (+)NCBIHuRef
CHM1_11580,563,191 - 80,596,880 (+)NCBICHM1_1
T2T-CHM13v2.01578,016,209 - 78,050,378 (+)NCBIT2T-CHM13v2.0
Fah
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81147,957,931 - 147,980,708 (-)NCBIGRCr8
mRatBN7.21138,548,830 - 138,571,599 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1138,548,834 - 138,571,505 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1146,501,260 - 146,524,074 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01153,670,263 - 153,693,077 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01146,545,471 - 146,568,281 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01146,713,663 - 146,736,339 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1146,713,676 - 146,736,261 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01147,640,316 - 147,662,920 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41140,851,975 - 140,876,187 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11140,930,382 - 140,954,593 (-)NCBI
Celera1130,566,888 - 130,589,532 (-)NCBICelera
Cytogenetic Map1q31NCBI
Fah
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955533904,295 - 921,730 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955533904,294 - 921,730 (+)NCBIChiLan1.0ChiLan1.0
FAH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21669,406,972 - 69,440,591 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11573,571,710 - 73,605,514 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01559,121,657 - 59,155,229 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11578,081,523 - 78,115,169 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1578,048,571 - 78,115,098 (+)Ensemblpanpan1.1panPan2
FAH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1357,300,422 - 57,326,546 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl357,300,441 - 57,326,486 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha359,958,877 - 59,985,019 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0357,726,930 - 57,753,060 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl357,702,957 - 57,753,270 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1357,232,805 - 57,258,945 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0357,439,515 - 57,465,634 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0357,786,369 - 57,812,502 (-)NCBIUU_Cfam_GSD_1.0
Fah
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640120,292,223 - 120,326,410 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647138,140,273 - 38,174,702 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647138,140,324 - 38,174,472 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl749,047,902 - 49,087,783 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1749,047,833 - 49,087,790 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2754,556,153 - 54,596,338 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FAH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1263,223,327 - 3,259,367 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl263,223,079 - 3,258,657 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048138,616,632 - 138,652,526 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fah
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249411,039,429 - 1,056,568 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249411,039,389 - 1,056,568 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fah
1331 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:553
Count of miRNA genes:387
Interacting mature miRNAs:437
Transcripts:ENSMUST00000032865, ENSMUST00000128460, ENSMUST00000134390, ENSMUST00000153126
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
27226781Tibl3_mtibia length 3, 5 week (mouse)774849748122199223Mouse
25314305Vmm6_mvariable multisystem mineralization 6, eye (mouse)761849748102749207Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
26884381Bzwq2_mbi-zygomatic width QTL 2, 5 week (mouse)76524974896949207Mouse
1301784Ses2_msalmonella enteritidis susceptibility 2 (mouse)Not determined767290094101290240Mouse
1301663Skull9_mskull morphology 9 (mouse)Not determined75732612191326352Mouse
14746989Manh62_mmandible shape 62 (mouse)775742528109742528Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745161966118693530Mouse
27226765Tibl18_mtibia length 18, 16 week (mouse)781849748126499172Mouse
1301383Aem2_manti-erythrocyte autoantibody modifier 2 (mouse)Not determined76413542498135653Mouse
1301514Rigs1_mradiation induced gastroschisis 1 (mouse)Not determined73628001592394346Mouse
4142500Morq1_mmodifier of Rs1 QTL 1 (mouse)Not determined80551681114551791Mouse
27095937Ulnl7_mulna length 7, 10 week (mouse)76644974898349207Mouse
11565101Tsve1_mvariable short tail (Tsv) enhancer 1 (mouse)75588950887142720Mouse
1300620Pgia21_mproteoglycan induced arthritis 21 (mouse)Not determined767290094101290240Mouse
13208555Lgth10_mbody length 10 (mouse)751649748125599172Mouse
26884408Bzwq13_mbi-zygomatic width QTL 13, 16 week (mouse)761749748121399223Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined739673887103510010Mouse
10054064Bwq11_mbody weight QTL 11 (mouse)Not determined75112495485125093Mouse
10053685Eae43_mexperimental allergic encephalomyelitis susceptibility 43 (mouse)Not determined75112495485125093Mouse
1301566Adip3_madiposity 3 (mouse)Not determined775394215109394346Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730199425108999207Mouse
1301155Bpq7_mblood pressure QTL 7 (mouse)Not determined770143137104143379Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)778649748136901729Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
4142212Png1_mPostnatal growth 1 (mouse)Not determined7432612192394346Mouse
1300654Bomd1_mbone mineral density 1 (mouse)Not determined768365595102365702Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765249748126499172Mouse
