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Gene: Fah (fumarylacetoacetate hydrolase) Mus musculus
Symbol: Fah
Name: fumarylacetoacetate hydrolase
RGD ID: 62225
Description: Exhibits fumarylacetoacetase activity. Involved in arginine catabolic process. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and skeleton. Used to study tyrosinemia type I. Human ortholog(s) of this gene implicated in tyrosinemia type I. Orthologous to human FAH (fumarylacetoacetate hydrolase); PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; INTERACTS WITH 1,1-dichloroethene; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: beta-diketonase; FAA; fumarylacetoacetase; sw; swst
Homo sapiens (human) : FAH (fumarylacetoacetate hydrolase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Fah (fumarylacetoacetate hydrolase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fah (fumarylacetoacetate hydrolase)
Pan paniscus (bonobo/pygmy chimpanzee) : FAH (fumarylacetoacetate hydrolase)
Canis lupus familiaris (dog) : FAH (fumarylacetoacetate hydrolase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fah (fumarylacetoacetate hydrolase)
Sus scrofa (pig) : FAH (fumarylacetoacetate hydrolase)
Chlorocebus sabaeus (African green monkey) : FAH (fumarylacetoacetate hydrolase)
Heterocephalus glaber (naked mole-rat) : Fah (fumarylacetoacetate hydrolase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl784,585,159 - 84,606,722 (-)EnsemblGRCm38mm10GRCm38
GRCm38784,585,159 - 84,605,942 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37791,733,669 - 91,754,452 (-)NCBIGRCm37mm9NCBIm37
MGSCv36784,461,355 - 84,481,937 (-)NCBImm8
Celera781,987,620 - 82,008,470 (-)NCBICelera
Cytogenetic Map7D3NCBI
cM Map748.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Fah
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 62225
Created: 2001-04-11
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.