27095903Scvln10_msacral vertebrae length 2, 10 week (mouse)781449748126499172Mouse
27226715Metcl3_mmetatarsal-calcaneal length 3, 5 week (mouse)767849748119499223Mouse
26884444Sklq8_mskull length QTL 8, 10 week (mouse)767849748124199223Mouse
25823170Hrsq7_mhost response to SARS QTL 7, log titer (mouse)754819589116822815Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
1301465Egrm3_mearly growth rate (mouse)Not determined75732612191326352Mouse
1300952Hcs1_mhepatocarcinogenesis susceptibility 1 (mouse)Not determined75732612191326352Mouse
4142319Powg_mpost-ovarectomy weight gain (mouse)Not determined7285710592582163Mouse
10412110Cctq1_mcentral corneal thickness QTL 1 (mouse)Not determined780551681114551791Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1301826Pgia3_mproteoglycan induced arthritis 3 (mouse)Not determined767290094101290240Mouse
26884418Bzwq7_mbi-zygomatic width QTL 7, 10 week (mouse)767849748105449207Mouse
10043973Obq29_mobesity QTL 29 (mouse)Not determined772263372106263372Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
12880418V125Dq6_mvitamin D active form serum level QTL 6 (mouse)75214974886149748Mouse
27226745Metcl9_mmetatarsal-calcaneal length 9, 10 week (mouse)774849748122199223Mouse
27095930Ulnl10_mulna length 10, 16 week (mouse)780849748126699172Mouse
27095923Pglq3_mpelvic girdle length QTL 3, 5 week (mouse)781249748124199223Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)761749748123699223Mouse
12801463Rta1_mretinal aging 1 (mouse)76716802789089989Mouse
11553865Stmm1c_mskin tumor modifier of MSM 1c (mouse)76578898699788986Mouse
26884451Sklq14_mskull length QTL 14, 16 week (mouse)767849748124999172Mouse
11553866Stmm1d_mskin tumor modifier of MSM 1d (mouse)76578898699788986Mouse
27095910Pglq13_mpelvic girdle length QTL 13, 16 week (mouse)773049748125699172Mouse
25314303Vmm4_mvariable multisystem mineralization 4, kidney (mouse)73729942587049208Mouse
11553869Stmm2b_mskin tumor modifier of MSM 2a (mouse)773725965107725965Mouse
27095907Scvln4_msacral vertebrae length 2, 5 week (mouse)769949748120499223Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000032865   ⟹   ENSMUSP00000032865
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl784,234,367 - 84,255,150 (-)Ensembl
GRCm38.p6 Ensembl784,585,159 - 84,605,942 (-)Ensembl
Ensembl Acc Id: ENSMUST00000128460   ⟹   ENSMUSP00000121439
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl784,244,737 - 84,255,930 (-)Ensembl
GRCm38.p6 Ensembl784,595,529 - 84,606,722 (-)Ensembl
Ensembl Acc Id: ENSMUST00000134390
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl784,250,829 - 84,254,937 (-)Ensembl
GRCm38.p6 Ensembl784,601,621 - 84,605,729 (-)Ensembl
Ensembl Acc Id: ENSMUST00000153126
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl784,250,285 - 84,251,308 (-)Ensembl
GRCm38.p6 Ensembl784,601,077 - 84,602,100 (-)Ensembl
Ensembl Acc Id: ENSMUST00000209112
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl784,246,256 - 84,255,112 (-)Ensembl
GRCm38.p6 Ensembl784,597,048 - 84,605,904 (-)Ensembl
RefSeq Acc Id: NM_010176   ⟹   NP_034306
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39784,234,367 - 84,255,150 (-)NCBI
GRCm38784,585,159 - 84,605,942 (-)ENTREZGENE
MGSCv37791,733,669 - 91,754,452 (-)RGD
Celera781,987,620 - 82,008,470 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_034306   ⟸   NM_010176
- UniProtKB: Q3TY87 (UniProtKB/Swiss-Prot),   Q9QW65 (UniProtKB/Swiss-Prot),   P35505 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000032865   ⟸   ENSMUST00000032865
Ensembl Acc Id: ENSMUSP00000121439   ⟸   ENSMUST00000128460
Protein Domains
Fumarylacetoacetase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35505-F1-model_v2 AlphaFold P35505 1-419 view protein structure

Promoters
RGD ID:8664689
Promoter ID:EPDNEW_M10376
Type:initiation region
Name:Fah_1
Description:Mus musculus fumarylacetoacetate hydrolase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38784,605,786 - 84,605,846EPDNEW
RGD ID:6841067
Promoter ID:MM_KWN:51416
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000061684,   OTTMUST00000061686
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36791,753,846 - 91,754,807 (-)MPROMDB
RGD ID:6841065
Promoter ID:MM_KWN:51417
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000061685
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36791,754,921 - 91,755,421 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95482 AgrOrtholog
Ensembl Genes ENSMUSG00000030630 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000032865 ENTREZGENE
  ENSMUST00000032865.17 UniProtKB/Swiss-Prot
  ENSMUST00000128460.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.30.230 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.850.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Fumarylacetoacetase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fumarylacetoacetase-like_C UniProtKB/Swiss-Prot
  Fumarylacetoacetase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fumarylacetoacetase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fumarylacetoacetase_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14085 UniProtKB/Swiss-Prot
MGD MGI:95482 ENTREZGENE
NCBI Gene 14085 ENTREZGENE
PANTHER FUMARYLACETOACETASE UniProtKB/Swiss-Prot
  FUMARYLACETOACETASE UniProtKB/TrEMBL
  FUMARYLACETOACETASE UniProtKB/TrEMBL
  PTHR43069 UniProtKB/Swiss-Prot
Pfam FAA_hydrolase UniProtKB/Swiss-Prot
  FAA_hydrolase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fah PhenoGen
Superfamily-SCOP SSF56529 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF63433 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3Z2R9_MOUSE UniProtKB/TrEMBL
  FAAA_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TY87 ENTREZGENE
  Q9QW65 ENTREZGENE
UniProt Secondary Q3TY87 UniProtKB/Swiss-Prot
  Q9QW65 UniProtKB/Swiss-Prot